T V Nguyen

..These results are consistent with the view that genetic profiling, when integrated in existing risk assessment models, can inform a more accurate prediction of fracture risk in an individual...

..The aim of this population based study was to describe, for the first time, the age- and sex specific occurrence of osteoporotic vertebral fractures in Norway...

..The aim of this study was to examine the effect of different reference ranges in bone mineral density on the diagnosis of osteoporosis...

..This study was designed to estimate the modifiable distribution and determinants of bone mineral density (BMD) among Iranian women in Australia...

..The present study was undertaken to test the hypothesis that lean mass is a better determinant of BMD than fat mass...

..This cross-sectional study was designed to examine the difference in bone mineral density (BMD), a primary predictor of fracture risk, between urban and rural Thai populations...

..The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians...

..This study sought to examine the association between vitamin D status, parathyroid hormone (PTH) and the risk of TB in a Vietnamese population...

..In elderly women, greater loss of BMD at the femoral neck was associated with increased risk of fracture, independent of baseline BMD and age...

..The combination of QUS and BMD measurements may improve the accuracy of identification of women who will sustain a fracture...

..Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women...

..It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years...

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..an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?..

..These findings clearly support the hypothesis that a large component of the variance in BMD is under genetic control, with strong evidence for a major gene locus influencing BMD transmission...

..These data suggest that although there are systematic differences between the UBIS and Achilles+ scanners in QUS measurements, the precision of the two instruments is equivalent...

..48. Clinical risk scores can be used to identify women likely to have low BMD (albeit with low specificity), but they are not a useful tool to identify women who will have a fracture...

..CONCLUSIONS: Age and gender were major determinants of variability of GH-responsive markers except for IGFBP-3 and ALS. Ethnicity is unlikely to confound the validity of a GH doping test based on IGF-I and these collagen markers...

..We have developed clinical nomograms for predicting 5-year and 10-year fracture risks for any elderly man or woman. The nomograms used age and information concerning fracture history, fall history, and BMD T-score or body weight...

..These findings indicate that BSAP and BMD are heritable and negatively correlated. However, the genetic loci influencing BSAP and BMD appear to be largely independent as are any environmental factors...

..Even though a high concordance between the densitometers was observed on a single measurement occasion, a significant discordance in longitudinal changes in BMD was observed...

..These data emphasize the importance of external validation before widespread clinical implementation of prognostic tools in different cohorts...

..Moreover, FNAL appears to have limited utility in the prediction of hip fracture risk and any role of HAL in the prediction of hip fracture does not relate to its major component of femoral neck length...

..While significant genetic influences on body mass index (BMI), total body and subcutaneous fat have been demonstrated, the inheritance of central abdominal obesity, has not been studied...

..We have developed a nomogram for predicting the absolute risk of hip fracture for any individual by using clinical factors, including age, prior fracture and fall, in addition to BMD that was based on a 15-year follow-up cohort study...

..0, 3.6) and a history of falls (women: RR = 1.9, 95% CI: 1.4, 2.6) were also significant. These data suggest that elderly men and women largely share common risk factors for upper limb fractures and that FNBMD is the primary risk factor...

..D.) years, as part of the Dubbo Osteoporosis Epidemiology Study (Australia)...

..Its use in the general population can result in a high false-positive rate and incur significant cost to the community...

..The nonograms presented here can be useful for individualizing the short- and intermediate-term prognosis of fracture risk and help identify high-risk individuals for intervention for appropriate management of osteoporosis...

..3 years, high bone resorption as assessed by S-ICTP was associated with increased risk of osteoporotic fracture, independent of BMD. Combining measurements of BMD and bone turnover may improve fracture prediction in elderly men...

..Among those with BMD T-scores < or = -2.5, the risks increased to 65% in women and 42% in men...

..Mortality increases after hip fractures in women and more so in men. Little is known, however, about mortality after other fractures. We investigated the mortality associated with all fracture types in elderly women and men...

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..Preventive strategies should simultaneously target reducing falls and improvement of bone strength in both men and women...

..To determine the reliability, consistency, and clinical utility of the Osteoporosis Assessment Questionnaire (OPAQ), an AIMS2 based self-assessment questionnaire...

..These results suggest that in the Thai population, low dietary calcium intake and low physical activity together with advancing years since menopause were independent risk factors for low BMD...

..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time...

..Results of genetic model-fitting analysis indicated genetic effects on bone loss account for approximately 40% of the between-individual variation in bone loss at the lumbar spine, forearm, and whole body...

