M Fenech

Summary

Country: Australia

Publications

  1. ncbi In vitro micronucleus technique to predict chemosensitivity
    Michael Fenech
    CSIRO Health Science and Nutrition, South Australia, Australia
    Methods Mol Med 111:3-32. 2005
  2. ncbi Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI 00250 Helsinki, Finland
    Mutat Res 617:33-45. 2007
  3. ncbi The micronucleus assay determination of chromosomal level DNA damage
    Michael Fenech
    CSIRO Human Nutrition, Adelaide BC, South Australia, Australia
    Methods Mol Biol 410:185-216. 2008
  4. ncbi Buccal micronucleus cytome assay
    Philip Thomas
    CSIRO Human Nutrition, Adelaide, South Australia
    Nat Protoc 4:825-37. 2009
  5. ncbi Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs)
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, Gouger Street, BC, SA, 5000, Adelaide, Australia
    Food Chem Toxicol 40:1113-7. 2002
  6. ncbi Genomic stability: a new paradigm for recommended dietary allowances (RDAs)
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide BC, SA, Australia
    Forum Nutr 56:97-100. 2003
  7. ncbi Chromosomal biomarkers of genomic instability relevant to cancer
    Michael Fenech
    Cooperative Research Centre for Diagnostics, CSIRO Health Sciences and Nutrition, PO Box 10041, Adelaide, BC, SA 5000, Australia
    Drug Discov Today 7:1128-37. 2002
  8. ncbi Biomarkers of genetic damage for cancer epidemiology
    Michael Fenech
    CSIRO Health Sciences and Nutrition, P O Box 10041, Gouger Street, SA 5000 Adelaide, BC, Australia
    Toxicology 181:411-6. 2002
  9. ncbi HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
    M Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:65-75. 2003
  10. ncbi Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Genomic Stability Project, P O Box 10041, Adelaide BC, Australia
    Mutat Res 504:131-6. 2002

Detail Information

Publications76

  1. ncbi In vitro micronucleus technique to predict chemosensitivity
    Michael Fenech
    CSIRO Health Science and Nutrition, South Australia, Australia
    Methods Mol Med 111:3-32. 2005
    ..The basic principles and methods (including detailed scoring criteria for all the genotoxicity and cytotoxicity end points) of the CBMN assay are described and areas for future development identified...
  2. ncbi Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI 00250 Helsinki, Finland
    Mutat Res 617:33-45. 2007
    ....
  3. ncbi The micronucleus assay determination of chromosomal level DNA damage
    Michael Fenech
    CSIRO Human Nutrition, Adelaide BC, South Australia, Australia
    Methods Mol Biol 410:185-216. 2008
    ..The basic principles and methods (including detailed scoring criteria for all the genotoxicity and cytotoxicity end points) of the CBMN assay are described and areas for future development identified...
  4. ncbi Buccal micronucleus cytome assay
    Philip Thomas
    CSIRO Human Nutrition, Adelaide, South Australia
    Nat Protoc 4:825-37. 2009
    ..The protocol in its current form takes approximately 4 h to complete from the time of buccal cell collection to the generation of stained slides for microscopic analysis...
  5. ncbi Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs)
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, Gouger Street, BC, SA, 5000, Adelaide, Australia
    Food Chem Toxicol 40:1113-7. 2002
    ..That there is a need for an international collaborative effort to establish RDAs for genomic stability is self-evident...
  6. ncbi Genomic stability: a new paradigm for recommended dietary allowances (RDAs)
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide BC, SA, Australia
    Forum Nutr 56:97-100. 2003
  7. ncbi Chromosomal biomarkers of genomic instability relevant to cancer
    Michael Fenech
    Cooperative Research Centre for Diagnostics, CSIRO Health Sciences and Nutrition, PO Box 10041, Adelaide, BC, SA 5000, Australia
    Drug Discov Today 7:1128-37. 2002
    ..In addition, the techniques for measuring the various chromosomal instability events are discussed with a focus on the cytokinesis-block micronucleus assay as an almost complete system for measuring these various genetic mishaps...
  8. ncbi Biomarkers of genetic damage for cancer epidemiology
    Michael Fenech
    CSIRO Health Sciences and Nutrition, P O Box 10041, Gouger Street, SA 5000 Adelaide, BC, Australia
    Toxicology 181:411-6. 2002
    ..Controlling DNA damage rate to its possible minimum is likely to have an important impact in preventing cancer and other DNA damage-related degenerative diseases including ageing...
