Research Topics
Genomes and Genes | Cecile KingSummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
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Publications
Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine modelsHelen M McGuire
Department of Immunology, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Diabetes 60:867-75. 2011..In addition, we assessed the role of IL-21 responsiveness in islet allograft rejection in mouse animal models...
T follicular helper (TFH) cells in normal and dysregulated immune responsesCecile King
Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
Annu Rev Immunol 26:741-66. 2008..Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies...- A fundamental role for interleukin-21 in the generation of T follicular helper cellsAlexis Vogelzang
Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Immunity 29:127-37. 2008..This study reveals a previously unappreciated role for Tfh cells in the formation of the GC and isotype switching through a CD4(+) T cell-intrinsic requirement for IL-21... - Emerging cellular networks for regulation of T follicular helper cellsCecile King
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Trends Immunol 33:59-65. 2012..We discuss how these new findings influence our understanding of Tfh cells... - The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditionsCecile King
Department of Immunology, The Scripps Research Institute, La Jolla, California, United States of America
PLoS ONE 6:e17049. 2011..These findings challenge the view that germ-free NOD mice have increased diabetes incidence and demonstrate that modulation of intestinal microbiota can prevent the development of type-1 diabetes... - New insights into the differentiation and function of T follicular helper cellsCecile King
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Nat Rev Immunol 9:757-66. 2009..Particular attention is paid to recent studies that support the idea that T(FH) cells are a separate T cell lineage and those that probe the relationship of T(FH) cells to other T helper cell subsets... 
A fine romance: T follicular helper cells and B cellsCecile King
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Immunity 34:827-9. 2011..Three papers in this issue of Immunity (Choi et al., 2011; Kerfoot et al., 2011; Kitano et al., 2011) provide information about the reciprocal relationship between B cells and Tfh cells...- A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunityHelen M McGuire
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Immunity 34:602-15. 2011..Thus, CCR9+ Th cells are a subset of IL-21-producing T helper cells that influence regional specification of autoimmune diseases that affect accessory organs of the digestive system... - Lineage specification and heterogeneity of T follicular helper cellsDi Yu
Immunology and Inflammation, Garvan Institute of Medical Research, Sydney, NSW, Australia
Curr Opin Immunol 21:619-25. 2009..This review focuses on current progress in unraveling the biology of Tfh cells in health and disease, and understanding the relationship of Tfh cells to other CD4(+) T cell lineages... - Loss of parity between IL-2 and IL-21 in the NOD Idd3 locusHelen M McGuire
Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
Proc Natl Acad Sci U S A 106:19438-43. 2009..Our findings indicate that a loss of locus parity after decreased IL-2 mRNA stability ensures that the high-expressing IL-21 allele persists in nature and provides a basis for autoimmunity... - Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cellsJae Ho Cho
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
Blood 118:116-28. 2011..The complex interplay between these various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo... - IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cellsMarcel Batten
Garvan Institute of Medical Research, Darlinghurst, Sydney NSW 2010, Australia
J Exp Med 207:2895-906. 2010..Together, our data show a nonredundant role for IL-27 in the development of T cell-dependent antibody responses... - Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signalingMia C Akerfeldt
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
Diabetes 57:3034-44. 2008..We tested whether ER stress was necessary for cytokine-induced beta-cell death and also whether ER stress gene activation was present in beta-cells of the NOD mouse model of type 1 diabetes... - Expression, purification and characterization of recombinant interleukin-21Carol M Y Lee
Garvan Institute of Medical Research, Darlinghurst Sydney, Australia
J Immunol Methods 362:185-9. 2010..The availability of milligram quantities of protein enabled us to generate monoclonal antibody fragments against the cytokine and will aid in further structural, biochemical and physiological analyses... - B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humansDanielle T Avery
Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
J Exp Med 207:155-71. 2010..STAT3-activating cytokines such as IL-21 thus underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients... - Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine TumorsKarlo D T Natividad
Immunological Diseases Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
PLoS ONE 8:e57469. 2013..This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent... - The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune diseaseAlexis Vogelzang
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Front Biosci 13:5304-15. 2008..Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases... - IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivoIvo Sonderegger
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Zurich, Switzerland
Eur J Immunol 38:1833-8. 2008..IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in vitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoimmunity in vivo in the absence of IL-21 or IL-21R...