Rheal A Towner

Summary

Affiliation: James Cook University
Country: Australia

Publications

  1. ncbi request reprint In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry)
    Rheal A Towner
    Department of Physiology and Pharmacology, North Queensland Magnetic Resonance Centre, School of Biomedical and Molecular Sciences, James Cook University, Molecular Sciences Building, Townsville, QLD, Australia
    Chem Biol Interact 139:231-50. 2002
  2. ncbi request reprint Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepatotoxicity in rats
    R A Towner
    North Queensland Magnetic Resonance Centre, James Cook University, Townsville, Australia
    Biochim Biophys Acta 1475:314-20. 2000
  3. ncbi request reprint Assessment of in vivo oxidative lipid metabolism following acute microcystin-LR-induced hepatotoxicity in rats
    Rheal A Towner
    Department of Physiology and Pharmacology, School of Biomedical Sciences, James Cook University, Townsville, Australia
    Free Radic Res 36:63-71. 2002
  4. ncbi request reprint In vivo detection of aflatoxin-induced lipid free radicals in rat bile
    R A Towner
    North Queensland Magnetic Resonance Centre and Department of Physiology and Pharmacology, School of Biomedical Sciences, Molecular Sciences Building, James Cook University, Townsville 4811 Queensland, Australia
    Biochim Biophys Acta 1573:55-62. 2002
  5. ncbi request reprint In vivo image-guided (1)H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model
    L M Foley
    North Queensland Magnetic Resonance Centre, Department of Physiology and Pharmacology, James Cook University, Townsville, Australia
    Biochim Biophys Acta 1526:230-6. 2001
  6. ncbi request reprint Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Toxicol Appl Pharmacol 207:237-44. 2005
  7. ncbi request reprint In vivo identification of aflatoxin-induced free radicals in rat bile
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Biol Med 35:1330-40. 2003
  8. ncbi request reprint In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging
    Rheal A Towner
    Small Animal MRI Core Facility, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Mol Imaging 6:18-29. 2007
  9. ncbi request reprint Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats
    Yoshiko Inoue
    Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
    Free Radic Res 41:972-80. 2007
  10. ncbi request reprint Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds
    Yasvir A Tesiram
    Small Animal MRI Core Facility, Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    NMR Biomed 21:345-56. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry)
    Rheal A Towner
    Department of Physiology and Pharmacology, North Queensland Magnetic Resonance Centre, School of Biomedical and Molecular Sciences, James Cook University, Molecular Sciences Building, Townsville, QLD, Australia
    Chem Biol Interact 139:231-50. 2002
    ....
  2. ncbi request reprint Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepatotoxicity in rats
    R A Towner
    North Queensland Magnetic Resonance Centre, James Cook University, Townsville, Australia
    Biochim Biophys Acta 1475:314-20. 2000
    ..01) than controls...
  3. ncbi request reprint Assessment of in vivo oxidative lipid metabolism following acute microcystin-LR-induced hepatotoxicity in rats
    Rheal A Towner
    Department of Physiology and Pharmacology, School of Biomedical Sciences, James Cook University, Townsville, Australia
    Free Radic Res 36:63-71. 2002
    ..This study strongly suggests that oxidative stress related processes are involved in in vivo microcystin-induced hepatotoxicity in mammals, and may play an integral role in MCLR-induced toxicity...
  4. ncbi request reprint In vivo detection of aflatoxin-induced lipid free radicals in rat bile
    R A Towner
    North Queensland Magnetic Resonance Centre and Department of Physiology and Pharmacology, School of Biomedical Sciences, Molecular Sciences Building, James Cook University, Townsville 4811 Queensland, Australia
    Biochim Biophys Acta 1573:55-62. 2002
    ..This indicates that oxidation of AFB1 generates free radical species via CYP metabolism and an iron-mediated redox mechanism...
  5. ncbi request reprint In vivo image-guided (1)H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model
    L M Foley
    North Queensland Magnetic Resonance Centre, Department of Physiology and Pharmacology, James Cook University, Townsville, Australia
    Biochim Biophys Acta 1526:230-6. 2001
    ..It is anticipated that this model will precede the application of the same technology to the non-invasive diagnosis and grading of human hepatocellular carcinoma...
  6. ncbi request reprint Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Toxicol Appl Pharmacol 207:237-44. 2005
    ..The results of our study suggest that MRS-detected alterations in lipid metabolism can be correlated with the grading of liver tumor tissue at different stages during the carcinogenesis process...
  7. ncbi request reprint In vivo identification of aflatoxin-induced free radicals in rat bile
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Biol Med 35:1330-40. 2003
    ..Trapped 4-POBN radical adducts were also detected in rat bile following the in vivo metabolism of aflatoxin-M1, one of the hydroxylated metabolites of AFB1...
  8. ncbi request reprint In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging
    Rheal A Towner
    Small Animal MRI Core Facility, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Mol Imaging 6:18-29. 2007
    ..This method has the ability to visualize in vivo the overexpression of c-MET at early developmental stages of tumor formation...
  9. ncbi request reprint Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats
    Yoshiko Inoue
    Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
    Free Radic Res 41:972-80. 2007
    ..The CD diet model is also considered as a model for non-alcoholic steatohepatitis (NASH) in humans and early expression of Fas could also be a good index of the progression of NASH...
  10. ncbi request reprint Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds
    Yasvir A Tesiram
    Small Animal MRI Core Facility, Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    NMR Biomed 21:345-56. 2008
    ....
  11. ncbi request reprint Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model
    Sabrina Doblas
    Oklahoma University Bioengineering Center, Norman, OK, USA
    Free Radic Biol Med 44:63-72. 2008
    ..The MR methods that we used also proved to be particularly suitable in following the angiogenic behavior and treatment response of a potential anti-glioma agent in a rat C6 glioma model...