Nikolai Petrovsky

Summary

Affiliation: Flinders University
Country: Australia

Publications

  1. Ali E, Petrovsky N. Calcium Signaling As a Therapeutic Target for Liver Steatosis. Trends Endocrinol Metab. 2019;: pubmed publisher
    ..This review highlights new findings on the role of impaired Ca2+ signaling in the development of steatosis and discusses potential new approaches to NAFLD treatment based on these new insights. ..
  2. Adney D, Wang L, van Doremalen N, Shi W, Zhang Y, Kong W, et al. Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and Alpacas. Viruses. 2019;11: pubmed publisher
    ..Together, these data indicate that induction of robust neutralizing humoral immune responses by vaccination of naïve animals reduces shedding that potentially could diminish the risk of zoonotic transmission. ..
  3. Weir C, Oksa A, Millar J, Alexander M, Kynoch N, Walton Weitz Z, et al. The Safety of an Adjuvanted Autologous Cancer Vaccine Platform in Canine Cancer Patients. Vet Sci. 2018;5: pubmed publisher
    ..M injections delivered to date, the vaccine was found to be very safe and no significant adverse reactions were observed. These results justify ongoing development and future controlled studies of this autologous vaccine approach. ..
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    Capitani M, Saade F, Havas K, Angeletti M, Concetti F, Agas D, et al. Plasmids encoding protein aggregation domains act as molecular adjuvants for DNA vaccines. Curr Gene Ther. 2014;14:161-9 pubmed
  5. Gordon D, Kelley P, Heinzel S, Cooper P, Petrovsky N. Immunogenicity and safety of Advaxâ„¢, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: a randomized controlled Phase 1 study. Vaccine. 2014;32:6469-77 pubmed publisher
    ..Advax may represent a suitable replacement for alum adjuvants in prophylactic human vaccines subject to confirmation of current results in larger studies. Australia and New Zealand Clinical Trial Registry: ACTRN12607000598482. ..
  6. Cooper P, Rajapaksha K, Barclay T, Ginic Markovic M, Gerson A, Petrovsky N. Inulin crystal initiation via a glucose-fructose cross-link of adjacent polymer chains: atomic force microscopy and static molecular modelling. Carbohydr Polym. 2015;117:964-72 pubmed publisher
    ..Completion of five H-bonded internal ring-domains would 'lock in' each new 6-fructose structural unit of each antiparallel helix pair to create a new isoform. All known properties of inulin isoforms follow readily from these concepts. ..
  7. Petrovsky N, Cooper P. Advaxâ„¢, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety. Vaccine. 2015;33:5920-6 pubmed publisher
    ..Advaxâ„¢ adjuvant represents a novel human adjuvant that enhances both humoral and cellular immunity. This review describes the discovery and development of Advaxâ„¢ adjuvant and research into its unique mechanism of action. ..
  8. Honda Okubo Y, Ong C, Petrovsky N. Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single-dose influenza vaccine protection. Vaccine. 2015;33:4892-900 pubmed publisher
  9. Petrovsky N. Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Nat Rev Endocrinol. 2010;6:131-8 pubmed publisher

More Information

Publications19

  1. Petrovsky N. Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs. Drug Saf. 2015;38:1059-74 pubmed publisher
    ..While existing adjuvants based on aluminium salts have a strong safety record, there are ongoing needs for new adjuvants and more intensive research into adjuvants and their effects. ..
  2. McPherson C, Chubet R, Holtz K, Honda Okubo Y, Barnard D, Cox M, et al. Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant. Methods Mol Biol. 2016;1403:269-84 pubmed publisher
    ..The methods herein described for rapid development of a highly protective SARS vaccine are equally suited to rapid development of vaccines against other fatal human coronavirus infections, e.g., the MERS coronavirus. ..
  3. Honda Okubo Y, Barnard D, Ong C, Peng B, Tseng C, Petrovsky N. Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology. J Virol. 2015;89:2995-3007 pubmed publisher
    ..Thus, delta inulin adjuvants may offer a unique ability to develop safer and more effective coronavirus vaccines. ..
  4. Barclay T, Rajapaksha H, Thilagam A, Qian G, Ginic Markovic M, Cooper P, et al. Physical characterization and in silico modeling of inulin polymer conformation during vaccine adjuvant particle formation. Carbohydr Polym. 2016;143:108-15 pubmed publisher
    ..5 nm thick comprising helically organized inulin chains orthogonal to the plane of the layer. These crystalline layers alternate with amorphous layers 2.4 nm thick, to give overall particle crystallinity of 78%. ..
  5. He Y, Cao Z, De Groot A, Brusic V, Schonbach C, Petrovsky N. Computational vaccinology and the ICoVax 2012 workshop. BMC Bioinformatics. 2013;14 Suppl 4:I1 pubmed publisher
    ..This Editorial provides a list of major challenges for the future of computational vaccinology and identifies developing themes that will expand and evolve over the next few years. ..
  6. request reprint
    Petrovsky N. The vaccines development forum. IDrugs. 2008;11:478-81 pubmed
  7. Gordon D, Sajkov D, Honda Okubo Y, Wilks S, Aban M, Barr I, et al. Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant. Vaccine. 2016;34:3780-6 pubmed publisher
    ..Hence, delta inulin may be a useful adjuvant for use in seasonal or pandemic influenza vaccines. Australia New Zealand Clinical Trial Registry: ACTRN12607000599471. ..
  8. Ali E, Rajapaksha H, Carr J, Petrovsky N. Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. Antiviral Res. 2016;133:14-22 pubmed publisher
    ..This review explores norovirus therapeutic options based on the strategy of blocking norovirus-HBGA binding. ..
  9. Adamson P, Al Kindi M, Wang J, Colella A, Chataway T, Petrovsky N, et al. Proteomic analysis of influenza haemagglutinin-specific antibodies following vaccination reveals convergent immunoglobulin variable region signatures. Vaccine. 2017;35:5576-5580 pubmed publisher
    ..This study illustrates the feasibility of using a proteomic approach to determine the expressed V region signatures of serum antibodies induced by vaccination. ..
  10. Petrovsky N, Larena M, Siddharthan V, Prow N, Hall R, Lobigs M, et al. An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. J Virol. 2013;87:10324-33 pubmed publisher
    ..In the absence of an approved human WNV vaccine, JE-ADVAX could provide an alternative approach for control of a major human WNV epidemic. ..