Nigel A J McMillan

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. pmc RNA interference for the treatment of papillomavirus disease
    Richa Singhania
    The University of Queensland Diamantina Institute, Brisbane, Australia
    Open Virol J 6:204-15. 2012
  2. pmc Potent inhibition of Hendra virus infection via RNA interference and poly I:C immune activation
    Jana L McCaskill
    The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia
    PLoS ONE 8:e64360. 2013
  3. pmc Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA
    Jana McCaskill
    University of Queensland Diamantina Institute, Brisbane, Australia
    Mol Ther Nucleic Acids 2:e96. 2013
  4. doi request reprint siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo
    Norliana Khairuddin
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Immunol Cell Biol 90:187-96. 2012
  5. doi request reprint In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours
    Norliana Khairuddin
    1 The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia 2 Immunotherapeutics Laboratory ITL and Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Immunol Cell Biol 92:156-63. 2014
  6. ncbi request reprint RNA interference for viral infections
    Stephen J Blake
    Australian Infectious Diseases Research Centre and Diamantina Institute, University of Queensland, Brisbane, QLD4072, Australia
    Curr Drug Targets 13:1411-20. 2012
  7. ncbi request reprint Dendrosome-based delivery of siRNA against E6 and E7 oncogenes in cervical cancer
    Tathagata Dutta
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Nanomedicine 6:463-70. 2010
  8. ncbi request reprint CCL2 and CXCL2 enhance survival of primary chronic lymphocytic leukemia cells in vitro
    Melinda Burgess
    Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia
    Leuk Lymphoma 53:1988-98. 2012
  9. doi request reprint Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer
    Tzu Yu Liu
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
    Biomacromolecules 14:2798-806. 2013

Collaborators

  • Istvan Toth
  • Glenn A Marsh
  • Lin Fa Wang
  • Tathagata Dutta
  • Norliana Khairuddin
  • Stephen J Blake
  • Richa Singhania
  • Melinda Burgess
  • Jana McCaskill
  • Mark A Behlke
  • Tzu Yu Liu
  • Jana L McCaskill
  • Paul J Hertzog
  • Raymond J Steptoe
  • Farah Firdaus
  • Sherry Wu
  • Zhongfan Jia
  • Waleed M Hussein
  • Antje Blumenthal
  • Zyta M Ziora
  • Timothy Doran
  • Michael J Monteiro
  • Rachel Allavena
  • Paul Monaghan
  • Mariusz Skwarczynski
  • Catherine Cheung
  • Devinder Gill
  • Michael P Gantier
  • Gunjeet Minhas
  • Sherry Y Wu
  • Fawzi F Bokhari
  • Bryan R G Williams
  • Karunya Ravindranath
  • Lynne Chambers
  • Daniel Clarke
  • Louise Knop
  • Peter Mollee

Detail Information

Publications9

  1. pmc RNA interference for the treatment of papillomavirus disease
    Richa Singhania
    The University of Queensland Diamantina Institute, Brisbane, Australia
    Open Virol J 6:204-15. 2012
    ..We discuss the idea of using RNAi with current treatments and address delivery of RNAi, the major issue holding back clinical adoption. Finally, we present our view of a potential path to the clinic...
  2. pmc Potent inhibition of Hendra virus infection via RNA interference and poly I:C immune activation
    Jana L McCaskill
    The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia
    PLoS ONE 8:e64360. 2013
    ..Our results demonstrate for the first time that RNAi and type I interferon stimulation are effective inhibitors of HeV replication in vitro and may provide an effective therapy for this highly lethal, zoonotic pathogen...
  3. pmc Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA
    Jana McCaskill
    University of Queensland Diamantina Institute, Brisbane, Australia
    Mol Ther Nucleic Acids 2:e96. 2013
    ..This approach may provide an attractive alternate therapeutic delivery strategy for the treatment of lung epithelium diseases.Molecular Therapy - Nucleic Acids (2013) 2, e96; doi:10.1038/mtna.2013.22; published online 4 June 2013...
  4. doi request reprint siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo
    Norliana Khairuddin
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Immunol Cell Biol 90:187-96. 2012
    ..Collectively, our work demonstrates for the first time that siRNA-induced immunostimulation can have antitumoral effects against HPV-driven tumors in vivo, even independent of gene silencing efficacy...
  5. doi request reprint In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours
    Norliana Khairuddin
    1 The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia 2 Immunotherapeutics Laboratory ITL and Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Immunol Cell Biol 92:156-63. 2014
    ..Our data suggest that selection of siRNA profile and delivery method based on tumour environment is crucial to developing siRNA-based therapies. ..
  6. ncbi request reprint RNA interference for viral infections
    Stephen J Blake
    Australian Infectious Diseases Research Centre and Diamantina Institute, University of Queensland, Brisbane, QLD4072, Australia
    Curr Drug Targets 13:1411-20. 2012
    ..Finally we examine innovative approaches being pursued at the Australian Infectious Diseases Research Centre including the use of high-throughput siRNA screens to identify new antiviral targets...
  7. ncbi request reprint Dendrosome-based delivery of siRNA against E6 and E7 oncogenes in cervical cancer
    Tathagata Dutta
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Nanomedicine 6:463-70. 2010
    ..Our results imply that dendrosomes hold potential for the delivery of siRNA and that a suitable targeting strategy could be useful for applications in vivo...
  8. ncbi request reprint CCL2 and CXCL2 enhance survival of primary chronic lymphocytic leukemia cells in vitro
    Melinda Burgess
    Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia
    Leuk Lymphoma 53:1988-98. 2012
    ..Our data support the concept that the CLL microenvironment is critical, and suggests that soluble factors are more important than physical interactions...
  9. doi request reprint Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer
    Tzu Yu Liu
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
    Biomacromolecules 14:2798-806. 2013
    ..These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant...