Genomes and Genes
- Alternative usage of Otx2 promoters during mouse developmentNicolas Fossat
LBMC, ENS Lyon, IFR128 Lyon Gerland, 69364 Lyon Cedex 07, France
Dev Dyn 233:154-60. 2005..The third promoter, which shows no activity in embryonic stem cells and is moderately expressed during embryogenesis, is mostly used in specific areas derived from the rostral part of the neural tube...
- A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptorsNicolas Fossat
IGFL, UMR CNRS 5242 INRA 1237 ENS, IFR128 Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
BMC Dev Biol 7:122. 2007..Yet, later expression and functions remain poorly characterized as specific reagents to detect the protein at any stage of development are still missing...
- Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockoutNicolas Fossat
BMC, UMR CNRS 5161 INRA 1237 ENS, IFR128 Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
EMBO Rep 7:824-30. 2006..The transient action of tamoxifen pulses allows time-course mutation. We demonstrate efficient temporal knockout and demarcate spatio-temporal windows in which Otx2 controls the head, brain structures and body development...
- Molecular dissection reveals decreased activity and not dominant negative effect in human OTX2 mutantsGilles Chatelain
LBMC, ENS Lyon, IFR128 Lyon Gerland, 46 allee d Italie, 69364, Lyon, Cedex 07, France
J Mol Med (Berl) 84:604-15. 2006..Molecular diagnostic of human mutant OTX2 proteins discriminates hypomorphic and loss of function mutations from other mutations that may not be relevant to ocular pathology...