John P Headrick

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. ncbi request reprint Age-related changes in ischemic tolerance in male and female mouse hearts
    Laura Willems
    Heart Foundation Research Center, School of Health Science, Griffith University, Southport, QLD 4217, Australia
    J Mol Cell Cardiol 38:245-56. 2005
  2. doi request reprint Cardiovascular adenosine receptors: expression, actions and interactions
    John P Headrick
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, QLD, Australia Electronic address
    Pharmacol Ther 140:92-111. 2013
  3. ncbi request reprint Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine
    Melissa E Reichelt
    Heart Foundation Research Centre, Griffith University, Southport, QLD 4217, Australia
    Exp Physiol 92:175-85. 2007
  4. ncbi request reprint Acute adenosinergic cardioprotection in ischemic-reperfused hearts
    John P Headrick
    Heart Foundation Research Centre, Griffith University, Southport, Queensland 4217, Australia
    Am J Physiol Heart Circ Physiol 285:H1797-818. 2003
  5. ncbi request reprint Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts
    Laura Willems
    Heart Foundation Research Center, Griffith University, Southport, QLD 4217, Australia
    Cardiovasc Res 71:79-87. 2006
  6. ncbi request reprint Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects
    Jason Peart
    Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Queensland 4217, Southport, Australia
    Cardiovasc Res 58:589-601. 2003
  7. pmc Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression
    John P Headrick
    Heart Foundation Research Centre, School of Health Science, Griffith University, Southport, QLD 4217, Australia
    J Physiol 549:823-33. 2003
  8. pmc Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts
    Melissa E Reichelt
    Heart Foundation Research Center, Griffith University, Southport, Queensland, Australia
    Antioxid Redox Signal 11:2641-50. 2009
  9. doi request reprint Cardiac and coronary function in the Langendorff-perfused mouse heart model
    Melissa E Reichelt
    Heart Foundation Research Centre, Griffith University, Southport, Queensland, Australia
    Exp Physiol 94:54-70. 2009
  10. ncbi request reprint Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress
    Kevin J Ashton
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, QLD 4217, Australia
    Exp Gerontol 41:189-204. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Age-related changes in ischemic tolerance in male and female mouse hearts
    Laura Willems
    Heart Foundation Research Center, School of Health Science, Griffith University, Southport, QLD 4217, Australia
    J Mol Cell Cardiol 38:245-56. 2005
    ..vascular injury, and functional vs. oncotic injury. Similar changes occur in males and females, though there is evidence of a protected phenotype in mature to middle-aged female vs. male hearts...
  2. doi request reprint Cardiovascular adenosine receptors: expression, actions and interactions
    John P Headrick
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, QLD, Australia Electronic address
    Pharmacol Ther 140:92-111. 2013
    ..This review outlines cardiovascular control by adenosine and the AR family in health and disease, including interactions between AR sub-types within the heart and vessels. ..
  3. ncbi request reprint Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine
    Melissa E Reichelt
    Heart Foundation Research Centre, Griffith University, Southport, QLD 4217, Australia
    Exp Physiol 92:175-85. 2007
    ....
  4. ncbi request reprint Acute adenosinergic cardioprotection in ischemic-reperfused hearts
    John P Headrick
    Heart Foundation Research Centre, Griffith University, Southport, Queensland 4217, Australia
    Am J Physiol Heart Circ Physiol 285:H1797-818. 2003
    ..Here we review current knowledge and some controversies regarding acute cardioprotection via adenosine and adenosine receptor activation...
  5. ncbi request reprint Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts
    Laura Willems
    Heart Foundation Research Center, Griffith University, Southport, QLD 4217, Australia
    Cardiovasc Res 71:79-87. 2006
    ..Herein we assess effects of ADA (and A1AR) deficiency on AR-mediated responses and ischaemic tolerance...
  6. ncbi request reprint Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects
    Jason Peart
    Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Queensland 4217, Southport, Australia
    Cardiovasc Res 58:589-601. 2003
    ..Signaling in adenosine-mediated preconditioning is controversial. We examined roles of mitochondrial (mito) K(ATP) channels, protein kinase C (PKC) and nitric oxide (NO)...
