Research Topics
| Jacqueline R CenterSummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
Risk of subsequent fracture after low-trauma fracture in men and womenJacqueline R Center
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
JAMA 297:387-94. 2007..There are few published long-term data on absolute risk of subsequent fracture (refracture) following initial low-trauma fracture in women and fewer in men...
Prevalence of vertebral fractures in women and men in the population-based Tromsø StudySvanhild Waterloo
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
BMC Musculoskelet Disord 13:3. 2012..The aim of this population based study was to describe, for the first time, the age- and sex specific occurrence of osteoporotic vertebral fractures in Norway...
The definition and clinical significance of nonvertebral fracturesJacqueline R Center
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Curr Osteoporos Rep 8:227-34. 2010..Recent evidence suggests these fractures form the bulk of costs to the community and herald an increased risk of refracture and premature mortality that applies to all types of nonvertebral, and not just hip, fractures...- Osteoporosis medication and reduced mortality risk in elderly women and menJacqueline R Center
Garvan Institute of Medical Research, and St Vincent s Hospital, Sydney, New South Wales, Australia
J Clin Endocrinol Metab 96:1006-14. 2011..Osteoporotic fractures are associated with premature mortality. Antiresorptive treatment reduces refracture but mortality reduction is unclear... - Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and womenJacqueline R Center
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 89:2776-82. 2004..It needs further exploration for a role in assessment of hip fracture risk across the sexes and particularly in men... - Bone turnover in elderly men: relationships to change in bone mineral densityTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
BMC Musculoskelet Disord 8:13. 2007..an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?.. - Residual lifetime risk of fractures in women and menNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
J Bone Miner Res 22:781-8. 2007..Among those with BMD T-scores < or = -2.5, the risks increased to 65% in women and 42% in men... - Enhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 geneBich N H Tran
Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010 Sydney, NSW, Australia
Calcif Tissue Int 85:379-88. 2009..The nonograms presented here can be useful for individualizing the short- and intermediate-term prognosis of fracture risk and help identify high-risk individuals for intervention for appropriate management of osteoporosis... - Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology StudyNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, UNSW, Australia
BMC Musculoskelet Disord 6:11. 2005..It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years... - Identification of high-risk individuals for hip fracture: a 14-year prospective studyNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
J Bone Miner Res 20:1921-8. 2005..Preventive strategies should simultaneously target reducing falls and improvement of bone strength in both men and women... - Incidence and risk factors for low trauma fractures in men with prostate cancerHenrik G Ahlborg
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Bone 43:556-60. 2008..The present study sought to determine the incidence of low trauma fracture in men with prostate cancer (PC), and to characterize the association between potential risk factors and fracture risk in these men... - Femoral neck bone loss predicts fracture risk independent of baseline BMDTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
J Bone Miner Res 20:1195-201. 2005..In elderly women, greater loss of BMD at the femoral neck was associated with increased risk of fracture, independent of baseline BMD and age... - Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and womenDana Bliuc
Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
JAMA 301:513-21. 2009..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture... - Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)Claire Y Wang
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
BMC Med Genet 7:57. 2006..The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians... - Association between beta-blocker use and fracture risk: the Dubbo Osteoporosis Epidemiology StudyShuman Yang
Osteoporosis and Bone Biology Research, Garvan Institute of Medical Research, Australia
Bone 48:451-5. 2011..In humans, high bone mass is associated with reduce fracture risk. The present study sought to test the hypothesis that BB use is associated with reduced fracture risk... - Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal womenTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, 2010, Darlinghurst, NSW, Australia
Osteoporos Int 15:49-55. 2004..48. Clinical risk scores can be used to identify women likely to have low BMD (albeit with low specificity), but they are not a useful tool to identify women who will have a fracture... - Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohortsPeter Y Liu
Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
J Clin Endocrinol Metab 92:3599-603. 2007..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time... - Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapyTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Curr Opin Endocrinol Diabetes Obes 15:481-8. 2008..Description of recent progress in genetics and pharmacogenetics of osteoporosis... - Barriers to effective management of osteoporosis in moderate and minimal trauma fractures: a prospective studyDana Bliuc
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
Osteoporos Int 16:977-82. 2005..This study highlights the need for further exploration of barriers to osteoporosis management... - Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology StudyKevin P Chang
Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
J Bone Miner Res 19:532-6. 2004..Approximately one-half of hip fractures occurred before 80 years in men and two-thirds before 85 years in women. The age distribution of hip fractures underlines the need for earlier intervention in osteoporosis... - Bone resorption and osteoporotic fractures in elderly men: the dubbo osteoporosis epidemiology studyChristian Meier
