Edward Kraegen

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Triglycerides, fatty acids and insulin resistance--hyperinsulinemia
    E W Kraegen
    Garvan Institute of Medical Research, St Vincent s Hospital Sydney NSW, Australia
    Exp Clin Endocrinol Diabetes 109:S516-26. 2001
  2. pmc Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle
    Michael J Boden
    Diabetes and Obesity Program, Garvan Institute for Medical Research, Darlinghurst, NSW, Australia 2010
    Am J Physiol Endocrinol Metab 303:E798-805. 2012
  3. ncbi request reprint AMP-activated protein kinase and muscle insulin resistance
    Edward W Kraegen
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Front Biosci (Landmark Ed) 14:4658-72. 2009
  4. pmc Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction
    Edward W Kraegen
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney NSW 2010, Australia
    Proc Natl Acad Sci U S A 105:7627-8. 2008
  5. doi request reprint Free fatty acids and skeletal muscle insulin resistance
    Edward W Kraegen
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Curr Opin Lipidol 19:235-41. 2008
  6. ncbi request reprint Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
    Edward W Kraegen
    Garvan Institute of Medical Research, Sydney NSW 2010 Australia
    Am J Physiol Endocrinol Metab 290:E471-9. 2006
  7. pmc Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistance
    Edward Kraegen
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    J R Soc Med 95:14-22. 2002
  8. ncbi request reprint The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity
    E W Kraegen
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Exp Clin Endocrinol Diabetes 109:S189-201. 2001
  9. ncbi request reprint Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats
    Ji Ming Ye
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Diabetes 55:2797-804. 2006
  10. ncbi request reprint AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    Miguel A Iglesias
    Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Diabetes 51:2886-94. 2002

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Triglycerides, fatty acids and insulin resistance--hyperinsulinemia
    E W Kraegen
    Garvan Institute of Medical Research, St Vincent s Hospital Sydney NSW, Australia
    Exp Clin Endocrinol Diabetes 109:S516-26. 2001
    ..In conclusion, evidence is growing that excess muscle and liver lipid accumulation causes or exacerbates insulin resistance in Syndrome X and in Type II diabetes; development of strategies to prevent this seem very worthwhile...
  2. pmc Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle
    Michael J Boden
    Diabetes and Obesity Program, Garvan Institute for Medical Research, Darlinghurst, NSW, Australia 2010
    Am J Physiol Endocrinol Metab 303:E798-805. 2012
    ..05), suggesting that this effect was mediated through an altered redox state. Thus interventions causing elevation of mitochondrial antioxidant activity may offer protection against diet-induced insulin resistance in skeletal muscle...
  3. ncbi request reprint AMP-activated protein kinase and muscle insulin resistance
    Edward W Kraegen
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Front Biosci (Landmark Ed) 14:4658-72. 2009
    ..These issues are important in considering the AMPK pathway as a therapeutic target in insulin resistant states...
  4. pmc Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction
    Edward W Kraegen
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney NSW 2010, Australia
    Proc Natl Acad Sci U S A 105:7627-8. 2008
  5. doi request reprint Free fatty acids and skeletal muscle insulin resistance
    Edward W Kraegen
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Curr Opin Lipidol 19:235-41. 2008
    ..Relevant mechanisms, however, are still not fully elucidated. Here we examine the latest evidence as to why lipids might accumulate in muscle and the possible mechanisms for lipid-induced insulin resistance...
  6. ncbi request reprint Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
    Edward W Kraegen
    Garvan Institute of Medical Research, Sydney NSW 2010 Australia
    Am J Physiol Endocrinol Metab 290:E471-9. 2006
    ..In contrast, it was not associated with increased whole tissue LCA-CoA content in any tissue or triglyceride in muscle, although both are observed at later times...
  7. pmc Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistance
    Edward Kraegen
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    J R Soc Med 95:14-22. 2002
  8. ncbi request reprint The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity
    E W Kraegen
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Exp Clin Endocrinol Diabetes 109:S189-201. 2001
    ..Recent work has also pointed to a possible role of lipids in beta cell deterioration ("lipotoxicity") associated with type 2 diabetes...
  9. ncbi request reprint Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats
    Ji Ming Ye
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Diabetes 55:2797-804. 2006
    ..Thus, our findings suggest that in addition to ameliorating insulin resistance, TZDs may enhance AMPK-stimulated glucose clearance into peripheral tissues in insulin-resistant states...
  10. ncbi request reprint AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    Miguel A Iglesias
    Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Diabetes 51:2886-94. 2002
    ..Independent of this, the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes...
  11. ncbi request reprint Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression
    Mark E Cleasby
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    Mol Endocrinol 21:215-28. 2007
    ..These data indicate distinct roles for Akt-1 and Akt-2 in muscle glucose metabolism and that moderate reductions in IRS-1 expression do not result in the development of insulin resistance in skeletal muscle in vivo...
  12. ncbi request reprint Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007
    ..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies...
  13. ncbi request reprint Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification
    Clinton R Bruce
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst
    Am J Physiol Endocrinol Metab 292:E1231-7. 2007
    ..05). These studies demonstrate that acute overexpression of CPT I in muscle leads to a repartitioning of FAs away from esterification and toward oxidation and highlight the importance of CPT I in regulating muscle FA metabolism...
  14. ncbi request reprint Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation
    Andrew J Hoy
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Am J Physiol Endocrinol Metab 293:E1358-64. 2007
    ..001). These results suggest that the reduced muscle glucose uptake in rats after 5 h of acute hyperglycemia is due more to the metabolic effects of excess glycogen storage than to a defect in insulin signaling or glucose transport...
