Research Topics
Genomes and Genes | Nigel TurnerSummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
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Publications
Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acidsNigel Turner
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Diabetes 58:2547-54. 2009..Here, we examined the tissue-specific effects of MCFAs on lipid metabolism and insulin action...
Limits to physical performance and metabolism across speciesNigel Turner
Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Curr Opin Clin Nutr Metab Care 9:691-6. 2006..The factors that determine each type of metabolic rate are not the same; however, all levels of energy expenditure are strongly linked with body size...- Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian heartsNigel Turner
Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, New South Wales, Australia
Physiol Biochem Zool 79:522-33. 2006.... - Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodentsNigel Turner
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Diabetes 56:2085-92. 2007..These findings suggest that high lipid availability does not lead to intramuscular lipid accumulation and insulin resistance in rodents by decreasing muscle mitochondrial fatty acid oxidative capacity... 
Is mitochondrial dysfunction a cause of insulin resistance?Nigel Turner
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Trends Endocrinol Metab 19:324-30. 2008....- An allometric comparison of microsomal membrane lipid composition and sodium pump molecular activity in the brain of mammals and birdsNigel Turner
Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia
J Exp Biol 208:371-81. 2005..Bird membranes also contained a relatively large percentage of 22:5 (n-6) as well as high levels of cholesterol. These results are discussed in relation to neurological function and the emerging field of membrane lipid rafts... - Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylationAndrew J Hoy
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, University of New South Wales, Sydney, New South Wales, Australia
Am J Physiol Endocrinol Metab 297:E67-75. 2009.... - Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidneyNigel Turner
Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia
Am J Physiol Regul Integr Comp Physiol 288:R301-10. 2005..These relationships are discussed with respect to the metabolic intensity of different-sized animals... - Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylationAndrew J Hoy
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Am J Physiol Endocrinol Metab 293:E1358-64. 2007..001). These results suggest that the reduced muscle glucose uptake in rats after 5 h of acute hyperglycemia is due more to the metabolic effects of excess glycogen storage than to a defect in insulin signaling or glucose transport... - PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscleJi Ming Ye
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, University of New South Wales, Sydney, NSW, Australia
Br J Pharmacol 163:556-66. 2011..The present study aimed to characterize the effects of PPARδ agonists during insulin resistance of the whole body, muscle and liver... - Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscleMichael J Boden
Diabetes and Obesity Program, Garvan Institute for Medical Research, Darlinghurst, NSW, Australia 2010
Am J Physiol Endocrinol Metab 303:E798-805. 2012..05), suggesting that this effect was mediated through an altered redox state. Thus interventions causing elevation of mitochondrial antioxidant activity may offer protection against diet-induced insulin resistance in skeletal muscle... - Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjectsLeonie K Heilbronn
Diabetes and Obesity Research Program, Garvan Institute for Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Clin Endocrinol Metab 92:1467-73. 2007..Impaired mitochondrial function in skeletal muscle is implicated in the development of insulin resistance. However, potential differences in fatness and fitness may influence previous results... - Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterificationClinton R Bruce
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst
Am J Physiol Endocrinol Metab 292:E1231-7. 2007..05). These studies demonstrate that acute overexpression of CPT I in muscle leads to a repartitioning of FAs away from esterification and toward oxidation and highlight the importance of CPT I in regulating muscle FA metabolism... - Insulin resistance is a cellular antioxidant defense mechanismKyle L Hoehn
Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Proc Natl Acad Sci U S A 106:17787-92. 2009..These data place mitochondrial superoxide at the nexus between intracellular metabolism and the control of insulin action potentially defining this as a metabolic sensor of energy excess... - Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscleKate G R Quinlan
Institute for Neuroscience and Muscle Research, The Children s Hospital at Westmead, Sydney, NSW, Australia
Hum Mol Genet 19:1335-46. 2010..We propose that the alteration in GPh activity in the absence of alpha-actinin-3 is a fundamental mechanistic link in the association between ACTN3 genotype and human performance... - Exercise alters the profile of phospholipid molecular species in rat skeletal muscleTodd W Mitchell
Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales 2522
