Jiri Neuzil

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. ncbi request reprint Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    FEBS Lett 580:5125-9. 2006
  2. ncbi request reprint Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    J Bioenerg Biomembr 39:65-72. 2007
  3. ncbi request reprint Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents
    Stephen J Ralph
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Recent Pat Anticancer Drug Discov 1:327-46. 2006
  4. ncbi request reprint Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis
    Renata Alleva
    Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Via Pupilli, 40136 Bologna, Italy
    Cancer Lett 232:226-35. 2006
  5. ncbi request reprint Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis
    Marco Tomasetti
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, via Ranieri 1, Ancona, Italy
    FEBS Lett 580:1925-31. 2006
  6. doi request reprint Classification of mitocans, anti-cancer drugs acting on mitochondria
    Jiri Neuzil
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Mitochondrion 13:199-208. 2013
  7. doi request reprint Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
    Jiri Neuzil
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Mol Nutr Food Res 55:1543-51. 2011
  8. ncbi request reprint Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects
    Jiri Neuzil
    School of Health Science, Griffith University, Southport, Queensland, Australia
    Curr Cancer Drug Targets 4:355-72. 2004
  9. ncbi request reprint Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University Gold Coast Campus, Southport, Queensland, Australia
    Mol Pharmacol 71:1185-99. 2007
  10. ncbi request reprint Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 343:1113-7. 2006

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    FEBS Lett 580:5125-9. 2006
    ..This model may provide a general mechanism for the action of inducers of apoptosis and anticancer drugs, mitocans, targeting mitochondria via ROS production...
  2. ncbi request reprint Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    J Bioenerg Biomembr 39:65-72. 2007
    ..In this mini-review we discuss the emerging significance of mitocans, as exemplified by alpha-TOS...
  3. ncbi request reprint Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents
    Stephen J Ralph
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Recent Pat Anticancer Drug Discov 1:327-46. 2006
    ..Undoubtedly, mitocans will become an integral part of modern weaponry in the fight to eliminate cancer...
  4. ncbi request reprint Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis
    Renata Alleva
    Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Via Pupilli, 40136 Bologna, Italy
    Cancer Lett 232:226-35. 2006
    ..We propose that alpha-TOS may be used as a drug or an adjuvant for treatment of osteosarcomas...
  5. ncbi request reprint Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis
    Marco Tomasetti
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, via Ranieri 1, Ancona, Italy
    FEBS Lett 580:1925-31. 2006
    ..Treatment with sub-lethal doses of alpha-TOS restored expression of DR4 and DR5. The ability of alpha-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli...
  6. doi request reprint Classification of mitocans, anti-cancer drugs acting on mitochondria
    Jiri Neuzil
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Mitochondrion 13:199-208. 2013
    ..The purpose of this review is to present in a concise manner the classification of compounds that hold a considerable promise as potential anti-cancer drugs...
  7. doi request reprint Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
    Jiri Neuzil
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Mol Nutr Food Res 55:1543-51. 2011
    ..TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species...
  8. ncbi request reprint Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects
    Jiri Neuzil
    School of Health Science, Griffith University, Southport, Queensland, Australia
    Curr Cancer Drug Targets 4:355-72. 2004
    ..The reasons for this optimism are reviewed in this article...
  9. ncbi request reprint Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University Gold Coast Campus, Southport, Queensland, Australia
    Mol Pharmacol 71:1185-99. 2007
    ....
  10. ncbi request reprint Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 343:1113-7. 2006
    ..We suggest that TAP1 may act as an intracellular shuttle for alpha-TOS, promoting apoptosis initiated by this vitamin E analogue, as shown here for MM cells...
  11. ncbi request reprint Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation
    Jiri Neuzil
    School of Health Sciences, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 314:186-91. 2004
    ....
  12. ncbi request reprint Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    Mol Aspects Med 28:607-45. 2007
    ..We use as an example the analogues of vitamin E that are proving to be cancer cell-specific and may soon be developed into efficient anti-cancer drugs...
