Kathleen M Knights


Affiliation: Flinders University
Country: Australia


  1. Knights K, Bowalgaha K, Miners J. Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction. Drug Metab Dispos. 2010;38:1011-4 pubmed publisher
  2. Miners J, Chau N, Rowland A, Burns K, McKinnon R, Mackenzie P, et al. Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia. Biochem Pharmacol. 2017;129:85-95 pubmed publisher
    ..Inhibition of other UGT1A1 substrates in vivo is likely. ..
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    Knights K, Drogemuller C. Xenobiotic-CoA ligases: kinetic and molecular characterization. Curr Drug Metab. 2000;1:49-66 pubmed
  4. Knights K, Winner L, Elliot D, Bowalgaha K, Miners J. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009;68:402-12 pubmed publisher
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    Knights K, Gasser R, Klemisch W. In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. Biochem Pharmacol. 2000;60:507-16 pubmed
    ..Predicting clearance of acitretin in vivo via this unique metabolic pathway will be a challenge, as the intracellular concentration of ethanol could never be predicted with any degree of accuracy in humans. ..