Geoffrey A Head
Chiu C, Jackson K, Hearn N, Steiner N, Head G, Lind J. Identification of genes with altered expression in male and female Schlager hypertensive mice. BMC Med Genet. 2014;15:101 pubmed publisher
..We show that female data can be used to refine candidate genes and pathways, as well as highlight potential mechanisms to explain the differences in prevalence and severity of disease between men and women. ..
Lim K, Barzel B, Burke S, Armitage J, Head G. Origin of Aberrant Blood Pressure and Sympathetic Regulation in Diet-Induced Obesity. Hypertension. 2016;68:491-500 pubmed publisher
..We conclude that the VMH is the likely origin of leptin-mediated sympathoexcitation and ?-MSH hypersensitivity that contribute to obesity-related hypertension. ..
Giam B, Kuruppu S, Head G, Kaye D, Rajapakse N. Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects. Nutrients. 2016;8: pubmed publisher
..These data suggest that l-arginine dependent NO production is impaired in the former group compared to the latter which may represent a novel mechanism contributing to hypertension in the setting of obesity. ..
Prior L, Davern P, Burke S, Lim K, Armitage J, Head G. Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. Hypertension. 2014;63:338-45 pubmed publisher
..We conclude that offspring from mothers consuming an HFD exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin. ..
Lee M, Hemmes R, Mynard J, Lambert E, Head G, Cheung M, et al
. Elevated sympathetic activity, endothelial dysfunction, and late hypertension after repair of coarctation of the aorta. Int J Cardiol. 2017;243:185-190 pubmed publisher