M A Febbraio
Kraakman M, Kammoun H, Allen T, Deswaerte V, Henstridge D, Estevez E, et al
. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab. 2015;21:403-16 pubmed publisher
Febbraio M, Rose John S, Pedersen B. Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases?. Clin Pharmacol Ther. 2010;87:396-8 pubmed publisher
..Although this treatment will certainly help in managing inflammatory disorders such as RA, we suggest that side effects of such blockade may be excess weight gain and hyperlipidemia. ..
Henstridge D, Bruce C, Pang C, Lancaster G, Allen T, Estevez E, et al
. Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice. Diabetologia. 2012;55:2769-2778 pubmed publisher
..Constitutive activation of JNK in skeletal muscle impairs insulin signalling at the level of IRS-1 and Akt, a process which results in the disruption of normal glucose clearance into the muscle. ..
Henstridge D, Bruce C, Drew B, Tory K, Kolonics A, Estevez E, et al
. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 2014;63:1881-94 pubmed publisher
..Thus, the increased oxidative metabolism associated with activation of HSP72 has potential clinical implications not only for type 2 diabetes but also for other disorders where mitochondrial function is compromised. ..