Richard K Le Leu

Summary

Affiliation: Flinders University
Country: Australia

Publications

  1. ncbi request reprint Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat
    R K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 23:713-9. 2002
  2. doi request reprint Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University, South Australia 5042, Australia
    Carcinogenesis 31:246-51. 2010
  3. ncbi request reprint Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 24:1347-52. 2003
  4. ncbi request reprint Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch
    Richard K Le Leu
    Department of Medicine, Flinders University, Bedford Park, Australia
    Cancer Biol Ther 6:1621-6. 2007
  5. ncbi request reprint Fermentation of starch and protein in the colon: implications for genomic instability
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Cancer Biol Ther 6:259-60. 2007
  6. ncbi request reprint A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042
    J Nutr 135:996-1001. 2005
  7. ncbi request reprint Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Carcinogenesis 28:240-5. 2007
  8. pmc Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Nutr Metab (Lond) 6:11. 2009
  9. doi request reprint Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes
    Ying Hu
    Department of Medicine, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, Australia
    Mutat Res 677:27-32. 2009
  10. doi request reprint Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon
    Jean Winter
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park
    Cancer Prev Res (Phila) 4:1920-8. 2011

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat
    R K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 23:713-9. 2002
    ....
  2. doi request reprint Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University, South Australia 5042, Australia
    Carcinogenesis 31:246-51. 2010
    ..lactis significantly protects against the development of CRC in the rat-azoxymethane model. Synbiotic combination of prebiotic and probiotic seems likely to be a superior preventive strategy to prebiotic alone...
  3. ncbi request reprint Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, 5042, Australia
    Carcinogenesis 24:1347-52. 2003
    ..Altering amounts of dietary RS changes fermentative activity in the colon. Increased RS is associated with enhanced AARGC. Changes in amount of fermentable substrate are capable of changing the biological response to DNA damage...
  4. ncbi request reprint Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch
    Richard K Le Leu
    Department of Medicine, Flinders University, Bedford Park, Australia
    Cancer Biol Ther 6:1621-6. 2007
    ..The protective effect of consumption of RS as dietary high-amylose cornstarch against colon cancer development appears to be related to active fermentation in the colon, particularly through production of butyrate...
  5. ncbi request reprint Fermentation of starch and protein in the colon: implications for genomic instability
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Cancer Biol Ther 6:259-60. 2007
  6. ncbi request reprint A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042
    J Nutr 135:996-1001. 2005
    ..Because the synbiotic combination of these agents facilitates the apoptotic response to DNA damage by a cancer initiator in the colon of rats, it warrants further study for its capacity to protect against colorectal cancer...
  7. ncbi request reprint Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats
    Richard K Le Leu
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Carcinogenesis 28:240-5. 2007
    ..These effects of RS not only protected against intestinal tumourigenesis but also ameliorated the tumour-enhancing effects of feeding indigestible protein...
  8. pmc Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of rats
    Richard K Le Leu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Nutr Metab (Lond) 6:11. 2009
    ..abstract:..
  9. doi request reprint Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes
    Ying Hu
    Department of Medicine, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, Australia
    Mutat Res 677:27-32. 2009
    ..It is highly sensitive and can be applied to the detection of early genetic alterations in carcinogen-based animal models...
  10. doi request reprint Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon
    Jean Winter
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park
    Cancer Prev Res (Phila) 4:1920-8. 2011
    ....
  11. pmc Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers
    Ying Hu
    Flinders Centre for Innovation in Cancer, Flinders University of South Australia, Adelaide, Australia
    PLoS ONE 8:e64362. 2013
    ..The preventive effect is associated with regulation of genetic and epigenetic biomarkers implicated in colonic carcinogenesis...
  12. doi request reprint Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon
    Ying Hu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park 5042, Australia
    Br J Nutr 104:17-23. 2010
    ....
  13. doi request reprint The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- mice
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Mol Nutr Food Res 52:558-66. 2008
    ..Further investigation to understand the variable effect of SM in preventing CRC is warranted...
  14. ncbi request reprint Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Adelaide, Australia
    Cancer Lett 248:234-44. 2007
