Genomes and Genes
Graeme P Young
Affiliation: Flinders University
- Advances in Fecal Occult Blood Tests: The FIT RevolutionGraeme P Young
Flinders Centre for Innovation in Cancer L3 100, Flinders University, Post Office Box 2100, Adelaide, SA, 5001, Australia
Dig Dis Sci 60:609-22. 2015..There is a wide choice of fecal occult blood tests (FOBTs) for colorectal cancer screening...
- Oral rehydration therapy in the second decade of the twenty-first centuryHenry J Binder
Department of Internal Medicine, Yale School of Medicine, P O Box 208019, New Haven, CT, 06520, USA
Curr Gastroenterol Rep 16:376. 2014..Significant efforts are now underway to establish this dual-action, modified HAMS-hypoosmolar ORS solution as the standard ORS for the treatment of dehydration from acute diarrhea...
- Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and SpainJason P Ross
CSIRO Preventative Health Flagship, Sydney, NSW, Australia
BMC Cancer 14:475. 2014..No study has yet taken advantage of all the genetic information provided by multiplex CRC families...
- A panel of genes methylated with high frequency in colorectal cancerSusan M Mitchell
CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, NSW, Australia
BMC Cancer 14:54. 2014..There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity and specificity of current cancer detection tests...
- Demographic, social cognitive and social ecological predictors of intention and participation in screening for colorectal cancerTess A Gregory
School of Psychology, University of Adelaide, Adelaide 5000, Australia
BMC Public Health 11:38. 2011..The aim of this study was to compare the social cognitive and social ecological predictors of intention to screen with predictors of participation...
- Which fecal occult blood test is best to screen for colorectal cancer?Graeme P Young
Flinders Centre for Cancer Prevention and Control, Flinders University, Room 3D230, Bedford Park, Adelaide, SA 5042, Australia
Nat Clin Pract Gastroenterol Hepatol 6:140-1. 2009..The latest generation of FITs should replace traditional GFOBTs in two-step (test then colonoscopy) screening for colorectal cancer...
- New stool screening tests for colorectal cancerGraeme P Young
Flinders Cancer Control Alliance, Flinders University, Adelaide, Australia
Digestion 76:26-33. 2007..The purpose of this review is to clarify the place of new-technology stool tests in screening for colorectal neoplasia...
- Dietary fibre and colorectal cancer: a model for environment--gene interactionsGraeme P Young
Department of Medicine, Flinders University of South Australia, Bedford Park, Adelaide, Australia
Mol Nutr Food Res 49:571-84. 2005..Activation of apoptosis and cell cycle arrest seem likely to be mechanisms that would enable correction of genomic events that drive oncogenesis. Butyrate itself can regulate gene expression by both epigenetic and direct effects...
- Diet and genomic stabilityGraeme P Young
Department of Medicine, Flinders University, Adelaide, Australia
Forum Nutr 60:91-6. 2007..Activation of apoptosis may be a key to protection...
- Resistant starch and colorectal neoplasiaGraeme P Young
Flinders University of South Australia, Department of Medicine, Bedford Park, Adelaide, South Australia, Australia 5042
J AOAC Int 87:775-86. 2004..These effects can be interpreted as reflecting improved colonic health, which might be of benefit in protection against CRC. Direct evidence for protection is still not available...
- Preventing cancer: dietary lifestyle or clinical intervention?Graeme P Young
Department of Medicine, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, Adelaide, Australia
Asia Pac J Clin Nutr 11:S618-31. 2002..With these Western cancers, we are fortunate that there are options for prevention. At least choices are available and some will suite certain circumstances and personalities more than others...
- Population-based screening for colorectal cancer: Australian research and implementationGraeme P Young
Flinders University Centre for Cancer Prevention and Control, Adelaide, South Australia, Australia
J Gastroenterol Hepatol 24:S33-42. 2009..CRC screening has progressed from a matter of irrelevance and distaste, to commonwealth government policy in the context of an organized program for all Australians...
- Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starchRichard K Le Leu
Department of Medicine, Flinders University, Bedford Park, Australia
Cancer Biol Ther 6:1621-6. 2007..The protective effect of consumption of RS as dietary high-amylose cornstarch against colon cancer development appears to be related to active fermentation in the colon, particularly through production of butyrate...
- Screening for colorectal cancer and advanced colorectal neoplasia in kidney transplant recipients: cross sectional prevalence and diagnostic accuracy study of faecal immunochemical testing for haemoglobin and colonoscopyMichael G Collins
Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
BMJ 345:e4657. 2012....
- Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasiaJoanne M Lane
Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park Adelaide, South Australia
Gastroenterology 139:1918-26. 2010..We investigated whether giving fecal immunochemical tests (FITs) for hemoglobin between surveillance colonoscopies resulted in earlier detection of neoplasia...
- Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colonJean Winter
Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park
Cancer Prev Res (Phila) 4:1920-8. 2011....
- Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probesYing Hu
Department of Medicine, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, Australia
Mutat Res 677:27-32. 2009..It is highly sensitive and can be applied to the detection of early genetic alterations in carcinogen-based animal models...
- Comparison of a brush-sampling fecal immunochemical test for hemoglobin with a sensitive guaiac-based fecal occult blood test in detection of colorectal neoplasiaAlicia Smith
Bowel Health Service, Repatriation General Hospital Daw Park, South Australia, Australia
Cancer 107:2152-9. 2006....
- Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkersYing Hu
Flinders Centre for Innovation in Cancer, Flinders University of South Australia, Adelaide, Australia
PLoS ONE 8:e64362. 2013..The preventive effect is associated with regulation of genetic and epigenetic biomarkers implicated in colonic carcinogenesis...
- Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colonYing Hu
Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park 5042, Australia
Br J Nutr 104:17-23. 2010....
- Exploring the validity of the continuum of resistance model for discriminating early from late and non-uptake of colorectal cancer screening: implications for the design of invitation and reminder lettersTess Gregory
School of Psychology, University of Adelaide, Adelaide, SA, 5000, Australia
Int J Behav Med 20:572-81. 2013..The continuum of resistance model contends that respondents lie at one end of a continuum and non-respondents at the other with respect to factors demonstrated to impact on screening participation...
- The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- miceYing Hu
Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
Mol Nutr Food Res 52:558-66. 2008..Further investigation to understand the variable effect of SM in preventing CRC is warranted...
- Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in ratsRichard K Le Leu
Flinders Centre for Cancer Prevention and Control, Flinders University, South Australia 5042, Australia
Carcinogenesis 31:246-51. 2010..lactis significantly protects against the development of CRC in the rat-azoxymethane model. Synbiotic combination of prebiotic and probiotic seems likely to be a superior preventive strategy to prebiotic alone...
- Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindacYing Hu
Department of Medicine, Flinders University of South Australia, Adelaide, Australia
Cancer Lett 248:234-44. 2007....
- Fermentation of starch and protein in the colon: implications for genomic instabilityRichard K Le Leu
Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
Cancer Biol Ther 6:259-60. 2007
- A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colonRichard K Le Leu
Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042
J Nutr 135:996-1001. 2005..Because the synbiotic combination of these agents facilitates the apoptotic response to DNA damage by a cancer initiator in the colon of rats, it warrants further study for its capacity to protect against colorectal cancer...
- Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutationsYing Hu
Department of Medicine, Flinders Cancer Control Alliance, Flinders University of South Australia, Adelaide, Australia
Cancer Res 68:4936-44. 2008..Suppression may be a consequence of enhanced apoptotic deletion of azoxymethane-induced DNA lesions and the subsequent reduction in frequency of K-ras mutations...
- The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjectsYing Hu
Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, SA, Australia
Br J Nutr 106:572-82. 2011..Changes in rectal selenoproteins are not predicted by changes in plasma Se; dairy-Se effectively regulates the expression of several rectal selenoproteins of relevance to the risk for CRC...
- Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in ratsRichard K Le Leu
Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
Carcinogenesis 28:240-5. 2007..These effects of RS not only protected against intestinal tumourigenesis but also ameliorated the tumour-enhancing effects of feeding indigestible protein...
- Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated ratsJulie M Clarke
Preventative Health National Research Flagship, Commonwealth Scientific and Industrial Research Organisation CSIRO Food and Nutritional Sciences, PO Box 10041, Adelaide BC, Adelaide, South Australia 5000, Australia
Carcinogenesis 33:197-202. 2012..We propose this pro-apoptotic function of butyrate plays a major role reducing tumour formation in the AOM-treated rat and that these data support a potential protective role of butyrate in CRC...
- Many participants in fecal occult blood test population screening have a higher-than-average risk for colorectal cancerDaniel L Worthley
Department of Gastroenterology and Hepatology, Flinders Medical Centre, South Australia, Australia
Eur J Gastroenterol Hepatol 18:1079-83. 2006..This study investigated the prevalence of higher-than-average risk characteristics, and rate of prior colonoscopy, in participants in fecal occult blood test screening programs...
- Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammationRichard K Le Leu
Preventative Health National Research Flagship, CSIRO, and CSIRO Animal, Food and Health Sciences, Adelaide, SA, Australia
Dig Dis Sci 58:3475-82. 2013..Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease...
- Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testingLawrence C LaPointe
Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, South Australia, Australia
PLoS ONE 7:e29059. 2012....
- Sulindac corrects defective apoptosis and suppresses azoxymethane-induced colonic oncogenesis in p53 knockout miceYing Hu
Department of Medicine Flinders University of South Australia, Adelaide, Australia
Int J Cancer 116:870-5. 2005..Sulindac is an effective chemopreventive agent in the presence of p53 dysfunction...
- Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trialKaren J Humphreys
Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
Cancer Prev Res (Phila) 7:786-95. 2014..These findings support increased resistant starch consumption as a means of reducing risk associated with an HRM diet...
- Colorectal cancer survival: An analysis of patients with metastatic disease synchronous and metachronous with the primary tumorRajiv Kumar
Department of Medical Oncology, Flinders Centre for Innovation in Cancer, Flinders Medical Centre, Bedford Park, Australia
Clin Colorectal Cancer 13:87-93. 2014..Whether metastatic colorectal cancer (mCRC) that presents synchronously with the primary lesion behaves differently from mCRC that appears metachronously to the primary disease is not clear...
- Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosisLaura S Nyskohus
Flinders Centre for Innovation in Cancer, Flinders University of South Australia, Australia
Mutat Res 758:80-6. 2013..In the colonic epithelium, apoptosis may be complementary to MGMT, in terms of minimising potentially mutagenic events and maintaining a healthy genome...
- Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer modelJonathan E Martin
Flinders Centre for Innovation in Cancer, GPO Box 2100, Adelaide, SA 5001, Australia
Anticancer Res 33:3581-8. 2013..01), but sulindac was more potent in inhibition of large ACF, p<0.05. COX-inhibiting sulindac achieved the greatest protective effect. The greater safety profile of Rac-FB should provide an advantage for chemoprevention. ..
- Psychosocial variables associated with colorectal cancer screening in South AustraliaStephen R Cole
Bowel Health Service, Repatriation General Hospital Daw Park, Daws Road, Daw Park, 5041 South Australia, Australia
Int J Behav Med 18:302-9. 2011..Population screening reduces mortality from colorectal cancer, yet factors associated with uptake of screening are incompletely understood...
- Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in ratsRichard K Le Leu
Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
Carcinogenesis 24:1347-52. 2003..Altering amounts of dietary RS changes fermentative activity in the colon. Increased RS is associated with enhanced AARGC. Changes in amount of fermentable substrate are capable of changing the biological response to DNA damage...
- Behavioural and demographic predictors of adherence to three consecutive faecal occult blood test screening opportunities: a population studyAmy Duncan
School of Psychology, The University of Adelaide, Adelaide 5005, South Australia, Australia
BMC Public Health 14:238. 2014....
- Selenium-rich foods: a promising approach to colorectal cancer preventionYing Hu
Department of Medicine Gastroenterology, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide 5042, Australia
Curr Pharm Biotechnol 13:165-72. 2012..Further clinical studies and development of tools for speciating Se in foods will enable progress to be made in determining desirable Se forms and foods with respect to providing safe and effective ways of reducing cancer risk...
- Shift to earlier stage at diagnosis as a consequence of the National Bowel Cancer Screening ProgramStephen R Cole
Bowel Health Service, Repatriation General Hospital, Adelaide, SA
Med J Aust 198:327-30. 2013..To assess the impact of the National Bowel Cancer Screening Program (NBCSP) in South Australia...
- Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancerJean Winter
Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia, Australia
Mol Nutr Food Res 58:550-8. 2014..By utilizing the western diet model of spontaneous CRC, we determined if feeding heme (as hemin chloride) equivalent to a high red meat diet would increase colonic DNA adducts and CRC and whether RS could abrogate such effects...
- Protocol for population testing of an Internet-based Personalised Decision Support system for colorectal cancer screeningCarlene J Wilson
Flinders Centre for Cancer Prevention and Control, School of Medicine, Flinders University, Sturt Road, Bedford Park, SA 5042, Australia
BMC Med Inform Decis Mak 10:50. 2010..The hypothesis is that exposure to (tailored) PDS will result in greater participation in screening than participation following exposure to non-tailored PDS or resulting from the current non-tailored, paper-based approach...
- Colorectal cancer screening in rural and remote areas: analysis of the National Bowel Cancer Screening Program data for South AustraliaAngelita Martini
Discipline of Public Health, Flinders University, Adelaide, South Australia, Australia
Rural Remote Health 11:1648. 2011....
- Choice of fecal occult blood tests for colorectal cancer screening: recommendations based on performance characteristics in population studies: a WHO (World Health Organization) and OMED (World Organization for Digestive Endoscopy) reportGraeme P Young
Department of Medicine Gastroenterology, Flinders University, Adelaide, Australia
Am J Gastroenterol 97:2499-507. 2002..Various FOBTs are now available with a wide range of evidence supporting their use. The purpose of this study was to review published data on the performance of these FOBTs to provide recommendations for their effective use in screening...
- Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of ratsRichard K Le Leu
Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
Nutr Metab (Lond) 6:11. 2009..abstract:..
- Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumoursYing Hu
Department of Medicine, Flinders University of South Australia, Adelaide, Australia
Int J Cancer 115:561-7. 2005..Subsequent studies are now warranted to test the converse, namely, that enhanced apoptotic response to carcinogen reduces risk for colorectal oncogenesis...
- Applying evidence-based guidelines improves use of colonoscopy resources in patients with a moderate risk of colorectal neoplasiaPeter A Bampton
Department of Gastroenterology and Hepatology, Flinders Medical Centre, Bedford Park, SA
Med J Aust 176:155-7. 2002..To determine whether applying National Health and Medical Research Council (NHMRC) guidelines for colorectal cancer prevention would reduce the number of follow-up colonoscopies...
- Reduced accumulation of specific microRNAs in colorectal neoplasiaMichael Z Michael
Department of Gastroenterology and Hepatology, Flinders Centre for Digestive Health, Flinders Medical Centre, South Australia, Australia
Mol Cancer Res 1:882-91. 2003..Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia...
- Rising incidence of early-onset colorectal cancer in Australia over two decades: report and reviewJoanne P Young
Department of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, South Australia, Australia South Australian Health and Medical Research Institute SAHMRI Colorectal Node, Basil Hetzel Institute for Translational Research, Woodville, South Australia, Australia School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
J Gastroenterol Hepatol 30:6-13. 2015....
- The relevance of the colon to zinc nutritionGeetha Lavaniya Gopalsamy
School of Medicine, Flinders University of South Australia, Adelaide 5001, Australia
Nutrients 7:572-83. 2015..However, given the observations in rodents and that feeding resistant starch to children is feasible, definitive studies utilising the dual stable isotope method in children with EE should be undertaken. ..
- Treatment patterns among colorectal cancer patients in South Australia: a demonstration of the utility of population-based data linkageKerri R Beckmann
School of Population Health, Facility of Health Sciences, University of Adelaide, Adelaide, Australia
J Eval Clin Pract 20:467-77. 2014..Disparities in CRC treatment were also explored...
- Ambivalence and its influence on participation in screening for colorectal cancerCandice Oster
University of Adelaide, Adelaide, South Australia, Australia
Qual Health Res 23:1188-201. 2013..The majority of participants expressed ambivalence about CRC screening, and the main cue to action was the opportunity to screen without being too inconvenienced. ..
