Research Topics
Genomes and Genes
Species | George D MellickSummaryAffiliation: Griffith University Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Single and dual task gait training in people with Parkinson's disease: a protocol for a randomised controlled trialSandra G Brauer
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD 4072 Australia
BMC Neurol 11:90. 2011..This study will address this issue by comparing single to dual task gait training...
TNF gene polymorphism and quantitative traits related to cardiovascular disease: getting to the heart of the matterGeorge D Mellick
Eskitis Institue for Cell and Molecular Therapies, Griffith University, Nathan Campus, Queensland 4111, Australia
Eur J Hum Genet 15:609-11. 2007- Passive smoking and Parkinson diseaseGeorge D Mellick
Institute of Cell and Molecular Therapies, Griffith University, School of Public Health, Nathan QLD 4111, Australia
Neurology 67:179-80. 2006 
Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilitiesGeorge D Mellick
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, QLD 4111, Australia
Expert Rev Mol Diagn 10:1035-50. 2010....- Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, AustraliaGeorge D Mellick
Eskitis Institute for Cellular and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia
Parkinsonism Relat Disord 15:105-9. 2009..G2019S mutation in LRRK2. No alpha-synuclein or DJ-1 variants were observed. Our data suggest that approximately 7% of early-onset PD cases seen in Queensland movement disorders clinics have mutations involving known PARK genes... - Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?Greg T Sutherland
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia
Mov Disord 24:833-8. 2009..No associations were seen for PRKN, PINK1, GBA, ATP13A2, HTRA2, NR4A2, and DJ1. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians... - Serotonin and dopamine transporter genes do not influence depression in Parkinson's diseaseNadeeka N W Dissanayaka
School of Medicine, University of Queensland, Brisbane, Australia
Mov Disord 24:111-5. 2009..No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD... - Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's diseaseGreg T Sutherland
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia
Mov Disord 24:449-52. 2009..Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians... - Common polymorphisms in dystonia-linked genes and susceptibility to the sporadic primary dystoniasJeremy R B Newman
Clinical Neuroscience Group, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Don Young Road, Nathan, Queensland, Australia
Parkinsonism Relat Disord 18:351-7. 2012..Further work is warranted to follow up the GCH1 SNPs and the subgroup analyses... - Validity and reliability of the Geriatric Anxiety Inventory in Parkinson's diseaseSally F Matheson
School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Brisbane, Australia
Australas J Ageing 31:13-6. 2012..To examine the psychometric properties of a novel anxiety rating scale, the Geriatric Anxiety Inventory (GAI) in Parkinson's disease (PD)... - Association of APOE with Parkinson disease age-at-onset in womenDaniel D Buchanan
University of Queensland, School of Medicine, Department of Neurology, Princess Alexandra Hospital, Brisbane, Australia
Neurosci Lett 411:185-8. 2007..0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders... - NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's diseaseAnthony L Cook
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
PLoS ONE 6:e21907. 2011..Transcriptomic analysis of Patient and Control hONS cells identified the NRF2 transcription factor signalling pathway as the most differentially expressed in Parkinson's disease... - Anxiety disorders in Parkinson's disease: prevalence and risk factorsNadeeka N W Dissanayaka
Neurology Research Centre, Royal Brisbane and Women s Hospital, Brisbane, Australia
Mov Disord 25:838-45. 2010..Anxiety adds to the complexity of PD, lowering patients' quality of life. Future research can be directed to identify reactive and organic nature of anxiety in PD... - Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's diseaseGeorge D Mellick
Department of Neurology, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Neurosci Lett 375:112-6. 2005..79, 95% CI 0.70-0.89, p=0.0001). Further study must now proceed to examine in detail this interesting and biologically plausible genetic association... - Factors associated with depression in Parkinson's diseaseNadeeka N W Dissanayaka
Neurology Research Centre, Royal Brisbane and Women s Hospital, Brisbane, Australia
J Affect Disord 132:82-8. 2011..The determinants of depression in PD are complex and poorly understood. We investigated the factors associated with depression in PD... - Test-retest repeatability of self-reported environmental exposures in Parkinson's disease cases and healthy controlsCoral E Gartner
School of Public Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
Parkinsonism Relat Disord 11:287-95. 2005..39-0.74). In general, we found that case and control participants provided similar rates of incongruent and missing responses for categorical and continuous occupational, domestic, lifestyle and medical exposures... - A cross-study transcriptional analysis of Parkinson's diseaseGreg T Sutherland
