R Holliday

Summary

Country: Australia

Publications

  1. ncbi request reprint A global view of the causes of ageing: an interview with Robin Holliday
    Robin Holliday
    Biogerontology 3:317-24. 2002
  2. ncbi request reprint Dual inheritance
    R Holliday
    Curr Top Microbiol Immunol 301:243-56. 2006
  3. ncbi request reprint Interconnections between genetics, ageing, pathology and medicine, as revealed in an interview with George Martin. Interview by Robin Holliday
    George Martin
    Biogerontology 7:297-303. 2006
  4. ncbi request reprint Evolution of optimal accuracy and stability in biological systems
    Robin Holliday
    The Australian Academy of Science, Canberra, Australia, 12 Roma Court, West Pennant Hills, N S W 2125, Australia
    Chem Biodivers 4:1972-8. 2007
  5. ncbi request reprint Epigenetics: a historical overview
    Robin Holliday
    Epigenetics 1:76-80. 2006
  6. ncbi request reprint Telomeres and telomerase: the commitment theory of cellular ageing revisited
    Robin Holliday
    Australian Academy of Science, Canberra, Australia
    Sci Prog 95:199-205. 2012
  7. ncbi request reprint DNA methylation and epigenotypes
    R Holliday
    Biochemistry (Mosc) 70:500-4. 2005
  8. ncbi request reprint Ageing and the extinction of large animals
    Robin Holliday
    Biogerontology 6:151-6. 2005
  9. ncbi request reprint Streptomycin, errors in mitochondria and ageing
    Robin Holliday
    Biogerontology 6:431-2. 2005
  10. ncbi request reprint Food, fertility and longevity
    Robin Holliday
    Biogerontology 7:139-41. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint A global view of the causes of ageing: an interview with Robin Holliday
    Robin Holliday
    Biogerontology 3:317-24. 2002
  2. ncbi request reprint Dual inheritance
    R Holliday
    Curr Top Microbiol Immunol 301:243-56. 2006
    ..There have also been innumerable studies on the abnormal de novo methylation and silencing of tumour suppressor genes in cancer cells...
  3. ncbi request reprint Interconnections between genetics, ageing, pathology and medicine, as revealed in an interview with George Martin. Interview by Robin Holliday
    George Martin
    Biogerontology 7:297-303. 2006
  4. ncbi request reprint Evolution of optimal accuracy and stability in biological systems
    Robin Holliday
    The Australian Academy of Science, Canberra, Australia, 12 Roma Court, West Pennant Hills, N S W 2125, Australia
    Chem Biodivers 4:1972-8. 2007
  5. ncbi request reprint Epigenetics: a historical overview
    Robin Holliday
    Epigenetics 1:76-80. 2006
    ..The human epigenome project will unravel the pattern of DNA methylation in different tissues, and will this determine whether the regulation of gene expression is at the level of DNA or chromatin, or both...
  6. ncbi request reprint Telomeres and telomerase: the commitment theory of cellular ageing revisited
    Robin Holliday
    Australian Academy of Science, Canberra, Australia
    Sci Prog 95:199-205. 2012
    ..The stochastic feature of the theory is the probability of the loss of the last uncommitted cells or the youngest committed cells. These cells have the longest lifespan and will give rise to the final population...
  7. ncbi request reprint DNA methylation and epigenotypes
    R Holliday
    Biochemistry (Mosc) 70:500-4. 2005
    ..Much is already known about the de novo methylation of tumor suppressor genes in cancer cells, but the significance of epigenetic defects during ageing and in some familial diseases remains to be determined...
  8. ncbi request reprint Ageing and the extinction of large animals
    Robin Holliday
    Biogerontology 6:151-6. 2005
    ..Fluctuating environments are more likely to promote the evolution of small short-lived species with high fecundity...
  9. ncbi request reprint Streptomycin, errors in mitochondria and ageing
    Robin Holliday
    Biogerontology 6:431-2. 2005
  10. ncbi request reprint Food, fertility and longevity
    Robin Holliday
    Biogerontology 7:139-41. 2006
    ..Hibernation is a natural form of calorie restriction, and in some cases may lengthen lifespan...
