Research Topics
| Jiri NeuzilSummaryAffiliation: Griffith University Country: Australia Publications
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Publications
Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteinsJiri Neuzil
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
FEBS Lett 580:5125-9. 2006..This model may provide a general mechanism for the action of inducers of apoptosis and anticancer drugs, mitocans, targeting mitochondria via ROS production...- Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex IIJiri Neuzil
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
J Bioenerg Biomembr 39:65-72. 2007..In this mini-review we discuss the emerging significance of mitocans, as exemplified by alpha-TOS... - Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documentsStephen J Ralph
School of Medical Science, Griffith University, Southport, QLD, Australia
Recent Pat Anticancer Drug Discov 1:327-46. 2006..Undoubtedly, mitocans will become an integral part of modern weaponry in the fight to eliminate cancer... - Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosisRenata Alleva
Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Via Pupilli, 40136 Bologna, Italy
Cancer Lett 232:226-35. 2006..We propose that alpha-TOS may be used as a drug or an adjuvant for treatment of osteosarcomas... - Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosisMarco Tomasetti
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, via Ranieri 1, Ancona, Italy
FEBS Lett 580:1925-31. 2006..Treatment with sub-lethal doses of alpha-TOS restored expression of DR4 and DR5. The ability of alpha-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli... - Targeting the mitochondrial electron transport chain complexes for the induction of apoptosis and cancer treatmentJakub Rohlena
Apoptosis Research Group, School of Medical Science and the Griffith Health Institute, Griffith University, Southporth, 4222 Qld, Australia
Curr Pharm Biotechnol 14:377-89. 2013..Furthermore, macromolecular complexes of the electron transport chain only rarely mutate in cancer, and represent useful targets for anti-cancer drug development when widely-applicable agents are sought... 
Classification of mitocans, anti-cancer drugs acting on mitochondriaJiri Neuzil
School of Medical Science, Griffith University, Southport, QLD, Australia
Mitochondrion 13:199-208. 2013..The purpose of this review is to present in a concise manner the classification of compounds that hold a considerable promise as potential anti-cancer drugs...- Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cellsJiri Neuzil
School of Medical Science, Griffith University, Southport, QLD, Australia
Mol Nutr Food Res 55:1543-51. 2011..TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species... - Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondriaJiri Neuzil
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
Mol Aspects Med 28:607-45. 2007..We use as an example the analogues of vitamin E that are proving to be cancer cell-specific and may soon be developed into efficient anti-cancer drugs... - Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effectsJiri Neuzil
School of Health Science, Griffith University, Southport, Queensland, Australia
Curr Cancer Drug Targets 4:355-72. 2004..The reasons for this optimism are reviewed in this article... - Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cellsJiri Neuzil
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 343:1113-7. 2006..We suggest that TAP1 may act as an intracellular shuttle for alpha-TOS, promoting apoptosis initiated by this vitamin E analogue, as shown here for MM cells... - Hepatic processing determines dual activity of alpha-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversionJiri Neuzil
Apoptosis Research Group, School of Medical Sciences, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 327:1024-7. 2005..Our finding epitomises a novel, general paradigm, according to which a drug can be converted in the liver into a product that has a different beneficial bioactivity... - Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silentJiri Neuzil
Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University Gold Coast Campus, Southport, Queensland, Australia
Mol Pharmacol 71:1185-99. 2007.... - Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulationJiri Neuzil
School of Health Sciences, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 314:186-91. 2004.... - alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signallingJiri Neuzil
Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith Institute of Health and Medical Research, Griffith University, Southport 4222, QLD, Australia
FEBS Lett 581:4611-5. 2007..We conclude that alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling... - Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name?Jiri Neuzil
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 355:855-9. 2007..Alternatively, agents or treatment regimens that enhance sensitivity of these therapy-resistant "tumour stem cells" to the current or emerging anti-tumour drugs would be of interest as well... - Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injuryJiri Neuzil
Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
Redox Rep 12:148-62. 2007..In conclusion, I/R results in apoptosis in cultured cardiac myocytes and heart tissue largely via generation of mitochondria-derived superoxide, with ensuing apoptosis during the reperfusion phase... - Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stressMichael Stapelberg
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, 4216 Queensland, Australia
J Biol Chem 280:25369-76. 2005..Our data suggest that alpha-TOS suppresses MM cell proliferation by disrupting the FGF-FGF receptor autocrine signaling loop by generating oxidative stress and point to the agent as a selective drug against thus far fatal mesotheliomas... - Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapyLan Feng Dong
School of Medical Science, Griffith University, Southport, Qld 4222, Australia
Free Radic Biol Med 50:1546-55. 2011..We propose that mitochondrially targeted delivery of anti-cancer agents offers a new paradigm for increasing the efficacy of compounds with anti-cancer activity... 
Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex IILan Feng Dong
School of Medical Science, Griffith University, Southport 4222, Queensland, Australia
J Biol Chem 286:3717-28. 2011....- CD133-positive cells are resistant to TRAIL due to up-regulation of FLIPRenata Zobalova
Apoptosis Research Group, School of Medical Science, Griffith Institute of Health and Medical Research, Griffith University Gold Coast Campus, Parklands Avenue, Southport, QLD, Australia
Biochem Biophys Res Commun 373:567-71. 2008..We conclude that high expression of FLIP is at least one of the reasons for resistance of CSCs to apoptosis induced by the death ligand TRAIL... - A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expressionXiu Fang Wang
Apoptosis Research Group and Genomics Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
Cancer Res 67:3337-44. 2007..We conclude that a conjugate of a peptide targeting alpha-TOS to erbB2-overexpressing cancer cells induces rapid apoptosis and efficiently suppresses erbB2-positive breast tumors... - Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stressLan Feng Dong
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia
Cancer Res 67:11906-13. 2007..We conclude that vitamin E analogues selectively kill angiogenic endothelial cells, suppressing tumor growth, which has intriguing clinical implications... - Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?Emma Swettenham
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia
J Neurochem 94:1448-56. 2005.... - Daxx inhibits stress-induced apoptosis in cardiac myocytesRenata Zobalova
Apoptosis Research Group, School of Medical Science, Griffith University and Griffith Institute of Health and Medical Research, Southport, Queensland, Australia
Redox Rep 13:263-70. 2008..Taken together, Daxx plays a protective role in cultured cardiomyocyte-like cells, at least under the conditions used... - The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection?Renata Zobalova
School of Medical Science, Griffith University, Southport, QLD, Australia
Antioxid Redox Signal 15:2989-3002. 2011.... - Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosisRenata Zobalova
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
Biofactors 34:231-5. 2008..Downregulation of FLIP by siRNA in CD133-high cells sensitised them to TRAIL killing. Thus, CD133-high cells may be resistant to TRAIL due to high expression of FLIP... - Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinateXiu-Fang Wang
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia
Mol Nutr Food Res 50:675-85. 2006..The results point to the novel group of vitamin E analogues as promising agents applicable to different types of tumours... - Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex IILan Feng Dong
Apoptosis Research Group and Genomic Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
Clin Cancer Res 15:1593-600. 2009..The purpose of this study was to elucidate the cellular target by which these agents, represented by alpha-tocopoheryl succinate (alpha-TOS), suppress tumors in vivo, with the focus on the mitochondrial complex II (CII)... - α-Tocopheryloxyacetic acid is superior to α-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stabilityLan Feng Dong
School of Medical Science, Griffith Health Institute, Griffith University, Southport, QLD, Australia
Int J Cancer 131:1052-8. 2012..We propose that α-TEA is a promising drug efficient against breast cancer, as documented by its effect on experimental HER2-positive breast carcinomas that present a considerable problem in cancer management... - Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell deathStephen J Ralph
School of Medical Science and Health Research Institute, Griffith University, Gold Coast, QLD, Australia 4222
Pharm Res 28:2695-730. 2011.... - Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathwayXiu-Fang Wang
Apoptosis Research Group, School of Health Science, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 326:282-9. 2005..Since erbB2 is frequently over-expressed in breast cancers and renders the neoplastic disease resistant to established treatment, our findings are of clinical interest... - The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapyStephen J Ralph
Genomic Research Centre, Griffith Institute of Health and Medical Research, School of Medical Science, Griffith University, Parklands Avenue, Southport, 4222 Qld, Australia
Mol Aspects Med 31:145-70. 2010..The last section concerns the relevance of these findings, their importance and significance for novel targeted approaches to anti-cancer therapy and selective triggering in cancer cells of the mitochondrial apoptotic pathway... - Future use of mitocans against tumour-initiating cells?Brian J Morrison
Queensland Institute of Medical Research, Queensland, Australia