  15. ncbi request reprint Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization
    Rachel N Danaher
    School of Biological Sciences, University of Auckland, Private Bag 92 019, Auckland, New Zealand
    Endocrinology 149:154-60. 2008
    ....
  16. ncbi request reprint Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance
    Emma Polkinghorne
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London, United Kingdom
    Am J Physiol Endocrinol Metab 294:E316-25. 2008
    ..03) but not TLR-4 mRNA. In conclusion, activation of the IkappaBKbeta-NF-kappaB pathway in muscle does not seem to be an important local mediator of insulin resistance...
  17. doi request reprint Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness
    Matthew J Watt
    St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Mol Endocrinol 22:1200-12. 2008
    ....
  18. doi request reprint Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    Nigel Turner
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    Diabetes 57:1414-8. 2008
    ..We investigated the mechanism of activation of AMPK by BBR and explored whether derivatization of BBR could improve its in vivo efficacy...
  19. ncbi request reprint Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats
    Bronwyn D Hegarty
    Diabetes and Metabolism Research Program, Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 51:1477-84. 2002
    ....
  20. ncbi request reprint Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways
    Katherine Baran
    Diabetes Research Group, The Garvan Institute of Medical Research, Darlinghurst NSW, Sydney, Australia
    Diabetes 51:152-8. 2002
    ....
  21. ncbi request reprint Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle
    Keld Fosgerau
    In Vivo Pharmacology, Rheoscience, Ledøje Bygade 23B, DK 2765 Ledøje Smørum, Denmark
    J Endocrinol 190:651-8. 2006
    ..07 vs 1.36 +/- 0.11, P = not significant). These results demonstrate the physiological relevance of the so-called 'reverse' Randle cycle, but surprisingly show that it may be more important in white rather than oxidative red muscle...
  22. ncbi request reprint Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
    Yun S Lee
    Department of Biological Sciences, Seoul National University, San 56 1, Sillim dong, Kwanak gu, Korea
    Diabetes 55:2256-64. 2006
    ..These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity...
  23. ncbi request reprint Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo
    Heidi A Parkes
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St Darlinghurst, New South Wales, 2010, Australia
    Am J Physiol Endocrinol Metab 291:E737-44. 2006
    ..05), and overexpression in rat liver increased [1-(14)C]palmitate clearance into liver TG. These in vitro and in vivo results suggest a pivotal role for ACSL1 in regulating TG synthesis in liver...
  24. ncbi request reprint Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy
    Seng Khee Gan
    Metabolism and Diabetes Research Program, Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 51:3163-9. 2002
    ..The results do not establish causation but emphasize the interrelationships among visceral fat, myocyte lipid, and insulin action...
  25. ncbi request reprint Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver
    Ji Ming Ye
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Endocrinology 143:4527-35. 2002
    ..This may be related to chronic elevation of adiponectin by thiazolidinediones...
  26. ncbi request reprint PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
    Ji Ming Ye
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 284:E531-40. 2003
    ..Additionally, it can counteract fatty liver, hepatic insulin resistance, and visceral adiposity generally associated with PPARalpha activation, but without hepatomegaly...
  27. ncbi request reprint Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men
    Seng Khee Gan
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Diabetes Care 26:1706-13. 2003
    ..To examine the effect of moderate intensity physical activity on the interactions between central abdominal adiposity, myocyte lipid content, and insulin action in overweight and obese, sedentary men...
  28. ncbi request reprint Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity
    Neil B Ruderman
    D Phil, Diabetes Unit, Boston Medical Center, 650 Albany Street, X825, Boston, Massachusetts 02118, USA
    Endocrinology 144:5166-71. 2003
    ..In addition, preliminary studies suggest that malonyl CoA and AMPK take part in fuel-sensing and signaling mechanisms in the hypothalamus that could regulate food intake and energy expenditure...
  29. ncbi request reprint Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity
    Seng Khee Gan
    Metabolism and Diabetes Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Obes Res 11:1295-305. 2003
    ..Using recent methods for measuring intramyocyte triglyceride, these relationships were studied in men with a broad range of adiposity...
  30. ncbi request reprint Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
    Asish K Saha
    Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Biochem Biophys Res Commun 314:580-5. 2004
    ..They also suggest that this activation of AMPK may be mediated by a change in cellular energy state. Whether these effects of pioglitazone contribute to its insulin-sensitizing and other actions in vivo remains to be determined...
  31. ncbi request reprint Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo--a study using the novel PPARalpha/gamma agonist tesaglitazar
    Bronwyn D Hegarty
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Sydney, New South Wales 2010, Australia
    Endocrinology 145:3158-64. 2004
    ....
  32. ncbi request reprint AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo
    Miguel A Iglesias
    Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 53:1649-54. 2004
    ..Therefore, a lesser effect of AICAR to alleviate muscle insulin resistance in red versus white muscle is not explained by a relatively greater effect on FA uptake in the red muscle...
  33. ncbi request reprint Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms
    Mark E Cleasby
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 53:3258-66. 2004
    ..In summary, metformin opposes the development of acute lipid-induced insulin resistance in the liver through alterations in multiple signaling pathways...
  34. ncbi request reprint Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    Chunli Yu
    Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:50230-6. 2002
    ..This in turn leads to decreased IRS-1 tyrosine phosphorylation and decreased activation of IRS-1-associated PI3-kinase activity resulting in decreased insulin-stimulated glucose transport activity...
  35. ncbi request reprint Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats
    Simon M Chalkley
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia 2010
    Am J Physiol Endocrinol Metab 282:E1231-8. 2002
    ....
  36. ncbi request reprint Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes
    Mark E Cleasby
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Diabetes 54:2702-11. 2005
    ....