  11. ncbi request reprint Aging is no longer an unsolved problem in biology
    Robin Holliday
    Australian Academy of Science, Canberra
    Ann N Y Acad Sci 1067:1-9. 2006
    ..We can therefore conclude that this evolved design is intrinsically related to the fact of aging. This in turn means that aging cannot be reversed, although it may be modulated, as, for example, by calorie restriction...
  12. ncbi request reprint Meiosis and sex: potent weapons in the competition between early eukaryotes and prokaryotes
    Robin Holliday
    Bioessays 28:1123-5. 2006
    ..Meiosis and sex could have arisen in an asexually reproducing species and formed a clonal population...
  13. ncbi request reprint Physics and the origins of molecular biology
    Robin Holliday
    J Genet 85:93-7. 2006
    ..The strength and success of molecular biology came from the many interactions between geneticists, physicists, chemists and biochemists. It was also characterized by a powerful combination of theoretical and experimental approaches...
  14. doi request reprint The extreme arrogance of anti-aging medicine
    Robin Holliday
    Australian Academy of Science, Canberra, Australia
    Biogerontology 10:223-8. 2009
    ..The anti-aging movement proposes in a few decades to reverse what has been the result of millions of years of evolution...
  15. ncbi request reprint The recombination, repair and modification of DNA
    Robin Holliday
    DNA Repair (Amst) 10:993-9. 2011
    ..The hypothesis that DNA methylation has a role in gene expression in higher organism is now supported by abundant evidence. Direct evidence that gene silencing in mammalian cells is causally related to DNA methylation has been obtained...
  16. ncbi request reprint The multiple and irreversible causes of aging
    Robin Holliday
    12 Roma Court, West Pennant Hills, Sydney, NSW 2125, Australia
    J Gerontol A Biol Sci Med Sci 59:B568-72. 2004
    ..The failure of maintenance is irreversible, although longevity may be modulated under certain circumstances, such as dietary restriction accompanied by a loss of fertility...
  17. ncbi request reprint The close relationship between biological aging and age-associated pathologies in humans
    Robin Holliday
    12 Roma Court, West Pennant Hills, Sydney, NSW 2125, Australia
    J Gerontol A Biol Sci Med Sci 59:B543-6. 2004
    ..The eventual failure to maintain the integrity of tissues and organs is the end result of the multiple causes of aging...
  18. ncbi request reprint Early studies on recombination and DNA repair in Ustilago maydis
    Robin Holliday
    DNA Repair (Amst) 3:671-82. 2004
    ..Much more recently, the revolution in molecular genetics has been in exploited in several laboratories working with Ustilago maydis, and these have produced some completely new insights into recombination and repair...
  19. ncbi request reprint Causes of aging
    R Holliday
    CSIRO Molecular Science, Sydney Laboratory, North Ryde, NSW, Australia
    Ann N Y Acad Sci 854:61-71. 1998
    ..The major aim of such research is to devise procedures to delay or prevent the onset of these diseases...
  20. ncbi request reprint A role for carnosine in cellular maintenance
    R Holliday
    CSIRO Division of Molecular Science, North Ryde, Sydney, NSW 1670, Australia
    Biochemistry (Mosc) 65:843-8. 2000
    ..In the absence of pyruvate, carnosine is cytotoxic to neoplastic and transformed human and rodent cells. None of these effects are seen with its optical isomer, D-carnosine...
  21. ncbi request reprint Human ageing and the origins of religion
    R Holliday
    Biogerontology 2:73-7. 2001
    ..Religion then became the basis for the moral code, and it provided an assurance of continual survival after death...
  22. ncbi request reprint Twenty years of ageing research at the Mill Hill laboratories
    Robin Holliday
    The Royal Society, 6 Carlton House Terrace, London SW1, UK
    Exp Gerontol 37:851-7. 2002
    ....
  23. ncbi request reprint Epigenetics comes of age in the twentyfirst century
    Robin Holliday
    J Genet 81:1-4. 2002
  24. pmc Understanding ageing
    R Holliday
    CSIRO Division of Biomolecular Engineering, Sydney Laboratory, North Ryde, NSW, Australia
    Philos Trans R Soc Lond B Biol Sci 352:1793-7. 1997
    ..The major aim of such research is to devise procedures to delay or prevent the onset of these diseases...