  9. ncbi HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
    M Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:65-75. 2003
    ....
  10. ncbi Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Genomic Stability Project, P O Box 10041, Adelaide BC, Australia
    Mutat Res 504:131-6. 2002
    ..These results also suggest that the CBMN assay may be a useful model for the study of the BFB cycle which may be one of the key mechanisms for the hypermutability phenotype required for the rapid evolution of cancer cells...
  11. ncbi Recommended dietary allowances (RDAs) for genomic stability
    M Fenech
    CSIRO Health Sciences and Nutrition, P O Box 10041, Gouger Street, Adelaide BC, SA 5000, Australia
    Mutat Res 480:51-4. 2001
    ..That there is a need for an international collaborative group to establish RDAs for genomic stability is self-evident and this paper is a call for such a process to begin...
  12. ncbi The role of folic acid and Vitamin B12 in genomic stability of human cells
    M Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Mutat Res 475:57-67. 2001
    ..Dietary intakes above the current RDI may be particularly important in those with extreme defects in the absorption and metabolism of these Vitamins, for which ageing is a contributing factor...
  13. ncbi The in vitro micronucleus technique
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, BC 5000, South Australia, Adelaide, Australia
    Mutat Res 455:81-95. 2000
    ..The basic principles and methods (including detailed scoring criteria for all the genotoxicity and cytotoxicity end-points) of the CBMN assay are described and areas for future development identified...
  14. ncbi Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide
    M Fenech
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, SA, Australia 5000
    Mutagenesis 14:605-12. 1999
    ..The integration of apoptosis and necrosis into the micronucleus assay may also be of practical use in radiosensitivity studies...
  15. ncbi A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, Adelaide BC, SA 5000, Australia
    Mutagenesis 15:329-36. 2000
    ..Scoring of micronuclei in cytokinesis-blocked binucleated cells is predicted by the model to provide consistent results under all culture conditions and based on these theoretical results should be considered the preferred choice...
  16. ncbi The HUman MicroNucleus Project--An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans
    M Fenech
    CSIRO Human Nutrition, Gouger Street, P O Box 10041, Adelaide, Australia
    Mutat Res 428:271-83. 1999
    ....
  17. ncbi Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency
    Sasja Beetstra
    CSIRO Human Nutrition, PO Box 10041, Gouger Street, Adelaide BC 5000, SA, Australia
    Carcinogenesis 27:517-24. 2006
    ..The results of this study suggest that moderate folate deficiency has a stronger effect on chromosomal instability than BRCA1 or BRCA2 mutations found in breast cancer families...
  18. ncbi Effect of common polymorphisms in folate uptake and metabolism genes on frequency of micronucleated lymphocytes in a South Australian cohort
    Varinderpal Dhillon
    Genome Health and Nutrigenomics Laboratory, CSIRO Human Nutrition, A Centre of Food Science Australia, Adelaide BC, SA, Australia
    Mutat Res 665:1-6. 2009
    ..5 per thousand) (P trend=0.015). The RFC G80A and MTR A2756G polymorphisms and their combinations may be important variables that substantially affect lymphocyte BN-MN frequency in this South Australian cohort...
  19. ncbi Micronucleus frequency in human lymphocytes is related to plasma vitamin B12 and homocysteine
    M Fenech
    CSIRO Human Nutrition, PO Box 10041 Gouger Street, Adelaide, Australia
    Mutat Res 428:299-304. 1999
    ..5 micromol/l and plasma B12 is above 300 pmol/l. Therefore, it is important to take account of the effect of B12 and HC when using the micronucleus assay for human biomonitoring studies...
  20. ncbi Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells
    M Fenech
    Department of Nutritional Genomics and DNA Damage Diagnostics, Commonwealth Scientific and Industrial Research Organisation Food and Nutritional Sciences, Gate 13 Kintore Avenue, PO Box 10041, Adelaide BC, South Australia 5000, Australia
    Mutagenesis 26:125-32. 2011
    ..NBUD represent the process of elimination of amplified DNA, DNA repair complexes and possibly excess chromosomes from aneuploid cells...
  21. ncbi Genome-health nutrigenomics and nutrigenetics: nutritional requirements or 'nutriomes' for chromosomal stability and telomere maintenance at the individual level
    Caroline Bull
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, South Australia 5000, Australia
    Proc Nutr Soc 67:146-56. 2008
    ..It is evident that developing effective strategies for defining nutrient doses and combinations or 'nutriomes' for genome-health maintenance at the individual level is essential for further progress in this research field...
  22. ncbi Increased consumption of wheat biofortified with selenium does not modify biomarkers of cancer risk, oxidative stress, or immune function in healthy Australian males
    Jing Wu
    Nutritional Genomics and Genome Damage Diagnostics Laboratory, CSIRO Human Nutrition, Food Science Australia, Adelaide, South Australia, Australia
    Environ Mol Mutagen 50:489-501. 2009
    ....
  23. ncbi Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei
    Sasja Beetstra
    CSIRO Health Sciences and Nutrition, P.O. Box 10041, Gouger Street, Adelaide BC 5000, SA, Australia
    Mutat Res 578:317-26. 2005
    ..The results of this study show that folate status has an important impact on chromosomal stability and is an important modifying factor of cellular sensitivity to radiation-induced genome damage...
  24. ncbi Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay
    Philip Thomas
    CSIRO Health Sciences and Nutrition, PO Box 10041 Adelaide BC, Adelaide, SA 5000, Australia
    Mutagenesis 18:187-94. 2003
    ..The CBMN assay allows NPB measurement to be achieved reliably because inhibition of cytokinesis prevents the loss of NPB that would otherwise occur if cells were allowed to divide...
  25. ncbi Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin
    A R Humpage
    Department of Clinical and Experimental Pharmacology, University of Adelaide Medical School, SA 5005, Adelaide, Australia
    Mutat Res 472:155-61. 2000
    ..C. raciborskii occurs in a number of human drinking water sources worldwide and so these findings may have important public health implications...
  26. ncbi The interactive effect of alcohol and folic acid on genome stability in human WIL2-NS cells measured using the cytokinesis-block micronucleus cytome assay
    Theodora Teo
    CSIRO Human Nutrition, P O Box 10041, Adelaide BC, South Australia 5000, Australia
    Mutat Res 657:32-8. 2008
    ....
  27. ncbi Moderate acute intake of de-alcoholized red wine, but not alcohol, is protective against radiation-induced DNA damage ex vivo -- results of a comparative in vivo intervention study in younger men
    W Greenrod
    CSIRO Health Sciences and Nutrition, Genome Health and Nutrigenomics Laboratory, PO Box 10041, Adelaide BC, SA 5000, Australia
    Mutat Res 591:290-301. 2005
    ..23). These preliminary data suggest that only the non-alcoholic fraction of red wine protects DNA from oxidative damage but this effect cannot be explained solely by plasma catechin...
  28. ncbi Chromosomal damage rate, aging, and diet
    M Fenech
    CSIRO Division of Human Nutrition, Adelaide SA, Australia
    Ann N Y Acad Sci 854:23-36. 1998
    ..However, only samples following red wine consumption produced a significant reduction in baseline MN frequency. The above results suggest that chromosome damage can be modulated, under selected circumstances, by diverse dietary factors...
  29. ncbi A quantitative real-time PCR method for absolute telomere length
    Nathan O'Callaghan
    Commonwealth Scientific and Industrial Research Organization CSIRO Human Nutrition, Adelaide, Australia
    Biotechniques 44:807-9. 2008
    ..The capability to generate absolute telomere length values should allow a more direct comparison of results between experiments within and between laboratories...
  30. ncbi Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease
    Philip Thomas
    CSIRO Human Nutrition, Adelaide BC, Adelaide, SA, Australia
    Mech Ageing Dev 129:183-90. 2008
    ..These results need to be replicated in larger studies and in cohorts of other neurodegenerative disorders to determine specificity of changes to Alzheimer's patients...
  31. ncbi Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease
    Philip Thomas
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, Adelaide, South Australia 5000, Australia
    Mutagenesis 23:57-65. 2008
    ....
  32. ncbi The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls
    Philip Thomas
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, Adelaide, SA 5000, Australia
    Mutat Res 638:37-47. 2008
    ..This study validates the use of a cytome approach to investigate DNA damage, cell death and cell proliferation in buccal cells with ageing...
  33. ncbi Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease
    Philip Thomas
    CSIRO Division of Human Nutrition, Adelaide, SA 5000, Australia
    Mutagenesis 22:371-9. 2007
    ..These promising results need to be replicated in larger studies and in cohorts of other neurodegenerative disorders to determine specificity of changes to Alzheimer's patients...
