Kin Chuen Leung

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases
    Kin Chuen Leung
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Endocrinology 148:2417-23. 2007
  2. pmc Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
    K C Leung
    Pituitary Research Unit and Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney NSW 2010, Australia
    Proc Natl Acad Sci U S A 100:1016-21. 2003
  3. ncbi request reprint Regulation of cytokine receptor signaling by nuclear hormone receptors: a new paradigm for receptor interaction
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    DNA Cell Biol 23:463-74. 2004
  4. ncbi request reprint Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitro
    Gary M Leong
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Endocrinology 145:5525-31. 2004
  5. doi request reprint The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial
    Udo Meinhardt
    Garvan Institute of Medical Research and St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Ann Intern Med 152:568-77. 2010
  6. ncbi request reprint Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men
    Klara Sjögren
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    Am J Physiol Endocrinol Metab 293:E364-71. 2007
  7. ncbi request reprint Estrogen regulation of growth hormone action
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Endocr Rev 25:693-721. 2004
  8. ncbi request reprint Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal women
    Ailish G Nugent
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Clin Endocrinol (Oxf) 59:690-8. 2003
  9. ncbi request reprint Physiological and pharmacological regulation of 20-kDa growth hormone
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 283:E836-43. 2002
  10. ncbi request reprint Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men
    Gudmundur Johannsson
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3989-94. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases
    Kin Chuen Leung
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Endocrinology 148:2417-23. 2007
    ..We provide the first evidence for a novel mechanism regulating GH signaling, in which SERMs enhance GH activation of the JAK2/STAT5 pathway in a cell-type-dependent manner by attenuating protein tyrosine phosphatase activities...
  2. pmc Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
    K C Leung
    Pituitary Research Unit and Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney NSW 2010, Australia
    Proc Natl Acad Sci U S A 100:1016-21. 2003
    ..In conclusion, estrogen inhibits GH signaling, an action mediated by SOCS-2. This paper provides evidence for regulatory interaction between a sex steroid and the GHJAKSTAT pathway, in which SOCS-2 plays a central mechanistic role...
  3. ncbi request reprint Regulation of cytokine receptor signaling by nuclear hormone receptors: a new paradigm for receptor interaction
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    DNA Cell Biol 23:463-74. 2004
    ..Better understanding of the regulatory interaction between these two classes of receptors potentially leads to new drug design and/or therapeutic strategies for treatment of cytokine-related diseases...
  4. ncbi request reprint Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitro
    Gary M Leong
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Endocrinology 145:5525-31. 2004
    ..In summary, estrogen, via ERalpha, up-regulated hepatic expression of SOCS-2 and -3, probably through transcriptional activation. This indicates a novel mechanism of estrogen regulation of cytokine action...
  5. doi request reprint The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial
    Udo Meinhardt
    Garvan Institute of Medical Research and St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Ann Intern Med 152:568-77. 2010
    ..Growth hormone is widely abused by athletes, frequently with androgenic steroids. Its effects on performance are unclear...
  6. ncbi request reprint Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men
    Klara Sjögren
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    Am J Physiol Endocrinol Metab 293:E364-71. 2007
    ..GH may regulate circadian function in skeletal muscle by modulating circadian gene expression with possible metabolic consequences...
  7. ncbi request reprint Estrogen regulation of growth hormone action
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Endocr Rev 25:693-721. 2004
    ..This represents a novel paradigm of steroid regulation of cytokine receptors and is likely to have significance for a diverse range of cytokine function...
  8. ncbi request reprint Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal women
    Ailish G Nugent
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Clin Endocrinol (Oxf) 59:690-8. 2003
    ..As progestogens attenuate the effects of oestrogen on circulating lipid levels according to their androgenic properties, we have investigated the impact of progestogen types on the hepatic endocrine effects of oestrogen...
  9. ncbi request reprint Physiological and pharmacological regulation of 20-kDa growth hormone
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 283:E836-43. 2002
    ..The 20-kDa GH level is reduced by administration of exogenous 22-kDa GH, suggesting rapid negative feedback regulation on pituitary release...
  10. ncbi request reprint Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men
    Gudmundur Johannsson
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3989-94. 2005
    ..The mechanisms underlying the sodium-retaining effects of GH are poorly understood...
  11. ncbi request reprint Protein metabolism in acromegaly: differential effects of short- and long-term treatment
    James Gibney
    Department of Endocrinology, St Vincent s Hospital, and Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia
    J Clin Endocrinol Metab 92:1479-84. 2007
    ..GH acutely increases body protein by stimulating protein synthesis and reducing protein oxidation...
  12. ncbi request reprint Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient women
    James Gibney
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3897-903. 2005
    ..The aim of this study was to determine whether selective estrogen receptor modulators display similar effects and whether these effects are magnified in GH-deficient (GHD) women because of the loss of GH feedback...
  13. doi request reprint Pharmacodynamics of growth hormone abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes
    Anne E Nelson
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst 2010, Sydney, NSW, Australia
    J Clin Endocrinol Metab 93:2213-22. 2008
    ..IGF axis proteins and collagen peptides are promising markers of GH abuse...
  14. ncbi request reprint Galanin in human pituitary adenomas: frequency and clinical significance
    Betty Leung
    Department of Anatomical Pathology, St Vincent s Hospital, Sydney, Australia
    Clin Endocrinol (Oxf) 56:397-403. 2002
    ....
  15. ncbi request reprint A novel bioassay for human somatogenic activity in serum samples supports the clinical reliability of immunoassays
    Jennifer E Rowland
    Department of Physiology and Pharmacology and Centre for Molecular and Cellular Biology, University of Queensland, St Lucia, Australia 4072
    Clin Endocrinol (Oxf) 56:475-85. 2002
    ..The results of this assay were compared with the Elegance two-site ELISA assay across 135 patient samples in a variety of clinical states...