Lyn R Griffiths

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. pmc Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia
    J Headache Pain 12:603-8. 2011
  2. pmc Investigation of homocysteine-pathway-related variants in essential hypertension
    Javed Y Fowdar
    Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, Qld 4222, Australia
    Int J Hypertens 2012:190923. 2012
  3. pmc The biology of the glutamatergic system and potential role in migraine
    C F Gasparini
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Building G05, Griffith University QLD 4222, Australia
    Int J Biomed Sci 9:1-8. 2013
  4. pmc The human μ-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients
    S Menon
    Genomics Research Centre Griffith Health Institute, Griffith University Gold Coast, Parklands Drive, Southport, Qld 4222, Australia
    J Headache Pain 13:513-9. 2012
  5. pmc A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays
    Keat Wei Loo
    Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    BMC Med Genet 13:34. 2012
  6. pmc Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
    Robert Curtain
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 6:32. 2005
  7. pmc Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility
    Daniela Formicola
    Institute of Genetics and Biophysics, Italian National Research Council, Naples, Italy
    BMC Med Genet 11:103. 2010
  8. pmc Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility
    Szu Min Hsieh
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Cancer 9:331. 2009
  9. pmc Stimulation of MMP-11 (stromelysin-3) expression in mouse fibroblasts by cytokines, collagen and co-culture with human breast cancer cell lines
    Saxon Selvey
    Genomics Research Center, School of Heath Science, Griffith University, Gold Coast, Australia
    BMC Cancer 4:40. 2004
  10. pmc Analysis of the MTHFR C677T variant with migraine phenotypes
    Annie Liu
    Genomics Research Centre, School of Medical Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, Australia, 9726
    BMC Res Notes 3:213. 2010

Collaborators

Detail Information

Publications91

  1. pmc Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia
    J Headache Pain 12:603-8. 2011
    ..g. polyglutamine variants) and further analyses in other population data sets are required to clarify the association of the KCNN3 gene and migraine risk in the general outbred population...
  2. pmc Investigation of homocysteine-pathway-related variants in essential hypertension
    Javed Y Fowdar
    Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, Qld 4222, Australia
    Int J Hypertens 2012:190923. 2012
    ..2367). Our findings therefore suggest no individual or interactive association between four prominent Hcy pathway markers and EH...
  3. pmc The biology of the glutamatergic system and potential role in migraine
    C F Gasparini
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Building G05, Griffith University QLD 4222, Australia
    Int J Biomed Sci 9:1-8. 2013
    ....
  4. pmc The human μ-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients
    S Menon
    Genomics Research Centre Griffith Health Institute, Griffith University Gold Coast, Parklands Drive, Southport, Qld 4222, Australia
    J Headache Pain 13:513-9. 2012
    ..Further investigations are required to fully understand the effect of this gene variant on migraine head pain including studies in males and in different migraine subtypes, as well as in response to head pain medication...
  5. pmc A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays
    Keat Wei Loo
    Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    BMC Med Genet 13:34. 2012
    ..Allele frequencies of MTHFR 677 C > T and eNOS +894 G > T and eNOS -786 T > C were calculated using the Hardy Weinberg equation...
  6. pmc Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
    Robert Curtain
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 6:32. 2005
    ..This gene plays a critical role in determining the firing pattern of neurons and acts to regulate intracellular calcium channels...
  7. pmc Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility
    Daniela Formicola
    Institute of Genetics and Biophysics, Italian National Research Council, Naples, Italy
    BMC Med Genet 11:103. 2010
    ..Genes involved in synthesis, metabolism and regulation of both glutamate and its receptors could be, therefore, considered as potential candidates for causing/predisposing to migraine when mutated...
  8. pmc Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility
    Szu Min Hsieh
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Cancer 9:331. 2009
    ..Therefore, this study investigated the potential relationship of SIPA1 and human breast cancer incidence by a germline SNP genotype frequency association study in a case-control Caucasian cohort in Queensland, Australia...
