A C Kotze

Summary

Country: Australia

Publications

  1. ncbi request reprint Relative potency of macrocyclic lactones in in vitro assays with larvae of susceptible and drug-resistant Australian isolates of Haemonchus contortus and H. placei
    Andrew C Kotze
    CSIRO Animal, Food and Health Sciences, Brisbane, QLD, Australia Electronic address
    Vet Parasitol 203:294-302. 2014
  2. doi request reprint Target-based and whole-worm screening approaches to anthelmintic discovery
    A C Kotze
    CSIRO Livestock Industries, 306 Carmody Rd, St Lucia, QLD 4067, Australia
    Vet Parasitol 186:118-23. 2012
  3. ncbi request reprint RNA interference in Haemonchus contortus: suppression of beta-tubulin gene expression in L3, L4 and adult worms in vitro
    Andrew C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, QLD 4067, Australia
    Mol Biochem Parasitol 145:101-10. 2006
  4. ncbi request reprint Toxicity of Bacillus thuringiensis to parasitic and free-living life-stages of nematode parasites of livestock
    A C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Int J Parasitol 35:1013-22. 2005
  5. ncbi request reprint Field evaluation of anthelmintic drug sensitivity using in vitro egg hatch and larval motility assays with Necator americanus recovered from human clinical isolates
    A C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Int J Parasitol 35:445-53. 2005
  6. ncbi request reprint A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites
    A C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Vet Parasitol 137:294-305. 2006
  7. pmc The potential impact of density dependent fecundity on the use of the faecal egg count reduction test for detecting drug resistance in human hookworms
    Andrew C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 2:e297. 2008
  8. ncbi request reprint Catalase induction protects Haemonchus contortus against hydrogen peroxide in vitro
    Andrew C Kotze
    CSIRO Livestock Industries, 120 Meiers Road, Indooroopilly, Queensland, 4068, Australia
    Int J Parasitol 33:393-400. 2003
  9. doi request reprint Exploring the anthelmintic properties of Australian native shrubs with respect to their potential role in livestock grazing systems
    A C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, QLD, 4067, Australia
    Parasitology 136:1065-80. 2009
  10. ncbi request reprint High-level ivermectin resistance in a field isolate of Haemonchus contortus associated with a low level of resistance in the larval stage: implications for resistance detection
    Andrew C Kotze
    CSIRO Livestock Industries, McMaster Laboratory, Locked Bag 1 Delivery Centre, Blacktown 2148, NSW, Australia
    Vet Parasitol 108:255-63. 2002

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Relative potency of macrocyclic lactones in in vitro assays with larvae of susceptible and drug-resistant Australian isolates of Haemonchus contortus and H. placei
    Andrew C Kotze
    CSIRO Animal, Food and Health Sciences, Brisbane, QLD, Australia Electronic address
    Vet Parasitol 203:294-302. 2014
    ..The study also highlights the usefulness of eprinomectin as a readily-available compound which is a more sensitive marker for ML resistance in in vitro larval development assays than the other commercial ML compounds examined. ..
  2. doi request reprint Target-based and whole-worm screening approaches to anthelmintic discovery
    A C Kotze
    CSIRO Livestock Industries, 306 Carmody Rd, St Lucia, QLD 4067, Australia
    Vet Parasitol 186:118-23. 2012
    ..Finally, the role of whole-worm screening approaches versus target-based screening is discussed briefly...
  3. ncbi request reprint RNA interference in Haemonchus contortus: suppression of beta-tubulin gene expression in L3, L4 and adult worms in vitro
    Andrew C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, QLD 4067, Australia
    Mol Biochem Parasitol 145:101-10. 2006
    ..We have shown that soaking in dsRNA is an effective method for RNAi with the parasitic stages of H. contortus, and, hence, may offer significant potential as a tool for studying gene function in this parasite species...
  4. ncbi request reprint Toxicity of Bacillus thuringiensis to parasitic and free-living life-stages of nematode parasites of livestock
    A C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Int J Parasitol 35:1013-22. 2005
    ....