  7. pmc Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression
    John P Headrick
    Heart Foundation Research Centre, School of Health Science, Griffith University, Southport, QLD 4217, Australia
    J Physiol 549:823-33. 2003
    ..This is independent of A1AR expression, and involves ineffective activation of a 5-HD-/diazoxide-sensitive process. The effects of A1AR overexpression indicate that the age-related failure in signalling can be overcome...
  8. pmc Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts
    Melissa E Reichelt
    Heart Foundation Research Center, Griffith University, Southport, Queensland, Australia
    Antioxid Redox Signal 11:2641-50. 2009
    ..These data reveal that local adenosine engages A1ARs during I/R to limit oxidant damage and enhance outcome selectively. Control of alpha-TOH/alpha-TQ levels may contribute to A1AR-dependent cardioprotection...
  9. doi request reprint Cardiac and coronary function in the Langendorff-perfused mouse heart model
    Melissa E Reichelt
    Heart Foundation Research Centre, Griffith University, Southport, Queensland, Australia
    Exp Physiol 94:54-70. 2009
    ..Finally, the model is applicable to the study of vascular reactivity, providing large responses and excellent reproducibility...
  10. ncbi request reprint Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress
    Kevin J Ashton
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, QLD 4217, Australia
    Exp Gerontol 41:189-204. 2006
    ....
  11. ncbi request reprint Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium
    Kevin J Ashton
    Heart Foundation Research Centre, Griffith University Gold Coast, Southport, QLD 4217, Australia
    Biochem Biophys Res Commun 312:367-72. 2003
    ..Reduced A(3) adenosine receptor transcription may contribute to impaired ischemic tolerance in aged hearts, whereas changes in Adora transcription induced by ischemia may impact on the post-ischemic phenotype at later time points...
  12. ncbi request reprint Aging-related changes in myocardial purine metabolism and ischemic tolerance
    Laura Willems
    Heart Foundation Research Center, School of Health Science, Griffith University, Gold Coast Campus Drive, Southport, QLD 4217, Australia
    Exp Gerontol 38:1169-77. 2003
    ..Mechanisms underlying this shift have yet to be determined. However, this may play a role in the marked decline in myocardial tolerance to ischemia with aging and senescence...
  13. ncbi request reprint Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart
    Amanda J Flood
    Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Southport, QLD 4217, Australia
    Cardiovasc Res 55:161-70. 2002
    ..To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts...
  14. pmc Mediators of coronary reactive hyperaemia in isolated mouse heart
    Amanda J Zatta
    Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Southport, QLD 4217, Australia
    Br J Pharmacol 144:576-87. 2005
    ..Synergistic effects of combined inhibitors implicate interplay between mediators, with compensatory changes occurring in K(ATP) channel, NO, and/or EDHF responses when one is individually blocked...
  15. ncbi request reprint Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium
    Laura Willems
    Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Queensland, 4217, Australia
    Pflugers Arch 453:433-41. 2007
    ..Nonetheless, the endogenous agonist adenosine exerts a modest inotropic action independently of flow and perfusion pressure. The basis of this response remains to be identified...
  16. pmc Opposing effects of age and calorie restriction on molecular determinants of myocardial ischemic tolerance
    Jason N Peart
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Queensland, Australia
    Rejuvenation Res 15:59-70. 2012
    ..Age and CR thus impact on distinct determinants of ischemic tolerance, although p70S6K signaling presents a point of convergence...
  17. ncbi request reprint Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues
    Kevin J Ashton
    Heart Foundation Research Centre, Griffith University Southport, QLD 4217, Australia
    J Mol Cell Cardiol 42:693-705. 2007
    ..However, some outcomes are both novel and controversial. This review outlines AR-modified murine models currently under study from the perspective of cardiovascular phenotype...