  34. ncbi Genome health nutrigenomics and nutrigenetics--diagnosis and nutritional treatment of genome damage on an individual basis
    Michael Fenech
    CSIRO, Human Nutrition, PO Box 10041, Adelaide BC, SA 5000, Australia
    Food Chem Toxicol 46:1365-70. 2008
    ..e. Genome Health Clinics...
  35. ncbi Cytokinesis-block micronucleus cytome assay
    Michael Fenech
    Genome Health Nutrigenomics Laboratory, CSIRO Human Nutrition, Food Science Australia, PO Box 10041, Adelaide 5000, South Australia, Australia
    Nat Protoc 2:1084-104. 2007
    ..The procedure can take up to 5 days to complete...
  36. ncbi Nutrition and genome health
    Michael Fenech
    CSIRO Human Nutrition, Adelaide, Australia
    Forum Nutr 60:49-65. 2007
    ..e. Genome Health Clinics)...
  37. ncbi Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer
    Sasja Beetstra
    Commonwealth Scientific and Industrial Research Organisation Human Nutrition, South Australia 5000, Australia
    Cancer Epidemiol Biomarkers Prev 17:2565-71. 2008
    ..76-13.9) and 3.9 (P=0.09; 95% confidence interval, 0.93-16.3), respectively]. The results of this study support the hypothesis that defects in methionine metabolism may be associated with breast cancer risk in BRCA carriers...
  38. ncbi Effects of surface chemistry on cytotoxicity, genotoxicity, and the generation of reactive oxygen species induced by ZnO nanoparticles
    Hong Yin
    CSIRO Materials Science and Engineering, CSIRO Future Manufacturing Flagship, Clayton VIC 3168, Australia
    Langmuir 26:15399-408. 2010
    ..The lowest toxicity was achieved with a surface coating of components from a cell culture medium...
  39. ncbi The lymphocyte cytokinesis-block micronucleus cytome assay and its application in radiation biodosimetry
    Michael Fenech
    CSIRO, PO Box 10041, Adelaide BC SA 5000, Australia
    Health Phys 98:234-43. 2010
    ..A brief account is also given of current developments in the automation of this technique and important knowledge gaps that need attention to further enhance the applicability of this important method for radiation biodosimetry...
  40. ncbi Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa
    Nathan J O'Callaghan
    CSIRO Human Nutrition and Food Science Australia, Adelaide, South Australia, Australia
    Rejuvenation Res 12:169-76. 2009
    ..56, p = 0.01, respectively). These results suggest that weight loss by caloric-restricted diets may contribute to the prevention of telomere shortening and DNA base damage, which are important initiating events in carcinogenesis...
  41. ncbi High protein-high red meat versus high carbohydrate weight loss diets do not differ in effect on genome stability and cell death in lymphocytes of overweight men
    Bianca Benassi-Evans
    Commonwealth Scientific and Industrial Research Organisation, Human Nutrition, South Australia, Australia
    Mutagenesis 24:271-7. 2009
    ..The results suggest that the effect of the HP weight loss diet on DNA damage measured using the CBMN-Cyt assay in PBLs was not different from that observed for the HC weight loss diet...
  42. ncbi A lifetime passion for micronucleus cytome assays--reflections from Down Under
    Michael Fenech
    CSIRO Human Nutrition, P O Box 10041, Adelaide BC, SA 5000, Australia
    Mutat Res 681:111-7. 2009
    ....
  43. ncbi Report on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007
    Michael Fenech
    Mutagenesis 24:199-201. 2009
    ..A follow-up workshop is planned at the 10th International Conference on Environmental Mutagens in Florence in 2009...
  44. ncbi Folate, DNA damage and the aging brain
    Michael Fenech
    CSIRO Food and Nutritional Sciences, Nutritional Genomics, Gate 13, Kintore Avenue, PO Box 10041, Adelaide BC, SA 5000, Australia
    Mech Ageing Dev 131:236-41. 2010
    ..In this brief review the current evidence that folate deficiency and associated metabolites, such as homocysteine, may accelerate DNA damage and aging of the brain is explored and important knowledge gaps are identified...