  13. ncbi request reprint Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name?
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 355:855-9. 2007
    ..Alternatively, agents or treatment regimens that enhance sensitivity of these therapy-resistant "tumour stem cells" to the current or emerging anti-tumour drugs would be of interest as well...
  14. ncbi request reprint Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
    Redox Rep 12:148-62. 2007
    ..In conclusion, I/R results in apoptosis in cultured cardiac myocytes and heart tissue largely via generation of mitochondria-derived superoxide, with ensuing apoptosis during the reperfusion phase...
  15. ncbi request reprint alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith Institute of Health and Medical Research, Griffith University, Southport 4222, QLD, Australia
    FEBS Lett 581:4611-5. 2007
    ..We conclude that alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling...
  16. ncbi request reprint Hepatic processing determines dual activity of alpha-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Sciences, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 327:1024-7. 2005
    ..Our finding epitomises a novel, general paradigm, according to which a drug can be converted in the liver into a product that has a different beneficial bioactivity...
  17. ncbi request reprint Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress
    Michael Stapelberg
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, 4216 Queensland, Australia
    J Biol Chem 280:25369-76. 2005
    ..Our data suggest that alpha-TOS suppresses MM cell proliferation by disrupting the FGF-FGF receptor autocrine signaling loop by generating oxidative stress and point to the agent as a selective drug against thus far fatal mesotheliomas...
  18. ncbi request reprint Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress
    Lan Feng Dong
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia
    Cancer Res 67:11906-13. 2007
    ..We conclude that vitamin E analogues selectively kill angiogenic endothelial cells, suppressing tumor growth, which has intriguing clinical implications...
  19. doi request reprint Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy
    Lan Feng Dong
    School of Medical Science, Griffith University, Southport, Qld 4222, Australia
    Free Radic Biol Med 50:1546-55. 2011
    ..We propose that mitochondrially targeted delivery of anti-cancer agents offers a new paradigm for increasing the efficacy of compounds with anti-cancer activity...
  20. pmc Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II
    Lan Feng Dong
    School of Medical Science, Griffith University, Southport 4222, Queensland, Australia
    J Biol Chem 286:3717-28. 2011
    ....
  21. ncbi request reprint A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression
    Xiu Fang Wang
    Apoptosis Research Group and Genomics Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
    Cancer Res 67:3337-44. 2007
    ..We conclude that a conjugate of a peptide targeting alpha-TOS to erbB2-overexpressing cancer cells induces rapid apoptosis and efficiently suppresses erbB2-positive breast tumors...
  22. doi request reprint CD133-positive cells are resistant to TRAIL due to up-regulation of FLIP
    Renata Zobalova
    Apoptosis Research Group, School of Medical Science, Griffith Institute of Health and Medical Research, Griffith University Gold Coast Campus, Parklands Avenue, Southport, QLD, Australia
    Biochem Biophys Res Commun 373:567-71. 2008
    ..We conclude that high expression of FLIP is at least one of the reasons for resistance of CSCs to apoptosis induced by the death ligand TRAIL...
  23. ncbi request reprint Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate
    Xiu Fang Wang
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia
    Mol Nutr Food Res 50:675-85. 2006
    ..The results point to the novel group of vitamin E analogues as promising agents applicable to different types of tumours...
  24. ncbi request reprint Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?
    Emma Swettenham
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia
    J Neurochem 94:1448-56. 2005
    ....
  25. doi request reprint Daxx inhibits stress-induced apoptosis in cardiac myocytes
    Renata Zobalova
    Apoptosis Research Group, School of Medical Science, Griffith University and Griffith Institute of Health and Medical Research, Southport, Queensland, Australia
    Redox Rep 13:263-70. 2008
    ..Taken together, Daxx plays a protective role in cultured cardiomyocyte-like cells, at least under the conditions used...
  26. doi request reprint The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection?
    Renata Zobalova
    School of Medical Science, Griffith University, Southport, QLD, Australia
    Antioxid Redox Signal 15:2989-3002. 2011
    ..Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors...
