Research Topics
| Dorit Samocha-BonetSummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?D Samocha-Bonet
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
Trends Endocrinol Metab 23:116-24. 2012..We propose that dynamic interventional studies in insulin-sensitive obese humans may increase understanding of the metabolic factors that play a role in obesity-associated insulin resistance in humans...
Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?Dorit Samocha-Bonet
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Trends Endocrinol Metab 21:83-8. 2010..We propose that lipotoxic intermediates and lipid peroxides in skeletal muscle interfere with insulin signaling and might cause insulin resistance in these 'at risk' individuals...
Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humansDorit Samocha-Bonet
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, Australia
PLoS ONE 7:e36320. 2012..High fat feeding induces insulin resistance and increases skeletal muscle oxidative stress in rodents, but there is controversy as to whether skeletal muscle mitochondrial biogenesis and function is altered...
Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humansCharmaine S Tam
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia
Diabetes 59:2164-70. 2010..The aim of this study was to assess whether overfeeding induces peripheral insulin resistance in lean and overweight humans, and, if so, whether it is associated with increased systemic and adipose tissue inflammation...
Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patientsDorit Samocha-Bonet
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
J Nutr 141:1233-8. 2011..These findings suggest that glutamine may be a novel agent for stimulating GLP-1 concentration and limiting postprandial glycemia in type 2 diabetes...