  45. ncbi Buccal micronucleus cytome assay
    Philip Thomas
    CSIRO Human Nutrition, Adelaide, SA, Australia
    Methods Mol Biol 682:235-48. 2011
    ..This protocol describes the current established methods for buccal cell collection, slide preparation, cellular and nuclear staining, and scoring criteria...
  46. ncbi Aleurone flour increases red-cell folate and lowers plasma homocyst(e)ine substantially in man
    Michael Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, Gouger Street, Adelaide BC, SA 5000, Australia
    Br J Nutr 93:353-60. 2005
    ..1 (8.2, 10.0) micromol/l at baseline to 6.8 (6.2, 7.5) micromol/l after 16 weeks. In conclusion, moderate dietary intake of ALF can increase red-cell folate and decrease plasma homocyst(e)ine substantially...
  47. ncbi Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability--results from a dietary intake and micronucleus inde
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, Australia, Women s and Children s Hospital, Adelaide, Australia
    Carcinogenesis 26:991-9. 2005
    ..The results from this study illustrate the strong impact of a wide variety of micronutrients and their interactions on genome health, depending on the level of intake...
  48. ncbi Commentary on the SFTG international collaborative study on the in vitro micronucleus test: to Cyt-B or not to Cyt-B?
    Michael Fenech
    Genome Health and Nutrigenomics Project, CSIRO Human Nutrition, Adelaide BC, SA, Australia
    Mutat Res 607:9-12. 2006
  49. ncbi The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis
    Michael Fenech
    Genome Health Nutrigenomics Laboratory, CSIRO Health Sciences and Nutrition, Cooperative Research Centre for Diagnostics, PO Box 10041, Adelaide BC, SA 5000, Australia
    Mutagenesis 20:255-69. 2005
    ..The review concludes with a vision for a paradigm shift in disease prevention strategy based on the diagnosis and nutritional treatment of genome/epigenome damage on an individual basis, i.e. The Genome Health Clinic...
  50. ncbi Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death
    Michael Fenech
    CSIRO Human Nutrition, Genome Health Nutrigenomics Project, P O Box 10041, Adelaide BC, Adelaide, SA 5000, Australia
    Mutat Res 600:58-66. 2006
    ....
  51. ncbi A review of genome mutation and Alzheimer's disease
    Philip Thomas
    CSIRO Health Sciences and Nutrition, PO Box 10041 Adelaide BC, Adelaide, South Australia 5000, Australia
    Mutagenesis 22:15-33. 2007
    ..These biomarkers could then be used in diagnosis and the evaluation of potentially effective preventative measures...
  52. ncbi Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007
    Michael Fenech
    CSIRO Human Nutrition, Adelaide, South Australia 5000, Australia
    Mutagenesis 22:3-4. 2007
  53. ncbi Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:45-64. 2003
    ....
  54. ncbi Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease
    Philip Thomas
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, Adelaide, SA 5000, Australia
    Mutat Res 661:25-34. 2009
    ..These results suggest potential protective effects of polyphenols against genomic instability events in different somatic tissues of a transgenic mouse model for AD...
  55. ncbi Methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease
    Philip Thomas
    CSIRO Human Nutrition, Adelaide BC, Adelaide, South Australia 5000
    Vitam Horm 79:375-92. 2008
    ..In this chapter, we consider the role that MTHFR plays in relation to folate metabolism and the possible contribution made in relation to certain important clinical outcomes...
  56. ncbi Cytokinesis-block micronucleus cytome assays for the determination of genotoxicity and cytotoxicity of cecal water in rats and fecal water in humans
    Bianca Benassi
    Division of Human Nutrition, Commonwealth Scientific and Industrial Research Organisation, P O Box 10041, Gouger Street, Adelaide, South Australia 5000, Australia
    Cancer Epidemiol Biomarkers Prev 16:2676-80. 2007
    ....
  57. ncbi The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro
    J W Crott
    Department of Physiology, Adelaide University, Adelaide, South Australia 5005, Australia
    Cancer Epidemiol Biomarkers Prev 10:1089-96. 2001
    ..Results show that the C677T polymorphism does not affect the ability of a cell to resist chromosome damage induced by folic acid deficiency in this in vitro system...
  58. ncbi The principal phenolic and alcoholic components of wine protect human lymphocytes against hydrogen peroxide- and ionizing radiation-induced DNA damage in vitro
    William Greenrod
    CSIRO Health Sciences and Nutrition, PO Box 10041, Adelaide BC, South Australia 5000, Australia
    Mutagenesis 18:119-26. 2003
    ..e. hydrogen peroxide and ionizing radiation, in this physiologically relevant in vitro system...
