Nigel Morrison

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. pmc Internal control genes for quantitative RT-PCR expression analysis in mouse osteoblasts, osteoclasts and macrophages
    Alexandre S Stephens
    School of Medical Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Res Notes 4:410. 2011
  2. pmc Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females
    Nigel A Morrison
    School of Medical Sciences, Griffith University, Gold Coast, Queensland, Australia
    PLoS ONE 8:e72740. 2013
  3. pmc Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)
    Claire Y Wang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    BMC Med Genet 7:57. 2006
  4. ncbi request reprint Vitamin D receptor genotypes influence the success of calcitriol therapy for recurrent vertebral fracture in osteoporosis
    Nigel A Morrison
    School of Health Sciences, Gold Coast Campus, Griffith University, Queensland, Australia
    Pharmacogenet Genomics 15:127-35. 2005
  5. ncbi request reprint Commentary: vitamin D receptor polymorphism and bone mineral density: effect size in Caucasians means detection is uncertain in small studies
    Nigel Morrison
    School of Health Science, Griffith University, Gold Coast, Australia
    Int J Epidemiol 33:989-94. 2004
  6. ncbi request reprint Gene array identification of osteoclast genes: differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor
    Christopher J Day
    School of Health Sciences, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia
    J Cell Biochem 91:303-15. 2004
  7. ncbi request reprint MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorption
    Michael S Kim
    School of Medical Science, Griffith University Gold Coast Campus, Queensland, Australia
    J Biol Chem 281:1274-85. 2006
  8. ncbi request reprint Optimized transfection of diced siRNA into mature primary human osteoclasts: inhibition of cathepsin K mediated bone resorption by siRNA
    Christina I Selinger
    School of Medical Sciences, Griffith University, Gold Coast Campus, Southport, QLD, 4215, Australia
    J Cell Biochem 96:996-1002. 2005
  9. ncbi request reprint Optimised real-time quantitative PCR assays for RANKL regulated genes
    Rouha M S Granfar
    School of Health Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD 4215, Australia
    Mol Cell Probes 19:119-26. 2005
  10. ncbi request reprint Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture
    Tanya Vaughan
    Genomics Research Center, School of Health Science, Gold Coast Campus Griffith University, Queensland, Australia
    J Bone Miner Res 17:1527-34. 2002