  27. doi request reprint Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis
    Renata Zobalova
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    Biofactors 34:231-5. 2008
    ..Downregulation of FLIP by siRNA in CD133-high cells sensitised them to TRAIL killing. Thus, CD133-high cells may be resistant to TRAIL due to high expression of FLIP...
  28. doi request reprint Mitochondrial complex II, a novel target for anti-cancer agents
    Katarina Kluckova
    Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic
    Biochim Biophys Acta 1827:552-64. 2013
    ..This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease...
  29. doi request reprint Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II
    Lan Feng Dong
    Apoptosis Research Group and Genomic Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
    Clin Cancer Res 15:1593-600. 2009
    ..The purpose of this study was to elucidate the cellular target by which these agents, represented by alpha-tocopoheryl succinate (alpha-TOS), suppress tumors in vivo, with the focus on the mitochondrial complex II (CII)...
  30. doi request reprint α-Tocopheryloxyacetic acid is superior to α-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stability
    Lan Feng Dong
    School of Medical Science, Griffith Health Institute, Griffith University, Southport, QLD, Australia
    Int J Cancer 131:1052-8. 2012
    ..We propose that α-TEA is a promising drug efficient against breast cancer, as documented by its effect on experimental HER2-positive breast carcinomas that present a considerable problem in cancer management...
  31. ncbi request reprint alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors
    Michael Stapelberg
    School of Health Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 318:636-41. 2004
    ..Our data suggest a novel mechanism by which a clinically intriguing agent selectively suppresses proliferation of cancer cells, as shown here for the untreatable mesotheliomas...
  32. ncbi request reprint Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity
    Adisa Tomic-Vatic
    School of Medical Science, Griffith University, Southport, Queensland, Australia
    Int J Cancer 117:188-93. 2005
    ....
  33. doi request reprint Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death
    Stephen J Ralph
    School of Medical Science and Health Research Institute, Griffith University, Gold Coast, QLD, Australia 4222
    Pharm Res 28:2695-730. 2011
    ....
  34. ncbi request reprint Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway
    Xiu Fang Wang
    Apoptosis Research Group, School of Health Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 326:282-9. 2005
    ..Since erbB2 is frequently over-expressed in breast cancers and renders the neoplastic disease resistant to established treatment, our findings are of clinical interest...
  35. doi request reprint The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy
    Stephen J Ralph
    Genomic Research Centre, Griffith Institute of Health and Medical Research, School of Medical Science, Griffith University, Parklands Avenue, Southport, 4222 Qld, Australia
    Mol Aspects Med 31:145-70. 2010
    ..The last section concerns the relevance of these findings, their importance and significance for novel targeted approaches to anti-cancer therapy and selective triggering in cancer cells of the mitochondrial apoptotic pathway...
  36. doi request reprint Future use of mitocans against tumour-initiating cells?
    Brian J Morrison
    Queensland Institute of Medical Research, Queensland, Australia
    Mol Nutr Food Res 53:147-53. 2009
    ..Therefore, knowledge of the molecular mechanism(s) of resistance of TICs to treatment and overcoming this problem will be essential in order to develop effective drug strategies for cancer therapy...
  37. ncbi request reprint Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells
    Ruth E Freeman
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Qld 9716, Australia
    FEBS Lett 580:2671-6. 2006
    ..Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to alpha-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties...
  38. doi request reprint Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
    Stephen J Ralph
    Genomic Research Centre, School of Medical Science, Griffith University, Parklands Avenue, Southport, 4222 Qld, Australia
    Mol Aspects Med 31:29-59. 2010
    ....
  39. doi request reprint Mitochondria as targets for cancer therapy
    Stephen J Ralph
    Genomic Research Centre, School of Medical Science, Griffith University, Southport, QLD, Australia
    Mol Nutr Food Res 53:9-28. 2009
    ..Such targets appear to be mitochondria, with very rare mutations, and mitocans can be expected to be very efficient drugs of choice for a number of different types of the neoplastic disease...