  5. ncbi request reprint Field evaluation of anthelmintic drug sensitivity using in vitro egg hatch and larval motility assays with Necator americanus recovered from human clinical isolates
    A C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Int J Parasitol 35:445-53. 2005
    ..While the assays proved effective in quantifying drug sensitivity in larvae of the drug-susceptible hookworms examined in this study, their ability to indicate drug resistance in larval or adult hookworms remains to be determined...
  6. ncbi request reprint A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites
    A C Kotze
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Vet Parasitol 137:294-305. 2006
    ..The assay therefore also has a potential role in drug discovery programmes in screening for new anthelmintics...
  7. pmc The potential impact of density dependent fecundity on the use of the faecal egg count reduction test for detecting drug resistance in human hookworms
    Andrew C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 2:e297. 2008
    ....
  8. ncbi request reprint Catalase induction protects Haemonchus contortus against hydrogen peroxide in vitro
    Andrew C Kotze
    CSIRO Livestock Industries, 120 Meiers Road, Indooroopilly, Queensland, 4068, Australia
    Int J Parasitol 33:393-400. 2003
    ..The ability of H contortus to increase its catalase activity may be crucial in allowing it to respond to the production of reactive oxygen species by host phagocytes in vivo...
  9. doi request reprint Exploring the anthelmintic properties of Australian native shrubs with respect to their potential role in livestock grazing systems
    A C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, QLD, 4067, Australia
    Parasitology 136:1065-80. 2009
    ....
  10. ncbi request reprint High-level ivermectin resistance in a field isolate of Haemonchus contortus associated with a low level of resistance in the larval stage: implications for resistance detection
    Andrew C Kotze
    CSIRO Livestock Industries, McMaster Laboratory, Locked Bag 1 Delivery Centre, Blacktown 2148, NSW, Australia
    Vet Parasitol 108:255-63. 2002
    ..This study highlights the need to examine this aspect of LDAs in order to detect the type of resistance displayed by IVPro H. contortus...
  11. ncbi request reprint Dose-response assay templates for in vitro assessment of resistance to benzimidazole and nicotinic acetylcholine receptor agonist drugs in human hookworms
    Andrew C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, Australia
    Am J Trop Med Hyg 81:163-70. 2009
    ..These assays will have immediate applicability in monitoring for the emergence of drug resistance in human hookworm populations...
  12. doi request reprint Animal grazing selectivity and plant chemistry issues impact on the potential of Rhagodia preissii as an anthelmintic shrub
    A C Kotze
    CSIRO Livestock Industries, St Lucia, QLD, Australia
    Parasitology 138:628-37. 2011
    ....
  13. pmc The effect of egg embryonation on field-use of a hookworm benzimidazole-sensitivity egg hatch assay in Yunnan Province, People's Republic of China
    Andrew C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, Australia
    PLoS Negl Trop Dis 5:e1203. 2011
    ..The current study aimed to evaluate an in vitro egg hatch assay for measuring the sensitivity of human hookworms to benzimidazole drugs in an isolated field setting in southern Yunnan province, People's Republic of China...
  14. ncbi request reprint Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: potential for drug-synergism through inhibition of nematode oxidative detoxification pathways
    A C Kotze
    CSIRO Livestock Industries, St Lucia, Australia
    Vet Parasitol 136:275-82. 2006
    ....
  15. ncbi request reprint An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species
    A C Kotze
    Commonwealth Scientific and Industrial Research Organisation Livestock Industries, St Lucia, Queensland 4067, Australia
    Am J Trop Med Hyg 71:608-16. 2004
    ....
  16. ncbi request reprint Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda)
    A C Kotze
    CSIRO Division of Animal Production, McMaster Laboratory, Blacktown, NSW, Australia
    Int J Parasitol 27:33-40. 1997
    ..It is apparent that H. contortus possesses cytochrome P450 monooxygenase activities; however, they may be important only in the free-living stages, and be of little significance in parasitic stages existing in oxygen-poor environments...
  17. ncbi request reprint Peroxide-supported in-vitro cytochrome P450 activities in Haemonchus contortus
    A C Kotze
    CSIRO Division of Animal Production, McMaster Laboratory, Blacktown, NSW, Australia
    Int J Parasitol 29:389-96. 1999
    ....
