Research Topics
| Edward KraegenSummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscleMichael J Boden
Diabetes and Obesity Program, Garvan Institute for Medical Research, Darlinghurst, NSW, Australia 2010
Am J Physiol Endocrinol Metab 303:E798-805. 2012..05), suggesting that this effect was mediated through an altered redox state. Thus interventions causing elevation of mitochondrial antioxidant activity may offer protection against diet-induced insulin resistance in skeletal muscle...
AMP-activated protein kinase and muscle insulin resistanceEdward W Kraegen
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
Front Biosci 14:4658-72. 2009..These issues are important in considering the AMPK pathway as a therapeutic target in insulin resistant states...- Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunctionEdward W Kraegen
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney NSW 2010, Australia
Proc Natl Acad Sci U S A 105:7627-8. 2008 
Free fatty acids and skeletal muscle insulin resistanceEdward W Kraegen
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
Curr Opin Lipidol 19:235-41. 2008..Relevant mechanisms, however, are still not fully elucidated. Here we examine the latest evidence as to why lipids might accumulate in muscle and the possible mechanisms for lipid-induced insulin resistance...- Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of ratsEdward W Kraegen
Garvan Institute of Medical Research, Sydney NSW 2010 Australia
Am J Physiol Endocrinol Metab 290:E471-9. 2006..In contrast, it was not associated with increased whole tissue LCA-CoA content in any tissue or triglyceride in muscle, although both are observed at later times... - Triglycerides, fatty acids and insulin resistance--hyperinsulinemiaE W Kraegen
Garvan Institute of Medical Research, St Vincent s Hospital Sydney NSW, Australia
Exp Clin Endocrinol Diabetes 109:S516-26. 2001..In conclusion, evidence is growing that excess muscle and liver lipid accumulation causes or exacerbates insulin resistance in Syndrome X and in Type II diabetes; development of strategies to prevent this seem very worthwhile... - Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistanceEdward Kraegen
Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, NSW 2010, Australia
J R Soc Med 95:14-22. 2002 - The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesityE W Kraegen
Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
Exp Clin Endocrinol Diabetes 109:S189-201. 2001..Recent work has also pointed to a possible role of lipids in beta cell deterioration ("lipotoxicity") associated with type 2 diabetes... - Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed ratsJi Ming Ye
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Diabetes 55:2797-804. 2006..Thus, our findings suggest that in addition to ameliorating insulin resistance, TZDs may enhance AMPK-stimulated glucose clearance into peripheral tissues in insulin-resistant states... - AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed ratsMiguel A Iglesias
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Diabetes 51:2886-94. 2002..Independent of this, the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes... - Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expressionMark E Cleasby
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
Mol Endocrinol 21:215-28. 2007..These data indicate distinct roles for Akt-1 and Akt-2 in muscle glucose metabolism and that moderate reductions in IRS-1 expression do not result in the development of insulin resistance in skeletal muscle in vivo... - Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humansYu Wang
Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
Clin Chem 53:34-41. 2007..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies... - Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterificationClinton R Bruce
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst
Am J Physiol Endocrinol Metab 292:E1231-7. 2007..05). These studies demonstrate that acute overexpression of CPT I in muscle leads to a repartitioning of FAs away from esterification and toward oxidation and highlight the importance of CPT I in regulating muscle FA metabolism... - Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylationAndrew J Hoy
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Am J Physiol Endocrinol Metab 293:E1358-64. 2007..001). These results suggest that the reduced muscle glucose uptake in rats after 5 h of acute hyperglycemia is due more to the metabolic effects of excess glycogen storage than to a defect in insulin signaling or glucose transport... - Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilizationRachel N Danaher
School of Biological Sciences, University of Auckland, Private Bag 92 019, Auckland, New Zealand
Endocrinology 149:154-60. 2008.... - Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistanceEmma Polkinghorne
Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London, United Kingdom
Am J Physiol Endocrinol Metab 294:E316-25. 2008..03) but not TLR-4 mRNA. In conclusion, activation of the IkappaBKbeta-NF-kappaB pathway in muscle does not seem to be an important local mediator of insulin resistance... - Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsivenessMatthew J Watt
St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
Mol Endocrinol 22:1200-12. 2008.... - Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionNigel Turner
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
Diabetes 57:1414-8. 2008..We investigated the mechanism of activation of AMPK by BBR and explored whether derivatization of BBR could improve its in vivo efficacy... - Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant ratsBronwyn D Hegarty
Diabetes and Metabolism Research Program, Garvan Institute of Medical Research, Sydney, Australia
Diabetes 51:1477-84. 2002.... - Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathwaysKatherine Baran
Diabetes Research Group, The Garvan Institute of Medical Research, Darlinghurst NSW, Sydney, Australia
Diabetes 51:152-8. 2002.... - Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscleKeld Fosgerau
In Vivo Pharmacology, Rheoscience, Ledøje Bygade 23B, DK 2765 Ledøje Smørum, Denmark
J Endocrinol 190:651-8. 2006..07 vs 1.36 +/- 0.11, P = not significant). These results demonstrate the physiological relevance of the so-called 'reverse' Randle cycle, but surprisingly show that it may be more important in white rather than oxidative red muscle... - Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesYun S Lee
Department of Biological Sciences, Seoul National University, San 56-1, Sillim-dong, Kwanak-Gu, Korea
Diabetes 55:2256-64. 2006..These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity... - Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivoHeidi A Parkes
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St. Darlinghurst, New South Wales, 2010, Australia
Am J Physiol Endocrinol Metab 291:E737-44. 2006..05), and overexpression in rat liver increased [1-(14)C]palmitate clearance into liver TG. These in vitro and in vivo results suggest a pivotal role for ACSL1 in regulating TG synthesis in liver... - Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophySeng Khee Gan
Metabolism and Diabetes Research Program, Garvan Institute of Medical Research, Sydney, Australia
Diabetes 51:3163-9. 2002..The results do not establish causation but emphasize the interrelationships among visceral fat, myocyte lipid, and insulin action... - Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liverJi Ming Ye
Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
Endocrinology 143:4527-35. 2002..This may be related to chronic elevation of adiponectin by thiazolidinediones... - PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegalyJi Ming Ye
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
Am J Physiol Endocrinol Metab 284:E531-40. 2003..Additionally, it can counteract fatty liver, hepatic insulin resistance, and visceral adiposity generally associated with PPARalpha activation, but without hepatomegaly... - Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese menSeng Khee Gan
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
Diabetes Care 26:1706-13. 2003.... - Minireview: malonyl CoA, AMP-activated protein kinase, and adiposityNeil B Ruderman
D Phil, Diabetes Unit, Boston Medical Center, 650 Albany Street, X825, Boston, Massachusetts 02118, USA
Endocrinology 144:5166-71. 2003..In addition, preliminary studies suggest that malonyl CoA and AMPK take part in fuel-sensing and signaling mechanisms in the hypothalamus that could regulate food intake and energy expenditure... - Insulin action, regional fat, and myocyte lipid: altered relationships with increased adipositySeng Khee Gan
Metabolism and Diabetes Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Obes Res 11:1295-305. 2003..However, visceral abdominal fat, which corresponds less closely to total adiposity, remains an important predictor of insulin resistance in men with both normal and increased adiposity... - Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivoAsish K Saha
Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Biochem Biophys Res Commun 314:580-5. 2004..They also suggest that this activation of AMPK may be mediated by a change in cellular energy state. Whether these effects of pioglitazone contribute to its insulin-sensitizing and other actions in vivo remains to be determined... - Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo--a study using the novel PPARalpha/gamma agonist tesaglitazarBronwyn D Hegarty
Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Sydney, New South Wales 2010, Australia
Endocrinology 145:3158-64. 2004.... - AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivoMiguel A Iglesias
Garvan Institute of Medical Research, Sydney, Australia
Diabetes 53:1649-54. 2004..Therefore, a lesser effect of AICAR to alleviate muscle insulin resistance in red versus white muscle is not explained by a relatively greater effect on FA uptake in the red muscle... - Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanismsMark E Cleasby
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
Diabetes 53:3258-66. 2004..In summary, metformin opposes the development of acute lipid-induced insulin resistance in the liver through alterations in multiple signaling pathways... - Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleChunli Yu
Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 277:50230-6. 2002..This in turn leads to decreased IRS-1 tyrosine phosphorylation and decreased activation of IRS-1-associated PI3-kinase activity resulting in decreased insulin-stimulated glucose transport activity... - Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar ratsSimon M Chalkley
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia 2010
Am J Physiol Endocrinol Metab 282:E1231-8. 2002.... - Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genesMark E Cleasby
Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Diabetes 54:2702-11. 2005....