  9. pmc Stimulation of MMP-11 (stromelysin-3) expression in mouse fibroblasts by cytokines, collagen and co-culture with human breast cancer cell lines
    Saxon Selvey
    Genomics Research Center, School of Heath Science, Griffith University, Gold Coast, Australia
    BMC Cancer 4:40. 2004
    ..Expressed in stromal fibroblasts adjacent to epithelial tumour cells, the mechanism of MT1-MMP and MMP-11 induction remains unknown...
  10. pmc Analysis of the MTHFR C677T variant with migraine phenotypes
    Annie Liu
    Genomics Research Centre, School of Medical Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, Australia, 9726
    BMC Res Notes 3:213. 2010
    ..Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender...
  11. ncbi Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis
    Lotti Tajouri
    Genomics Research Centre, School of Medical Science, Griffith University Gold Coast, Southport, QLD 4215, Australia
    Brain Res Bull 69:327-31. 2006
    ..15 and P=0.32, respectively). Hence, results from the present study do not support a major role for either functional gene mutation in MS susceptibility...
  12. doi An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
    Brain Res 1255:148-52. 2009
    ....
  13. ncbi Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland 4215, Australia
    J Neurol Sci 252:9-12. 2007
    ..50) and Btg1 (P = 0.45) marker. Our results do not support a role for these two ESR1 markers in multiple sclerosis susceptibility, however other markers within ESR1 should not be excluded for potential involvement in the disorder...
  14. ncbi Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, QLD 4215, Australia
    Brain Res Bull 64:9-13. 2004
    ..4, P(genotype) = 0.15; chi(2) = 3.4, P(allele) = 0.082) and for each subtype of MS (P > 0.05). This suggests that there is no direct association of this iNOS gene variant with MS susceptibility...
  15. pmc A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland 4222, Australia
    Neurogenetics 13:261-6. 2012
    ..Association of SNPs within these neurotransmitter-related genes suggests a disrupted serotoninergic system that is perhaps specific to the Norfolk Island pedigree, but that might provide clues to understanding migraine more generally...
  16. ncbi Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma
    Robert A Smith
    Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, QLD, Australia
    Cancer Lett 255:77-84. 2007
    ..372 and 0.655, respectively). Androgen receptor mRNA also remained unaffected (p=0.174)...
  17. ncbi Detection of mRNA levels for the estrogen alpha, estrogen beta and androgen nuclear receptor genes in archival breast cancer tissue
    Robert A Smith
    Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Cancer Lett 237:248-55. 2006
    ..This increased expression in late stage breast tumours may have implications to the treatment of breast tumours, particularly those lacking expression of other nuclear receptor genes...
  18. doi High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to Non-Hodgkin's lymphoma
    Carlos Aya-Bonilla
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, Australia
    Genes Chromosomes Cancer 52:467-79. 2013
    ....
  19. pmc Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
    Francesca Fernandez
    Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 9:109. 2008
    ..In this study, we have focused on the subunit GABA A receptors type epsilon (GABRE) and type theta (GABRQ) genes and their involvement in migraine...
  20. pmc Association analysis of chromosome 1 migraine candidate genes
    Francesca Fernandez
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 8:57. 2007
    ..In this study, we have undertaken a large genomic investigation involving candidate genes that lie within the chromosome 1q23 and 1q31 regions using an association analysis approach...
  21. doi Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population
    Jason Mackenzie
    Genomics Research Centre, School of Health Medical Science, Griffith University, Gold Coast, Southport, Queensland 4215, Australia
    J Neurol Sci 280:62-4. 2009
    ..To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population...
  22. doi Investigation of the [-/A]8 and C1236T genetic variations within the human Toll-like receptor 3 gene for association with multiple sclerosis
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
    Neurol Res 32:438-41. 2010
    ....
  23. ncbi Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, Australia
    J Neurogenet 19:25-38. 2005
    ..Our results support a role for the VDR gene increasing the risk of developing multiple sclerosis, particularly the progressive clinical subtypes of MS...