  25. ncbi request reprint Gene silencing and endogenous DNA methylation in mammalian cells
    R Holliday
    Division of Molecular Science, Sydney Laboratory P O Box 184, North Ryde, NSW, Sydney, Australia
    Mutat Res 400:361-8. 1998
    ..It seems that 5-methyldCMP deaminase can be down-regulated in transformed cells, and this can promote de novo methylation by incorporation of 5-methyldCTP derived from 5-methyldCMP...
  26. pmc Evidence for gene silencing by endogenous DNA methylation
    R Holliday
    Commonwealth Scientific and Industrial Research Organization, Molecular Science, Sydney Laboratory, P O Box 184, North Ryde NSW 2113, Australia
    Proc Natl Acad Sci U S A 95:8727-32. 1998
    ..It also has low 5-methyl-dCMP deaminase activity. Another HAM+ strain has high deaminase activity and a very low frequency of gene silencing. The starting strain, CHO K1, has a phenotype intermediate between HAM- and HAM+...
  27. pmc Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine
    R Holliday
    CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia
    Br J Cancer 73:966-71. 1996
    ..It is well known that tumour cells are more dependent on glycolysis than normal cells. A reduction of glycolysis intermediates by carnosine may deplete their energy supply, but this effect is totally reversed by pyruvate...
  28. ncbi request reprint John Robert Stanley Fincham: 11 August 1926 - 9 February 2005
    Robin Holliday
    Biogr Mem Fellows R Soc 52:83-95. 2006
    ..He was also a practitioner and lover of sports and in his early career was politically active. His successes in life made him an extraordinarily talented man who achieved much as a leader in genetics in the UK and internationally...
  29. pmc The homologous recombination system of Ustilago maydis
    William K Holloman
    Cornell University Weill Medical College, Department of Microbiology and Immunology, NY 10021, USA
    Fungal Genet Biol 45:S31-9. 2008
    ..These include the use of a BRCA2 homolog and its modifier Dss1 rather than Rad52 as a mediator of Rad51, the presence of only a single Rad51 paralog, and the absence of Dmc1 and auxiliary meiotic proteins...
  30. ncbi request reprint Towards understanding the extreme radiation resistance of Ustilago maydis
    William K Holloman
    Cornell University Weill Medical College, Department of Microbiology and Immunology, New York, NY 10021, USA
    Trends Microbiol 15:525-9. 2007
    ..maydis. Evolution of a system enabling the survival of U. maydis under such conditions could be a secondary consequence of adaptation to an environment of continual genotoxic stress encountered in its habitat...
  31. ncbi request reprint Francis Crick (1916-2004)
    Robin Holliday
    12 Roma Court, West Pennant Hills, Sydney, NSW 2125, Australia
    Cell 119:1-2. 2004
  32. ncbi request reprint Evolution of human longevity, population pressure and the origins of warfare
    Robin Holliday
    pond com
    Biogerontology 6:363-8. 2005
    ..This inevitably occurred at the same time as man gradually gained more control over his environment, and achieved far more reproductive success than is seen in hunter-gatherers living in a harsh, stressful environment...
  33. ncbi request reprint The early years of molecular biology: personal recollections
    Robin Holliday
    Notes Rec R Soc Lond 57:195-208. 2003
    ..Nevertheless, proteins can chemically modify DNA, and this is now known to have strong effects on gene expression...
  34. ncbi request reprint Creationism and the wheel
    Robin Holliday
    Bioessays 25:620-1. 2003
  35. ncbi request reprint DNA methylation and epigenetic inheritance
    Robin Holliday
    Sydney Laboratory, CSIRO Molecular Science, P O Box 184, North Ryde, New South Wales 2113, Australia
    Methods 27:179-83. 2002
    ..Nevertheless, much more information is required about the effects of DNA-damaging agents in changing DNA methylation and gene activity and also about the role of epimutations in tumor progression...