Research Topics
| Jennifer A Marshall GravesSummaryCountry: Australia Publications
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Publications
How the gene content of human sex chromosomes evolvedJennifer A Marshall Graves
Research School of Biological Sciences, The Australian National University, Canberra, Australia
Curr Opin Genet Dev 16:219-24. 2006..Comparisons between the gene content of the X and Y in humans, distantly related mammals, and other vertebrates, define the evolutionary past of our sex chromosomes and suggest how special selective forces act on the X and Y...
Evolution from XIST-independent to XIST-controlled X-chromosome inactivation: epigenetic modifications in distantly related mammalsJulie Chaumeil
Comparative Genomics Group, Evolution Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia
PLoS ONE 6:e19040. 2011....
Are some chromosomes particularly good at sex? Insights from amniotesDenis O'Meally
Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia
Chromosome Res 20:7-19. 2012..Here, we review recent gene mapping data, examine the evolutionary relationships of amniote sex chromosomes and argue that gene content can predispose some chromosomes to a specialized role in sex determination...- Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolutionVeronica J Murtagh
Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia
Genome Res 22:498-507. 2012..Thus, the small marsupial Y chromosome is surprisingly rich in ancient genes that are retained in at least Australian marsupials and evolved from testis-brain expressed genes on the X... - Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammalsJanine E Deakin
ARC Centre of Excellence for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
Chromosome Res 16:1159-75. 2008..Frequent rearrangement of the X, along with the absence of a marsupial XIST gene, suggests that inactivation of the marsupial X chromosome does not depend on a whole-chromosome repression by a control locus... - Molecular marker suggests rapid changes of sex-determining mechanisms in Australian dragon lizardsTariq Ezaz
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, GPO Box 475, Canberra, ACT 2601, Australia
Chromosome Res 17:91-8. 2009.... - Physical mapping of the elephant X chromosome: conservation of gene order over 105 million yearsClaudia Leticia Rodríguez Delgado
Comparative Genomics Group, Research School of Biology, The Australian National University, GPO Box 475, ACT 2601, Canberra, Australia
Chromosome Res 17:917-26. 2009.... - Specific patterns of histone marks accompany X chromosome inactivation in a marsupialEdda Koina
Research School of Biological Sciences, The Australian National University, Canberra, ACT, 0200, Australia
Chromosome Res 17:115-26. 2009..A better understanding of the epigenetic mechanisms underlying X inactivation in marsupials will provide important insights into the evolution of this complex process... - Globin gene structure in a reptile supports the transpositional model for amniote α- and β-globin gene evolutionVidushi S Patel
Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia
Chromosome Res 18:897-907. 2010..Our data from a reptile species provide further evidence to support the transpositional model for the evolution of β-globin gene cluster in amniotes... - Origin and evolution of candidate mental retardation genes on the human X chromosome (MRX)Margaret L Delbridge
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
BMC Genomics 9:65. 2008..The human X chromosome has a biased gene content. One group of genes that is over-represented on the human X are those expressed in the brain, explaining the large number of sex-linked mental retardation (MRX) syndromes... - Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere lengthHannah S Bender
Research School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia
PLoS ONE 7:e46195. 2012..Comparative studies in five distantly related marsupials and a monotreme indicate that telomere dimorphism evolved at least 50 million years ago... - Genomic restructuring in the Tasmanian devil facial tumour: chromosome painting and gene mapping provide clues to evolution of a transmissible tumourJanine E Deakin
Research School of Biology, The Australian National University, Canberra, Australia
PLoS Genet 8:e1002483. 2012..Differences between strains are limited, reflecting the unusually stable nature of DFTD. Finally, our detailed maps of both the devil and tumour karyotypes provide a physical framework for future genomic investigations into DFTD... - Characterization, chromosomal location, and genomic neighborhood of a ratite ortholog of a gene with gonadal expression in mammalsDANIEL E JANES
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA Comparative Genomics Group, Research School of Biological Sciences, Australian National University, PO Box 475, Canberra ACT 2601, Australia
Integr Comp Biol 48:505-11. 2008..Future experimentation will report the expression of SubA in ratites, other birds, and nonavian reptiles... - Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus)Daniel McMillan
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
Chromosome Res 15:961-74. 2007..We have established an agreed nomenclature and identified anchor BAC clones for each chromosome that will ensure unambiguous gene localizations... - Construction and evolution of imprinted loci in mammalsTimothy A Hore
Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
Trends Genet 23:440-8. 2007..Here, we use comparisons between different mammalian groups to chart the course of evolution of two related epigenetic regulatory systems in mammals: genomic imprinting and X-chromosome inactivation... - Origin and evolution of spermatogenesis genes on the human sex chromosomesMargaret L Delbridge
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra ACT 2601, Australia
Soc Reprod Fertil Suppl 65:1-17. 2007..The X is more complicated - it has evolved male-advantage genes because of its representation as a single copy in males, where it is exposed to selection for male-advantage genes... - The degenerate Y chromosome--can conversion save it?Jennifer A Marshall Graves
Research School of Biological Sciences, The Australian National University, Canberra, ACT, Australia
Reprod Fertil Dev 16:527-34. 2004..Perhaps it will even speed up the decline of the Y chromosome and the onset of a new round of sex-chromosome differentiation. The struggle to preserve males may perhaps lead to hominid speciation... - Autosomal location of genes from the conserved mammalian X in the platypus (Ornithorhynchus anatinus): implications for mammalian sex chromosome evolutionPaul D Waters
Comparative Genomics Group, Research Group of Biological Science, The Australian National University, Canberra, ACT, 2601, Australia
Chromosome Res 13:401-10. 2005..Since these genes lie on the X in marsupials and eutherians, and also on the homologous region of chicken chromosome 4, this represents a loss from the monotreme X rather than an additional evolutionary stratum of the human X... - Sex chromosome specialization and degeneration in mammalsJennifer A Marshall Graves
Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
Cell 124:901-14. 2006..The Y chromosome seems to be a product of a perverse evolutionary process that does not select the fittest Y, which may cause its degradation and ultimate extinction... - Evolution and comparative analysis of the MHC Class III inflammatory regionJanine E Deakin
ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
BMC Genomics 7:281. 2006..We also discuss the extent of sequence conservation across the entire region and identify elements conserved in evolution... - Evolution of the testis-determining gene--the rise and fall of SRYJennifer A Marshall Graves
Research School of Biological Sciences, The Australian National University, Canberra, ACT
Novartis Found Symp 244:86-97; discussion 97-101, 203-6, 253-7. 2002..It has no central role in sex determination, and can be replaced as a trigger and lost, as have many other Y-borne genes in recent evolutionary history. The mole vole has evidently accomplished this... - Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complexKatherine Belov
Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, The University of Sydney, Camden, Australia
PLoS Biol 4:e46. 2006.... - Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequencesTarjei S Mikkelsen
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 447:167-77. 2007..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation... - The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammalsCarol A Edwards
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
BMC Evol Biol 7:157. 2007..There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome... - Complex events in the evolution of the human pseudoautosomal region 2 (PAR2)Fadi J Charchar
Department of Genetics, La Trobe University, Bundoora, Victoria 3086, Australia
Genome Res 13:281-6. 2003..The present gene order on the human X also requires two inversions. The complicated evolutionary pathway supports the hypothesis that terminal interchromosomal rearrangements are common in regions unpaired at meiosis...