J Appl Physiol 97:1823-9. 2004..Even though little is known about the physiological or pathophysiological role of specific phospholipid molecular species in skeletal muscle, it is likely that this remodeling will have an impact on a range of cellular functions... - Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humansDorit Samocha-Bonet
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, Australia
PLoS ONE 7:e36320. 2012..High fat feeding induces insulin resistance and increases skeletal muscle oxidative stress in rodents, but there is controversy as to whether skeletal muscle mitochondrial biogenesis and function is altered... - IRS1-independent defects define major nodes of insulin resistanceKyle L Hoehn
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
Cell Metab 7:421-33. 2008..These findings indicate that while insulin resistance is associated with multiple deficiencies, the most deleterious defects and the origin of insulin resistance occur independently of IRS... - The evolution of insulin resistance in muscle of the glucose infused ratAmanda E Brandon
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
Arch Biochem Biophys 509:133-41. 2011..These results indicate that, in the presence of a nutrient overload, alterations in muscle insulin signaling occur, but after insulin resistance develops and appropriate changes in energy/nutrient sensing pathways occur... - Adult-onset PYY overexpression in mice reduces food intake and increases lipogenic capacityYan chuan Shi
Neuroscience Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
Neuropeptides 46:173-82. 2012..Taken together, these findings demonstrate that under physiological conditions, PYY reduces food intake while enhancing lipogenic capacity and insulin action, likely contributing to fuel assimilation in the postprandial state... - Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistanceJuan C Molero
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Diabetes 55:708-15. 2006..These studies are consistent with a role for c-Cbl in regulating nutrient partitioning in skeletal muscle and emphasize the potential of c-Cbl as a therapeutic target in the treatment of obesity and type 2 diabetes... - Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin actionJuan C Molero
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Diabetes 55:3411-7. 2006..These results indicate that c-Cbl ubiquitin ligase activity, but not c-Cbl-dependent activation of PI 3-kinase, plays a key role in the regulation of whole-body energy metabolism... - Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscleNigel Turner
Metabolic Research Centre, Department of Biomedical Sciences, University of Wollongong, New South Wales, Australia
J Appl Physiol 96:974-80. 2004.... - Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolismNigel Turner
Metabolic Research Centre, University of Wollongong, 2522, Wollongong, NSW, Australia
Naturwissenschaften 90:521-3. 2003.... - Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid compositionSally C Faulks
School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
J Gerontol A Biol Sci Med Sci 61:781-94. 2006..Changes in the fatty acid composition of phospholipids from liver, kidneys, heart, brain, and skeletal muscle were observed following 1 month of CR... - Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunctionEdward W Kraegen
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney NSW 2010, Australia
Proc Natl Acad Sci U S A 105:7627-8. 2008 - The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat dietTodd W Mitchell
School of Health Sciences, University of Wollongong, NSW 2522, Australia E mail
Int J Mol Sci 11:3954-64. 2010..These data suggest a possible reduction in phospholipid remodeling in the trained animals. This results in a decrease in the phospholipid n-3 to n-6 ratio that may in turn influence endurance capacity... - Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionNigel Turner
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
Diabetes 57:1414-8. 2008..We investigated the mechanism of activation of AMPK by BBR and explored whether derivatization of BBR could improve its in vivo efficacy... - How might you compare mitochondria from different tissues and different species?A J Hulbert
Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
J Comp Physiol B 176:93-105. 2006..The molecular activity of mitochondrial cytochromes was found to be significantly positively correlated with the relative polyunsaturation of mitochondrial membrane lipids... - Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposityKyle L Hoehn
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Cell Metab 11:70-6. 2010..We conclude that negative energy balance is a prerequisite for weight reduction, and increased fatty acid oxidation per se has little, if any, effect to reduce adiposity... - AMP-activated protein kinase and muscle insulin resistanceEdward W Kraegen
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
Front Biosci 14:4658-72. 2009..These issues are important in considering the AMPK pathway as a therapeutic target in insulin resistant states... - Sodium pump molecular activity and membrane lipid composition in two disparate ectotherms, and comparison with endothermsNigel Turner
Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, Wollongong, NSW, 2522, Australia
J Comp Physiol B 175:77-85. 2005..003) correlation was observed between sodium pump molecular activity and the content of 22:6 (n-3) in the surrounding membrane. These results are discussed in relation to recent work which shows a similar relationship in endotherms... - The ω-3 and ω-6 fats in meals: a proposal for a simple new labelNigel Turner
Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia
Nutrition 27:719-26. 2011..Our goal in this study was to analyze the PUFA content of whole meals and produce a simple measurement to estimate the intake of these fatty acids... - New insight into the mechanism by which acute physical exercise ameliorates insulin resistanceAndrew J Hoy
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
J Physiol 586:2251-2. 2008 - An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performanceDaniel G MacArthur
Institute for Neuromuscular Research, The Children s Hospital at Westmead, Sydney 2145, NSW, Australia
Hum Mol Genet 17:1076-86. 2008..These findings provide the first mechanistic explanation for the reported associations between R577X and human athletic performance and muscle function... - Altered feeding differentially regulates circadian rhythms and energy metabolism in liver and muscle of ratsJane Reznick
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, 2010 Australia
Biochim Biophys Acta 1832:228-38. 2013..These data demonstrate that a mismatch of feeding and light/dark cycle disrupts tissue metabolism in muscle with significant consequences for whole body energy homeostasis... - Molecular activity of sodium pumps in the kidney of mammals and birdsNigel Turner
Metabolic Research Centre, University of Wollongong, New South Wales, Australia 2522
Ann N Y Acad Sci 986:606-7. 2003 - Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activityLei Zhang
Neuroscience Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst NSW 2010, Sydney, Australia
Am J Physiol Regul Integr Comp Physiol 299:R1618-28. 2010.... - High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidationKim Cheng
Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, NSW, Australia
PLoS ONE 7:e40868. 2012..We believe a number of gene expression changes occurred to produce this defect, with emphasis on Sirt3 and Nampt, two genes that have been implicated in maintenance of glucose homeostasis... - Grb10 regulates the development of fiber number in skeletal muscleLowenna J Holt
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
FASEB J 26:3658-69. 2012..In addition, Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions... - Fatty acid relationships in former cannabis users with schizophreniaSharon Monterrubio
Department of Psychology and Illawarra Institute for Mental Health, University of Wollongong, Northfields Avenue, NSW, 2522, Australia
Prog Neuropsychopharmacol Biol Psychiatry 30:280-5. 2006..Future research may determine whether these FAs are involved in hypothesised links between anandamide abnormalities, cannabis use and stress in schizophrenia... - Why are some mitochondria more powerful than others: insights from comparisons of muscle mitochondria from three terrestrial vertebratesHelga Guderley
Helga Guderley, Dép de Biologie, Universite Laval, Quebec, P Q Canada
Comp Biochem Physiol B Biochem Mol Biol 142:172-80. 2005..We suggest that the numbers of CCO and ANT together with the poly-unsaturation of phospholipids explain the higher oxidative capacities in muscle mitochondria from rats and cane toads... - Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathwayMin Jia Tan
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Chem Biol 15:263-73. 2008..These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity... - Modulation of Na,K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kineticsFlemming Cornelius
Department of Biophysics, University of Aarhus, Ole Worms Alle 185, DK 8000, Denmark
Biochemistry 42:8541-9. 2003.... - Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birdsMartin D Brand
MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
Biochem J 376:741-8. 2003..These correlations echo those seen in mammalian liver mitochondria, suggesting that they too are general for endotherms... - Electric field strength of membrane lipids from vertebrate species: membrane lipid composition and Na+-K+-ATPase molecular activityThomas Starke-Peterkovic
School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia
Am J Physiol Regul Integr Comp Physiol 288:R663-70. 2005..The fact that the dipole potential is maintained at a relatively constant value over a wide range of animal species suggests that it may play a fundamental role in ensuring correct ion pump conformation and function within the membrane... - Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscleSarah J Lessard
Exercise Metabolism Group, RMIT University School of Medical Sciences, Bundoora, Victoria, Australia
Endocrinology 145:5665-70. 2004..Our data suggest, therefore, that rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle... - The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed miceMisak Yazdi
AstraZeneca Research and Development, Pepparedsleden 1, S 431 83 Molndal, Sweden
Biochem Biophys Res Commun 369:1065-70. 2008..Thus, GPAT1-deficiency does not protect against HFD-induced obesity, hepatic steatosis or whole body glucose intolerance... - Cholesterol effect on the dipole potential of lipid membranesThomas Starke-Peterkovic
School of Chemistry, University of Sydney, Sydney NSW 2006, Australia
Biophys J 90:4060-70. 2006..We suggest that this could be associated with a maximum in the strength of DMPC-cholesterol intermolecular forces at this composition...