Jacqueline R Center

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Risk of subsequent fracture after low-trauma fracture in men and women
    Jacqueline R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    JAMA 297:387-94. 2007
  2. pmc Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study
    Svanhild Waterloo
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    BMC Musculoskelet Disord 13:163. 2012
  3. pmc Prevalence of vertebral fractures in women and men in the population-based Tromsø Study
    Svanhild Waterloo
    Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    BMC Musculoskelet Disord 13:3. 2012
  4. doi request reprint Osteoporosis medication and reduced mortality risk in elderly women and men
    Jacqueline R Center
    Garvan Institute of Medical Research, and St Vincent s Hospital, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 96:1006-14. 2011
  5. doi request reprint The definition and clinical significance of nonvertebral fractures
    Jacqueline R Center
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Osteoporos Rep 8:227-34. 2010
  6. ncbi request reprint Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women
    Jacqueline R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 89:2776-82. 2004
  7. pmc Bone turnover in elderly men: relationships to change in bone mineral density
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    BMC Musculoskelet Disord 8:13. 2007
  8. ncbi request reprint Residual lifetime risk of fractures in women and men
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 22:781-8. 2007
  9. doi request reprint Enhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 gene
    Bich N H Tran
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010 Sydney, NSW, Australia
    Calcif Tissue Int 85:379-88. 2009
  10. pmc Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology Study
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, UNSW, Australia
    BMC Musculoskelet Disord 6:11. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Risk of subsequent fracture after low-trauma fracture in men and women
    Jacqueline R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    JAMA 297:387-94. 2007
    ..There are few published long-term data on absolute risk of subsequent fracture (refracture) following initial low-trauma fracture in women and fewer in men...
  2. pmc Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study
    Svanhild Waterloo
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    BMC Musculoskelet Disord 13:163. 2012
    ..The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk...
  3. pmc Prevalence of vertebral fractures in women and men in the population-based Tromsø Study
    Svanhild Waterloo
    Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    BMC Musculoskelet Disord 13:3. 2012
    ..The aim of this population based study was to describe, for the first time, the age- and sex specific occurrence of osteoporotic vertebral fractures in Norway...
  4. doi request reprint Osteoporosis medication and reduced mortality risk in elderly women and men
    Jacqueline R Center
    Garvan Institute of Medical Research, and St Vincent s Hospital, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 96:1006-14. 2011
    ..Osteoporotic fractures are associated with premature mortality. Antiresorptive treatment reduces refracture but mortality reduction is unclear...
  5. doi request reprint The definition and clinical significance of nonvertebral fractures
    Jacqueline R Center
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Osteoporos Rep 8:227-34. 2010
    ..Recent evidence suggests these fractures form the bulk of costs to the community and herald an increased risk of refracture and premature mortality that applies to all types of nonvertebral, and not just hip, fractures...
  6. ncbi request reprint Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women
    Jacqueline R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 89:2776-82. 2004
    ..It needs further exploration for a role in assessment of hip fracture risk across the sexes and particularly in men...
  7. pmc Bone turnover in elderly men: relationships to change in bone mineral density
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    BMC Musculoskelet Disord 8:13. 2007
    ..an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?..
  8. ncbi request reprint Residual lifetime risk of fractures in women and men
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 22:781-8. 2007
    ..Among those with BMD T-scores < or = -2.5, the risks increased to 65% in women and 42% in men...
  9. doi request reprint Enhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 gene
    Bich N H Tran
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010 Sydney, NSW, Australia
    Calcif Tissue Int 85:379-88. 2009
    ..The nonograms presented here can be useful for individualizing the short- and intermediate-term prognosis of fracture risk and help identify high-risk individuals for intervention for appropriate management of osteoporosis...
  10. pmc Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology Study
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, UNSW, Australia
    BMC Musculoskelet Disord 6:11. 2005
    ..It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years...
  11. ncbi request reprint Identification of high-risk individuals for hip fracture: a 14-year prospective study
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, New South Wales, Australia
    J Bone Miner Res 20:1921-8. 2005
    ..The combination of these risk factors accounted for 57% and 37% of hip fractures in women and men, respectively...
  12. doi request reprint Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women
    Dana Bliuc
    Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    JAMA 301:513-21. 2009
    ..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture...
  13. ncbi request reprint Incidence and risk factors for low trauma fractures in men with prostate cancer
    Henrik G Ahlborg
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Bone 43:556-60. 2008
    ..The present study sought to determine the incidence of low trauma fracture in men with prostate cancer (PC), and to characterize the association between potential risk factors and fracture risk in these men...
