Research Topics
| Katherine SamarasSummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in human immunodeficiency virus-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: six casesKatherine Samaras
Department of Endocrinology, St Vincent s Hospital and St Vincent s Clinic, Darlinghurst, New South Wales, 2010, Australia
J Clin Endocrinol Metab 90:4394-8. 2005....- Bariatric surgery for type 2 diabetes: to whom and when?K Samaras
Department of Endocrinology St Vincent s Hospital, Diabetes and Obesity Group, Garvan Institute of Medical Research, Sydney, Australia
Minerva Endocrinol 38:47-58. 2013..The question of when bariatric surgery should be offered in the course of obesity-associated diabetes is discussed. Current guidelines and specialist society recommendations for bariatric surgery in diabetes are summarized... 
Reduced arterial stiffness after weight loss in obese type 2 diabetes and impaired glucose tolerance: the role of immune cell activation and insulin resistanceKatherine Samaras
Diabetes Program, Garvan Institute of Medical Research, Darlinghurst, Australia
Diab Vasc Dis Res 10:40-8. 2013..005). In morbidly obese dysglycaemic subjects, modest weight loss reduces arterial stiffness, the magnitude of which relates to improved markers of inflammation...- Take heart: bariatric surgery in obese patients with severe heart failure. Two case reportsK Samaras
Diabetes Program, Garvan Institute of Medical Research, Australia
Heart Lung Circ 21:847-9. 2012..In selected patients with severe heart failure and concomitant morbid obesity, bariatric surgery may be a reasonable treatment option... - The value of the metabolic syndrome concept in elderly adults: is it worth less than the sum of its parts?Katherine Samaras
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
J Am Geriatr Soc 60:1734-41. 2012..To determine whether the metabolic syndrome (MetS) or its components were more closely associated with disease states and inflammation in elderly adults... - The burden of diabetes and hyperlipidemia in treated HIV infection and approaches for cardiometabolic careKatherine Samaras
Department of Endocrinology, St Vincent s Hospital, Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia
Curr HIV/AIDS Rep 9:206-17. 2012..It also reviews the current evidence base and clinical guidelines for diabetes and lipid management and cardiometabolic prevention in HIV-infected HAART recipients... - Prevalence and pathogenesis of diabetes mellitus in HIV-1 infection treated with combined antiretroviral therapyKatherine Samaras
Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Acquir Immune Defic Syndr 50:499-505. 2009..It also reviews the current understanding of mechanisms involved in the pathogenesis of type 2 diabetes in cART considering insulin resistance and insulin secretion, both requisites for the development of type 2 diabetes mellitus... - Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in healthKatherine Samaras
Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Obes Surg 20:108-13. 2010.... - Prevalence of metabolic syndrome in HIV-infected patients receiving highly active antiretroviral therapy using International Diabetes Foundation and Adult Treatment Panel III criteria: associations with insulin resistance, disturbed body fat compartmentalKatherine Samaras
Diabetes and Obesity Programme, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
Diabetes Care 30:113-9. 2007..The purpose of this study was to report the prevalence of metabolic syndrome in HIV-infected patients and compare insulin resistance and total body, limb, and visceral fat and adipokines in those with and without metabolic syndrome... - Dietary intake in HIV-infected men with lipodystrophy: relationships with body composition, visceral fat, lipid, glucose and adipokine metabolismKatherine Samaras
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Curr HIV Res 7:454-61. 2009..Only interventional, prospective studies will determine whether any nutritional strategy can assist in ameliorating the metabolic complications associated with HIV lipodystrophy... - Metabolic consequences and therapeutic options in highly active antiretroviral therapy in human immunodeficiency virus-1 infectionKatherine Samaras
Diabetes Program, Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, 384 Victoria St, Darlinghurst, NSW 2010, Australia
J Antimicrob Chemother 61:238-45. 2008..The efficacy of therapeutic interventions for insulin resistance, hyperlipidaemia, body fat partitioning disorders and metabolic syndrome is summarized... - Proinflammatory markers, insulin sensitivity, and cardiometabolic risk factors in treated HIV infectionKatherine Samaras
St Vincent s Hospital, Darlinghurst, New South Wales, Australia
Obesity (Silver Spring) 17:53-9. 2009..These factors may contribute to the accelerated diabetogenesis and cardiac risk observed in treated HIV infection... - Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influencesJerry R Greenfield
Department of Endocrinology, St Vincent's Hospital, Sydney, Australia
Circulation 109:3022-8. 2004..These relationships are likely to contribute significantly to prospective associations between CRP and type 2 diabetes and coronary events... - Effect of pravastatin on body composition and markers of cardiovascular disease in HIV-infected men--a randomized, placebo-controlled studyPatrick W G Mallon
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
AIDS 20:1003-10. 2006..To determine the effect of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pravastatin, on markers of cardiovascular risk and lipodystrophy in HIV-infected, protease inhibitor (PI)-treated men with hypercholesterolaemia... 