  18. ncbi request reprint Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance
    Melissa E Reichelt
    Heart Foundation Research Centre, Griffith University, Southport, QLD, Australia
    Circ Res 96:363-7. 2005
    ..Data indicate the function of intrinsically activated A1ARs appears primarily to be enhancement of postischemic contractility and limitation of cell death...
  19. ncbi request reprint Protecting murine hearts from ischaemia-reperfusion using selective inhibitors of adenosine metabolism
    Laura Willems
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, Queensland, Australia
    Clin Exp Pharmacol Physiol 32:179-83. 2005
    ..However, cardioprotection via either enzyme inhibitor requires an alternative purine-salvage pathway to be functional and was reduced in aged hearts known to be increasingly susceptible to ischaemic damage...
  20. ncbi request reprint Enhanced adenosine A(2B) mediated coronary response in reserpinised rat heart
    Roselyn B Rose'Meyer
    Heart Foundation Research Centre, School of Health Sciences, Griffith University, PMB50 Gold Coast Mail Centre, 9726, Queensland, Australia
    Naunyn Schmiedebergs Arch Pharmacol 367:266-73. 2003
    ..05). Catecholamine depletion with reserpinisation enhances the responsiveness of the coronary resistance vessels to endogenous adenosine through activation of the A(2B) adenosine receptor...
  21. pmc Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats
    Daniel Donner
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University Gold Coast, QLD 4217, Australia
    Dis Model Mech 6:457-66. 2013
    ..However, OB hearts are resistant to further RISK modulation and cardioprotection via acute δ-OR agonism...
  22. ncbi request reprint P2 purinoceptor-mediated cardioprotection in ischemic-reperfused mouse heart
    Shirley Wee
    Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
    J Pharmacol Exp Ther 323:861-7. 2007
    ..Endogenous nucleotides may also play a protective role, as evidenced by effects of P2 antagonists, although this warrants further investigation...
  23. ncbi request reprint Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine
    Benjamin Hack
    Heart Foundation Research Center, Griffith University, Gold Coast Campus, Southport, QLD, 4217, Australia
    Mol Cell Biochem 287:165-75. 2006
    ..Correlation of post-ischemic cardiovascular outcomes with specific oxidative events (glutathione redox state, alpha-TQ) supports an important anti-oxidant component to adenosinergic protection...
  24. ncbi request reprint Adenosine-mediated cardioprotection in the aging myocardium
    Laura Willems
    Heart Foundation Research Centre, School of Health Science, Griffith University, Southport, QLD 4217, Australia
    Cardiovasc Res 66:245-55. 2005
    ..Here we review data on the effects of aging on cardiovascular AR transcription and expression, generation of signal (adenosine formation), and protective signaling coupled to ARs...
  25. doi request reprint Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts
    Jason N Peart
    Heart Foundation Research Center, Griffith University, Gold Coast Mail Center, QLD, 9726, Australia
    Basic Res Cardiol 103:454-63. 2008
    ..In summary, kappa-ORs afford cardioprotection primarily when activated prior to and not after reperfusion. This protection may involve activation of the PI3 kinase (PI3K) pathway and mitochondrial (mito) K (ATP) channels...
  26. ncbi request reprint Adenosinergic cardioprotection: multiple receptors, multiple pathways
    Jason N Peart
    Heart Foundation Research Center, Griffith University, PMB 50 Gold Coast Mail Center, QLD, 4217, Australia
    Pharmacol Ther 114:208-21. 2007
    ....
  27. ncbi request reprint Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart
    Amanda J Zatta
    Heart Foundation Research Centre, Griffith University Southport, QLD 4217, Australia
    Life Sci 78:2426-37. 2006
    ..Finally, findings suggest this form of post-ischemic coronary injury is unrelated to endothelin or oxidant stress, but may involve modulation of Ca2+ overload and/or related ionic perturbations...