  18. ncbi request reprint Investigation of intestinal nematode responses to naphthalophos and pyrantel using a larval development assay
    A C Kotze
    CSIRO Animal Production, McMaster Laboratory, Blacktown, NSW, Australia
    Int J Parasitol 29:1093-9. 1999
    ..This study has highlighted the varied suitability of the larval development assay technique for resistance detection with different combinations of drugs and parasite species...
  19. ncbi request reprint The requirement for early exposure of Haemonchus contortus larvae to Bacillus thuringiensis for effective inhibition of larval development
    R J Akhurst
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Vet Parasitol 150:97-103. 2007
    ....
  20. doi request reprint Dual oxidase 2 and glutathione peroxidase gene expression are elevated in hyperimmunized sheep challenged with Haemonchus contortus
    M S Lees
    CSIRO Livestock Industries, 306 Carmody Road, St Lucia, Queensland 4067, Australia
    Vet Parasitol 179:113-22. 2011
    ....
  21. ncbi request reprint Haemonchus contortus: in vitro drug screening assays with the adult life stage
    J O'Grady
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Rd, St Lucia, QLD 4067, Australia
    Exp Parasitol 106:164-72. 2004
    ..A lack of activity in subsequent in vivo trials could, therefore, be most likely attributable to host pharmacokinetic factors rather than an intrinsic lack of activity of the drug towards the adult parasite...
  22. doi request reprint Molecular cloning and characterisation of ovine dual oxidase 2
    M S Lees
    CSIRO Livestock Industries, St Lucia, Queensland, Australia
    Gene 500:40-6. 2012
    ..Possible transcription factor families that may regulate this process were identified as Kruppel-like factors (KLF), ETS-factors, erythroid growth receptor factors (EGRF) and myogenic differentiation factors (MYOD)...
  23. ncbi request reprint cDNA cloning and expression patterns of a peroxiredoxin, a catalase and a glutathione peroxidase from Haemonchus contortus
    N H Bagnall
    Queensland Bioscience Precinct, CSIRO Livestock Industries, 306 Carmody Rd, QLD 4068 St Lucia, Australia
    Parasitol Res 94:283-9. 2004
    ....
  24. ncbi request reprint Oxidase activities in macrocyclic-resistant and -susceptible Haemonchus contortus
    A C Kotze
    CSIRO Animal Production, McMaster Laboratory, Blacktown, NSW, Australia
    J Parasitol 86:873-6. 2000
    ..It is apparent that oxidase activities toward the 2 substrates are not enhanced in the resistant isolate, suggesting that the observed resistance to macrocyclic lactones may not involve enhanced oxidative metabolism...
  25. ncbi request reprint Haemonchus contortus utilises catalase in defence against exogenous hydrogen peroxide in vitro
    A C Kotze
    CSIRO Livestock Industries, Locked Bag 1 Delivery Centre, Blacktown, NSW, 2148, Australia
    Int J Parasitol 31:1563-71. 2001
    ....
  26. doi request reprint Strategies for the storage of Ancylostoma caninum third-stage larvae
    S R Kopp
    School of Veterinary Science, University of Queensland, Queensland, Australia
    J Parasitol 94:755-6. 2008
    ..Motility and migratory ability of cryopreserved larvae was only significantly higher (P < 0.01) than room temperature-stored larvae from 4 and 5 mo onward, respectively...
  27. pmc Cyclotide interactions with the nematode external surface
    Michelle L Colgrave
    University of Queensland Institute for Molecular Bioscience, Brisbane, Australia
    Antimicrob Agents Chemother 54:2160-6. 2010
    ....
  28. ncbi request reprint Effect of ivermectin on feeding by Haemonchus contortus in vivo
    James C Sheriff
    CSIRO Livestock Industries, Clunies Ross Street, Prospect, NSW 2148, Australia Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
    Vet Parasitol 128:341-6. 2005
    ..contortus in vivo under these experimental conditions. The results are discussed in relation to the dynamics of the expulsion of H. contortus from sheep following ivermectin treatment...