  40. pmc Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress
    Koichi Ito
    School of Medical Science, Griffith Health Institute, Griffith University, Southport, QLD, Australia
    Angiogenesis 14:293-307. 2011
    ....
  41. ncbi request reprint Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Sciences, Griffith University, Southport, Queensland, Australia
    Redox Rep 10:187-97. 2005
    ....
  42. ncbi request reprint Targeting the mitochondrial electron transport chain complexes for the induction of apoptosis and cancer treatment
    Jakub Rohlena
    Apoptosis Research Group, School of Medical Science and the Griffith Health Institute, Griffith University, Southporth, 4222 Qld, Australia
    Curr Pharm Biotechnol 14:377-89. 2013
    ..Furthermore, macromolecular complexes of the electron transport chain only rarely mutate in cancer, and represent useful targets for anti-cancer drug development when widely-applicable agents are sought...
  43. ncbi request reprint Malignant mesothelioma: biology, diagnosis and therapeutic approaches
    Marco Tomasetti
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
    Curr Mol Pharmacol 2:190-206. 2009
    ..Blood tests make screening of target populations an attractive strategy. Many current gene and protein expression studies aim to identify clinically useful biomarkers and new therapeutic targets for improved management of MM...
  44. ncbi request reprint Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis
    Alexei Terman
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Exp Gerontol 38:863-76. 2003
    ..Our findings suggest that imperfect autophagic recycling of these critical organelles may underlie the progressive mitochondrial damage, which characterizes aging post-mitotic cells...
  45. ncbi request reprint Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover
    Alexei Terman
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, SE 58185, Linkoping, Sweden
    Ann N Y Acad Sci 1019:70-7. 2004
    ..Overall, our findings emphasize the importance of mitochondrial turnover in postmitotic aging and provide further support for the mitochondrial-lysosomal axis theory of aging...
  46. ncbi request reprint Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling
    Tobias Weber
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Biochemistry 42:4277-91. 2003
    ..These data provide an insight into the molecular mechanism, by which alpha-TOS kills malignant cells, and advocate its testing as a potential anticancer agent or adjuvant...
  47. ncbi request reprint The European perspective on vitamin E: current knowledge and future research
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 76:703-16. 2002
    ..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have...
  48. ncbi request reprint Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo
    Tobias Weber
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, 80336 Germany
    Clin Cancer Res 8:863-9. 2002
    ..Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential...
  49. ncbi request reprint Vitamin E analogues and immune response in cancer treatment
    Marco Tomasetti
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
    Vitam Horm 76:463-91. 2007
    ..These findings are indicative of a novel strategy for cancer treatment that involves enhanced immune system surveillance...
  50. pmc Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability
    Jiri Neuzil
    Department of Pathology II, University Hospital, Linköping 581 85, Sweden
    Biochem J 362:709-15. 2002
    ..These findings indicate that lysosomal destabilization may partially or fully explain the induction of apoptosis in cultured cells by alpha-TOS and the mechanism whereby this agent exerts in vivo anti-tumour effects...
  51. ncbi request reprint A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease?
    Marco Tomasetti
    Department of Molecular Pathology and Innovative Therapies, University Polytechnic of Marche, Ancona, Italy
    Int J Cancer 109:641-2. 2004
    ..Compared to untreated animals, the agent increased their survival >3-fold. Our finding warrants further testing of vitamin E analogues as potential antimesothelioma drugs...
  52. ncbi request reprint Alpha-tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion
    Jiri Neuzil
    Faculty of Health Sciences, Division of Pathology II, University of Linkoping, Linkoping, Sweden
    Biochem Biophys Res Commun 293:1309-13. 2002
    ..That is, the conversion of the pro-vitamin E form, alpha-TOS, to the corresponding vitamin form, alpha-tocopherol, makes this anti-neoplastic agent active against inflammatory diseases like atherosclerosis...