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
PLoS ONE 4:e4955. 2009..Our findings suggest that there is greater concordance in PD whole-genome expression profiling when standardised pathway membership rather than ranked gene list is used for comparison... - Markers of disease severity are associated with malnutrition in Parkinson's diseaseJamie M Sheard
School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia Movement Neuroscience Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
PLoS ONE 8:e57986. 2013..Few studies have explored which of these factors are of particular importance in malnutrition in PD. The aim was to identify the determinants of nutritional status in people with Parkinson's disease (PWP)... - Prevalence of Parkinson's disease in metropolitan and rural Queensland: a general practice surveyCatherine M Peters
Centre for Health Research (Public Health, Queensland University of Technology, Brisbane, Queensland, Australia
J Clin Neurosci 13:343-8. 2006..Support from neurologists was perceived by GPs to be very good in cities, but poor in remote areas... - Validity of Hamilton Depression Inventory in Parkinson's diseaseNadeeka N W Dissanayaka
School of Medicine, University of Queensland, Brisbane, Australia
Mov Disord 22:399-403. 2007..The HDI exhibited an optimal cutoff for discriminating between depressed and nondepressed PD patients of 13.5/14.0 and is a valid instrument to use in the setting of PD... - Case-only study of interactions between genetic polymorphisms of GSTM1, P1, T1 and Z1 and smoking in Parkinson's diseaseYifu Deng
Centre for Health Research, School of Public Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
Neurosci Lett 366:326-31. 2004..02 for trend). These data suggest that one or more GSTP1 polymorphisms may interact with cigarette smoking to influence the risk for PD... - Malnutrition in a sample of community-dwelling people with Parkinson's diseaseJamie M Sheard
School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
PLoS ONE 8:e53290. 2013..However, the prevalence of malnutrition in Parkinson's disease is not yet well defined. The aim of this study is to provide an estimate of the extent of malnutrition in community-dwelling people with Parkinson's disease... - Disease-specific, neurosphere-derived cells as models for brain disordersNicholas Matigian
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia
Dis Model Mech 3:785-98. 2010..They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery... - Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international studyAlexis Elbaz
INSERM, Unit 708, Paris, France
Lancet Neurol 5:917-23. 2006..INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease... - UCHL1 is a Parkinson's disease susceptibility geneDemetrius M Maraganore
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Ann Neurol 55:512-21. 2004..These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies... - Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's diseaseYue Huang
Prince of Wales Medical Research Institute, University of New South Wales, Australia
Mov Disord 22:982-9. 2007..Our results demonstrate that the G2019S mutation carriers share the same ancestors who migrated to Australia originally from Europe and that other LRRK2 mutations (R1441H and A1442P) can be found in this population... - Tau haplotypes regulate transcription and are associated with Parkinson's diseaseJohn B J Kwok
Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Ann Neurol 55:329-34. 2004..Our data suggest that an increase in expression of the MAPT gene is a susceptibility factor in idiopathic PD... - Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer diseaseMia E L Blomqvist
Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
Neurogenetics 5:115-9. 2004..Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner... - Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's diseaseYifu Deng
Ann Neurol 55:897. 2004 - GSK3B polymorphisms alter transcription and splicing in Parkinson's diseaseJohn B J Kwok
Garvan Institute of Medical Research, University of New South Wales, Barker Street, Randwick, Sydney NSW 2031, Australia
Ann Neurol 58:829-39. 2005..64; p = 0.007; (H1/H1 individuals: odds ratio, 0.68; p < 0.001). Ours results suggest GSK3B polymorphisms alter transcription and splicing and interact with Tau haplotypes to modify disease risk in PD... - Parkinson's disease and family historyAnnabella N Sellbach
University of Queensland, School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane Qld 4102, Australia
Parkinsonism Relat Disord 12:399-409. 2006..Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up... - Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson diseaseDemetrius M Maraganore
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
JAMA 296:661-70. 2006..Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking... - Age-environment and gene-environment interactions in the pathogenesis of Parkinson's diseaseDavid G Le Couteur
Centre for Education and Research on Ageing and the ANZAC Research Institute, University of Sydney, Concord RG Hospital, NSW, Australia
Rev Environ Health 17:51-64. 2002..Common final pathways for aging, environmental, and genetic mechanisms can thus exist, involving both direct neurotoxicity and alpha-synuclein aggregation...