Georg Ramm

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. ncbi A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160
    Georg Ramm
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Biol Chem 281:29174-80. 2006
  2. ncbi Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association
    Jacqueline Stöckli
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Mol Endocrinol 22:2703-15. 2008
  3. ncbi Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane
    Yvonne Ng
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Biol Chem 285:2245-57. 2010
  4. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
  5. ncbi CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    Ming Fai Yip
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 8:384-98. 2008
  6. ncbi Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes
    Yvonne Ng
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Cell Metab 7:348-56. 2008
  7. ncbi The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes
    Shi Xiong Tan
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Mol Cell Biol 32:4946-59. 2012
  8. ncbi The GLUT4 code
    Mark Larance
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    Mol Endocrinol 22:226-33. 2008
  9. ncbi GLUT4 trafficking in a test tube
    Georg Ramm
    Garvan Institute of Medical Research, Darlinghust, NSW, Australia
    Cell Metab 2:150-2. 2005
  10. ncbi Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006

Collaborators

Detail Information

Publications12

  1. ncbi A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160
    Georg Ramm
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Biol Chem 281:29174-80. 2006
    ..These data show that the insulin-dependent association of 14-3-3 with AS160 plays an important role in GLUT4 trafficking in adipocytes...
  2. ncbi Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association
    Jacqueline Stöckli
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Mol Endocrinol 22:2703-15. 2008
    ....
  3. ncbi Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane
    Yvonne Ng
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Biol Chem 285:2245-57. 2010
    ..These data indicate the utility of hierarchical cluster analysis for identifying functionally related biological nodes and highlight the importance of subcellular partitioning of key signaling components for biological specificity...
  4. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
    ..These findings support an important role for AS160 in the insulin regulated trafficking of GLUT4...
  5. ncbi CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    Ming Fai Yip
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 8:384-98. 2008
    ..These data suggest that insulin regulates Myo1c function via CaMKII-dependent phosphorylation, and these events play a role in insulin-regulated GLUT4 trafficking in adipocytes likely involving Myo1c motor activity...
  6. ncbi Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes
    Yvonne Ng
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Cell Metab 7:348-56. 2008
    ..These results show that activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes to an extent similar to insulin...
  7. ncbi The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes
    Shi Xiong Tan
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Mol Cell Biol 32:4946-59. 2012
    ..We propose a model wherein AS160 acts as a regulatory switch in the docking and/or fusion of GSVs with the PM...
  8. ncbi The GLUT4 code
    Mark Larance
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    Mol Endocrinol 22:226-33. 2008
    ..Many are now taking on this challenge...
  9. ncbi GLUT4 trafficking in a test tube
    Georg Ramm
    Garvan Institute of Medical Research, Darlinghust, NSW, Australia
    Cell Metab 2:150-2. 2005
    ..In this issue of Cell Metabolism, Holman and colleagues reconstitute this process in vitro, providing a system that promises new breakthroughs in our understanding of this important metabolic process...
  10. ncbi Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006
    ..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
  11. ncbi The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity
    Elaine C Thomas
    Centre for Diabetes and Endocrine Research, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Australia
    Int J Biochem Cell Biol 38:1686-99. 2006
    ....
  12. ncbi Endosomes: multipurpose designs for integrating housekeeping and specialized tasks
    Martin Sachse
    Department of Cell Biology, AZU Rm G02 525, 3584 CX Utrecht, The Netherlands
    Histochem Cell Biol 117:91-104. 2002
    ..In the second part, adaptations of endosomes that allow their functioning in specialized processes, such as antigen presentation, synaptic vesicle formation, and glucose transport, will be addressed...