George D Mellick

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. pmc A cross-study transcriptional analysis of Parkinson's disease
    Greg T Sutherland
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
    PLoS ONE 4:e4955. 2009
  2. pmc Single and dual task gait training in people with Parkinson's disease: a protocol for a randomised controlled trial
    Sandra G Brauer
    School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD 4072 Australia
    BMC Neurol 11:90. 2011
  3. ncbi request reprint Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilities
    George D Mellick
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, QLD 4111, Australia
    Expert Rev Mol Diagn 10:1035-50. 2010
  4. ncbi request reprint TNF gene polymorphism and quantitative traits related to cardiovascular disease: getting to the heart of the matter
    George D Mellick
    Eskitis Institue for Cell and Molecular Therapies, Griffith University, Nathan Campus, Queensland 4111, Australia
    Eur J Hum Genet 15:609-11. 2007
  5. ncbi request reprint Passive smoking and Parkinson disease
    George D Mellick
    Institute of Cell and Molecular Therapies, Griffith University, School of Public Health, Nathan QLD 4111, Australia
    Neurology 67:179-80. 2006
  6. doi request reprint Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia
    George D Mellick
    Eskitis Institute for Cellular and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia
    Parkinsonism Relat Disord 15:105-9. 2009
  7. doi request reprint Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
    Greg T Sutherland
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia
    Mov Disord 24:833-8. 2009
  8. pmc Markers of disease severity are associated with malnutrition in Parkinson's disease
    Jamie M Sheard
    School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    PLoS ONE 8:e57986. 2013
  9. ncbi request reprint Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
    Greg T Sutherland
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia
    Mov Disord 24:449-52. 2009
  10. doi request reprint Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
    Nadeeka N W Dissanayaka
    School of Medicine, University of Queensland, Brisbane, Australia
    Mov Disord 24:111-5. 2009

