Cecile King

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. pmc Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models
    Helen M McGuire
    Department of Immunology, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Diabetes 60:867-75. 2011
  2. doi T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
  3. doi A fundamental role for interleukin-21 in the generation of T follicular helper cells
    Alexis Vogelzang
    Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 29:127-37. 2008
  4. doi Emerging cellular networks for regulation of T follicular helper cells
    Cecile King
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Trends Immunol 33:59-65. 2012
  5. pmc The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions
    Cecile King
    Department of Immunology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e17049. 2011
  6. ncbi A fine romance: T follicular helper cells and B cells
    Cecile King
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 34:827-9. 2011
  7. doi New insights into the differentiation and function of T follicular helper cells
    Cecile King
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nat Rev Immunol 9:757-66. 2009
  8. doi A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity
    Helen M McGuire
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 34:602-15. 2011
  9. pmc Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
    Helen M McGuire
    Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 106:19438-43. 2009
  10. doi Lineage specification and heterogeneity of T follicular helper cells
    Di Yu
    Immunology and Inflammation, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Curr Opin Immunol 21:619-25. 2009

Collaborators

Detail Information

Publications19

  1. pmc Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models
    Helen M McGuire
    Department of Immunology, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Diabetes 60:867-75. 2011
    ..In addition, we assessed the role of IL-21 responsiveness in islet allograft rejection in mouse animal models...
  2. doi T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
    ..Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies...
  3. doi A fundamental role for interleukin-21 in the generation of T follicular helper cells
    Alexis Vogelzang
    Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 29:127-37. 2008
    ..This study reveals a previously unappreciated role for Tfh cells in the formation of the GC and isotype switching through a CD4(+) T cell-intrinsic requirement for IL-21...
  4. doi Emerging cellular networks for regulation of T follicular helper cells
    Cecile King
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Trends Immunol 33:59-65. 2012
    ..We discuss how these new findings influence our understanding of Tfh cells...
  5. pmc The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions
    Cecile King
    Department of Immunology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e17049. 2011
    ..These findings challenge the view that germ-free NOD mice have increased diabetes incidence and demonstrate that modulation of intestinal microbiota can prevent the development of type-1 diabetes...
  6. ncbi A fine romance: T follicular helper cells and B cells
    Cecile King
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 34:827-9. 2011
    ..Three papers in this issue of Immunity (Choi et al., 2011; Kerfoot et al., 2011; Kitano et al., 2011) provide information about the reciprocal relationship between B cells and Tfh cells...
  7. doi New insights into the differentiation and function of T follicular helper cells
    Cecile King
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nat Rev Immunol 9:757-66. 2009
    ..Particular attention is paid to recent studies that support the idea that T(FH) cells are a separate T cell lineage and those that probe the relationship of T(FH) cells to other T helper cell subsets...
  8. doi A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity
    Helen M McGuire
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 34:602-15. 2011
    ..Thus, CCR9+ Th cells are a subset of IL-21-producing T helper cells that influence regional specification of autoimmune diseases that affect accessory organs of the digestive system...
  9. pmc Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
    Helen M McGuire
    Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 106:19438-43. 2009
    ..Our findings indicate that a loss of locus parity after decreased IL-2 mRNA stability ensures that the high-expressing IL-21 allele persists in nature and provides a basis for autoimmunity...
  10. doi Lineage specification and heterogeneity of T follicular helper cells
    Di Yu
    Immunology and Inflammation, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Curr Opin Immunol 21:619-25. 2009
    ..This review focuses on current progress in unraveling the biology of Tfh cells in health and disease, and understanding the relationship of Tfh cells to other CD4(+) T cell lineages...
  11. pmc Interleukin-27 signaling promotes immunity against endogenously arising murine tumors
    Karlo D T Natividad
    Immunological Diseases Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 8:e57469. 2013
    ..This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent...
  12. doi Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells
    Jae Ho Cho
    Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    Blood 118:116-28. 2011
    ..The complex interplay between these various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo...
  13. pmc IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    Marcel Batten
    Garvan Institute of Medical Research, Darlinghurst, Sydney NSW 2010, Australia
    J Exp Med 207:2895-906. 2010
    ..Together, our data show a nonredundant role for IL-27 in the development of T cell-dependent antibody responses...
  14. pmc Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
    Mia C Akerfeldt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 57:3034-44. 2008
    ..We tested whether ER stress was necessary for cytokine-induced beta-cell death and also whether ER stress gene activation was present in beta-cells of the NOD mouse model of type 1 diabetes...
  15. doi IL-21-producing Th cells in immunity and autoimmunity
    Sue M Liu
    Immunological Diseases Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010
    J Immunol 191:3501-6. 2013
    ....
  16. pmc B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    Danielle T Avery
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 207:155-71. 2010
    ..STAT3-activating cytokines such as IL-21 thus underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients...
  17. doi Expression, purification and characterization of recombinant interleukin-21
    Carol M Y Lee
    Garvan Institute of Medical Research, Darlinghurst Sydney, Australia
    J Immunol Methods 362:185-9. 2010
    ..The availability of milligram quantities of protein enabled us to generate monoclonal antibody fragments against the cytokine and will aid in further structural, biochemical and physiological analyses...
  18. ncbi The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease
    Alexis Vogelzang
    Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Front Biosci 13:5304-15. 2008
    ..Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases...
  19. doi IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    Ivo Sonderegger
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 38:1833-8. 2008
    ..IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in vitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoimmunity in vivo in the absence of IL-21 or IL-21R...