  29. doi request reprint The use of DNA markers to map anthelmintic resistance loci in an intraspecific cross of Haemonchus contortus
    P W Hunt
    CSIRO, F D McMaster Laboratory, Chiswick, New England Highway, Armidale, N S W 2350, Australia
    Parasitology 137:705-17. 2010
    ..The data we obtained suggest that marker association can be used to link neutral markers with resistance, but also that more markers and perhaps more inbred laboratory strains would make the procedure more likely to succeed...
  30. pmc Phenotypic characterization of two Ancylostoma caninum isolates with different susceptibilities to the anthelmintic pyrantel
    Steven R Kopp
    School of Veterinary Science, University of Queensland, Brisbane, Australia
    Antimicrob Agents Chemother 52:3980-6. 2008
    ..Our data indicate a complex pattern of nAchRs in this species and suggest that the two isolates differ in their relative sensitivities to agonists targeting different nAchRs...
  31. pmc Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity
    Yen Hua Huang
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 285:10797-805. 2010
    ..Our data clearly highlight the residues crucial for nematocidal and hemolytic activity in cyclotides, and demonstrate that the nematocidal activity of cyclotides can be increased by incorporation of basic amino acids...
  32. ncbi request reprint A pair of adjacent genes, cry5Ad and orf2-5Ad, encode the typical N- and C-terminal regions of a Cry5Adelta-endotoxin as two separate proteins in Bacillus thuringiensis strain L366
    Ian J Lenane
    CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, QLD, Australia
    FEMS Microbiol Lett 278:115-20. 2008
    ..thuringiensis strain L366...
  33. doi request reprint An ortholog of the ecdysone receptor protein (EcR) from the parasitic nematode Haemonchus contortus
    Lloyd D Graham
    CSIRO Food and Nutritional Sciences, P O Box 52, North Ryde, NSW 1670, Australia
    Mol Biochem Parasitol 171:104-7. 2010
    ..Recombinant co-expression of HcEcR DE/F segments with a phthirapteran USP DE/F segment in insect cells resulted in stable proteins which did not heterodimerize or bind [(3)H]ponasterone A...
  34. ncbi request reprint Effects of macrocyclic lactone anthelmintics on feeding and pharyngeal pumping in Trichostrongylus colubriformis in vitro
    J C Sheriff
    Faculty of Veterinary Science, University of Sydney, NSW, Australia
    Parasitology 125:477-84. 2002
    ....
  35. doi request reprint Evaluation of reference genes for real-time PCR quantification of gene expression in the Australian sheep blowfly, Lucilia cuprina
    N H Bagnall
    CSIRO Commonwealth Scientific and Industrial Research Organization Livestock Industries, St Lucia, Brisbane, Queensland 4067, Australia
    Med Vet Entomol 24:176-81. 2010
    ..GAPDH was shown to be a poor reference gene. The reference gene recommendations in this study will be of use to laboratories investigating gene expression in L. cuprina and related blowfly species...
  36. ncbi request reprint The anthelmintic activity of the cyclotides: natural variants with enhanced activity
    Michelle L Colgrave
    CSIRO Livestock Industries, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Chembiochem 9:1939-45. 2008
    ..The relative anthelmintic activities of the natural variants assayed against nematode larvae correlated with the number of charged residues present in their sequence...
  37. doi request reprint Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms
    Michelle L Colgrave
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Acta Trop 109:163-6. 2009
    ..This study demonstrates that cyclotides have promising activity in vitro against important parasites of companion animals and humans...
  38. doi request reprint Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep
    Michelle L Colgrave
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    Biochemistry 47:5581-9. 2008
    ..These results demonstrate that the cyclotides show potential for use in the control of gastrointestinal nematode parasites...
  39. ncbi request reprint High-level pyrantel resistance in the hookworm Ancylostoma caninum
    Steven R Kopp
    School of Veterinary Science, University of Queensland, 4072 QLD, Australia
    Vet Parasitol 143:299-304. 2007
    ..They further indicate that the faecal egg count reduction test needs to be used with caution with this parasite...
  40. doi request reprint Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum
    Steven R Kopp
    School of Veterinary Science, University of Queensland, Australia
    Vet Parasitol 152:284-93. 2008
    ..caninum. The present study also indicates that potential exists for the novel LAMA or the LMA to be of use in detecting pyrantel resistance in the human hookworms, Necator americanus and Ancylostoma duodenale...