  28. pmc The adenosine A₂A receptor - myocardial protectant and coronary target in endotoxemia
    Melissa E Reichelt
    Heart Foundation Research Center, Griffith University, Southport QLD, Australia
    Int J Cardiol 166:672-80. 2013
    ..This study evaluated the cardiovascular role of intrinsic A₂A adenosine receptor (A₂AAR) activity during lipopolysaccharide (LPS)-induced inflammation...
  29. ncbi request reprint Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression
    Kevin J Ashton
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, Queensland, Australia
    Cardiovasc Res 57:715-26. 2003
    ..To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A(1) adenosine receptors (A(1)ARs)...
  30. pmc Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection
    Jason N Peart
    Heart Foundation Research Center, Griffith University, Queensland, 9726, Australia
    J Mol Cell Cardiol 42:972-80. 2007
    ..These data indicate that aging-related loss of delta-opioid-mediated cardioprotection involves failure to activate p38 MAPK and HSP27. Direct targeting of this pathway elicits comparable protection in both age groups...
  31. ncbi request reprint Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine
    Jason Peart
    Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Southport, Queensland 4217, Australia
    Am J Physiol Heart Circ Physiol 284:H519-27. 2003
    ..Adenosine provides additional and substantial protection via phosphorylation to 5'-AMP, primarily during reperfusion...
  32. ncbi request reprint Effects of A(3) adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart
    Glenn J Harrison
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, QLD, Australia
    Cardiovasc Res 53:147-55. 2002
    ..To characterize effects of A(3) adenosine receptor (A(3)AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart...
  33. ncbi request reprint Study of the novel non-xanthine heterocyclic compound GU285 as a potent non-selective adenosine receptor antagonist in the rat
    Fiona A Harden
    National Heart Foundation Centre for Cardiovascular Research, Griffith University, Gold Coast, Australia
    Arzneimittelforschung 52:175-81. 2002
    ..These data demonstrate that in the rat, GU285 is a potent, non-selective adenosine receptor antagonist that maintains its activity in vivo...
  34. ncbi request reprint Adenosine receptor subtypes mediating coronary vasodilation in rat hearts
    Andrea K Hinschen
    Heart Foundation Research Center, School of Health Science, Griffith University Gold Coast Campus, Southport, QLD 4215, Australia
    J Cardiovasc Pharmacol 41:73-80. 2003
    ..The magnitude of the coronary dilator response is reduced with age and does not involve A2A or A1 ARs...
  35. doi request reprint Voluntary running in mice beneficially modulates myocardial ischemic tolerance, signaling kinases, and gene expression patterns
    Boris P Budiono
    Heart Foundation Research Centre, Griffith Health Institute, Griffith Univ, Gold Coast, Queensland, Australia
    Am J Physiol Regul Integr Comp Physiol 302:R1091-100. 2012
    ..Transcriptomic data implicate inflammatory/immune and sarcomeric modulation in activity-dependent protection...
  36. ncbi request reprint Pyruvate-dependent preconditioning and cardioprotection in murine myocardium
    Amanda Flood
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, Queensland, Australia
    Clin Exp Pharmacol Physiol 30:145-52. 2003
    ..The response appears unrelated to glycolytic inhibition, but may be mediated via transient changes in adenosine levels and/or cellular Ca2+...
  37. doi request reprint Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium
    Jason N Peart
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Australia
    Exp Gerontol 50:72-81. 2014
    ..Differential changes in proteins governing caveolar and mitochondrial function may contribute to signal dysfunction and stress-intolerance...
  38. ncbi request reprint Non-analgesic effects of opioids: cardiovascular effects of opioids and their receptor systems
    John P Headrick
    Heart Foundation Research Centre, Griffith Health Institute, Griffith University, QLD, Australia
    Curr Pharm Des 18:6090-100. 2012
    ..This review highlights and discusses current knowledge and recent findings regarding physiological and pathophysiological modulation of the heart and vessels by the opioid receptor system...
  39. doi request reprint Adenosine and its receptors in the heart: regulation, retaliation and adaptation
    John P Headrick
    Griffith Health Institute, Griffith University, Southport QLD, Australia
    Biochim Biophys Acta 1808:1413-28. 2011
    ....
