Roger S Holmes


Affiliation: Griffith University
Country: Australia


  1. Holmes R. Polyploidy among salmonid aldehyde dehydrogenase genes and proteins. Chem Biol Interact. 2019;303:22-26 pubmed publisher
    ..Phylogenetic studies of salmon and rainbow trout ALDH3A2 genes and proteins suggested that salmonid gene tetraploidy has occurred in at least 2 distinct stages of ALDH3A2 gene evolution. ..
  2. Holmes R, Rout U. Comparative studies of vertebrate Beta integrin genes and proteins: ancient genes in vertebrate evolution. Biomolecules. 2011;1:3-31 pubmed publisher
  3. Holmes R. Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36). Biomolecules. 2012;2:389-414 pubmed publisher
    ..These suggested that CD36 originated in an ancestral genome and was subsequently duplicated to form three vertebrate CD36 gene family members, SCARB1, SCARB2 and CD36. ..
  4. Holmes R, Barron K, Krupenko N. Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution. Biomolecules. 2018;8: pubmed publisher
    ..Phylogenetic analysis of the vertebrate CerS1⁻6 gene families relationships supports a major role for the CerS6 enzyme that is strongly conserved throughout vertebrate evolution. ..
  5. Holmes R. Opossum alcohol dehydrogenases: Sequences, structures, phylogeny and evolution: evidence for the tandem location of ADH genes on opossum chromosome 5. Chem Biol Interact. 2009;178:8-15 pubmed publisher
    ..Percentage substitution rates were examined for ADHs during vertebrate evolution which indicated that ADH3 is evolving at a much slower rate to that of the other ADH classes. ..
  6. Holmes R, Goldberg E. Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs. Comput Biol Chem. 2009;33:379-85 pubmed publisher
  7. Holmes R. Comparative and evolutionary studies of vertebrate ALDH1A-like genes and proteins. Chem Biol Interact. 2015;234:4-11 pubmed publisher
  8. Holmes R. Opossum aldehyde dehydrogenases: evidence for four ALDH1A1-like genes on chromosome 6 and ALDH1A2 and ALDH1A3 genes on chromosome 1. Biochem Genet. 2009;47:609-24 pubmed publisher
    ..It is proposed that the common ancestor for ALDH1A genes predates the appearance of birds during vertebrate evolution. ..
  9. Holmes R. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). Comp Biochem Physiol Part D Genomics Proteomics. 2010;5:45-54 pubmed publisher

More Information


  1. Holmes R, Hempel J. Comparative studies of vertebrate aldehyde dehydrogenase 3: sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. Chem Biol Interact. 2011;191:113-21 pubmed publisher
  2. Holmes R. Comparative and evolutionary studies of ALDH18A1 genes and proteins. Chem Biol Interact. 2017;276:2-8 pubmed publisher
    ..A more recent Aldh18a1 gene duplication event has apparently occurred with a primordial rat genome. ..
  3. Holmes R. Comparative and evolutionary studies of mammalian arylsulfatase and sterylsulfatase genes and proteins encoded on the X-chromosome. Comput Biol Chem. 2017;68:71-77 pubmed publisher
  4. Holmes R. Comparative studies of vertebrate iduronate 2-sulfatase (IDS) genes and proteins: evolution of A mammalian X-linked gene. 3 Biotech. 2017;7:22 pubmed publisher
    ..These suggested that IDS has originated in an invertebrate ancestral genome and retained throughout vertebrate evolution and conserved on marsupial and eutherian X-chromosomes, with the exception of rat Ids on chromosome 8. ..