Mark von Itzstein

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. ncbi request reprint The war against influenza: discovery and development of sialidase inhibitors
    Mark von Itzstein
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Nat Rev Drug Discov 6:967-74. 2007
  2. doi request reprint Avian influenza virus, a very sticky situation
    Mark von Itzstein
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Curr Opin Chem Biol 12:102-8. 2008
  3. doi request reprint Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design
    Mark von Itzstein
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Curr Opin Struct Biol 18:558-66. 2008
  4. ncbi request reprint STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core
    Thomas Haselhorst
    Institute for Glycomics, Griffith University, Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Glycobiology 17:68-81. 2007
  5. doi request reprint Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility
    Santosh Rudrawar
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Org Biomol Chem 10:8628-39. 2012
  6. doi request reprint Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
    Mark J Kraschnefski
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Glycobiology 19:194-200. 2009
  7. pmc Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV
    Xing Yu
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:509-11. 2008
  8. doi request reprint Exploring the interactions of unsaturated glucuronides with influenza virus sialidase
    Beenu Bhatt
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    J Med Chem 55:8963-8. 2012
  9. doi request reprint Synthesis of simple heparanase substrates
    Andrew G Pearson
    Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia
    Org Biomol Chem 9:4614-25. 2011
  10. pmc Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa
    Mark J Kraschnefski
    Institute for Glycomics, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:989-93. 2005

Collaborators

Detail Information

Publications49

  1. ncbi request reprint The war against influenza: discovery and development of sialidase inhibitors
    Mark von Itzstein
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Nat Rev Drug Discov 6:967-74. 2007
    ..This article provides a historical perspective on the discovery and development of these drugs--zanamivir and oseltamivir--and highlights the value of structure-based drug design in this process...
  2. doi request reprint Avian influenza virus, a very sticky situation
    Mark von Itzstein
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Curr Opin Chem Biol 12:102-8. 2008
    ..This has provided new opportunity for the development of Group 1-specific anti-influenza drugs. Furthermore, a number of next generation sialidase inhibitors as anti-influenza drugs have also been developed...
  3. doi request reprint Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design
    Mark von Itzstein
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Curr Opin Struct Biol 18:558-66. 2008
    ..The role of siglecs and galectins in a range of disease processes such as inflammation, apoptosis and cancer progression has also inspired significant structure-based inhibitor design research...
  4. ncbi request reprint STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core
    Thomas Haselhorst
    Institute for Glycomics, Griffith University, Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Glycobiology 17:68-81. 2007
    ..NMR spectroscopic, molecular modeling, and infectivity inhibition results are in excellent agreement and provide valuable information for the design of inhibitors of rotavirus infection...
  5. doi request reprint Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility
    Santosh Rudrawar
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Org Biomol Chem 10:8628-39. 2012
    ..This new class of inhibitors, which can 'trap' the open 150-loop form of the sialidase, should prove useful as probes of 150-loop flexibility...
  6. doi request reprint Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
    Mark J Kraschnefski
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Glycobiology 19:194-200. 2009
    ....
  7. pmc Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV
    Xing Yu
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:509-11. 2008
    ..X-ray diffraction data were collected to a resolution of 2.0 A and the crystallographic structure of NCDV VP8*(64-224) was determined by molecular replacement...
  8. doi request reprint Exploring the interactions of unsaturated glucuronides with influenza virus sialidase
    Beenu Bhatt
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    J Med Chem 55:8963-8. 2012
    ..The parent compound inhibits influenza virus sialidase at a sub-μM level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated...
  9. doi request reprint Synthesis of simple heparanase substrates
    Andrew G Pearson
    Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia
    Org Biomol Chem 9:4614-25. 2011
    ..These compounds represent the simplest substrates of heparanase reported to date...
  10. pmc Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa
    Mark J Kraschnefski
    Institute for Glycomics, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:989-93. 2005
    ..Two crystal forms (trigonal P3(2)21 and monoclinic P2(1)) have been obtained and X-ray diffraction data have been collected, enabling determination of the VP8*(64-223) structure by molecular replacement...
  11. ncbi request reprint A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase
    Thomas Haselhorst
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Glycoconj J 23:371-5. 2006
    ....
  12. doi request reprint Novel structural insights into rotavirus recognition of ganglioside glycan receptors
    Xing Yu
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    J Mol Biol 413:929-39. 2011
    ..These novel results also indicate the potential binding interactions of rotavirus VP8* with other sialic acid-containing gangliosides...
  13. ncbi request reprint Modelling, synthesis and biological evaluation of novel glucuronide-based probes of Vibrio cholerae sialidase
    Maretta C Mann
    Institute for Glycomics, Griffith University Gold Coast Campus, Australia
    Bioorg Med Chem 14:1518-37. 2006
    ..cholerae sialidase complexed with Neu5Ac2en (1). All Neu5Ac2en mimetics tested were found to inhibit V. cholerae sialidase as determined using a standard fluorometric assay...
  14. doi request reprint Sialic acid dependence in rotavirus host cell invasion
    Thomas Haselhorst
    Institute for Glycomics, Gold Coast Campus, Griffith University, Parklands Drive, Southport, Queensland 4222, Australia
    Nat Chem Biol 5:91-3. 2009
    ..This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses...
  15. ncbi request reprint Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*)
    Helen Blanchard
    Institute for Glycomics, Griffith University, Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland, 9726, Australia
    J Mol Biol 367:1215-26. 2007
    ....
  16. ncbi request reprint Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane
    Andrea Maggioni
    Institute for Glycomics, Gold Coast Campus Griffith University, Queensland 4222, Australia
    Biochem Biophys Res Commun 362:779-84. 2007
    ..coli and mixed phosphatidylcholine-E. coli inner membrane proteoliposomes incorporating recombinant CMP-sialic acid transporter to accumulate CMP-sialic acid in vitro...
  17. pmc Structural basis of rotavirus strain preference toward N-acetyl- or N-glycolylneuraminic acid-containing receptors
    Xing Yu
    Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
    J Virol 86:13456-66. 2012
    ....
  18. ncbi request reprint Unsaturated N-acetyl- D-glucosaminuronic acid glycosides as inhibitors of influenza virus sialidase
    Maretta C Mann
    Institute for Glycomics, Griffith University, Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Glycoconj J 23:127-33. 2006
    ..We have employed a sialidase inhibition assay for biological evaluation of the target compounds and to our delight these mimetics have displayed significant inhibition of influenza virus sialidase...
  19. ncbi request reprint Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria
    Chris B Davis
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Carbohydr Res 342:1773-80. 2007
    ..Both Galf 9-heptadecyl thioglycoside and sulfone displayed in vitro inhibition (MIC) of the growth of Mycobacterium smegmatis below 5 microg/mL, while Galf 1-octyl thioglycoside gave no inhibition at or below 32 microg/mL...
  20. ncbi request reprint Anti-influenza drug discovery: are we ready for the next pandemic?
    Tasneem Islam
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB50, Gold Coast Mail Centre, Queensland 9726, Australia
    Adv Carbohydr Chem Biochem 61:293-352. 2007
  21. ncbi request reprint Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy
    Thomas Haselhorst
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Biochem Biophys Res Commun 359:866-70. 2007
    ....
  22. ncbi request reprint The evolution of galactose alpha2,3-sialyltransferase: Ciona intestinalis ST3GAL I/II and Takifugu rubripes ST3GAL II sialylate Galbeta1,3GalNAc structures on glycoproteins but not glycolipids
    Friederike Lehmann
    Institute for Glycomics, Gold Coast Campus, Griffith University, QLD, 4222, Australia
    Glycoconj J 25:323-34. 2008
    ..This suggests that during the evolution of the ST3Gal II, probably following the separation of the teleosts, a significant shift in substrate specificity enabling the sialylation of gangliosides took place...
  23. ncbi request reprint The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection
    Angela Liakatos
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Bioorg Med Chem 14:739-57. 2006
    ....