  24. pmc A new method to detect loss of heterozygosity using cohort heterozygosity comparisons
    Michael R Green
    Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Parklands Drive, Southport, Queensland, Australia
    BMC Cancer 10:195. 2010
    ..Regions of LOH are defined by consistent decreases in heterozygosity across a genetic region in the case cohort compared to the control cohort...
  25. pmc Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits
    Miles C Benton
    Genomics Research Centre, Griffith Health Institute, Griffith University, Southport, Qld 4222, Australia
    Am J Hum Genet 93:1087-99. 2013
    ..Future studies are required for further assessing the functional importance of these eQTLs and whether the findings here also relate to outbred populations. ..
  26. ncbi Investigation of hormone receptor genes in migraine
    Natalie J Colson
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    Neurogenetics 6:17-23. 2005
    ..2 times more likely to suffer migraine. Hence, variants of these steroid hormone receptor genes appear to act synergistically to increase the risk of migraine by a factor of three...
  27. ncbi The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians
    Stephanie Heux
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Australia
    Hypertens Res 27:663-7. 2004
    ..57, 95% confidence interval: 1.04-2.37, p=0.03). These findings require further investigation in large independent samples, but suggest that essential hypertension, like CVD, may be mildly influenced by the MTHFR C677T variant...
  28. ncbi The role of adenosine-related genes variants in susceptibility to essential hypertension
    Kirsty Wright
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    J Hypertens 22:1519-22. 2004
    ..To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH)...
  29. pmc No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility
    Natalie J Colson
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, 9726, Australia
    BMC Med Genet 7:12. 2006
    ....
  30. ncbi Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility
    Rod A Lea
    Genomic Research Centre, School of Health Science, Griffith University, Parklands Drive, Southport, QLD 4217, Australia
    Brain Res Mol Brain Res 136:112-7. 2005
    ..47-5.72, P = 0.002). In Caucasians, the ACE D allele confers a weak independent risk to migraine susceptibility and also appears to act in combination with the C677T variant in the MTHFR gene to confer a stronger influence on the disease...
  31. ncbi Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material
    Larisa M Haupt
    Genomics Research Centre, School of Medical Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Mol Cell Probes 22:83-9. 2008
    ..These expression profiles may provide markers for early breast cancer diagnoses and present potential therapeutic targets...
  32. ncbi The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups
    Natalie J Colson
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    Neurogenetics 5:129-33. 2004
    ..Our findings support the hypothesis that genetic variation in hormone receptors, in particular the ESR1 gene, may play a role in migraine...
  33. pmc Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island
    Stuart Macgregor
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Hum Genet 18:67-72. 2010
    ..In conclusion, both founder effect and extreme admixture have substantially influenced the genetic architecture of a variety of CVD-related traits in this population...
  34. pmc Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Queensland, Australia
    Gene 494:119-23. 2012
    ..05). In conclusion, a genome-wide linkage analysis and follow-up association analysis of migraine in the genetic isolate of Norfolk Island provided evidence for migraine susceptibility loci on chromosomes 9q22.22 and 13q33.1...
  35. pmc In vitro and in vivo MMP gene expression localisation by In Situ-RT-PCR in cell culture and paraffin embedded human breast cancer cell line xenografts
    Larisa M Haupt
    Genomics Research Centre, Griffith University Gold Coast, School of Medical Science, Queensland, 4217, Australia
    BMC Cancer 6:18. 2006
    ..As MMPs are not stored intracellularly, the ability to localise their expression to their cells of origin is difficult...
  36. pmc The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura
    Rod A Lea
    Genomics Research Centre, School of Health Science, Griffith University, Queensland, Australia
    BMC Med 2:3. 2004
    ..To determine whether the C677T variant in the MTHFR gene is associated with migraine susceptibility we utilised unrelated and family-based case-control study designs...
  37. doi Genetic variation in cytokine-related genes and migraine susceptibility
    Shani Stuart
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia
    Twin Res Hum Genet 16:1079-86. 2013
    ..Haplotype analysis showed that none of the tested haplotypes were significantly associated with migraine. ..
