Adam J Karpala

Summary

Country: Australia

Publications

  1. ncbi IFN-gamma enhances immune responses to E. coli infection in the chicken
    Vijaya Janardhana
    CSIRO, Livestock Industries, AAHL, Victoria, Australia
    J Interferon Cytokine Res 27:937-46. 2007
  2. doi Molecular cloning, expression, and characterization of chicken IFN -lambda
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Interferon Cytokine Res 28:341-50. 2008
  3. doi Highly pathogenic (H5N1) avian influenza induces an inflammatory T helper type 1 cytokine response in the chicken
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    J Interferon Cytokine Res 31:393-400. 2011
  4. pmc Visualising single molecules of HIV-1 and miRNA nucleic acids
    Kate L Jones
    Centre for Virology, Burnet Institute, Melbourne, Australia
    BMC Cell Biol 14:21. 2013
  5. doi Identifying innate immune pathways of the chicken may lead to new antiviral therapies
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia
    Vet Immunol Immunopathol 148:100-9. 2012
  6. doi Ontogeny of the interferon system in chickens
    Adam J Karpala
    CSIRO, Livestock Industries, AAHL, 5, Portarlington Road, Geelong, Victoria, 3220 Australia
    J Reprod Immunol 94:169-74. 2012
  7. ncbi Immune responses to dsRNA: implications for gene silencing technologies
    Adam J Karpala
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria
    Immunol Cell Biol 83:211-6. 2005
  8. doi Characterization of chicken Mda5 activity: regulation of IFN-β in the absence of RIG-I functionality
    Adam J Karpala
    Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Victoria 3220, Australia
    J Immunol 186:5397-405. 2011
  9. ncbi Activation of the TLR3 pathway regulates IFNbeta production in chickens
    Adam J Karpala
    CSIRO, Livestock Industries, AAHL, 5, Portarlington Road, Victoria 3220, Australia
    Dev Comp Immunol 32:435-44. 2008
  10. doi Toll-like receptor 7 ligands inhibit influenza A infection in chickens
    Cameron R Stewart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Interferon Cytokine Res 32:46-51. 2012

Collaborators

Detail Information

Publications12

  1. ncbi IFN-gamma enhances immune responses to E. coli infection in the chicken
    Vijaya Janardhana
    CSIRO, Livestock Industries, AAHL, Victoria, Australia
    J Interferon Cytokine Res 27:937-46. 2007
    ..Cumulatively, these findings are indicative of in vivo enhancement of immune responses due to ChIFN-gamma. However, administration of ChIFN-gamma protein did not mitigate the development of air sac lesions following E. coli infection...
  2. doi Molecular cloning, expression, and characterization of chicken IFN -lambda
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Interferon Cytokine Res 28:341-50. 2008
    ..Our results demonstrate that in the chicken, as in human, the antiviral activity demonstrated by ChIFN-lambda supports its inclusion in therapeutic strategies directed against viral infections...
  3. doi Highly pathogenic (H5N1) avian influenza induces an inflammatory T helper type 1 cytokine response in the chicken
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    J Interferon Cytokine Res 31:393-400. 2011
    ....
  4. pmc Visualising single molecules of HIV-1 and miRNA nucleic acids
    Kate L Jones
    Centre for Virology, Burnet Institute, Melbourne, Australia
    BMC Cell Biol 14:21. 2013
    ..Here, we offer a generic and highly sensitive visualization approach (oligo fluorescent in situ hybridization, O-FISH) that can be used to detect such nucleic acids using a single-oligonucleotide probe of 19-26 nucleotides in length...
  5. doi Identifying innate immune pathways of the chicken may lead to new antiviral therapies
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia
    Vet Immunol Immunopathol 148:100-9. 2012
    ..This review outlines important mammalian antiviral mechanisms that have been modulated to strengthen viral immunity and highlights the potential application of these strategies in the chicken, especially in regards, to AI...
  6. doi Ontogeny of the interferon system in chickens
    Adam J Karpala
    CSIRO, Livestock Industries, AAHL, 5, Portarlington Road, Geelong, Victoria, 3220 Australia
    J Reprod Immunol 94:169-74. 2012
    ....
  7. ncbi Immune responses to dsRNA: implications for gene silencing technologies
    Adam J Karpala
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria
    Immunol Cell Biol 83:211-6. 2005
    ..Thus, it is beneficial to understand all aspects of the immune response to dsRNA in order to manipulate these systems and minimize unwanted non-specific effects...
  8. doi Characterization of chicken Mda5 activity: regulation of IFN-β in the absence of RIG-I functionality
    Adam J Karpala
    Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Victoria 3220, Australia
    J Immunol 186:5397-405. 2011
    ..Collectively, although Mda5 is functionally active in the chicken, the absence of an apparent RIG-I-like function may contribute to the chicken's susceptibility to highly pathogenic influenza...
  9. ncbi Activation of the TLR3 pathway regulates IFNbeta production in chickens
    Adam J Karpala
    CSIRO, Livestock Industries, AAHL, 5, Portarlington Road, Victoria 3220, Australia
    Dev Comp Immunol 32:435-44. 2008
    ..The interrelationship between TLR3 and interferon as well as the observed increase in TLR3 and IFNbeta expression during H5N1 avian influenza infection indicates the importance of these molecules in viral infections in chickens...
  10. doi Toll-like receptor 7 ligands inhibit influenza A infection in chickens
    Cameron R Stewart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Interferon Cytokine Res 32:46-51. 2012
    ..These results demonstrate that nucleic acid-sensing TLR ligands show considerable potential as antivirals in chickens and could be incorporated into antiviral strategies...
  11. pmc Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian influenza H5N1
    Cameron R Stewart
    Infection and Immunity, The Commonwealth Scientific and Industrial Research Organisation Australian Animal Health Laboratory, Geelong, Victoria, Australia
    PLoS ONE 6:e21552. 2011
    ..These data demonstrate the ability of an immunostimulatory motif to improve the performance of an RNAi-based antiviral, a finding that may influence the design of future RNAi-based anti-influenza therapeutics...
  12. ncbi H5N1 infection causes rapid mortality and high cytokine levels in chickens compared to ducks
    Simon Burggraaf
    CSIRO Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia School of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia
    Virus Res 185:23-31. 2014
    ..These observations support that hypercytokinemia may contribute to pathogenesis in chickens, whilst the lower cytokine response in ducks may be a factor in their apparent resistance to disease and decreased mortality. ..