Richard K Le Leu

Summary

Affiliation: Flinders University
Country: Australia

Publications

  1. ncbi Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat
    R K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 23:713-9. 2002
  2. ncbi Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University, South Australia 5042, Australia
    Carcinogenesis 31:246-51. 2010
  3. ncbi Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch
    Richard K Le Leu
    Department of Medicine, Flinders University, Bedford Park, Australia
    Cancer Biol Ther 6:1621-6. 2007
  4. ncbi Fermentation of starch and protein in the colon: implications for genomic instability
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Cancer Biol Ther 6:259-60. 2007
  5. ncbi Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Carcinogenesis 28:240-5. 2007
  6. ncbi A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042
    J Nutr 135:996-1001. 2005
  7. ncbi Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 24:1347-52. 2003
  8. ncbi Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Nutr Metab (Lond) 6:11. 2009
  9. ncbi Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes
    Ying Hu
    Department of Medicine, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, Australia
    Mutat Res 677:27-32. 2009
  10. ncbi Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon
    Jean Winter
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park
    Cancer Prev Res (Phila) 4:1920-8. 2011

Collaborators

Detail Information

Publications21

  1. ncbi Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat
    R K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 23:713-9. 2002
    ....
  2. ncbi Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University, South Australia 5042, Australia
    Carcinogenesis 31:246-51. 2010
    ..lactis significantly protects against the development of CRC in the rat-azoxymethane model. Synbiotic combination of prebiotic and probiotic seems likely to be a superior preventive strategy to prebiotic alone...
  3. ncbi Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch
    Richard K Le Leu
    Department of Medicine, Flinders University, Bedford Park, Australia
    Cancer Biol Ther 6:1621-6. 2007
    ..The protective effect of consumption of RS as dietary high-amylose cornstarch against colon cancer development appears to be related to active fermentation in the colon, particularly through production of butyrate...
  4. ncbi Fermentation of starch and protein in the colon: implications for genomic instability
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Cancer Biol Ther 6:259-60. 2007
  5. ncbi Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Carcinogenesis 28:240-5. 2007
    ..These effects of RS not only protected against intestinal tumourigenesis but also ameliorated the tumour-enhancing effects of feeding indigestible protein...
  6. ncbi A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042
    J Nutr 135:996-1001. 2005
    ..Because the synbiotic combination of these agents facilitates the apoptotic response to DNA damage by a cancer initiator in the colon of rats, it warrants further study for its capacity to protect against colorectal cancer...
  7. ncbi Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 24:1347-52. 2003
    ..Altering amounts of dietary RS changes fermentative activity in the colon. Increased RS is associated with enhanced AARGC. Changes in amount of fermentable substrate are capable of changing the biological response to DNA damage...
  8. ncbi Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Nutr Metab (Lond) 6:11. 2009
    ..abstract:..
  9. ncbi Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes
    Ying Hu
    Department of Medicine, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, Australia
    Mutat Res 677:27-32. 2009
    ..It is highly sensitive and can be applied to the detection of early genetic alterations in carcinogen-based animal models...
  10. ncbi Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon
    Jean Winter
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park
    Cancer Prev Res (Phila) 4:1920-8. 2011
    ....
  11. ncbi Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon
    Ying Hu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park 5042, Australia
    Br J Nutr 104:17-23. 2010
    ....
  12. ncbi The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- mice
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Mol Nutr Food Res 52:558-66. 2008
    ..Further investigation to understand the variable effect of SM in preventing CRC is warranted...
  13. ncbi Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations
    Ying Hu
    Department of Medicine, Flinders Cancer Control Alliance, Flinders University of South Australia, Adelaide, Australia
    Cancer Res 68:4936-44. 2008
    ..Suppression may be a consequence of enhanced apoptotic deletion of azoxymethane-induced DNA lesions and the subsequent reduction in frequency of K-ras mutations...
  14. ncbi Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Adelaide, Australia
    Cancer Lett 248:234-44. 2007
    ....
  15. ncbi Dietary fibre and colorectal cancer: a model for environment--gene interactions
    Graeme P Young
    Department of Medicine, Flinders University of South Australia, Bedford Park, Adelaide, Australia
    Mol Nutr Food Res 49:571-84. 2005
    ..Activation of apoptosis and cell cycle arrest seem likely to be mechanisms that would enable correction of genomic events that drive oncogenesis. Butyrate itself can regulate gene expression by both epigenetic and direct effects...
  16. ncbi The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects
    Ying Hu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, SA, Australia
    Br J Nutr 106:572-82. 2011
    ..Changes in rectal selenoproteins are not predicted by changes in plasma Se; dairy-Se effectively regulates the expression of several rectal selenoproteins of relevance to the risk for CRC...
  17. ncbi Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative
    Chantel B Westley
    School of Biological Sciences, Flinders University, Adelaide, SA, Australia
    Cancer Biol Ther 9:371-9. 2010
    ..Nevertheless, the protective effect of ME against CRC in vivo clearly substantiates further research into the chemopreventative efficacy of Muricidae natural products...
  18. ncbi R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production
    Jonathan E Martin
    Flinders Ctr for Cancer Prevention and Control, Flinders Univ, South Australia, 5042
    Am J Physiol Gastrointest Liver Physiol 298:G860-4. 2010
    ..001). In conclusion, R-flurbiprofen at a dose of 30 mg/kg body wt per day was well tolerated by the animals and, along with sulindac at 30 mg/day body wt, showed protection against the development of colon cancer in the rat-AOM model...
  19. ncbi Resistant starch and colorectal neoplasia
    Graeme P Young
    Flinders University of South Australia, Department of Medicine, Bedford Park, Adelaide, South Australia, Australia 5042
    J AOAC Int 87:775-86. 2004
    ..These effects can be interpreted as reflecting improved colonic health, which might be of benefit in protection against CRC. Direct evidence for protection is still not available...
  20. ncbi Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Adelaide, Australia
    Int J Cancer 115:561-7. 2005
    ..Subsequent studies are now warranted to test the converse, namely, that enhanced apoptotic response to carcinogen reduces risk for colorectal oncogenesis...
  21. ncbi Preventing cancer: dietary lifestyle or clinical intervention?
    Graeme P Young
    Department of Medicine, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, Adelaide, Australia
    Asia Pac J Clin Nutr 11:S618-31. 2002
    ..With these Western cancers, we are fortunate that there are options for prevention. At least choices are available and some will suite certain circumstances and personalities more than others...