  38. ncbi Phenotypical characterisation of the isolated norfolk island population focusing on epidemiological indicators of cardiovascular disease
    Claire Bellis
    Genomics Research Centre, School of Medical Science, Griffith University, Gold Coast, Gold Coast Mail Centre Queensland, Australia
    Hum Hered 60:211-9. 2005
    ..Our objective was to assess the population of Norfolk Island, several thousand km off the eastern coast of Australia, as a genetic isolate of potential use for cardiovascular disease (CVD) gene mapping...
  39. doi Investigation of APOE isoforms and the association between APOE E3 and E4 with migraine in the Australian Caucasian population
    Shani Stuart
    School of Medical Science, Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia
    Neuroreport 24:499-503. 2013
    ..The study found no significant association between the tested variants and migraine for any of the APOE variants investigated...
  40. ncbi A genetic variant located in miR-423 is associated with reduced breast cancer risk
    Robert A Smith
    Genomics Research Centre, Griffith Health Institute, Griffith University, QLD, Australia
    Cancer Genomics Proteomics 9:115-8. 2012
    ..Using an association approach, this research examined the effects of the rs6505162 SNP, an A > C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development...
  41. pmc An X chromosome association scan of the Norfolk Island genetic isolate provides evidence for a novel migraine susceptibility locus at Xq12
    Bridget H Maher
    Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia
    PLoS ONE 7:e37903. 2012
    ..The strongest effect SNP (rs102834, joint P = 1.63 × 10(-5)) is located within the 5'UTR of the HEPH gene, which is involved in iron homeostasis in the brain and may represent a novel pathway for involvement in migraine pathogenesis...
  42. doi Integrative genomic profiling reveals conserved genetic mechanisms for tumorigenesis in common entities of non-Hodgkin's lymphoma
    Michael R Green
    Genomics Research Centre, Griffith Health Institute, Griffith University, QLD, Australia
    Genes Chromosomes Cancer 50:313-26. 2011
    ..Integrative genomic profiling identifies common central survival mechanisms and highlights them as attractive targets for directed therapy...
  43. ncbi Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, 4215 Australia
    J Neurol Sci 218:25-8. 2004
    ..05). Statistical analysis indicated that there is no association of this nNOS variant and MS and hence the gene does not appear to play a genetically significant role in disease susceptibility...
  44. ncbi Age-related changes in cardiac adenosine receptor expression
    Tamsin L Jenner
    School of Health Sciences, Griffith University Gold Coast Campus, Southport, QLD 9726, Australia
    Mech Ageing Dev 125:211-7. 2004
    ..Ultimately, these findings show an age-related reduction in adenosine A(1) and A(2A) receptor expression in rat heart...
  45. pmc Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate
    Hannah C Cox
    Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Gold Coast, QLD, Australia
    Hum Hered 68:55-64. 2009
    ..An individual's risk of developing cardiovascular disease (CVD) is influenced by genetic factors. This study focussed on mapping genetic loci for CVD-risk traits in a unique population isolate derived from Norfolk Island...
  46. ncbi Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree
    Astrid J Rodriguez-Acevedo
    Genomics Research Centre, Griffith Health Institute, Griffith University, Australia
    Cephalalgia 33:1139-47. 2013
    ..Here, we report the results of an association study of these genes in a migraine pedigree from the genetic isolate of Norfolk Island, a population descended from a small number of Isle of Man "Bounty Mutineer" and Tahitian founders...
  47. doi Association of a GRIA3 gene polymorphism with migraine in an Australian case-control cohort
    Bridget H Maher
    Genomics Research Centre, Griffith Health Institute, Griffith University, Southport, QLD, Australia
    Headache 53:1245-9. 2013
    ..In addition, the GRIA3 gene is coded within a previously identified migraine susceptibility locus at Xq24. This study investigated the previously associated polymorphisms in both genes in an Australian case-control population...
  48. doi Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk: a case control study
    Dominik J Jedlinski
    Griffith Health Institute, Griffith University Gold Coast, Southport, Australia
    Twin Res Hum Genet 14:417-21. 2011
    ..As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups...