Collaborators

Detail Information

Publications36

  1. pmc A cross-study transcriptional analysis of Parkinson's disease
    Greg T Sutherland
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
    PLoS ONE 4:e4955. 2009
    ..Our findings suggest that there is greater concordance in PD whole-genome expression profiling when standardised pathway membership rather than ranked gene list is used for comparison...
  2. pmc Single and dual task gait training in people with Parkinson's disease: a protocol for a randomised controlled trial
    Sandra G Brauer
    School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD 4072 Australia
    BMC Neurol 11:90. 2011
    ..This study will address this issue by comparing single to dual task gait training...
  3. ncbi request reprint Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilities
    George D Mellick
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, QLD 4111, Australia
    Expert Rev Mol Diagn 10:1035-50. 2010
    ....
  4. ncbi request reprint TNF gene polymorphism and quantitative traits related to cardiovascular disease: getting to the heart of the matter
    George D Mellick
    Eskitis Institue for Cell and Molecular Therapies, Griffith University, Nathan Campus, Queensland 4111, Australia
    Eur J Hum Genet 15:609-11. 2007
  5. ncbi request reprint Passive smoking and Parkinson disease
    George D Mellick
    Institute of Cell and Molecular Therapies, Griffith University, School of Public Health, Nathan QLD 4111, Australia
    Neurology 67:179-80. 2006
  6. doi request reprint Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia
    George D Mellick
    Eskitis Institute for Cellular and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia
    Parkinsonism Relat Disord 15:105-9. 2009
    ..G2019S mutation in LRRK2. No alpha-synuclein or DJ-1 variants were observed. Our data suggest that approximately 7% of early-onset PD cases seen in Queensland movement disorders clinics have mutations involving known PARK genes...
  7. doi request reprint Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
    Greg T Sutherland
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia
    Mov Disord 24:833-8. 2009
    ..No associations were seen for PRKN, PINK1, GBA, ATP13A2, HTRA2, NR4A2, and DJ1. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians...
  8. pmc Markers of disease severity are associated with malnutrition in Parkinson's disease
    Jamie M Sheard
    School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    PLoS ONE 8:e57986. 2013
    ..Few studies have explored which of these factors are of particular importance in malnutrition in PD. The aim was to identify the determinants of nutritional status in people with Parkinson's disease (PWP)...
  9. ncbi request reprint Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
    Greg T Sutherland
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia
    Mov Disord 24:449-52. 2009
    ..Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians...
  10. doi request reprint Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
    Nadeeka N W Dissanayaka
    School of Medicine, University of Queensland, Brisbane, Australia
    Mov Disord 24:111-5. 2009
    ..No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD...
  11. doi request reprint Common polymorphisms in dystonia-linked genes and susceptibility to the sporadic primary dystonias
    Jeremy R B Newman
    Clinical Neuroscience Group, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Don Young Road, Nathan, Queensland, Australia
    Parkinsonism Relat Disord 18:351-7. 2012
    ..Further work is warranted to follow up the GCH1 SNPs and the subgroup analyses...
  12. doi request reprint Validity and reliability of the Geriatric Anxiety Inventory in Parkinson's disease
    Sally F Matheson
    School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Australas J Ageing 31:13-6. 2012
    ..To examine the psychometric properties of a novel anxiety rating scale, the Geriatric Anxiety Inventory (GAI) in Parkinson's disease (PD)...
  13. ncbi request reprint Anxiety disorders in Parkinson's disease: prevalence and risk factors
    Nadeeka N W Dissanayaka
    Neurology Research Centre, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Mov Disord 25:838-45. 2010
    ..Anxiety adds to the complexity of PD, lowering patients' quality of life. Future research can be directed to identify reactive and organic nature of anxiety in PD...
  14. ncbi request reprint Association of APOE with Parkinson disease age-at-onset in women
    Daniel D Buchanan
    University of Queensland, School of Medicine, Department of Neurology, Princess Alexandra Hospital, Brisbane, Australia
    Neurosci Lett 411:185-8. 2007
    ..0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders...
  15. doi request reprint Factors associated with depression in Parkinson's disease
    Nadeeka N W Dissanayaka
    Neurology Research Centre, Royal Brisbane and Women s Hospital, Brisbane, Australia
    J Affect Disord 132:82-8. 2011
    ..The determinants of depression in PD are complex and poorly understood. We investigated the factors associated with depression in PD...
  16. pmc NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease
    Anthony L Cook
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
    PLoS ONE 6:e21907. 2011
    ..Transcriptomic analysis of Patient and Control hONS cells identified the NRF2 transcription factor signalling pathway as the most differentially expressed in Parkinson's disease...
  17. ncbi request reprint Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease
    George D Mellick
    Department of Neurology, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Neurosci Lett 375:112-6. 2005
    ..79, 95% CI 0.70-0.89, p=0.0001). Further study must now proceed to examine in detail this interesting and biologically plausible genetic association...
  18. ncbi request reprint Test-retest repeatability of self-reported environmental exposures in Parkinson's disease cases and healthy controls
    Coral E Gartner
    School of Public Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Parkinsonism Relat Disord 11:287-95. 2005
