Linda M Fletcher

Summary

Country: Australia

Publications

  1. ncbi Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Gastroenterology 122:281-9. 2002
  2. doi Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
    Darrell H G Crawford
    School of Medicine, The University of Queensland, Greenslopes Private Hospital, Brisbane, Australia
    Hepatology 49:418-25. 2009
  3. doi Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury
    Terrence C H Tan
    1 School of Medicine, University of Queensland, Brisbane, QLD, Australia 2 Gallipoli Medical Research Centre, Greenslopes Hospital, Brisbane, QLD, Australia 3 Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Lab Invest 93:1295-312. 2013
  4. ncbi A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis
    Terrence C H Tan
    School of Medicine, University of Queensland, Brisbane, Queensland, Australia Gallipoli Medical Research Centre, Greenslopes Hospital, Brisbane, Queensland, Australia Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 37:1619-31. 2013
  5. ncbi The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis
    Terrence C H Tan
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia
    Liver Int 32:1391-9. 2012
  6. ncbi Steatosis is a cofactor in liver injury in hemochromatosis
    Elizabeth E Powell
    School of Medicine, The University of Queensland, Brisbane, Australia
    Gastroenterology 129:1937-43. 2005
  7. ncbi Screening for hemochromatosis in asymptomatic subjects with or without a family history
    Lawrie W Powell
    Centre for the Advancement of Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland 4029, Australia
    Arch Intern Med 166:294-301. 2006
  8. doi Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response
    Mandy L Heritage
    School of Medicine and Gallipoli Research Foundation University of Queensland, Brisbane, Australia
    Alcohol Clin Exp Res 33:1391-400. 2009
  9. ncbi BMI but not stage or etiology of nonalcoholic liver disease affects the diagnostic utility of carbohydrate-deficient transferrin
    Kevin J Fagan
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia Centre for Liver Disease Research, School of Medicine, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 37:1771-8. 2013
  10. ncbi Hemochromatosis and alcoholic liver disease
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Alcohol 30:131-6. 2003