  49. ncbi Investigation of two Wnt signalling pathway single nucleotide polymorphisms in a breast cancer-affected Australian population
    Plamena N Gabrovska
    Genomics Research Centre, Griffith Health Institute, Griffith University, Australia
    Twin Res Hum Genet 14:562-7. 2011
    ....
  50. ncbi The role of vascular and hormonal genes in migraine susceptibility
    Natalie J Colson
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, QLD 9726, Australia
    Mol Genet Metab 88:107-13. 2006
    ..We propose that the potential role of vascular and hormonal genes in this disorder warrants further investigation...
  51. pmc Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR
    Matthew P Johnson
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, QLD 9726, Australia
    Nucleic Acids Res 32:e55. 2004
    ..We present here a novel approach to effectively determine ambiguous genotypes generated from a real-time PCR platform. Application of our three novel criteria provides an easy to use semi-automated genotype confirmation protocol...
  52. ncbi A pharmacogenomic evaluation of migraine therapy
    Matthew P Johnson
    Griffith University, Genomics Research Centre, School of Medical Science, PMB 50 GCMC Gold Coast, Queensland, Australia
    Expert Opin Pharmacother 8:1821-35. 2007
    ..The authors also discuss pharmacogenomic considerations for more individualized migraine prophylactic treatments...
  53. doi Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation
    Saras Menon
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Pharmacogenet Genomics 22:741-9. 2012
    ..The current study examined the genotypic effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene variants on the occurrence of migraine in response to vitamin supplementation...
  54. ncbi An investigation of the 5-HT2C receptor gene as a migraine candidate gene
    Matthew P Johnson
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Australia
    Am J Med Genet B Neuropsychiatr Genet 117:86-9. 2003
    ..Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition...
  55. ncbi Cytogenetic alterations in nonmelanoma skin cancer: a review
    Kevin J Ashton
    Genomics Research Centre, Griffith University Gold Coast, Queensland, Australia
    Genes Chromosomes Cancer 43:239-48. 2005
    ....
  56. ncbi An assessment of MMP and TIMP gene expression in cell lines and stroma - tumour differences in microdissected breast cancer biopsies
    Albert S Mellick
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast Campus, Southport, Australia
    Tumour Biol 24:258-70. 2003
    ..We have identified patterns of gene expression that may further reveal aspects of breast carcinogenesis, and a robust method for examining changes in clinically important genes using archival biopsies and across stroma-tumour boundaries...
  57. ncbi A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach
    Matthew P Johnson
    Genomics Research Centre, School of Medical Science, Griffith University, PMB 50 GCMC, 9726 Gold Coast, QLD, Australia
    J Hum Genet 50:607-10. 2005
    ..Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility...
  58. ncbi Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix
    Rachel K Okolicsanyi
    Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
    Dev Biol 388:1-10. 2014
    ..Here we summarise the current literature and highlight the potential for HSPG directed neural lineage fate specification in hMSCs, which may provide a new model for brain damage repair...
  59. doi An envirogenomic signature is associated with risk of IBD-related surgery in a population-based Crohn's disease cohort
    Bushra F Nasir
    Genomics Research Centre, Griffith Health Institute, School of Medical Sciences, Griffith University, Gold Coast Campus, Southport, 4222, QLD, Australia
    J Gastrointest Surg 17:1643-50. 2013
    ..Identification of CD patients at high risk of requiring surgery may assist clinicians to decide on a top-down or step-up treatment approach...
  60. pmc In silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non-Hodgkin's lymphoma (NHL)
    Carlos Aya-Bonilla
    Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    BMC Genomics 15:390. 2014
    ..The present study aimed to determine the cellular pathways affected by the inactivation of these TSGs including PTPRJ in FL and DLBCL tumourigenesis...
  61. pmc Expression of glucocorticoid and progesterone nuclear receptor genes in archival breast cancer tissue
    Robert A Smith
    Genomics Research Centre and Wesley Research Institute, Griffith University Gold Coast, Queensland, Australia
    Breast Cancer Res 5:R9-12. 2003
    ..In order to investigate these findings further, we conducted the present study to determine whether expression levels of the progesterone and glucocorticoid nuclear receptor genes vary in different breast cancer grades...