  24. ncbi request reprint Endosialidase NF appears to bind polySia DP5 in a helical conformation
    Thomas Haselhorst
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Chembiochem 7:1875-7. 2006
  25. ncbi request reprint Cracking the code for H5N1-bird flu and beyond
    Robin J Thomson
    Institute for Glycomics, Griffith University, Gold Coast Campus, Parklands Drive, Southport, Queensland 4222, Australia
    Curr Drug Deliv 6:343-6. 2009
    ..Important advances in the interrogation of influenza virus' surface glycoprotein haemagglutinin by NMR spectroscopy have been made in recent times. An overview of some of these advances is provided...
  26. ncbi request reprint Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity
    David J Tindal
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Bioorg Med Chem Lett 17:1655-8. 2007
    ..This is comparable or improved activity compared to the parent 4-hydroxy compound...
  27. doi request reprint Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysis
    Beenu Bhatt
    Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia
    Bioorg Med Chem Lett 22:7623-6. 2012
    ..For the α-L-threo-hex-4-en derivative this conformation is equivalent to that of Neu5Ac2en, and opposite to that seen for alkyl O-glycosides with the same overall stereochemistry...
  28. ncbi request reprint Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase
    Thomas Haselhorst
    Institute for Glycomics, Griffith University Gold Coast Campus, Queensland, Australia
    Proteins 56:346-53. 2004
    ....
  29. pmc Differential carbohydrate recognition by Campylobacter jejuni strain 11168: influences of temperature and growth conditions
    Christopher J Day
    Institute for Glycomics, Griffith University Gold Coast Campus, Queensland, Australia
    PLoS ONE 4:e4927. 2009
    ..jejuni to a Caco-2 intestinal cell line. Our data suggests that the binding of mannose and/or N-acetylneuraminic acid may provide the initial interactions important for colonisation following environmental exposure...
  30. doi request reprint Differential carbohydrate binding and cell surface glycosylation of human cancer cell lines
    Nadia X Arndt
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    J Cell Biochem 112:2230-40. 2011
    ..The findings of this study provide the groundwork for further investigation into the numerous glycan-lectin interactions that are exhibited by immortalised cell lines...
  31. ncbi request reprint An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors
    Maretta C Mann
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Bioorg Med Chem Lett 14:5555-8. 2004
    ..Elaboration of glucosaminuronides 15 and 18 provided novel sialylmimetics 21 and 22, which showed inhibition of Vibrio cholerae sialidase...
  32. ncbi request reprint Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents
    David J Owen
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Bioorg Med Chem Lett 17:2274-7. 2007
    ..The most potent compound, the Galf N,N-didecyl sulfenamide 8d, displayed anti-mycobacterial activity (MIC) of 1 microg/mL in a cell based assay against a representative strain of Mycobacterium smegmatis...
  33. doi request reprint Avian influenza H5-containing virus-like particles (VLPs): host-cell receptor specificity by STD NMR spectroscopy
    Thomas Haselhorst
    Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, 4222, Australia
    Angew Chem Int Ed Engl 47:1910-2. 2008
  34. pmc Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8
    Stacy A Scott
    Institute for Glycomics, Griffith University, PMB 50, Gold Coast Mail Centre, Queensland 9726, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:617-20. 2005
    ..Diffraction data have been collected to 2.3 A resolution, enabling the determination of the VP8* structure by molecular replacement...
  35. doi request reprint C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD22): Towards Potent Siglec Inhibitors for Immunoglycotherapy
    Sørge Kelm
    Centre for Biomolecular Interactions Bremen, Department of Biology and Chemistry, University of Bremen, 28334 Bremen Germany http www cbib uni bremen de Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland, 4222 Australia http www griffith edu au glycomics
    Angew Chem Int Ed Engl 52:3616-20. 2013
    ..This approach gives a lead compound that has sub-micromolar affinity for Siglec-2 and may provide a pathway for immunoglycotherapy strategies for autoimmune diseases and B cell derived non-Hodgkin's lymphoma...
  36. pmc Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
    Santosh Rudrawar
    Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia
    Nat Commun 1:113. 2010
    ..This is the first direct proof that compounds may be developed to selectively target the pandemic A/H1N1, avian A/H5N1 and other group-1 sialidase-containing viruses, based on an open 150-loop conformation of the enzyme...