  40. doi request reprint Sustained cardioprotection: exploring unconventional modalities
    Jason N Peart
    Heart Foundation Research Centre, Griffith University, Australia
    Vascul Pharmacol 49:63-70. 2008
    ..This review considers briefly drawbacks to conventional PC, and focuses on alternate strategies for generating prolonged states of cardiac protection...
  41. ncbi request reprint A3 adenosine receptor-mediated protection of the ischemic heart
    John P Headrick
    Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, QLD 4217, Australia
    Vascul Pharmacol 42:271-9. 2005
    ..This review addresses current knowledge and controversy regarding the protective actions (and associated signaling) of A3ARs in ischemic-reperfused heart...
  42. doi request reprint Clinical cardioprotection and the value of conditioning responses
    Jason N Peart
    Heart Foundation Research Centre, Griffith University, Queensland, 9726, Australia
    Am J Physiol Heart Circ Physiol 296:H1705-20. 2009
    ..This review focuses on these features, raising questions about current research strategies, and the suitability of these widely studied phenomena as rational candidates for clinical translation...
  43. doi request reprint Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning
    Grant Williams-Pritchard
    Heart Foundation Research Centre, Griffith Univ, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Am J Physiol Heart Circ Physiol 300:H2161-8. 2011
    ..Myocardial survival kinase activation (Erk1/2, Akt) by A(1)AR agonism is similarly MMP/HB-EGF/EGFR dependent. Thus MMP-mediated EGFR activation appears essential to cardiac protection and signaling via A(1)ARs and preconditioning...
  44. pmc Sustained ligand-activated preconditioning via δ-opioid receptors
    Jason N Peart
    Heart Foundation Research Centre, Griffith University, Southport, Australia
    J Pharmacol Exp Ther 336:274-81. 2011
    ..Mechanisms underlying SLP may be useful targets for manipulation of ischemic tolerance in young or aged myocardium...
  45. ncbi request reprint The role of adenosine-related genes variants in susceptibility to essential hypertension
    Kirsty Wright
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    J Hypertens 22:1519-22. 2004
    ..To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH)...
  46. ncbi request reprint Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia
    Redox Rep 12:148-62. 2007
    ..In conclusion, I/R results in apoptosis in cultured cardiac myocytes and heart tissue largely via generation of mitochondria-derived superoxide, with ensuing apoptosis during the reperfusion phase...
  47. ncbi request reprint Gene expression profile of mouse myocardium with transgenic overexpression of A1 adenosine receptors
    Amy R Lankford
    Department of Pediatrics and Cardiovascular Research Center, University of Virginia Health System, Charlottesville Virginia 22908, USA
    Physiol Genomics 11:81-9. 2002
    ..These data illustrate genes with chronically altered patterns of expression in A(1) transgenic mouse myocardium that may be related to adenosine receptor overexpression-mediated cardioprotection...
  48. ncbi request reprint Apparent activation of cardiovascular A1 adenosine receptors by A3 agonists
    John P Headrick
    Am J Physiol Heart Circ Physiol 282:H793-6. 2002
  49. ncbi request reprint Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine
    Hajime Kin
    Department of Cardiothoracic Surgery, Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree Street, NE Atlanta, GA 30308 2225, USA
    Cardiovasc Res 67:124-33. 2005
    ....
  50. ncbi request reprint Adenosine-mediated cardioprotection in ischemic-reperfused mouse heart
    Jason Peart
    National Heart Foundation Research Center, Griffith University Gold Coast Campus, Southport, QLD Australia
    J Cardiovasc Pharmacol 39:117-29. 2002
    ..Data indicate that cardioprotection with exogenous adenosine in asanguinous hearts involves purine salvage and activation of A3 but not A1 or A2A receptors...
  51. ncbi request reprint A1 adenosine receptor overexpression decreases stunning from anoxia-reoxygenation: role of the mitochondrial K(ATP) channel
    Rachael J Cerniway
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Basic Res Cardiol 97:232-8. 2002
    ....