  62. ncbi Chromosomal aberrations in squamous cell carcinoma and solar keratoses revealed by comparative genomic hybridization
    Kevin J Ashton
    Genomics Research Centre, Griffith University Gold Coast, Bundall, Queensland, Australia
    Arch Dermatol 139:876-82. 2003
    ....
  63. ncbi Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer
    Joanne E Curran
    Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, Parklands Drive, 9726, Southport, QLD, Australia
    Cancer Lett 188:103-7. 2002
    ..Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population...
  64. ncbi Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis
    Lotti Tajouri
    School of Health Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD 4215, Australia
    Brain Res Mol Brain Res 119:170-83. 2003
    ....
  65. ncbi The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population
    Melanie A Carless
    Genomics Research Center, School of Health Science, Griffith University, Gold Coast, QLD, Australia
    J Invest Dermatol 119:1373-8. 2002
    ....
  66. ncbi Sibpair studies implicate chromosome 18 in essential hypertension
    Sue Rutherford
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Australia
    Am J Med Genet A 126:241-7. 2004
    ..Further investigation is required to conclusively determine the extent to which ADCYAP1 polymorphisms are involved in essential hypertension...
  67. doi The role of the MTHFR gene in migraine
    Shani Stuart
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Southport, QLD, Australia
    Headache 52:515-20. 2012
    ..Further studies will continue to build a gene profile of variants involved in the complex disease migraine and improve understanding of the underlying genetic causes of this disorder...
  68. doi Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study
    Diego Chacon-Cortes
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia
    Mol Biol Rep 39:5961-6. 2012
    ..This highlights a modified salting out method as a suitable choice to be used in laboratories and research centres, particularly when dealing with a large number of samples...
  69. doi Detection of a novel mutation in the CACNA1A gene
    Shani Stuart
    Genomics Research Centre, Griffith Health Institute, Griffith University, Brisbane, Australia
    Twin Res Hum Genet 15:120-5. 2012
    ..New information will allow for diagnostic procedures to be constantly updated, thus improving accuracy of diagnosis. It is possible that new information will also aid the development of new therapeutic agents for the treatment of FHM...
  70. doi Investigation of lymphotoxin α genetic variants in migraine
    Lotta E Oikari
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Building G05, Griffith University QLD 4222, Australia
    Gene 512:527-31. 2013
    ..Although the present study did not support a role for the tested LTA variants in migraine, investigation of other variants within the LTA gene is still warranted...
  71. doi Cytogenetics of melanoma and nonmelanoma skin cancer
    Melanie A Carless
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, Bundall, QLD, Australia
    Adv Exp Med Biol 624:227-40. 2008
    ..This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers...
  72. ncbi Differential gene expression in breast cancer cell lines and stroma-tumor differences in microdissected breast cancer biopsies revealed by display array analysis
    Albert S Mellick
    Genomics Research Centre, School of Health Science, Gold Coast Campus of Griffith University, Gold Coast, Queensland, Australia
    Int J Cancer 100:172-80. 2002
    ..Use of microdissection and the DD-PCR array protocol allowed us to identify factors whose localized expression within the breast may play a role in abnormal breast development or breast carcinogenesis...
  73. ncbi Dopamine receptor genes and migraine with and without aura: an association study
    A Graeme Shepherd
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    Headache 42:346-51. 2002
    ..To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine...
  74. doi Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs
    Prue N Plummer
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Gene 490:32-6. 2011
    ..This study also identifies GABRA3 and GABBR2 as potential biomarkers to select migraineurs that may be more responsive to GABA agonists with future investigations in this area warranted...
  75. ncbi A typical migraine susceptibility region localizes to chromosome 1q31
    Rod A Lea
    Genomics Research Centre, School of Health Sciences, Griffith University, Southport, Queensland, Australia
    Neurogenetics 4:17-22. 2002
    ....
