Lowenna J Holt

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. pmc Grb10 and Grb14: enigmatic regulators of insulin action--and more?
    Lowenna J Holt
    University of Cambridge, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Biochem J 388:393-406. 2005
  2. doi request reprint Grb10 regulates the development of fiber number in skeletal muscle
    Lowenna J Holt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    FASEB J 26:3658-69. 2012
  3. doi request reprint Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation
    Nancy Mokbel
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Cell Physiol 229:1753-64. 2014
  4. pmc Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
    Lowenna J Holt
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Mol Endocrinol 23:1406-14. 2009
  5. ncbi request reprint Adapter protein connections: the MRL and Grb7 protein families
    Lowenna J Holt
    Garvan Institute of Medical Research, St Vincent s Hospital, Cancer Research Program, Sydney, NSW, Australia
    Growth Factors 23:193-201. 2005
  6. ncbi request reprint Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14
    Rafael S Depetris
    Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 20:325-33. 2005
  7. pmc Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life
    Florentia M Smith
    University of Bath, Developmental Biology Program and Centre for Regenerative Medicine, Department of Biology and Biochemistry, Claverton Down, Bath BA2 7AY, United Kingdom
    Mol Cell Biol 27:5871-86. 2007

Collaborators

Detail Information

Publications7

  1. pmc Grb10 and Grb14: enigmatic regulators of insulin action--and more?
    Lowenna J Holt
    University of Cambridge, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Biochem J 388:393-406. 2005
    ....
  2. doi request reprint Grb10 regulates the development of fiber number in skeletal muscle
    Lowenna J Holt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    FASEB J 26:3658-69. 2012
    ..In addition, Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions...
  3. doi request reprint Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation
    Nancy Mokbel
    Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Cell Physiol 229:1753-64. 2014
    ..These data demonstrate an important role for Grb10 as a link between muscle growth and metabolism with therapeutic implications for diseases, such as muscle wasting and type 2 diabetes...
  4. pmc Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
    Lowenna J Holt
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Mol Endocrinol 23:1406-14. 2009
    ....
  5. ncbi request reprint Adapter protein connections: the MRL and Grb7 protein families
    Lowenna J Holt
    Garvan Institute of Medical Research, St Vincent s Hospital, Cancer Research Program, Sydney, NSW, Australia
    Growth Factors 23:193-201. 2005
  6. ncbi request reprint Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14
    Rafael S Depetris
    Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 20:325-33. 2005
    ..Together with the crystal structure of the SH2 domain, we present a model for the interaction of Grb14 with the insulin receptor, which indicates how Grb14 functions as a selective protein inhibitor of insulin signaling...
  7. pmc Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life
    Florentia M Smith
    University of Bath, Developmental Biology Program and Centre for Regenerative Medicine, Department of Biology and Biochemistry, Claverton Down, Bath BA2 7AY, United Kingdom
    Mol Cell Biol 27:5871-86. 2007
    ..Thus, Grb10 forms a link between fetal growth and glucose-regulated metabolism in postnatal life and is a candidate for involvement in the process of fetal programming of adult metabolic health...