..The present study sought to determine the incidence of low trauma fracture in men with prostate cancer (PC), and to characterize the association between potential risk factors and fracture risk in these men...

..Approximately one-half of hip fractures occurred before 80 years in men and two-thirds before 85 years in women. The age distribution of hip fractures underlines the need for earlier intervention in osteoporosis...

..Description of recent progress in genetics and pharmacogenetics of osteoporosis...

..It needs further exploration for a role in assessment of hip fracture risk across the sexes and particularly in men...

..There are few published long-term data on absolute risk of subsequent fracture (refracture) following initial low-trauma fracture in women and fewer in men...

..Osteoporotic fractures are associated with premature mortality. Antiresorptive treatment reduces refracture but mortality reduction is unclear...

..Subsequent population-based studies of the association between the LRP5 gene and BMD have yielded conflicting results. The present study was aimed at examining the association between LRP5 gene and BMD by using meta-analysis...

..We evaluated the utility of multiple biomarkers from distinct biologic pathways as potential predictive markers of response to pancreatectomy and patient survival...

..Low baseline BMD, rate of BMD loss, weight loss, and weight fluctuation are significant predictors of all-cause mortality in elderly men and women, independent of each other and of age, incident fracture, and concomitant diseases...

..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture...

..This study addressed the role of p14(ARF) as a potential prognostic marker in this disease...

..However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD...

..Therefore, use of r-HuEPO in athletes should not affect the validity of a GH doping test using these GH-responsive markers...

..This study utilized the Bayesian approach to combine existing evidence and update the association with consideration of potential bias...

..These findings provide insights into barriers that need to be overcome if preventive strategies and intervention programs can be developed to reduce the overall burden of osteoporosis in the community...

..90. CONCLUSIONS: In postmenopausal women with osteoporosis or low BMD, bisphosphonate treatment is associated with reduced risk of hip fracture...

..Among the cell cycle-regulatory molecules studied, p16(INK4A) expression is the most predictive molecular marker of disease outcome...

..Simple measures like vitamin D and calcium supplementation and use of hip protectors can reduce hip fractures, particularly in institutionalised and housebound elderly people..

..It is not known which factors are associated with fracture in nonosteoporotic elderly. The aim of this study was to assess the association between fall-related risk factors and fracture risk in men and women without osteoporosis...

..The prognostic model and approach presented in this study may help improve the individualization and management of osteoporosis...

..CONCLUSION: Vertebral deformity was a strong predictor of subsequent risk of fractures, particularly symptomatic vertebral fracture, and may modify fracture-associated mortality in both elderly men and women...

..We sought to determine short-term within-subject variability of these markers in a large cohort of healthy individuals...

..The aim of this study was to determine the predictive value of selected abnormal clinical observations in a ward population for subsequent in-hospital mortality...

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..To develop and validate sex-specific equations for predicting percentage body fat (%BF) in rural Thai population, based on BMI and anthropometric measurements...

..These data are thus consistent with the hypothesis that the urban-rural difference in BMD at a weight-bearing site is in part associated with the urban-rural difference in lean mass...

..Osteoporosis is a growing health problem not only in women but also in men. However, there is a scarcity of epidemiologic data to study osteoporosis in Thai men...

..Estimated vFNBMD shows only small sex-correlated differences in bone density. Estimated vFNBMD was more sensitive than aFNBMD, when used to define the osteoporotic cut-offs in men, while it was less sensitive than aFNBMD in women...

..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture...

..The instrument-derived T-score is not appropriate for the diagnosis of osteoporosis in the Vietnamese population...

..In addition to possible shared (pleiotropic) genetic and environmental effects, each of the BMD variables may also be determined by site-specific genetic factors...

..In conclusion, for the Thai population, BMI is a reasonably useful indicator of obesity; however, the cut-off values of BMI for diagnosing obesity should be lowered to 27 kg/m2 in men and 25 kg/m2 in women...

..CONCLUSIONS: Serum concentrations of cathepsin K appear to reflect osteoclastic activity in patients with postmenopausal osteoporosis and Paget's disease of bone and may hold promise as a marker of osteoclast activity...

..The objectives of the present study were to estimate the prevalence of MetS and to find an optimal BMI cut-off value for defining obesity in the Thai population...

..We prospectively examined the relationship between serum levels of testosterone and estradiol and future fracture risk in community-dwelling men...