  37. ncbi request reprint Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy
    Thomas Haselhorst
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 60 Gold Coast Mail Centre, Queensland 9726, Australia
    Biochem Biophys Res Commun 327:565-70. 2005
    ..Furthermore, proton-decoupled (31)P NMR spectroscopy was successfully used to follow the enzyme reaction and clearly confirmed the appearance of CMP-Sia and the inorganic pyrophosphate by-product...
  38. ncbi request reprint Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier
    Joe Tiralongo
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Glycobiology 16:73-81. 2006
    ..Kinetic studies carried out with CMP-Neu5Ac and established CMP-Neu5Ac antagonist's evaluated natural conformation of the reconstituted protein and clearly demonstrate that the transporter acts as a simple mobile carrier...
  39. doi request reprint Exposing the flexibility of human parainfluenza virus hemagglutinin-neuraminidase
    Moritz Winger
    Institute for Glycomics, Gold Coast Campus, Griffith University Queensland, 4222, Australia
    J Am Chem Soc 134:18447-52. 2012
    ....
  40. doi request reprint Accessing C-1 phosphonylated 2-acylamino uronic acids via 2-nitro-glycals
    Beenu Bhatt
    Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia
    J Org Chem 76:4099-104. 2011
    ..Reversing the reaction order resulted in the exclusive formation of the β-D-gluco-configured phosphonate. In both cases the thermodynamic 1,2-trans-di-equatorial phosphonylation product is obtained...
  41. ncbi request reprint NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi
    Thomas Haselhorst
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland, 9726, Australia
    Glycobiology 14:895-907. 2004
    ..The association of the asialo acceptor with the active site is an absolute requirement for the transfer reaction to proceed...
  42. ncbi request reprint Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid
    Andrew G Pearson
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50, Gold Coast Mail Centre, Australia
    Carbohydr Res 340:2077-85. 2005
    ..This paper rationalises the formation of each of these products, and reports our efforts in trying to optimise the formation of the alpha-fluoride 16...
  43. ncbi request reprint Carbohydrates as inhibitors of rotaviral infection
    Milton J Kiefel
    Centre for Biomolecular Science and Drug Discovery, Griffith University Gold Coast Campus, PMB 50, Gold Coast Mail Centre, Queensland 9726, Australia
    Methods Enzymol 363:395-412. 2003
  44. ncbi request reprint An investigation of the activity of recombinant rat skeletal muscle cytosolic sialidase
    Samia Albouz-Abo
    Department of Medicinal Chemistry, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia
    FEBS Lett 579:1034-8. 2005
    ..This result further supports the notion that all sialidases appear to be retaining enzymes...
  45. ncbi request reprint Sialic acid recognition by Vibrio cholerae neuraminidase
    Ibrahim Moustafa
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, Scotland
    J Biol Chem 279:40819-26. 2004
    ..The discovery of the sialic acid binding site in the N-lectin-like domain suggests that this might help target VCNA to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme...
  46. ncbi request reprint Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus
    Charlotte Ryan
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland, UK
    Glycoconj J 23:135-41. 2006
    ..These results highlight the striking difference between the influenza neuraminidase and paramyxovirus HN active sites, and provide a platform for the development of improved HN inhibitors...
  47. pmc Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion
    Viatcheslav Zaitsev
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom
    J Virol 78:3733-41. 2004
    ..Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface...
  48. ncbi request reprint Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly
    Aleksander Hinek
    Cardiovascular Research Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Biol Chem 281:3698-710. 2006
    ..In turn, the exposed galactosugars interact with the galectin domain of EBP, thereby inducing the release of transported tropoelastin molecules and facilitating their subsequent assembly into elastic fibers...
  49. ncbi request reprint A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides)
    David J Owen
    Department of Medicinal Chemistry, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Carbohydr Res 337:2017-22. 2002
    ..A procedure for the efficient hydrolysis of the introduced nitrile group to produce the methyl ester is reported, along with procedures for the synthesis of both the corresponding alpha,beta-unsaturated, and 3-deoxy ester derivatives...