  14. ncbi request reprint Femoral neck bone loss predicts fracture risk independent of baseline BMD
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    J Bone Miner Res 20:1195-201. 2005
    ..In elderly women, greater loss of BMD at the femoral neck was associated with increased risk of fracture, independent of baseline BMD and age...
  15. doi request reprint Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes in critically ill patients
    Priya Nair
    Intensive Care Unit, St Vincents Hospital, Victoria Street, Darlinghurst, Sydney, Australia
    Intensive Care Med 39:267-74. 2013
    ....
  16. pmc Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)
    Claire Y Wang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    BMC Med Genet 7:57. 2006
    ..The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians...
  17. ncbi request reprint Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, 2010, Darlinghurst, NSW, Australia
    Osteoporos Int 15:49-55. 2004
    ..48. Clinical risk scores can be used to identify women likely to have low BMD (albeit with low specificity), but they are not a useful tool to identify women who will have a fracture...
  18. ncbi request reprint Barriers to effective management of osteoporosis in moderate and minimal trauma fractures: a prospective study
    Dana Bliuc
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    Osteoporos Int 16:977-82. 2005
    ..This study highlights the need for further exploration of barriers to osteoporosis management...
  19. doi request reprint Association between beta-blocker use and fracture risk: the Dubbo Osteoporosis Epidemiology Study
    Shuman Yang
    Osteoporosis and Bone Biology Research, Garvan Institute of Medical Research, Australia
    Bone 48:451-5. 2011
    ..In humans, high bone mass is associated with reduce fracture risk. The present study sought to test the hypothesis that BB use is associated with reduced fracture risk...
  20. ncbi request reprint Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 92:3599-603. 2007
    ..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time...
  21. doi request reprint Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapy
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Curr Opin Endocrinol Diabetes Obes 15:481-8. 2008
    ..Description of recent progress in genetics and pharmacogenetics of osteoporosis...
  22. doi request reprint Genetic profiling and individualized prognosis of fracture
    Bich N H Tran
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Bone Miner Res 26:414-9. 2011
    ..85 was around 25. These results suggest that genetic profiling could enhance the predictive accuracy of fracture prognosis and help to identify high-risk individuals for appropriate management of osteoporosis or intervention...
  23. ncbi request reprint Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study
    Kevin P Chang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    J Bone Miner Res 19:532-6. 2004
    ..Approximately one-half of hip fractures occurred before 80 years in men and two-thirds before 85 years in women. The age distribution of hip fractures underlines the need for earlier intervention in osteoporosis...
  24. ncbi request reprint Asymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective study
    Chatlert Pongchaiyakul
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Bone Miner Res 20:1349-55. 2005
    ..In elderly men and women, asymptomatic vertebral deformity was found to be associated with subsequent risk of symptomatic fractures, particularly vertebral fracture, and increased risk of mortality after a fracture...
  25. ncbi request reprint Bone resorption and osteoporotic fractures in elderly men: the dubbo osteoporosis epidemiology study
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    J Bone Miner Res 20:579-87. 2005
    ..3 years, high bone resorption as assessed by S-ICTP was associated with increased risk of osteoporotic fracture, independent of BMD. Combining measurements of BMD and bone turnover may improve fracture prediction in elderly men...
  26. ncbi request reprint Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:6575-9. 2005
    ..Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women...
  27. ncbi request reprint Contribution of hip strength indices to hip fracture risk in elderly men and women
    Henrik G Ahlborg
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia, and Department of Orthopaedics, Malmo University Hospital, Sweden
    J Bone Miner Res 20:1820-7. 2005
    ..However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD...
  28. ncbi request reprint Risk factors for fracture in nonosteoporotic men and women
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 92:955-62. 2007
    ..It is not known which factors are associated with fracture in nonosteoporotic elderly. The aim of this study was to assess the association between fall-related risk factors and fracture risk in men and women without osteoporosis...
  29. ncbi request reprint The impact of nonhip nonvertebral fractures in elderly women and men
    Dana Bliuc
    Osteoporosis and Bone Biology D B, T V N, J A E, J R C, and Clinical Translational and Advanced Education J A E, Garvan Institute of Medical Research, Sydney 2010, Australia, St Vincent s Hospital Clinical School J A E, J R C, Sydney, 2010 Australia Faculty of Medicine T V N, J A E, J R C, University of New South Wales, Sydney, 2052 Australia Clinical Excellence and Research, School of Medicine, University of Notre Dame Medical School, Sydney, 2010 Australia
    J Clin Endocrinol Metab 99:415-23. 2014
    ..Nonhip nonvertebral fractures represent half of all osteoporotic fractures; however, their contribution to the burden of refracture and premature mortality is unclear...
