Ida J Llewellyn-Smith

Summary

Affiliation: Flinders University
Country: Australia

Publications

  1. doi Immunoperoxidase detection of neuronal antigens in full-thickness whole mount preparations of hollow organs and thick sections of central nervous tissue
    Ida J Llewellyn-Smith
    Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    J Neurosci Methods 196:1-11. 2011
  2. ncbi Glutamate and GABA content of calbindin-immunoreactive nerve terminals in the rat intermediolateral cell column
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    Auton Neurosci 98:7-11. 2002
  3. ncbi Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    Neurosci Lett 351:115-9. 2003
  4. ncbi GABA in the control of sympathetic preganglionic neurons
    Ida J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    Clin Exp Pharmacol Physiol 29:507-13. 2002
  5. ncbi Distribution and amino acid content of enkephalin-immunoreactive inputs onto juxtacellularly labelled bulbospinal barosensitive neurons in rat rostral ventrolateral medulla
    I J Llewellyn-Smith
    Department of Medicine, Flinders University, Bedford Park, SA, Australia
    Neuroscience 108:307-22. 2001
  6. ncbi Enkephalin-immunoreactive interneurons extensively innervate sympathetic preganglionic neurons regulating the pelvic viscera
    Ida J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 488:278-89. 2005
  7. ncbi Effects of spinal cord injury on synaptic inputs to sympathetic preganglionic neurons
    Ida J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    Prog Brain Res 152:11-26. 2006
  8. ncbi Changes in synaptic inputs to sympathetic preganglionic neurons after spinal cord injury
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 435:226-40. 2001
  9. ncbi VGLUT1 and VGLUT2 innervation in autonomic regions of intact and transected rat spinal cord
    Ida J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 503:741-67. 2007
  10. doi Anatomy of synaptic circuits controlling the activity of sympathetic preganglionic neurons
    Ida J Llewellyn-Smith
    Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    J Chem Neuroanat 38:231-9. 2009