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
J Bone Miner Res 20:579-87. 2005..3 years, high bone resorption as assessed by S-ICTP was associated with increased risk of osteoporotic fracture, independent of BMD. Combining measurements of BMD and bone turnover may improve fracture prediction in elderly men... - Asymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective studyChatlert Pongchaiyakul
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
J Bone Miner Res 20:1349-55. 2005..CONCLUSION: Vertebral deformity was a strong predictor of subsequent risk of fractures, particularly symptomatic vertebral fracture, and may modify fracture-associated mortality in both elderly men and women... - Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly womenTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 90:6575-9. 2005..Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women... - Contribution of hip strength indices to hip fracture risk in elderly men and womenHenrik G Ahlborg
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia, and Department of Orthopaedics, Malmo University Hospital, Sweden
J Bone Miner Res 20:1820-7. 2005..However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD... - Risk factors for fracture in nonosteoporotic men and womenNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 92:955-62. 2007..It is not known which factors are associated with fracture in nonosteoporotic elderly. The aim of this study was to assess the association between fall-related risk factors and fracture risk in men and women without osteoporosis... - Genetic profiling and individualized prognosis of fractureBich N H Tran
Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
J Bone Miner Res 26:414-9. 2011..85 was around 25. These results suggest that genetic profiling could enhance the predictive accuracy of fracture prognosis and help to identify high-risk individuals for appropriate management of osteoporosis or intervention... - Absolute fracture-risk prediction by a combination of calcaneal quantitative ultrasound and bone mineral densityMei Y Chan
Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
Calcif Tissue Int 90:128-36. 2012..These results suggest that calcaneal QUS is an independent predictor of fracture risk and that a combination of QUS and BMD measurement could improve the predictive accuracy of fracture risk in elderly women... - Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and womenNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
J Bone Miner Res 22:1147-54. 2007..Low baseline BMD, rate of BMD loss, weight loss, and weight fluctuation are significant predictors of all-cause mortality in elderly men and women, independent of each other and of age, incident fracture, and concomitant diseases... - Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?Paul Lee
Department of Endocrinology, St Vincent s Hospital, Sydney, NSW 2010, Australia
Intensive Care Med 35:2028-32. 2009..We present a hypothetic model demonstrating how vitamin D deficiency may be an unrecognized contributor to adverse outcome in intensive care patients... - Adequacy of vitamin D replacement in severe deficiency is dependent on body mass indexPaul Lee
Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Sydney, New South Wales, Australia 2010
Am J Med 122:1056-60. 2009..Obesity is associated with hypovitaminosis D. Whether body mass index (BMI) determines the replacement dose of vitamin D to achieve sufficiency is unclear... - Timing of repeat BMD measurements: development of an absolute risk-based prognostic modelSteven A Frost
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
J Bone Miner Res 24:1800-7. 2009..The prognostic model and approach presented in this study may help improve the individualization and management of osteoporosis... - Osteoporosis: underrated, underdiagnosed and undertreatedTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Med J Aust 180:S18-22. 2004..Simple measures like vitamin D and calcium supplementation and use of hip protectors can reduce hip fractures, particularly in institutionalised and housebound elderly people.. - Bone mineral density-independent association of quantitative ultrasound measurements and fracture risk in womenTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
Osteoporos Int 15:942-7. 2004..The combination of QUS and BMD measurements may improve the accuracy of identification of women who will sustain a fracture... - Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes in critically ill patientsPriya Nair
Intensive Care Unit, St Vincents Hospital, Victoria Street, Darlinghurst, Sydney, Australia
Intensive Care Med 39:267-74. 2013.... - α-Actinin-3 deficiency is associated with reduced bone mass in human and mouseNan Yang
Institute for Neuroscience and Muscle Research, The Children s Hospital at Westmead, Sydney 2145, NSW, Australia
Bone 49:790-8. 2011..Given the high frequency of R577X in the general population, the potential role of ACTN3 R577X as a factor influencing variations in BMD in elderly humans warrants further study... - Genetic determination of bone mineral density: evidence for a major geneTuan V Nguyen
Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 88:3614-20. 2003..These findings clearly support the hypothesis that a large component of the variance in BMD is under genetic control, with strong evidence for a major gene locus influencing BMD transmission... - Transplant recipients on the edge of the hypocalcemia abyssPaul Lee
Department of Endocrinology, St Vincent s Hospital, New South Wales, Australia
J Heart Lung Transplant 28:93-5. 2009..Regular surveillance of calcium homeostasis should be incorporated into routine clinical care of transplant recipients... - Multiple genetic loci for bone mineral density and fracturesUnnur Styrkarsdottir
deCODE Genetics, Reykjavik, Iceland
N Engl J Med 358:2355-65. 2008..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture... - Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology StudyChristian Meier
Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland
Arch Intern Med 168:47-54. 2008..We prospectively examined the relationship between serum levels of testosterone and estradiol and future fracture risk in community-dwelling men...