Mol Nutr Food Res 53:147-53. 2009..Therefore, knowledge of the molecular mechanism(s) of resistance of TICs to treatment and overcoming this problem will be essential in order to develop effective drug strategies for cancer therapy... - Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activityAdisa Tomic-Vatic
School of Medical Science, Griffith University, Southport, Queensland, Australia
Int J Cancer 117:188-93. 2005.... - alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptorsMichael Stapelberg
School of Health Science, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 318:636-41. 2004..Our data suggest a novel mechanism by which a clinically intriguing agent selectively suppresses proliferation of cancer cells, as shown here for the untreatable mesotheliomas... - Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cellsRuth E Freeman
Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Qld 9716, Australia
FEBS Lett 580:2671-6. 2006..Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to alpha-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties... - Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic triggerStephen J Ralph
Genomic Research Centre, School of Medical Science, Griffith University, Parklands Avenue, Southport, 4222 Qld, Australia
Mol Aspects Med 31:29-59. 2010.... - Mitochondria as targets for cancer therapyStephen J Ralph
Genomic Research Centre, School of Medical Science, Griffith University, Southport, QLD, Australia
Mol Nutr Food Res 53:9-28. 2009..Such targets appear to be mitochondria, with very rare mutations, and mitocans can be expected to be very efficient drugs of choice for a number of different types of the neoplastic disease... - Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stressKoichi Ito
School of Medical Science, Griffith Health Institute, Griffith University, Southport, QLD, Australia
Angiogenesis 14:293-307. 2011.... - Mitochondrial complex II, a novel target for anti-cancer agentsKatarina Kluckova
Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic
Biochim Biophys Acta 1827:552-64. 2013..This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease... - Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart researchJiri Neuzil
Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Sciences, Griffith University, Southport, Queensland, Australia
Redox Rep 10:187-97. 2005.... - Malignant mesothelioma: biology, diagnosis and therapeutic approachesMarco Tomasetti
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
Curr Mol Pharmacol 2:190-206. 2009..Blood tests make screening of target populations an attractive strategy. Many current gene and protein expression studies aim to identify clinically useful biomarkers and new therapeutic targets for improved management of MM... - Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosisAlexei Terman
Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
Exp Gerontol 38:863-76. 2003..Our findings suggest that imperfect autophagic recycling of these critical organelles may underlie the progressive mitochondrial damage, which characterizes aging post-mitotic cells... - Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnoverAlexei Terman
Division of Pathology II, Faculty of Health Sciences, Linkoping University, SE 58185, Linkoping, Sweden
Ann N Y Acad Sci 1019:70-7. 2004..Overall, our findings emphasize the importance of mitochondrial turnover in postmitotic aging and provide further support for the mitochondrial-lysosomal axis theory of aging... - Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signalingTobias Weber
Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
Biochemistry 42:4277-91. 2003..These data provide an insight into the molecular mechanism, by which alpha-TOS kills malignant cells, and advocate its testing as a potential anticancer agent or adjuvant... - The European perspective on vitamin E: current knowledge and future researchRegina Brigelius-Flohe
German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
Am J Clin Nutr 76:703-16. 2002..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have... - Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivoTobias Weber
Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, 80336 Germany
Clin Cancer Res 8:863-9. 2002..Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential... - Vitamin E analogues and immune response in cancer treatmentMarco Tomasetti
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
Vitam Horm 76:463-91. 2007..These findings are indicative of a novel strategy for cancer treatment that involves enhanced immune system surveillance... - Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instabilityJiri Neuzil
Department of Pathology II, University Hospital, Linköping 581 85, Sweden
Biochem J 362:709-15. 2002..These findings indicate that lysosomal destabilization may partially or fully explain the induction of apoptosis in cultured cells by alpha-TOS and the mechanism whereby this agent exerts in vivo anti-tumour effects... - A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease?Marco Tomasetti