The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing StudyJulian N Trollor
Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, 34 Botany Road, Sydney, NSW, Australia
Age (Dordr) 34:1295-308. 2012..Additional research is required to elucidate the pathophysiology and longitudinal development of these relationships...- Moderate alcohol consumption, estrogen replacement therapy, and physical activity are associated with increased insulin sensitivity: is abdominal adiposity the mediator?Jerry R Greenfield
Department of Endocrinology, St Vincent s Hospital, Sydney, Australia
Diabetes Care 26:2734-40. 2003..the contribution of abdominal adiposity to these relationships; and 3). whether gene-environment interactions mediate these associations... - Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: evidence for gene-environment interactionJerry R Greenfield
Department of Endocrinology, St. Vincent's Hospital, Darlinghurst, 2010 Sydney, Australia
J Clin Endocrinol Metab 88:5381-6. 2003..In conclusion, genetic risk modulates relationships between dietary factors and adiposity. Lower abdominal fat may mediate associations between dietary intake and type 2 diabetes risk... - Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophySeng Khee Gan
Metabolism and Diabetes Research Program, Garvan Institute of Medical Research, Sydney, Australia
Diabetes 51:3163-9. 2002..The results do not establish causation but emphasize the interrelationships among visceral fat, myocyte lipid, and insulin action... - Beneficial postprandial effect of a small amount of alcohol on diabetes and cardiovascular risk factors: modification by insulin resistanceJerry R Greenfield
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia
J Clin Endocrinol Metab 90:661-72. 2005..02) and HC meal (increase, 362 +/- 36 vs. 205 +/- 34 kcal/d; P = 0.0009), but suppressed fat and carbohydrate oxidation. Some of our findings may be mechanisms for lower diabetes and cardiovascular risks in moderate drinkers... - Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetesKatherine Samaras
1 Department of Endocrinology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia 2 Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Obesity (Silver Spring) 18:884-9. 2010..Increased production of these proinflammatory molecules by VAT may explain the links observed between visceral obesity, insulin resistance, and diabetes risk... - No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, placebo-controlled trialAndrew Carr
St Vincent s Hospital, Sydney, Australia
Lancet 363:429-38. 2004..We postulated that rosiglitazone would improve HIV lipoatrophy... - Low bone mineral density, renal dysfunction, and fracture risk in HIV infection: a cross-sectional studyAlexandra Calmy
HIV, Immunology and Infectious Diseases Unit, University of New South Wales, Sydney, Australia
J Infect Dis 200:1746-54. 2009..The role of proximal renal tubular dysfunction (PRTD) and alterations in bone metabolism in HIV-related low BMD are incompletely understood... - Systemic inflammation is associated with MCI and its subtypes: the Sydney Memory and Aging StudyJulian N Trollor
Department of Developmental Disability Neuropsychiatry, University of New South Wales, 34 Botany Road, Sydney, NSW 2052, Australia
Dement Geriatr Cogn Disord 30:569-78. 2010..This study examines the relationship between systemic inflammation and MCI subtypes... - Physical activity reduces genetic susceptibility to increased central systolic pressure augmentation: a study of female twinsJerry R Greenfield
Department of Endocrinology, St Vincent s Hospital, Sydney, Australia
J Am Coll Cardiol 42:264-70. 2003..We sought to examine associations between the augmentation index (AI) and metabolic, adiposity, and lifestyle factors, independent of genetic influences, and to determine whether gene-environment interactions modulate these relationships... - Regional intra-subject variability in abdominal adiposity limits usefulness of computed tomographyJerry R Greenfield
Diabetes and Metabolism Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney NSW 2010, Australia
Obes Res 10:260-5. 2002.... - The Association between Pulse Wave Velocity and Cognitive Function: The Sydney Memory and Ageing StudyJoel Singer
Brain and Aging Research Program, School of Psychiatry, University of New South Wales, Sydney, Australia Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
PLoS ONE 8:e61855. 2013..This study examined the relationship between carotid-femoral PWV and specific domains of cognitive function in a non-demented elderly sample... - Efficacy of metformin for prevention of weight gain in psychiatric populations: a reviewHannah Newall
Faculty of Medicine, University of New South Wales, NSW, Australia