    ..39-0.74). In general, we found that case and control participants provided similar rates of incongruent and missing responses for categorical and continuous occupational, domestic, lifestyle and medical exposures...
  19. ncbi request reprint Prevalence of Parkinson's disease in metropolitan and rural Queensland: a general practice survey
    Catherine M Peters
    Centre for Health Research Public Health, Queensland University of Technology, Brisbane, Queensland, Australia
    J Clin Neurosci 13:343-8. 2006
    ..Support from neurologists was perceived by GPs to be very good in cities, but poor in remote areas...
  20. pmc Malnutrition in a sample of community-dwelling people with Parkinson's disease
    Jamie M Sheard
    School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    PLoS ONE 8:e53290. 2013
    ..However, the prevalence of malnutrition in Parkinson's disease is not yet well defined. The aim of this study is to provide an estimate of the extent of malnutrition in community-dwelling people with Parkinson's disease...
  21. ncbi request reprint Validity of Hamilton Depression Inventory in Parkinson's disease
    Nadeeka N W Dissanayaka
    School of Medicine, University of Queensland, Brisbane, Australia
    Mov Disord 22:399-403. 2007
    ..The HDI exhibited an optimal cutoff for discriminating between depressed and nondepressed PD patients of 13.5/14.0 and is a valid instrument to use in the setting of PD...
  22. ncbi request reprint Case-only study of interactions between genetic polymorphisms of GSTM1, P1, T1 and Z1 and smoking in Parkinson's disease
    Yifu Deng
    Centre for Health Research, School of Public Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Neurosci Lett 366:326-31. 2004
    ..02 for trend). These data suggest that one or more GSTP1 polymorphisms may interact with cigarette smoking to influence the risk for PD...
  23. ncbi request reprint Rare POLG1 CAG variants do not influence Parkinson's disease or polymerase gamma function
    Steven R Bentley
    Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia
    Mitochondrion 15:65-8. 2014
    ..427) or Complex I activity (p=0.639) were not different in cells derived from individuals with different POLG1 genotypes. These data provide no evidence to suggest CAG repeat length in POLG1 affects PD susceptibility. ..
  24. ncbi request reprint NMR fingerprints of the drug-like natural-product space identify iotrochotazine A: a chemical probe to study Parkinson's disease
    Tanja Grkovic
    Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, 4111 Australia
    Angew Chem Int Ed Engl 53:6070-4. 2014
    ..Compound 1 at 1 μM was not cytotoxic but specifically affected the morphology and cellular distribution of lysosomes and early endosomes...
  25. doi request reprint The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer
    Jordan Follett
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia
    Traffic 15:230-44. 2014
    ..In summary, we find that the expression of Vps35 D620N leads to endosomal alterations and trafficking defects that may partly explain its action in PD. ..
  26. doi request reprint Disease-specific, neurosphere-derived cells as models for brain disorders
    Nicholas Matigian
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia
    Dis Model Mech 3:785-98. 2010
    ..They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery...
  27. pmc Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Lancet Neurol 5:917-23. 2006
    ..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...
  28. ncbi request reprint UCHL1 is a Parkinson's disease susceptibility gene
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Ann Neurol 55:512-21. 2004
    ..These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies...
  29. ncbi request reprint Tau haplotypes regulate transcription and are associated with Parkinson's disease
    John B J Kwok
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Ann Neurol 55:329-34. 2004
    ..Our data suggest that an increase in expression of the MAPT gene is a susceptibility factor in idiopathic PD...
  30. ncbi request reprint Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease
    Mia E L Blomqvist
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Neurogenetics 5:115-9. 2004
    ..Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner...
  31. ncbi request reprint Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease
    Yifu Deng
    Ann Neurol 55:897. 2004
  32. ncbi request reprint GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    John B J Kwok
    Garvan Institute of Medical Research, University of New South Wales, Barker Street, Randwick, Sydney NSW 2031, Australia
    Ann Neurol 58:829-39. 2005
    ..64; p = 0.007; (H1/H1 individuals: odds ratio, 0.68; p < 0.001). Ours results suggest GSK3B polymorphisms alter transcription and splicing and interact with Tau haplotypes to modify disease risk in PD...
  33. ncbi request reprint Parkinson's disease and family history
    Annabella N Sellbach
    University of Queensland, School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane Qld 4102, Australia
    Parkinsonism Relat Disord 12:399-409. 2006
    ..Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up...
  34. ncbi request reprint Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 296:661-70. 2006
    ..Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking...
  35. ncbi request reprint Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease
    Yue Huang
    Prince of Wales Medical Research Institute, University of New South Wales, Australia
    Mov Disord 22:982-9. 2007
    ..Our results demonstrate that the G2019S mutation carriers share the same ancestors who migrated to Australia originally from Europe and that other LRRK2 mutations (R1441H and A1442P) can be found in this population...
  36. ncbi request reprint Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease
    David G Le Couteur
    Centre for Education and Research on Ageing and the ANZAC Research Institute, University of Sydney, Concord RG Hospital, NSW, Australia
    Rev Environ Health 17:51-64. 2002
    ..Common final pathways for aging, environmental, and genetic mechanisms can thus exist, involving both direct neurotoxicity and alpha-synuclein aggregation...