  30. doi request reprint Excess mortality attributable to hip-fracture: a relative survival analysis
    Steven A Frost
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St Vincent s Hospital, Australia
    Bone 56:23-9. 2013
    ..Individuals with hip fracture are at substantially increased risk of mortality. The aim of this study was to estimate the excess mortality attributable to hip fracture in elderly men and women...
  31. doi request reprint Association between abdominal obesity and fracture risk: a prospective study
    Shuman Yang
    Division of Musculoskeletal Diseases, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 98:2478-83. 2013
    ..However, the relationship between abdominal fat mass (aFM) and fracture risk is unclear because of limited prospective data. The present study sought to examine the association between aFM, BMD, and fracture risk...
  32. doi request reprint Absolute fracture-risk prediction by a combination of calcaneal quantitative ultrasound and bone mineral density
    Mei Y Chan
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    Calcif Tissue Int 90:128-36. 2012
    ..These results suggest that calcaneal QUS is an independent predictor of fracture risk and that a combination of QUS and BMD measurement could improve the predictive accuracy of fracture risk in elderly women...
  33. doi request reprint Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Intensive Care Med 35:2028-32. 2009
    ..We present a hypothetic model demonstrating how vitamin D deficiency may be an unrecognized contributor to adverse outcome in intensive care patients...
  34. doi request reprint Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Sydney, New South Wales, Australia 2010
    Am J Med 122:1056-60. 2009
    ..Obesity is associated with hypovitaminosis D. Whether body mass index (BMI) determines the replacement dose of vitamin D to achieve sufficiency is unclear...
  35. ncbi request reprint Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and women
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 22:1147-54. 2007
    ..Low baseline BMD, rate of BMD loss, weight loss, and weight fluctuation are significant predictors of all-cause mortality in elderly men and women, independent of each other and of age, incident fracture, and concomitant diseases...
  36. doi request reprint Timing of repeat BMD measurements: development of an absolute risk-based prognostic model
    Steven A Frost
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 24:1800-7. 2009
    ..The prognostic model and approach presented in this study may help improve the individualization and management of osteoporosis...
  37. doi request reprint Compound risk of high mortality following osteoporotic fracture and refracture in elderly women and men
    Dana Bliuc
    Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Clinical Excellence and Research, School of Medicine, University of Notre Dame Medical School, Sydney, Australia
    J Bone Miner Res 28:2317-24. 2013
    ..The majority of the mortality and refractures occurred in the first 5 years following the initial fracture. However, excess mortality was observed for up to 10 years postfracture, predominantly related to that after refracture...
  38. ncbi request reprint Osteoporosis: underrated, underdiagnosed and undertreated
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Med J Aust 180:S18-22. 2004
    ..Simple measures like vitamin D and calcium supplementation and use of hip protectors can reduce hip fractures, particularly in institutionalised and housebound elderly people..
  39. ncbi request reprint Bone mineral density-independent association of quantitative ultrasound measurements and fracture risk in women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Osteoporos Int 15:942-7. 2004
    ..The combination of QUS and BMD measurements may improve the accuracy of identification of women who will sustain a fracture...
  40. doi request reprint Individualized fracture risk assessment: progresses and challenges
    Tuan V Nguyen
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Curr Opin Rheumatol 25:532-41. 2013
    ..The present review examines the validation of risk prediction models in osteoporosis and identifies some major challenges...
  41. doi request reprint α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse
    Nan Yang
    Institute for Neuroscience and Muscle Research, The Children s Hospital at Westmead, Sydney 2145, NSW, Australia
    Bone 49:790-8. 2011
    ..Given the high frequency of R577X in the general population, the potential role of ACTN3 R577X as a factor influencing variations in BMD in elderly humans warrants further study...
  42. ncbi request reprint Genetic determination of bone mineral density: evidence for a major gene
    Tuan V Nguyen
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 88:3614-20. 2003
    ..These findings clearly support the hypothesis that a large component of the variance in BMD is under genetic control, with strong evidence for a major gene locus influencing BMD transmission...
  43. doi request reprint Transplant recipients on the edge of the hypocalcemia abyss
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, New South Wales, Australia
    J Heart Lung Transplant 28:93-5. 2009
    ..Regular surveillance of calcium homeostasis should be incorporated into routine clinical care of transplant recipients...
  44. doi request reprint Multiple genetic loci for bone mineral density and fractures
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 358:2355-65. 2008
    ..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture...
  45. doi request reprint Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study
    Christian Meier
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland
    Arch Intern Med 168:47-54. 2008
    ..We prospectively examined the relationship between serum levels of testosterone and estradiol and future fracture risk in community-dwelling men...