    ....
  15. ncbi request reprint Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations
    Ying Hu
    Department of Medicine, Flinders Cancer Control Alliance, Flinders University of South Australia, Adelaide, Australia
    Cancer Res 68:4936-44. 2008
    ..Suppression may be a consequence of enhanced apoptotic deletion of azoxymethane-induced DNA lesions and the subsequent reduction in frequency of K-ras mutations...
  16. ncbi request reprint Dietary fibre and colorectal cancer: a model for environment--gene interactions
    Graeme P Young
    Department of Medicine, Flinders University of South Australia, Bedford Park, Adelaide, Australia
    Mol Nutr Food Res 49:571-84. 2005
    ..Activation of apoptosis and cell cycle arrest seem likely to be mechanisms that would enable correction of genomic events that drive oncogenesis. Butyrate itself can regulate gene expression by both epigenetic and direct effects...
  17. doi request reprint The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects
    Ying Hu
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, SA, Australia
    Br J Nutr 106:572-82. 2011
    ..Changes in rectal selenoproteins are not predicted by changes in plasma Se; dairy-Se effectively regulates the expression of several rectal selenoproteins of relevance to the risk for CRC...
  18. doi request reprint R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production
    Jonathan E Martin
    Flinders Ctr for Cancer Prevention and Control, Flinders Univ, South Australia, 5042
    Am J Physiol Gastrointest Liver Physiol 298:G860-4. 2010
    ..001). In conclusion, R-flurbiprofen at a dose of 30 mg/kg body wt per day was well tolerated by the animals and, along with sulindac at 30 mg/day body wt, showed protection against the development of colon cancer in the rat-AOM model...
  19. ncbi request reprint Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative
    Chantel B Westley
    School of Biological Sciences, Flinders University, Adelaide, SA, Australia
    Cancer Biol Ther 9:371-9. 2010
    ..Nevertheless, the protective effect of ME against CRC in vivo clearly substantiates further research into the chemopreventative efficacy of Muricidae natural products...
  20. doi request reprint Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis
    Laura S Nyskohus
    Flinders Centre for Innovation in Cancer, Flinders University of South Australia, Australia
    Mutat Res 758:80-6. 2013
    ..In the colonic epithelium, apoptosis may be complementary to MGMT, in terms of minimising potentially mutagenic events and maintaining a healthy genome...
  21. ncbi request reprint Resistant starch and colorectal neoplasia
    Graeme P Young
    Flinders University of South Australia, Department of Medicine, Bedford Park, Adelaide, South Australia, Australia 5042
    J AOAC Int 87:775-86. 2004
    ..These effects can be interpreted as reflecting improved colonic health, which might be of benefit in protection against CRC. Direct evidence for protection is still not available...
  22. doi request reprint Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer
    Jean Winter
    Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia, Australia
    Mol Nutr Food Res 58:550-8. 2014
    ..By utilizing the western diet model of spontaneous CRC, we determined if feeding heme (as hemin chloride) equivalent to a high red meat diet would increase colonic DNA adducts and CRC and whether RS could abrogate such effects...
  23. pmc Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs
    Chantel B Westley
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Evid Based Complement Alternat Med 2013:837370. 2013
    ..Overall however, oral administration of muricid extract containing brominated indoles does not result in severe clinical toxicity...
  24. ncbi request reprint Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Adelaide, Australia
    Int J Cancer 115:561-7. 2005
    ..Subsequent studies are now warranted to test the converse, namely, that enhanced apoptotic response to carcinogen reduces risk for colorectal oncogenesis...
  25. doi request reprint 6-bromoisatin found in muricid mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis, preventing early stage tumor formation in a colorectal cancer rodent model
    Babak Esmaeelian
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide 5001, Australia
    Mar Drugs 12:17-35. 2014
    ..However, 6-bromoisatin caused a decrease in the plasma level of potassium, suggesting a diuretic effect. In conclusion this study supports 6-bromoisatin in Muricidae extracts as a promising lead for prevention of colorectal cancer...
  26. doi request reprint Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster
    Karen J Humphreys
    Flinders Centre for Cancer Prevention and Control, School of Medicine, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
    Mol Carcinog 52:459-74. 2013
    ..This is the first study to identify competing roles for miR-17-92 cluster members, in the context of HDI-induced changes in CRC cells...
  27. ncbi request reprint Preventing cancer: dietary lifestyle or clinical intervention?
    Graeme P Young
    Department of Medicine, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, Adelaide, Australia
    Asia Pac J Clin Nutr 11:S618-31. 2002
    ..With these Western cancers, we are fortunate that there are options for prevention. At least choices are available and some will suite certain circumstances and personalities more than others...