Peter Iliades

Summary

Country: Australia

Publications

  1. ncbi request reprint Promoter strength of folic acid synthesis genes affects sulfa drug resistance in Saccharomyces cerevisiae
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia 3052
    Microb Drug Resist 9:249-55. 2003
  2. pmc Dihydropteroate synthase mutations in Pneumocystis jiroveci can affect sulfamethoxazole resistance in a Saccharomyces cerevisiae model
    Peter Iliades
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 48:2617-23. 2004
  3. ncbi request reprint Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Vic, Australia
    Fungal Genet Biol 41:1053-62. 2004
  4. pmc Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs
    Peter Iliades
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 49:741-8. 2005
  5. ncbi request reprint Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, 3052, Australia
    Microb Drug Resist 11:1-8. 2005
  6. ncbi request reprint The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae
    Michael C Lawrence
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Mol Biol 348:655-70. 2005
  7. ncbi request reprint A rapid assay for dihydropteroate synthase activity suitable for identification of inhibitors
    Ross T Fernley
    CSIRO, Molecular and Health Technologies, Parkville, VIC 3052, Australia
    Anal Biochem 360:227-34. 2007
  8. ncbi request reprint Analysis in Escherichia coli of Plasmodium falciparum dihydropteroate synthase (DHPS) alleles implicated in resistance to sulfadoxine
    Janette Berglez
    Biomolecular Research Institute, CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, VIC 3052, Australia
    Int J Parasitol 34:95-100. 2004

Detail Information

Publications8

  1. ncbi request reprint Promoter strength of folic acid synthesis genes affects sulfa drug resistance in Saccharomyces cerevisiae
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia 3052
    Microb Drug Resist 9:249-55. 2003
    ..However, high FOL1 expression levels resulted in increased susceptibility to sulfamethoxazole in pABA free media. These data suggest that up-regulation of FOL1 expression can lead to sulfa drug resistance in Saccharomyces cerevisiae...
  2. pmc Dihydropteroate synthase mutations in Pneumocystis jiroveci can affect sulfamethoxazole resistance in a Saccharomyces cerevisiae model
    Peter Iliades
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 48:2617-23. 2004
    ..Upregulated PABA synthesis was thus implicated as a mechanism for sulfa drug resistance for mutants having two DHPS substitutions...
  3. ncbi request reprint Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Vic, Australia
    Fungal Genet Biol 41:1053-62. 2004
    ..Functional complementation allowed evaluation of DHPS mutations implicated with sulfa drug resistance...
  4. pmc Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs
    Peter Iliades
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 49:741-8. 2005
    ..We propose that SCP, SMP, and SDZ should be considered for clinical evaluation against PCP or for future development of novel sulfa drug compounds...
  5. ncbi request reprint Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, 3052, Australia
    Microb Drug Resist 11:1-8. 2005
    ..Two sulfa drugs (sulfachloropyridazine and sulfathiazole) were identified that had higher inhibitory potential than sulfamethoxazole, which is currently the preferred treatment for PCP...
  6. ncbi request reprint The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae
    Michael C Lawrence
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Mol Biol 348:655-70. 2005
    ..cerevisiae and probably other fungal species...
  7. ncbi request reprint A rapid assay for dihydropteroate synthase activity suitable for identification of inhibitors
    Ross T Fernley
    CSIRO, Molecular and Health Technologies, Parkville, VIC 3052, Australia
    Anal Biochem 360:227-34. 2007
    ....
  8. ncbi request reprint Analysis in Escherichia coli of Plasmodium falciparum dihydropteroate synthase (DHPS) alleles implicated in resistance to sulfadoxine
    Janette Berglez
    Biomolecular Research Institute, CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, VIC 3052, Australia
    Int J Parasitol 34:95-100. 2004
    ..All mutant alleles remained sensitive to sulfachloropyridazine and sulfacetamide. These results suggest new drugs that could be tried for effective malaria treatment...