Kathleen M Knights

Summary

Affiliation: Flinders University
Country: Australia

Publications

  1. Knights K, Bowalgaha K, Miners J. Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction. Drug Metab Dispos. 2010;38:1011-4 pubmed publisher
    ....
  2. Miners J, Chau N, Rowland A, Burns K, McKinnon R, Mackenzie P, et al. Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia. Biochem Pharmacol. 2017;129:85-95 pubmed publisher
    ..Inhibition of other UGT1A1 substrates in vivo is likely. ..
  3. request reprint
    Knights K, Drogemuller C. Xenobiotic-CoA ligases: kinetic and molecular characterization. Curr Drug Metab. 2000;1:49-66 pubmed
    ....
  4. Knights K, Winner L, Elliot D, Bowalgaha K, Miners J. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009;68:402-12 pubmed publisher
    ....
  5. request reprint
    Knights K, Gasser R, Klemisch W. In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. Biochem Pharmacol. 2000;60:507-16 pubmed
    ..Predicting clearance of acitretin in vivo via this unique metabolic pathway will be a challenge, as the intracellular concentration of ethanol could never be predicted with any degree of accuracy in humans. ..

Detail Information

Publications5

  1. Knights K, Bowalgaha K, Miners J. Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction. Drug Metab Dispos. 2010;38:1011-4 pubmed publisher
    ....
  2. Miners J, Chau N, Rowland A, Burns K, McKinnon R, Mackenzie P, et al. Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia. Biochem Pharmacol. 2017;129:85-95 pubmed publisher
    ..Inhibition of other UGT1A1 substrates in vivo is likely. ..
  3. request reprint
    Knights K, Drogemuller C. Xenobiotic-CoA ligases: kinetic and molecular characterization. Curr Drug Metab. 2000;1:49-66 pubmed
    ....
  4. Knights K, Winner L, Elliot D, Bowalgaha K, Miners J. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009;68:402-12 pubmed publisher
    ....
  5. request reprint
    Knights K, Gasser R, Klemisch W. In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. Biochem Pharmacol. 2000;60:507-16 pubmed
    ..Predicting clearance of acitretin in vivo via this unique metabolic pathway will be a challenge, as the intracellular concentration of ethanol could never be predicted with any degree of accuracy in humans. ..