- A population-based study of metastatic colorectal cancer in individuals aged ≥ 80 years: findings from the South Australian Clinical Registry for Metastatic Colorectal CancerRajiv Kumar
Department of Medical Oncology, Flinders Medical Center, Bedford Park, South Australia 5042, Australia
Cancer 119:722-8. 2013..Life expectancy is increasing, and more patients are presenting with cancer at an advanced age (≥80 years). Optimal management for this group of patients has not been well defined...
- Mannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivityDaniel L Worthley
Department of Gastroenterology and Hepatology, Flinders Medical Centre, Australia
Eur J Gastroenterol Hepatol 19:147-52. 2007..Helicobacter pylori is one of the most common human infections and can bind mannose-binding lectin. Therefore, we examined whether mannose-binding lectin status influences the prevalence of H. pylori infection...
- Map of differential transcript expression in the normal human large intestineLawrence C LaPointe
Department of Medicine, Flinders University of South Australia, Adelaide, Australia
Physiol Genomics 33:50-64. 2008..These patterns describe an expression map of individual transcript variation as well as multigene expression patterns along the large intestine. This is the first gene expression map of an entire human organ...
- Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshopGraeme P Young
From the School of Medicine, Flinders University of South Australia, Adelaide, Australia GPY, EKM, GLG, and ILB Washington University School of Medicine, St Louis, MO DHA and MJM Yale University School of Medicine, New Haven, CT HJB the Department of Medical Gastroenterology, Christian Medical College Vellore, Vellore, India BSR and Enteric and Diarrheal Diseases, The Bill and Melinda Gates Foundation, Seattle, WA TGB
Am J Clin Nutr 100:1198-207. 2014..This requires careful consideration of the zinc product to be used as well as strategies for its delivery. ..
- Sensitive and selective amplification of methylated DNA sequences using helper-dependent chain reaction in combination with a methylation-dependent restriction enzymesKeith N Rand
CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, NSW 1670, Australia
Nucleic Acids Res 41:e15. 2013..A detection sensitivity of 0.1% methylated DNA in a background of unmethylated DNA was achieved, which was similar to the well-established Heavy Methyl method that requires bisulphite-treated DNA...
- Patient and carer perceptions of cancer care in South AustraliaKerri R Beckmann
Cancer Council South Australia, PO Box 929, Unley, Adelaide, SA 5061, Australia
Aust Health Rev 33:645-55. 2009..Results also highlighted inadequate discharge processes. Carers were more likely than patients to report negative experiences. Perceptions of care also differed by cancer type...
- Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese populationWai Man Wong
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
Cancer 97:2420-4. 2003..Tokyo, Japan), in a Chinese population referred for colonoscopy...
- Fecal DNA for colorectal-cancer screeningDaniel L Worthley
N Engl J Med 352:1384-5; author reply 1384-5. 2005
- Screening with a fecal multitarget DNA testGraeme P Young
Gastroenterology 129:757-9; discussion 759. 2005
- Participant satisfaction with fecal occult blood test screening for colorectal cancerDaniel L Worthley
J Gastroenterol Hepatol 22:142-3. 2007
- Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrheaP Raghupathy
Department of Child Health, Christian Medical College, Vellore, India
J Pediatr Gastroenterol Nutr 42:362-8. 2006....
- A randomized controlled trial of glucose versus amylase resistant starch hypo-osmolar oral rehydration solution for adult acute dehydrating diarrheaBalakrishnan S Ramakrishna
Wellcome Trust Research Laboratory, Christian Medical College, Vellore, India
PLoS ONE 3:e1587. 2008..Reduction of gross diarrhea rate in excess of that seen over time with intravenous therapy and appropriate antibiotics is not usually achieved by oral glucose-electrolyte rehydration therapy for cholera and cholera-like diarrheas...
- Evaluation of oral rehydration solution by whole-gut perfusion in rats: effect of osmolarity, sodium concentration and resistant starchSandeep Subramanya
Wellcome Trust Research Laboratory, Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India
J Pediatr Gastroenterol Nutr 43:568-75. 2006..Adding amylase-resistant starch (RS) to ORS is expected to increase colonic fluid absorption. This study used combined small and large bowel perfusion to evaluate combinations of reduced osmolarity and starch in ORS...