L K Heilbronn

Summary

Country: Australia

Publications

  1. ncbi 360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to energy restricted diets in overweight subjects
    L K Heilbronn
    Department of Physiology, University of Adelaide, PO Box 10041, Adelaide, S A Australia
    Atherosclerosis 150:187-92. 2000
  2. ncbi Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women
    L K Heilbronn
    Department of Physiology, Adelaide University, Adelaide, South Australia
    Arterioscler Thromb Vasc Biol 21:968-70. 2001
  3. ncbi Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women
    Leonie K Heilbronn
    Department of Physiology, University of Adelaide, South Australia, Australia
    Atherosclerosis 162:419-24. 2002
  4. ncbi Effect of energy restriction, weight loss, and diet composition on plasma lipids and glucose in patients with type 2 diabetes
    L K Heilbronn
    Department of Physiology, University of Adelaide, Australia
    Diabetes Care 22:889-95. 1999
  5. ncbi Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans
    D Wilkinson
    Hyperbaric Unit, Royal Adelaide Hospital, The University of Adelaide, Adelaide, SA, Australia
    Diabet Med 29:986-9. 2012
  6. ncbi -308 Nco I polymorphism of tumour necrosis factor alpha in overweight Caucasians
    Alison M Morris
    Department of Physiology, Adelaide University, Adelaide, SA 5000, Australia
    Diabetes Res Clin Pract 62:197-201. 2003
  7. ncbi Calorie restriction and aging: review of the literature and implications for studies in humans
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 78:361-9. 2003
  8. ncbi Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    Leonie K Heilbronn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
    Curr Pharm Des 14:1225-30. 2008
  9. ncbi Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
  10. ncbi Effect of calorie restriction on resting metabolic rate and spontaneous physical activity
    Corby K Martin
    Department of Health Psychology, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2964-73. 2007

Collaborators

Detail Information

Publications20

  1. ncbi 360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to energy restricted diets in overweight subjects
    L K Heilbronn
    Department of Physiology, University of Adelaide, PO Box 10041, Adelaide, S A Australia
    Atherosclerosis 150:187-92. 2000
    ..Therefore, weight loss as a treatment to reduce CVD risk factors may be more effective in subjects with the apoA-IV-1/1 variant as compared to those with the apoA-IV-1/2 variant, especially in subjects with type 2 diabetes...
  2. ncbi Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women
    L K Heilbronn
    Department of Physiology, Adelaide University, Adelaide, South Australia
    Arterioscler Thromb Vasc Biol 21:968-70. 2001
    ..6%, P=0.001). This study confirms recent observations that BMI is associated with CRP, a marker for low-grade systemic inflammation. Furthermore, we observed that CRP was lowered in proportion to weight loss...
  3. ncbi Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women
    Leonie K Heilbronn
    Department of Physiology, University of Adelaide, South Australia, Australia
    Atherosclerosis 162:419-24. 2002
    ..Improved insulin sensitivity during weight loss did not change this relationship in women with high fasting insulin or type 2 diabetes...
  4. ncbi Effect of energy restriction, weight loss, and diet composition on plasma lipids and glucose in patients with type 2 diabetes
    L K Heilbronn
    Department of Physiology, University of Adelaide, Australia
    Diabetes Care 22:889-95. 1999
    ..To determine the optimal diet for improving glucose and lipid profiles in obese patients with type 2 diabetes during moderate energy restriction...
  5. ncbi Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans
    D Wilkinson
    Hyperbaric Unit, Royal Adelaide Hospital, The University of Adelaide, Adelaide, SA, Australia
    Diabet Med 29:986-9. 2012
    ..However, the mechanisms of this effect are not clear. The aim of this study was to determine whether peripheral insulin sensitivity by hyperinsulinaemic euglycaemic clamp is increased in patients presenting for hyperbaric oxygen therapy...
  6. ncbi -308 Nco I polymorphism of tumour necrosis factor alpha in overweight Caucasians
    Alison M Morris
    Department of Physiology, Adelaide University, Adelaide, SA 5000, Australia
    Diabetes Res Clin Pract 62:197-201. 2003
    ..The AA variant at position -308 in the promoter region of the TNFalpha gene does not influence the amount of weight lost in overweight and obese men and women on a 30% energy restricted diet...
  7. ncbi Calorie restriction and aging: review of the literature and implications for studies in humans
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 78:361-9. 2003
    ..Future studies in nonobese humans should focus on the effects of prolonged CR on metabolic rate, on neuroendocrine adaptations, on diverse biomarkers of aging, and on predictors of chronic age-related diseases...
  8. ncbi Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    Leonie K Heilbronn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
    Curr Pharm Des 14:1225-30. 2008
    ....
  9. ncbi Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
    ....
  10. ncbi Effect of calorie restriction on resting metabolic rate and spontaneous physical activity
    Corby K Martin
    Department of Health Psychology, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2964-73. 2007
    ..Additionally, it is unknown if changes in SPA, measured in a respiratory chamber, reflect changes in free-living physical activity level (PAL)...
  11. ncbi Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 367:725-8. 2008
    ..32, p=0.03). We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription...
  12. ncbi Impaired fat oxidation after a single high-fat meal in insulin-sensitive nondiabetic individuals with a family history of type 2 diabetes
    Leonie K Heilbronn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, New South Wales, Australia
    Diabetes 56:2046-53. 2007
    ..In conclusion, an impaired ability to increase fatty acid oxidation precedes the development of insulin resistance in genetically susceptible individuals. PGC1alpha and FAT/CD36 are likely candidates in mediating this response...
  13. ncbi Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
    Koichiro Azuma
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Endocrinol Metab 293:E435-42. 2007
    ..In summary, T2DM, compared with similarly obese nondiabetic men and women, is associated with less leg FM and greater trunk FM and hepatic fat...
  14. ncbi Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects
    Leonie K Heilbronn
    Diabetes and Obesity Research Program, Garvan Institute for Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 92:1467-73. 2007
    ..Impaired mitochondrial function in skeletal muscle is implicated in the development of insulin resistance. However, potential differences in fatness and fitness may influence previous results...
  15. ncbi Decreased expression of adipogenic genes in obese subjects with type 2 diabetes
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1543-52. 2006
    ....
  16. ncbi The effect of high- and low-glycemic index energy restricted diets on plasma lipid and glucose profiles in type 2 diabetic subjects with varying glycemic control
    Leonie K Heilbronn
    Department of Physiology, Adelaide University, Health Sciences and Nutrition, South Australia, Australia
    J Am Coll Nutr 21:120-7. 2002
    ..Lowering the glycemic index of high carbohydrate, low fat diets increases the fall in LDL cholesterol in subjects with type 2 diabetes with low glucose tolerance, but has little effect on glycemic control...
  17. ncbi Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
    ..Studies of longer duration are required to determine if calorie restriction attenuates the aging process in humans. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00099151...
  18. ncbi Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Res 13:574-81. 2005
    ..However, the increased expression in SIRT1 suggests that alternate day fasting may improve stress resistance, a commonly observed feature of calorie-restricted rodents...
  19. ncbi Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 81:69-73. 2005
    ..Adding one small meal on a fasting day may make this approach to dietary restriction more acceptable...
  20. ncbi Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes Care 29:1337-44. 2006
    ..CONCLUSIONS: Large adipocytes lead to lipid deposition in visceral and hepatic tissues, promoting insulin resistance. Calorie restriction by diet alone or with exercise reverses this trend...