Lowenna J Holt

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. pmc Grb10 and Grb14: enigmatic regulators of insulin action--and more?
    Lowenna J Holt
    University of Cambridge, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Biochem J 388:393-406. 2005
  2. doi request reprint Grb10 regulates the development of fiber number in skeletal muscle
    Lowenna J Holt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    FASEB J 26:3658-69. 2012
  3. pmc Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
    Lowenna J Holt
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Mol Endocrinol 23:1406-14. 2009
  4. ncbi request reprint Adapter protein connections: the MRL and Grb7 protein families
    Lowenna J Holt
    Garvan Institute of Medical Research, St Vincent s Hospital, Cancer Research Program, Sydney, NSW, Australia
    Growth Factors 23:193-201. 2005
  5. ncbi request reprint Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14
    Rafael S Depetris
    Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 20:325-33. 2005
  6. pmc Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life
    Florentia M Smith
    University of Bath, Developmental Biology Program and Centre for Regenerative Medicine, Department of Biology and Biochemistry, Claverton Down, Bath BA2 7AY, United Kingdom
    Mol Cell Biol 27:5871-86. 2007

Collaborators

Detail Information

Publications6

  1. pmc Grb10 and Grb14: enigmatic regulators of insulin action--and more?
    Lowenna J Holt
    University of Cambridge, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Biochem J 388:393-406. 2005
    ....
  2. doi request reprint Grb10 regulates the development of fiber number in skeletal muscle
    Lowenna J Holt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    FASEB J 26:3658-69. 2012
    ..In addition, Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions...
  3. pmc Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
    Lowenna J Holt
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Mol Endocrinol 23:1406-14. 2009
    ....
  4. ncbi request reprint Adapter protein connections: the MRL and Grb7 protein families
    Lowenna J Holt
    Garvan Institute of Medical Research, St Vincent s Hospital, Cancer Research Program, Sydney, NSW, Australia
    Growth Factors 23:193-201. 2005
  5. ncbi request reprint Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14
    Rafael S Depetris
    Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 20:325-33. 2005
    ..Together with the crystal structure of the SH2 domain, we present a model for the interaction of Grb14 with the insulin receptor, which indicates how Grb14 functions as a selective protein inhibitor of insulin signaling...
  6. pmc Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life
    Florentia M Smith
    University of Bath, Developmental Biology Program and Centre for Regenerative Medicine, Department of Biology and Biochemistry, Claverton Down, Bath BA2 7AY, United Kingdom
    Mol Cell Biol 27:5871-86. 2007
    ..Thus, Grb10 forms a link between fetal growth and glucose-regulated metabolism in postnatal life and is a candidate for involvement in the process of fetal programming of adult metabolic health...