  53. ncbi request reprint Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties
    Joan L Buss
    Department of Physiology, McGill University, Sir Mortimer B Davis Jewish General Hospital, 3755 Chemin de la Cote Ste Catherine, Montreal, Que, Canada H3T 1E2
    Biochem Pharmacol 65:161-72. 2003
    ..Moreover, analogs of these agents lacking the iron-chelating moiety were non-toxic...
  54. ncbi request reprint Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs
    Joan L Buss
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
    Arch Biochem Biophys 421:1-9. 2004
    ..In summary, PIH analogs and their Fe(3+) complexes are redox active in the intracellular environment. The contribution of oxidative stress to the overall mechanism of toxicity varies across the series...
  55. ncbi request reprint Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gamma
    Wolfgang Erl
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Munchen, Germany
    Eur J Immunol 34:241-50. 2004
    ..Our findings show that PGA1 and PGJ2 induce apoptosis in endothelial cells independent of PPARgamma. As the synthesis of PGJ2 is increased at sites of inflammation, our results may suggest a possible mechanism for endothelial damage...
  56. ncbi request reprint Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting?
    Alexei Terman
    Division of Pathology II, Linkoping University, Linkoping, 58185, Sweden
    Exp Cell Res 274:9-15. 2002
    ..These findings give further support for the involvement of lysosomal enzymes in apoptosis and suggest I-cells as a suitable model for studying the role of lysosomes in programmed cell death...
  57. ncbi request reprint Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1
    Renata Alleva
    Department of Anaesthesiology, Rizzoli Orthopaedic Institute, 40100 Bologna, Italy
    Biochem Biophys Res Commun 331:1515-21. 2005
    ..Knocking down E2F1 rendered the alpha-TOS-sensitive cells rather resistant to the apoptotic stimulus inducing a marked and prolonged cell growth arrest. We conclude that alpha-TOS induces cell growth arrest or apoptosis involving E2F1...
  58. ncbi request reprint alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy
    Renata Alleva
    Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
    Biochem Biophys Res Commun 333:404-10. 2005
    ..Taken together, we demonstrated an adjuvant effect of LA in HBO therapy used for impaired wound healing treatment. We propose that LA may be used to further promote the beneficial effects of HBO therapy...
  59. ncbi request reprint alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner
    Yan Zhao
    Department of Nutrition and Food, Harbin Medical University, Harbin, Heilongjiang Province, China
    Cancer Lett 247:345-52. 2007
    ..We conclude that ERK1/2 and JNK positively regulate apoptosis induced in gastric cancer cells by alpha-TOS...
  60. ncbi request reprint Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide
    Paul K Witting
    ANZAC Research Institute, Concord Hospital, Concord, NSW, Australia
    Biochem Biophys Res Commun 348:485-93. 2006
    ..These data indicate that (i) Mb promotes oxidative damage to cultured CM and (ii) Mb may be a useful target for the design of inhibitors of myocardial IR injury...
  61. ncbi request reprint Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex
    Lubomir Prochazka
    Veterinary Research Institute, Department of Immunology, Brno, Czech Republic
    Arch Biochem Biophys 462:54-61. 2007
    ..Inhibition of GJIC was linked to rapid hyperphosphorylation of connexin-43 and disappearance of connexon clusters from membranes, which was not observed in the case of CDDP...
  62. pmc alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy
    Renata Alleva
    Department of Anesthesiology, IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
    Mol Med 14:175-83. 2008
    ..The disruption of the positive autocrine feedback loops that maintain the chronic wound state promotes progression of the healing process...
  63. doi request reprint Profiling tumor-associated markers for early detection of malignant mesothelioma: an epidemiologic study
    Monica Amati
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Via Tronto 10 A, Torrette di Ancona, Ancona, Italy
    Cancer Epidemiol Biomarkers Prev 17:163-70. 2008
    ..The combination of blood biomarkers and radiographic findings could be used to stratify the risk of mesothelioma in asbestos-exposed populations...