  76. ncbi Molecular mechanisms of migraine: prospects for pharmacogenomics
    Kelly L Rogers
    Genomics Research Centre, Griffith University Gold Coast, Gold Coast Mail Centre, Southport, Queensland 9726, Australia
    Am J Pharmacogenomics 3:329-43. 2003
    ..Genetic profiling, combined with our knowledge of therapeutic response to drugs, should enable the development of specific, individually-tailored treatment...
  77. doi Current status of pharmacogenomics testing for anti-tumor drug therapies: approaches to non-melanoma skin cancer
    Rebecca Grealy
    Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Gold Coast, Queensland, Australia
    Mol Diagn Ther 13:65-72. 2009
    ..If the savings generated by reducing adverse events negate the costs of developing these tests, pharmacogenomic testing may increasingly inform personalized NMSC treatment...
  78. ncbi The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis
    Roselyn B Rose'Meyer
    School of Health Sciences, Griffith University, GCMC PMB 50, Gold Coast, QLD 9726, Australia
    Brain Res Brain Res Protoc 11:9-18. 2003
    ..No change was found in ADORA(2B) or ER-alpha. Analysis of absolute copy number in this study revealed a correlation between receptor expression in response to ovariectomy, and relative receptor subtype abundance in the brain...
  79. pmc Gene expression studies in multiple sclerosis
    Lotti Tajouri
    Genomics Research Centre, School of Medical Science, Griffith University Gold Coast, Southport, Queensland, 4215 Australia
    Curr Genomics 8:181-9. 2007
    ..This review will focus on the results of these studies...
  80. doi Investigation of the role of the GABRG2 gene variant in migraine
    Timothy Chen
    Griffith Health Institute, Genomics Research Centre, Griffith University, Queensland, Australia
    J Neurol Sci 318:112-4. 2012
    ..The results did not support a role for the tested GABRG2 variant in migraine...
  81. doi Identification of molecular genetic factors that influence migraine
    Bridget H Maher
    Genomics Research Centre, School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia
    Mol Genet Genomics 285:433-46. 2011
    ....
  82. ncbi Minor head trauma-induced sporadic hemiplegic migraine coma
    Robert P Curtain
    Genomics Research Centre, School of Medical Science, Griffith University, Gold Coast, Queensland, Australia
    Pediatr Neurol 34:329-32. 2006
    ..We conclude that the Serine-218-Leucine mutation in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene is involved in sporadic hemiplegic migraine, delayed cerebral edema and coma after minor head trauma...
  83. pmc Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility
    Stefan Kammerer
    Sequenom, Inc, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 102:2004-9. 2005
    ..Although the potential functional relevance of the A794G variation requires further biological validation, we conclude that variations in the NuMA gene are likely responsible for the observed increased breast cancer risk...
  84. ncbi Prospects for whole genome linkage disequilibrium mapping in domestic dog breeds
    Changbaig Hyun
    Companion Animal Sciences, School of Veterinary Science, University of Queensland, St Lucia, QLD 4072, Australia
    Mamm Genome 14:640-9. 2003
    ..In this study, LD mapping confirmed the location of the copper toxicosis in Bedlington terrier gene (CT-BT) and was able to do so in a population that was refractory to traditional linkage analysis...
  85. ncbi Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus
    Stefan Kammerer
    Sequenom, Inc, San Diego, California, USA
    Cancer Res 64:8906-10. 2004
    ..Because ICAMs are suitable targets for antibodies and small molecules, these findings may not only provide diagnostic and prognostic markers but also new therapeutic opportunities in breast and prostate cancer...
  86. doi Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population
    Georgia E Hume
    Inflammatory Bowel Disease Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Inflamm Bowel Dis 14:585-90. 2008
    ..We aimed to investigate the relationship between TLR4 A299G and TLR5 N392ST, and an Australian inflammatory bowel disease cohort, and to explore the strength of association between TLR4 A299G and CD using global meta-analysis...
  87. ncbi Authors response to: critique of "chromosome 17 and inducible nitric oxide synthase gene in human essential hypertension" by Rutherford et al. in Human Genetics published on-line September 2001
    Lyn R Griffiths
    Hum Genet 110:100-3. 2002