Collaborators

Detail Information

Publications18

  1. pmc Internal control genes for quantitative RT-PCR expression analysis in mouse osteoblasts, osteoclasts and macrophages
    Alexandre S Stephens
    School of Medical Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Res Notes 4:410. 2011
    ..abstract:..
  2. pmc Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females
    Nigel A Morrison
    School of Medical Sciences, Griffith University, Gold Coast, Queensland, Australia
    PLoS ONE 8:e72740. 2013
    ..These findings suggest that the 11A allele is a biologically relevant polymorphism that influences serum CTx and confers enhanced fracture risk in a site-selective manner related to intramembranous bone ossification. ..
  3. pmc Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)
    Claire Y Wang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    BMC Med Genet 7:57. 2006
    ..The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians...
  4. ncbi request reprint Vitamin D receptor genotypes influence the success of calcitriol therapy for recurrent vertebral fracture in osteoporosis
    Nigel A Morrison
    School of Health Sciences, Gold Coast Campus, Griffith University, Queensland, Australia
    Pharmacogenet Genomics 15:127-35. 2005
    ..4x10(-5)). Response to both calcium and calcitriol therapy is dependent on genetic variation at the VDR locus and two loci in the VDR gene may contribute to this effect...
  5. ncbi request reprint Commentary: vitamin D receptor polymorphism and bone mineral density: effect size in Caucasians means detection is uncertain in small studies
    Nigel Morrison
    School of Health Science, Griffith University, Gold Coast, Australia
    Int J Epidemiol 33:989-94. 2004
  6. ncbi request reprint Gene array identification of osteoclast genes: differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor
    Christopher J Day
    School of Health Sciences, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia
    J Cell Biochem 91:303-15. 2004
    ....
  7. ncbi request reprint MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorption
    Michael S Kim
    School of Medical Science, Griffith University Gold Coast Campus, Queensland, Australia
    J Biol Chem 281:1274-85. 2006
    ..We propose that the MCP-1-induced TRAP(+)/CTR(+) multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity...
  8. ncbi request reprint Optimized transfection of diced siRNA into mature primary human osteoclasts: inhibition of cathepsin K mediated bone resorption by siRNA
    Christina I Selinger
    School of Medical Sciences, Griffith University, Gold Coast Campus, Southport, QLD, 4215, Australia
    J Cell Biochem 96:996-1002. 2005
    ..018) and resorbed area (P = 0.013). We also show that FuGENE 6 is an effective lipid transfection reagent with which to transfect primary human osteoclasts, that does not produce off-target effects...
  9. ncbi request reprint Optimised real-time quantitative PCR assays for RANKL regulated genes
    Rouha M S Granfar
    School of Health Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD 4215, Australia
    Mol Cell Probes 19:119-26. 2005
    ..As an example, the regulation of expression of the chemokine RANTES in osteoclasts is demonstrated. These gene assays have potential utility in a variety of cell types, tissues and organs, in addition to macrophages and osteoclasts...
  10. ncbi request reprint Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture
    Tanya Vaughan
    Genomics Research Center, School of Health Science, Gold Coast Campus Griffith University, Queensland, Australia
    J Bone Miner Res 17:1527-34. 2002
    ..The A allele was associated with increased BMD and was protective against a common form of osteoporotic fracture, suggesting that RUNX2 variants may be related to genetic effects on BMD and osteoporosis...
  11. ncbi request reprint NFAT expression in human osteoclasts
    Christopher J Day
    School of Health Sciences, Griffith University, Gold Coast Campus, Parklands Drive, Southport, Queensland 4215, Australia
    J Cell Biochem 95:17-23. 2005
    ..The NFATc1 variants expressed by human osteoclasts are not those normally expressed by effector T-cells but are similar to those seen in naïve T-cells...
  12. ncbi request reprint The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells
    Justin A Boddey
    Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
    Cell Microbiol 9:514-31. 2007
    ..Mutation of lfpA significantly reduced expression of the tested host genes, relative to the response to wild-type B. pseudomallei. We also show that lfpA is required for optimal virulence in vivo...
  13. ncbi request reprint Association of functionally different RUNX2 P2 promoter alleles with BMD
    James D Doecke
    School of Medical Science, Gold Coast Campus, Griffith University, Queensland, Australia
    J Bone Miner Res 21:265-73. 2006
    ..Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2 promoter SNPs were functionally different in gel-shift and promoter activity assays...
  14. ncbi request reprint RUNX2 alleles associated with BMD in Scottish women; interaction of RUNX2 alleles with menopausal status and body mass index
    Tanya Vaughan
    School of Health Science, Griffith University Gold Coast Campus, 4215 Queensland, Australia
    Bone 34:1029-36. 2004
    ..Glutamine variants and an alanine insertion were identified within the group. These data suggest that the RUNX2 alleles are associated with BMD in a menopause- and weight-dependent manner...
  15. ncbi request reprint Differential gene expression in breast cancer cell lines and stroma-tumor differences in microdissected breast cancer biopsies revealed by display array analysis
    Albert S Mellick
    Genomics Research Centre, School of Health Science, Gold Coast Campus of Griffith University, Gold Coast, Queensland, Australia
    Int J Cancer 100:172-80. 2002
    ..Use of microdissection and the DD-PCR array protocol allowed us to identify factors whose localized expression within the breast may play a role in abnormal breast development or breast carcinogenesis...
  16. ncbi request reprint Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES
    Michael S Kim
    School of Medical Sciences, Griffith University Gold Coast Campus, Queensland 9726, Australia
    J Cell Biochem 97:512-8. 2006
    ..0 x 10(-10)), while RANTES treatment resulted in twofold repression (P = 1.0 x 10(-4)). Since CCR2b and CCR4 are MCP-1 receptors, these data support the existence of an MCP-1 autocrine loop in human osteoclasts differentiated using RANKL...
  17. ncbi request reprint MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation
    Michael S Kim
    School of Medical Science, Griffith University Gold Coast Campus, Queensland 4215, Australia
    J Biol Chem 280:16163-9. 2005
    ....
  18. ncbi request reprint Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling
    Cathy J Aitken
    Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, Geelong, Victoria 3220, Australia
    J Bone Miner Res 19:2057-64. 2004
    ..Adenoviral overexpression of TBP-2 in osteoclast precursors inhibits Trx-1 expression, osteoclast formation, and AP-1 binding activity. TBP-2 and Trx-1 are key regulators of osteoclastogenesis...