Detail Information

Publications26

  1. doi Immunoperoxidase detection of neuronal antigens in full-thickness whole mount preparations of hollow organs and thick sections of central nervous tissue
    Ida J Llewellyn-Smith
    Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    J Neurosci Methods 196:1-11. 2011
    ..The method has several advantages. The resin-embedded tissue does not degrade; the immunostaining is non-fading and permanent and neurochemically defined features can be mapped at large scale without confocal microscopy...
  2. ncbi Glutamate and GABA content of calbindin-immunoreactive nerve terminals in the rat intermediolateral cell column
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    Auton Neurosci 98:7-11. 2002
    ..Our anatomical methods cannot differentiate whether this third group is a subset of the GABAergic terminals or a separate population capable of co-releasing the two amino acids...
  3. ncbi Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    Neurosci Lett 351:115-9. 2003
    ..Since SPN involved in cardiovascular control cluster in the IML of mid- and lower thoracic cord, these findings suggest that orexin affects blood pressure by acting on supraspinal neurons rather than SPN...
  4. ncbi GABA in the control of sympathetic preganglionic neurons
    Ida J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    Clin Exp Pharmacol Physiol 29:507-13. 2002
    ..9. Taken together, these data indicate that GABAergic transmission to SPN may be much more complicated than suggested by the currently available electrophysiological studies...
  5. ncbi Distribution and amino acid content of enkephalin-immunoreactive inputs onto juxtacellularly labelled bulbospinal barosensitive neurons in rat rostral ventrolateral medulla
    I J Llewellyn-Smith
    Department of Medicine, Flinders University, Bedford Park, SA, Australia
    Neuroscience 108:307-22. 2001
    ..The data suggest that endogenous enkephalin inhibits amino acid release from terminals that innervate bulbospinal barosensitive neurons of the rostral ventrolateral medulla...
  6. ncbi Enkephalin-immunoreactive interneurons extensively innervate sympathetic preganglionic neurons regulating the pelvic viscera
    Ida J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 488:278-89. 2005
    ..The persistence of the dense ENK innervation after complete cord transection indicates that the ENK-IR input to SPNs arises predominantly from intraspinal sources...
  7. ncbi Effects of spinal cord injury on synaptic inputs to sympathetic preganglionic neurons
    Ida J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    Prog Brain Res 152:11-26. 2006
    ..Furthermore, sympathetic pelvic visceral control may be more easily restored after an injury because it is less dependent on the re-establishment of direct synaptic input from regrowing brain axons...
  8. ncbi Changes in synaptic inputs to sympathetic preganglionic neurons after spinal cord injury
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 435:226-40. 2001
    ..In summary, SPNs participate in vasomotor control after SCI despite profound denervation. An altered balance of excitatory and inhibitory inputs may explain injury-induced hypotension...
  9. ncbi VGLUT1 and VGLUT2 innervation in autonomic regions of intact and transected rat spinal cord
    Ida J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 503:741-67. 2007
    ..Increased VGLUT1 immunoreactivity after transection may correlate with increased glutamatergic transmission to PPN...
  10. doi Anatomy of synaptic circuits controlling the activity of sympathetic preganglionic neurons
    Ida J Llewellyn-Smith
    Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    J Chem Neuroanat 38:231-9. 2009
    ..This information is likely to be important if we are to understand how the central nervous system differentially regulates sympathetic outflow to different target tissues...
  11. ncbi GABA- and glutamate-immunoreactive synapses on sympathetic preganglionic neurons projecting to the superior cervical ganglion
    I J Llewellyn-Smith
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, Australia
    J Auton Nerv Syst 71:96-110. 1998
    ..This increased excitatory input to sympathoadrenal neurons may explain the predominant activation of these neurons following baroreceptor unloading...
  12. ncbi Neurochemistry of nerve fibers apposing sympathetic preganglionic neurons activated by sustained hypotension
    Jane B Minson
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University of South Australia, Bedford Park, Adelaide, South Australia 5042, Australia
    J Comp Neurol 449:307-18. 2002
    ..Other fibers show topographic differences in their contacts with Fos-IR SPN, suggesting that subgroups of hypotension-sensitive SPN are targeted by particular neuron groups...
  13. ncbi Immunoreactivity for cocaine- and amphetamine-regulated transcript in rat sympathetic preganglionic neurons projecting to sympathetic ganglia and the adrenal medulla
    Natalie M Fenwick
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 495:422-33. 2006
    ..These results indicate that CART occurs in barosensitive SPN, nonbarosensitive SPN, and interneurons. Thus, CART is not an exclusive marker for cardiovascular SPN but is likely to influence many autonomic activities...
  14. ncbi Cocaine- and amphetamine-regulated transcript in catecholamine and noncatecholamine presympathetic vasomotor neurons of rat rostral ventrolateral medulla
    Kathleen J Burman
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 476:19-31. 2004
    ..After fluorescent detection of CART and biotinamide, all 13 neurons were found to be CART-IR. These results suggest that, in rat RVLM, all catecholamine and noncatecholamine presympathetic vasomotor neurons contain CART...
  15. doi Variability in the occurrence of nitric oxide synthase immunoreactivity in different populations of rat sympathetic preganglionic neurons
    Julia M Hinrichs
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, South Australia, 5042, Australia
    J Comp Neurol 514:492-506. 2009
    ..Our data indicate that there are no anatomical differences between nitric oxide-synthesizing SPN in normotensive SD and hypertensive SHR...
  16. doi Innervation of the rat uterus at estrus: a study in full-thickness, immunoperoxidase-stained whole-mount preparations
    Greta J E Gnanamanickam
    Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, South Australia 5042, Australia
    J Comp Neurol 519:621-43. 2011
    ....
  17. ncbi GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons
    Kathleen J Burman
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University of South Australia, Bedford Park, SA 5042, Australia
    Brain Res 970:35-46. 2003
    ..In the neurons that lack GABA(B)R2, the GABA(B)R1 subunit may act alone or with another protein...
  18. ncbi Neuropeptide Y mRNA expression in interneurons in rat spinal cord
    J B Minson
    Cardiovascular Medicine and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia
    Auton Neurosci 93:14-20. 2001
    ..The location of some of these neurons, and their proximity to sympathetic preganglionic neurons, suggest some NPY-containing interneurons are likely to be involved in spinal as well as supraspinal autonomic reflex pathways...
  19. ncbi Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons
    K J Burman
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University of South Australia, South Australia 5042, Bedford Park, Australia
    Brain Res 915:238-43. 2001
    ..The distribution of Fos/NK1 receptor SPN suggested that substance P may preferentially target sympathoadrenal SPN...
  20. ncbi Patterns of colocalization of GABA, glutamate and glycine immunoreactivities in terminals that synapse on dendrites of noradrenergic neurons in rat locus coeruleus
    J Somogyi
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    Eur J Neurosci 14:219-28. 2001
    ..The almost complete colocalization of glycine with GABA suggests that the inhibitory input to locus coeruleus is predominantly GABAergic with a contribution from glycine in about half of the GABAergic boutons...
  21. ncbi Nitric oxide limits pressor responses to sympathetic activation in rat spinal cord
    L F Arnolda
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, SA 5042, Australia
    Hypertension 36:1089-92. 2000
    ..These results indicate that endogenous synthesis of NO in the spinal cord limits the pressor response to stimulation of spinal NMDA receptors...
  22. ncbi Tracer-toxins: cholera toxin B-saporin as a model
    I J Llewellyn-Smith
    Department of Medicine, Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, SA 5042, Bedford Park, Australia
    J Neurosci Methods 103:83-90. 2000
    ....
  23. pmc Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla
    Ida J Llewellyn-Smith
    Cardiovascular Medicine, Physiology and Centre for Neuroscience, School of Medicine, Flinders University, Bedford Park, SA 5042, Australia Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA
    Auton Neurosci 177:114-22. 2013
    ..NMDA receptors on bulbospinal neurons in the rostral ventral medulla likely influence sympathoexcitation in normal and pathological conditions...
  24. ncbi Ultrastructural localization of P2X3 receptors in rat sensory neurons
    I J Llewellyn-Smith
    Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University, South Australia, Australia
    Neuroreport 9:2545-50. 1998
    ..These observations identify sites from which ATP could be released to influence sensory signalling within the central nervous system...
  25. pmc Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7936-44. 2008
    ....
  26. ncbi Opioid signalling in the rat rostral ventrolateral medulla
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Clin Exp Pharmacol Physiol 29:238-42. 2002
    ....