Int Clin Psychopharmacol 27:69-75. 2012..Further studies with adequate statistical power are required to determine the efficacy of metformin in those with chronic psychotic illness... - Insulin levels in insulin resistance: phantom of the metabolic opera?Katherine Samaras
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales
Med J Aust 185:159-61. 2006..Individuals "at risk" of diabetes and atherosclerotic cardiac disease can be identified simply and inexpensively, using classic clinical techniques, such as history-taking, physical examination, and very basic investigations... - Effect of postprandial insulinemia and insulin resistance on measurement of arterial stiffness (augmentation index)Jerry R Greenfield
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Int J Cardiol 114:50-6. 2007..Whether physiological postprandial insulinemia similarly affects AIx measurements, and whether insulin resistance modifies this response, has not been studied... - The heart of the matter: cardiometabolic care in youth with psychosisJackie Curtis
Eastern Suburbs Mental Health Programme, Bondi Centre, Sydney, New South Wales, Australia
Early Interv Psychiatry 6:347-53. 2012.... - Postprandial lipid effects of low-dose ritonavir vs. raltegravir in HIV-uninfected adultsKatherine Samaras
Diabetes Program, Garvan Institute of Medical Research, and Department of Endocrinology, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
AIDS 24:1727-31. 2010..Half this risk appears attributable to fasting dyslipidemia, but half remains unexplained. We compared the fasting and postprandial effects of low-dose ritonavir and raltegravir on cardiovascular and metabolic risk factors... - Metabolic abnormalities in an early psychosis service: a retrospective, naturalistic cross-sectional studyJackie Curtis
Early Psychosis Programme, Bondi Centre, South Eastern Sydney Local Health Network, School of Psychiatry, University of New South Wales, Sydney, Australia
Early Interv Psychiatry 5:108-14. 2011..This study examined the prevalence of such abnormalities in a specialist early-intervention community mental health team... - Insulin resistance, intra-abdominal fat, cardiovascular risk factors, and androgens in healthy young women with type 1 diabetes mellitusJerry R Greenfield
Diabetes and Metabolism Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia
J Clin Endocrinol Metab 87:1036-40. 2002..Our results demonstrate greater insulin resistance in a group of premenopausal women with type 1 diabetes compared with nondiabetic controls, unrelated to abdominal adiposity, lipids, or androgens... - In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNAPatrick W G Mallon
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, NSW 2010, Australia
J Infect Dis 191:1686-96. 2005..The effects of this mitochondrial dysfunction on lipid metabolism, at a molecular level in vivo, have not been described... - Early changes in adipokine levels and baseline limb fat may predict HIV lipoatrophy over 2 years following initiation of antiretroviral therapyA Calmy
St Vincent s Hospital, Sydney, Australia
HIV Med 9:101-10. 2008..We investigated whether metabolic and body composition parameters could predict the development of LD over 2 years in adults initiating antiretroviral therapy (ART)... - Evaluation of pituitary function in the fatigued patient: a review of 59 casesJerry R Greenfield
Department of Endocrinology, St Vincent's Hospital and St Vincent's Clinic and the Garvan Institute of Medical Research, Sydney, Australia
Eur J Endocrinol 154:147-57. 2006..Whether physiological glucocorticoid replacement improves symptoms in this patient group is yet to be established... - Transplant recipients on the edge of the hypocalcemia abyssPaul Lee
Department of Endocrinology, St Vincent s Hospital, New South Wales, Australia
J Heart Lung Transplant 28:93-5. 2009..Regular surveillance of calcium homeostasis should be incorporated into routine clinical care of transplant recipients... - Coeliac disease in an Indian patient: an important diagnosis to considerPaul Lee
Department of Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia
Med J Aust 189:336-7. 2008 - Type 1 diabetes is not associated with increased central abdominal obesityJerry R Greenfield
Diabetes Care 26:2703; author reply 2703-4. 2003 - Contribution of metabolic and anthropometric abnormalities to cardiovascular disease risk factorsCarl Grunfeld
Circulation 118:e20-8. 2008 - Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infectionHandan Wand
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Australia
AIDS 21:2445-53. 2007..Metabolic syndrome (MS) identifies individuals at risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Little is known about MS and its consequences following initiation of antiretroviral therapy (ART)... - Heritability of body fat using DXAKatherine Samaras
Obes Res 13:2210; author reply 2211. 2005 - Insulin resistance: more important to identify than quantifyKatherine Samaras
Nephrology (Carlton) 10:597-8. 2005