Collaborators

Detail Information

Publications21

  1. ncbi Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Gastroenterology 122:281-9. 2002
    ....
  2. doi Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
    Darrell H G Crawford
    School of Medicine, The University of Queensland, Greenslopes Private Hospital, Brisbane, Australia
    Hepatology 49:418-25. 2009
    ..78; P = 0.01). Conclusion: In HH, the measurement of hyaluronic acid in patients with serum ferritin >1,000 microg/L is a noninvasive, accurate, and cost-effective method for the diagnosis of cirrhosis. (HEPATOLOGY 2009;49:418-425.)...
  3. doi Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury
    Terrence C H Tan
    1 School of Medicine, University of Queensland, Brisbane, QLD, Australia 2 Gallipoli Medical Research Centre, Greenslopes Hospital, Brisbane, QLD, Australia 3 Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Lab Invest 93:1295-312. 2013
    ..We conclude that iron toxicity may modulate hepatic stress signaling pathways by impairing adaptive cellular compensatory mechanisms in alcohol- and obesity-induced liver injury...
  4. ncbi A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis
    Terrence C H Tan
    School of Medicine, University of Queensland, Brisbane, Queensland, Australia Gallipoli Medical Research Centre, Greenslopes Hospital, Brisbane, Queensland, Australia Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 37:1619-31. 2013
    ..The role of specific dietary fats in influencing the development of co-toxic alcoholic liver disease needs further evaluation and is investigated in this study...
  5. ncbi The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis
    Terrence C H Tan
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia
    Liver Int 32:1391-9. 2012
    ..We investigated the potential role of serum hepcidin as a biomarker of advanced liver disease...
  6. ncbi Steatosis is a cofactor in liver injury in hemochromatosis
    Elizabeth E Powell
    School of Medicine, The University of Queensland, Brisbane, Australia
    Gastroenterology 129:1937-43. 2005
    ....
  7. ncbi Screening for hemochromatosis in asymptomatic subjects with or without a family history
    Lawrie W Powell
    Centre for the Advancement of Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland 4029, Australia
    Arch Intern Med 166:294-301. 2006
    ..This study compared screening for hemochromatosis in subjects with or without a family history...
  8. doi Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response
    Mandy L Heritage
    School of Medicine and Gallipoli Research Foundation University of Queensland, Brisbane, Australia
    Alcohol Clin Exp Res 33:1391-400. 2009
    ..Since chronic alcohol consumption is also associated with disturbances in iron metabolism, we investigated the effects of alcohol consumption on hepcidin mRNA expression in Hfe(-/-) mice...
  9. ncbi BMI but not stage or etiology of nonalcoholic liver disease affects the diagnostic utility of carbohydrate-deficient transferrin
    Kevin J Fagan
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia Centre for Liver Disease Research, School of Medicine, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 37:1771-8. 2013
    ..This study was designed to determine whether alcohol-independent factors influence CDT levels in patients with chronic liver disease (CLD)...
  10. ncbi Hemochromatosis and alcoholic liver disease
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Alcohol 30:131-6. 2003
    ..In addition, the cumulative effects of other forms of liver injury may result when iron and alcohol are present concurrently. Clearly, the addition of dietary iron in subjects homozygous for hemochromatosis would be unwise...
  11. doi Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis
    Peng Li
    Therapeutics Research Centre, School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Drug Metab Dispos 39:571-9. 2011
    ....
  12. doi Multiphoton microscopy can visualize zonal damage and decreased cellular metabolic activity in hepatic ischemia-reperfusion injury in rats
    Camilla A Thorling
    The University of Queensland, School of Medicine, Woolloongabba, Queensland, 4102, Australia
    J Biomed Opt 16:116011. 2011
    ..This provides a simple noninvasive technique useful for following progressive liver injury without external markers...
  13. pmc Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers
    Kevin J Fagan
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Woolloongabba 4102, Brisbane, Queensland, Australia
    BMC Gastroenterol 14:97. 2014
    ..The aim of this study was to determine the factors that affect diagnostic sensitivity in patients with sustained heavy alcohol intake...
  14. doi Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways
    Kim R Bridle
    School of Medicine, University of Queensland, Gallipoli Research Centre, Greenslopes Private Hospital, Brisbane, Queensland, Australia
    Liver Transpl 15:1315-24. 2009
    ....
  15. ncbi Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis
    Darrell H G Crawford
    Queensland Liver Transplant Service and The University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Hepatology 39:1655-62. 2004
    ..Our data suggest that iron excess in HH does not wholly depend on intestinal iron absorption but is also influenced by liver factors that moderate iron metabolism...
  16. doi Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis
    Terrence C H Tan
    School of Medicine, University of Queensland, Australia
    Am J Physiol Gastrointest Liver Physiol 301:G865-76. 2011
    ....
  17. ncbi Effect of alcohol on iron storage diseases of the liver
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, QLD 4102, Australia
    Best Pract Res Clin Gastroenterol 17:663-77. 2003
    ..This review discusses the concomitant effects of alcohol and iron on the pathogenesis of liver disease. We also discuss the implications of co-existent alcohol and iron in end-stage liver disease...
  18. ncbi Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model
    Yu Hong Zou
    Therapeutics Research Centre, School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia
    Drug Metab Pharmacokinet 25:442-9. 2010
    ....
  19. ncbi Concordance of iron indices in homozygote and heterozygote sibling pairs in hemochromatosis families: implications for family screening
    Peter W Whiting
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Australia
    J Hepatol 37:309-14. 2002
    ....
  20. ncbi Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease
    Kimr Bridle
    Southern Medical School, University of Queensland, Brisbane, Australia
    Alcohol Clin Exp Res 30:106-12. 2006
    ..Both CCAAT enhancer binding protein alpha (C/EBPalpha) and interleukin 6 (IL-6) have been shown to regulate hepcidin gene transcription...
  21. ncbi Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis
    Kim R Bridle
    Hepatic Fibrosis Group, Population Health and Clinical Sciences Division, The Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Herston, QLD 4029, Australia
    J Hepatol 38:426-33. 2003
    ..The aim of the current study was to examine the hepatic gene expression of potential proinflammatory and profibrogenic cytokines in haemochromatosis...