  59. ncbi Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA, Australia
    Neurotox Res 15:3-14. 2009
    ..Conclusively, polyphenol-rich GSE prevents the Abeta deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD...
  60. ncbi Comparison of DNA damage and repair following radiation challenge in buccal cells and lymphocytes using single-cell gel electrophoresis
    V S Dhillon
    CSIRO Health Sciences and Nutrition, Gate No. 13, Kintore Avenue, PO Box 10041 Adelaide BC, Adelaide, SA 5000, Australia
    Int J Radiat Biol 80:517-28. 2004
    ....
  61. ncbi Folate and methionine metabolism in autism: a systematic review
    Penelope A E Main
    Sansom Institute, University of South Australia, Adelaide, Australia
    Am J Clin Nutr 91:1598-620. 2010
    ..Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism...
  62. ncbi The case for strategic international alliances to harness nutritional genomics for public and personal health
    Jim Kaput
    Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
    Br J Nutr 94:623-32. 2005
    ....
  63. ncbi A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro
    Xu Wang
    School of Life Sciences, Yunnan Normal University, Kunming, Yunnan, 650092, People's Republic of China
    Mutagenesis 18:81-6. 2003
    ....
  64. ncbi An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  65. ncbi hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo
    Raluca A Mateuca
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Mutagenesis 23:35-41. 2008
    ..Understanding the complexity of the relationships between exposure, DNA repair and MN frequencies require larger scale studies and complementary biomarkers...
  66. ncbi Report from the in vitro micronucleus assay working group
    Micheline Kirsch-Volders
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, Brussels 1050, Belgium
    Mutat Res 540:153-63. 2003
    ..7. Statistics: statistical significance should not be the sole factor for determining positive results. Biological meaning should serve as a guideline. Examples of statistical analyses are given...
  67. ncbi Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes
    Michiyo Kimura
    The National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Nutr 134:48-56. 2004
    ..042). This preliminary investigation suggests that MTHFR C677T polymorphism and riboflavin affect genome instability; however, the effect is relatively small compared with that of folic acid...
  68. ncbi The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
    ....
  69. ncbi Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers
    Randa A El-Zein
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 1439, USA
    Cancer Epidemiol Biomarkers Prev 17:1111-9. 2008
    ..9-100.0), PPV = 98.7 and NPV = 95.6. The simplicity, rapidity, and sensitivity of the assay together with potential for automation make it a valuable tool for screening and prioritizing potential cases for intensive screening...
  70. ncbi A comparison of folic acid deficiency-induced genomic instability in lymphocytes of breast cancer patients and normal non-cancer controls from a Chinese population in Yunnan
    Xu Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China
    Mutagenesis 21:41-7. 2006
    ....
  71. ncbi The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  72. ncbi Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21
    Xu Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Mutat Res 551:167-80. 2004
    ..MF was not more efficient than FA in preventing aneuploidy in this in vitro system. We conclude that folate deficiency is a risk factor for chromosomes 17 and 21 aneuploidy...
  73. ncbi Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes
    Susan T Mashiyama
    Department of Cell and Molecular Biology, University of California, Berkley, CA 94720, USA
    Anal Biochem 330:58-69. 2004
    ..The assay requires 3 microg of DNA per folate-deficient sample, but more may be required for baseline DNA-uracil detection in healthy humans...
  74. ncbi Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project
    Stefano Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi, Genoa, Italy
    Mutat Res 543:155-66. 2003
    ..The presence of an interaction between smoking habit and occupational exposure to genotoxic agents should be always tested...
  75. ncbi Health benefits of herbs and spices: the past, the present, the future
    Linda C Tapsell
    National Centre of Excellence in Functional Foods, University of Wollongong, NSW
    Med J Aust 185:S4-24. 2006
    ..With time, we can expect to see a greater body of scientific evidence supporting the benefits of herbs and spices in the overall maintenance of health and protection from disease...
  76. ncbi Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells
    Ayako Sugisawa
    Department of Food Science Research for Health, IAI National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan
    Mutat Res 559:97-103. 2004
    ..These results suggest that physiological concentration of tea constituents are not genotoxic but rather anti-genotoxic against ROS, although their preventive effects are slightly different depending on their chemical structure...