Department of Molecular Pathology and Innovative Therapies, University Polytechnic of Marche, Ancona, Italy
Int J Cancer 109:641-2. 2004..Compared to untreated animals, the agent increased their survival >3-fold. Our finding warrants further testing of vitamin E analogues as potential antimesothelioma drugs... - Alpha-tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversionJiri Neuzil
Faculty of Health Sciences, Division of Pathology II, University of Linkoping, Linkoping, Sweden
Biochem Biophys Res Commun 293:1309-13. 2002..That is, the conversion of the pro-vitamin E form, alpha-TOS, to the corresponding vitamin form, alpha-tocopherol, makes this anti-neoplastic agent active against inflammatory diseases like atherosclerosis... - Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating propertiesJoan L Buss
Department of Physiology, McGill University, Sir Mortimer B. Davis Jewish General Hospital, 3755 Chemin de la Cote-Ste-Catherine, Montreal, Que, Canada H3T 1E2
Biochem Pharmacol 65:161-72. 2003..Moreover, analogs of these agents lacking the iron-chelating moiety were non-toxic... - Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogsJoan L Buss
Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
Arch Biochem Biophys 421:1-9. 2004..In summary, PIH analogs and their Fe(3+) complexes are redox active in the intracellular environment. The contribution of oxidative stress to the overall mechanism of toxicity varies across the series... - Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gammaWolfgang Erl
Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Munchen, Germany
Eur J Immunol 34:241-50. 2004..Our findings show that PGA1 and PGJ2 induce apoptosis in endothelial cells independent of PPARgamma. As the synthesis of PGJ2 is increased at sites of inflammation, our results may suggest a possible mechanism for endothelial damage... - Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting?Alexei Terman
Division of Pathology II, Linkoping University, Linkoping, 58185, Sweden
Exp Cell Res 274:9-15. 2002..These findings give further support for the involvement of lysosomal enzymes in apoptosis and suggest I-cells as a suitable model for studying the role of lysosomes in programmed cell death... - Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1Renata Alleva
Department of Anaesthesiology, Rizzoli Orthopaedic Institute, 40100 Bologna, Italy
Biochem Biophys Res Commun 331:1515-21. 2005..Knocking down E2F1 rendered the alpha-TOS-sensitive cells rather resistant to the apoptotic stimulus inducing a marked and prolonged cell growth arrest. We conclude that alpha-TOS induces cell growth arrest or apoptosis involving E2F1... - alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapyRenata Alleva
Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
Biochem Biophys Res Commun 333:404-10. 2005..Taken together, we demonstrated an adjuvant effect of LA in HBO therapy used for impaired wound healing treatment. We propose that LA may be used to further promote the beneficial effects of HBO therapy... - alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic mannerYan Zhao
Department of Nutrition and Food, Harbin Medical University, Harbin, Heilongjiang Province, China
Cancer Lett 247:345-52. 2007..We conclude that ERK1/2 and JNK positively regulate apoptosis induced in gastric cancer cells by alpha-TOS... - Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxidePaul K Witting
ANZAC Research Institute, Concord Hospital, Concord, NSW, Australia
Biochem Biophys Res Commun 348:485-93. 2006..These data indicate that (i) Mb promotes oxidative damage to cultured CM and (ii) Mb may be a useful target for the design of inhibitors of myocardial IR injury... - Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complexLubomir Prochazka
Veterinary Research Institute, Department of Immunology, Brno, Czech Republic
Arch Biochem Biophys 462:54-61. 2007..Inhibition of GJIC was linked to rapid hyperphosphorylation of connexin-43 and disappearance of connexon clusters from membranes, which was not observed in the case of CDDP... - alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapyRenata Alleva
Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
Mol Med 14:175-83. 2008..The disruption of the positive autocrine feedback loops that maintain the chronic wound state promotes progression of the healing process... - Profiling tumor-associated markers for early detection of malignant mesothelioma: an epidemiologic studyMonica Amati
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Via Tronto 10 A, Torrette di Ancona, Ancona, Italy
Cancer Epidemiol Biomarkers Prev 17:163-70. 2008..The combination of blood biomarkers and radiographic findings could be used to stratify the risk of mesothelioma in asbestos-exposed populations...