Research Topics
Species | Andrew J SinclairSummaryAffiliation: Deakin University Country: Australia Publications
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Publications
Omega 3 fatty acids and the brain: review of studies in depressionAndrew J Sinclair
School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
Asia Pac J Clin Nutr 16:391-7. 2007..It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties...
Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary sourceDenovan P Begg
School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia
Hypertens Res 33:808-13. 2010..The differences observed between DEF, SUF-F and SUF-C phenotypes indicate that body fat and leptin may be involved in omega-3 fatty acid deficiency hypertension...- Effects of zinc and DHA on the epigenetic regulation of human neuronal cellsNadia Sadli
NeuroAllergy Research Laboratory NARL, School of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia
Cell Physiol Biochem 29:87-98. 2012..Our novel findings show the opposing effects of zinc and DHA on the epigenetic regulation of human neuronal cells and highlight the potential benefit of dietary intake of DHA for management of neurodegenerative diseases... - Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertensionDenovan P Begg
School of Medicine, Deakin University, Geelong, Victoria, Australia
Hypertens Res 35:381-7. 2012..The data may indicate that hypertension resulting from ω-3 DEF is mediated by the central adrenergic system... - Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cellsGunveen Kaur
Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, 3217 Victoria, Australia
Prostaglandins Leukot Essent Fatty Acids 85:155-61. 2011..The gene expression profiling of the lipogenic genes repeated at 8h confirmed that the inhibitory effect of DPA on mRNA expression levels of the lipogenic genes was most likely due to DPA itself and not due to its conversion into EPA... - Docosapentaenoic acid (22:5n-3): a review of its biological effectsGunveen Kaur
Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, 3217 Victoria, Australia
Prog Lipid Res 50:28-34. 2011..However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA... - Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in ratsGunveen Kaur
School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds 3217, Victoria, Australia
Br J Nutr 103:32-7. 2010..Future studies should examine the physiological effect of DPA in tissues such as liver and heart... - A short-term n-3 DPA supplementation study in humansEliza Miller
School of Exercise and Nutrition Sciences, Deakin University, Burwood, Vic, 3126, Australia
Eur J Nutr 52:895-904. 2013..The aim of this study was to investigate the uptake and incorporation of pure DPA and EPA into human plasma and RBC lipids... - Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acidsGiovanni M Turchini
School of Life and Environmental Sciences, Deakin University, Warrnambool, Vic, Australia
Crit Rev Food Sci Nutr 52:795-803. 2012..Such information, when available, would then avoid misleading information and empower consumers to make a more informed choice in their food purchasing behavior... 
Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytesElizabeth Manickam
Molecular Nutrition Unit, School of Exercise and Nutrition Sciences, Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University, Melbourne, Victoria, Australia
Lipids Health Dis 9:57. 2010..Cells were supplemented with 100 microM FA during 7-day differentiation...- Thirst deficits in aged rats are reversed by dietary omega-3 fatty acid supplementationDenovan P Begg
School of Psychological Science, La Trobe University, Melbourne, Victoria, Australia
Neurobiol Aging 33:2422-30. 2012..Hypothalamic PGE(2) was negatively correlated with drinking induced by both dehydration and hypertonicity. The results indicate that PGE(2) may be the underlying mechanism of the reduced thirst observed in aging... - Dietary protein level interacts with omega-3 polyunsaturated fatty acid deficiency to induce hypertensionDenovan P Begg
School of Medicine, Deakin University, Geelong, Australia
Am J Hypertens 23:125-8. 2010..We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in omega-3 fatty acids... - The role of eicosanoids in the brainDaniella Tassoni
Deakin University, School of Exercise and Nutrition Sciences, 221 Burwood Highway, Burwood, Victoria 3125, Australia
Asia Pac J Clin Nutr 17:220-8. 2008..In contrast, DHA-derived compounds can prevent neuroinflammation. Clearly, the eicosanoids are very important for the normal functioning of the brain, while the PUFA themselves are important in membrane structure and function... - Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cellsCenk Suphioglu
Faculty of Science and Technology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia
Br J Nutr 103:344-51. 2010..Such novel information provides possible clues to the molecular basis of neuroprotection by Zn and DHA that may contribute to the future treatment, prevention and management of neurodegenerative diseases such as Alzheimer's disease... - Does perinatal omega-3 polyunsaturated fatty acid deficiency increase appetite signaling?Michael L Mathai
Howard Florey Institute, University of Melbourne, 3010 Victoria, Australia
Obes Res 12:1886-94. 2004..To investigate the effect of maternal dietary omega-3 polyunsaturated fatty acid (PUFA) deficiency and repletion on food appetite signaling... - Immune function and adjustment style: do they predict survival in breast cancer?Richard H Osborne
Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Australia
Psychooncology 13:199-210. 2004.... - Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiencyJames A Armitage
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, 3010 Victoria, Australia
Lipids 38:459-64. 2003..These findings indicate that inadequate levels of DHA in the perinatal period are associated with altered blood pressure control in later life. The way in which these long-term effects are produced remains to be elucidated... - Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acidsBarbara J Meyer
Department of Biomedical Science and Smart Foods Centre, University of Wollongong, Wollongong NSW 2522, Australia
Lipids 38:391-8. 2003..2 g per day) and emphasize the need for strategies to increase the availability and consumption of n-3-containing foods... - Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humansYolande L Yep
Department of Food Science, RMIT University, Melbourne, Victoria, Australia
Asia Pac J Clin Nutr 11:285-91. 2002..05) at the endpoint compared with the baseline. This study showed that a low dose of LC n-3 PUFA, consumed as MTO-enriched bread, was bioavailable, as measured by an increase in LC n-3 PUFA levels in the plasma of human subjects... - Relationship between platelet phospholipid FA and mean platelet volume in healthy menDuo Li
Department of Food Science, RMIT University, Melbourne 3001, Australia
Lipids 37:901-6. 2002..003) and 22:5n-3 (P = 0.001). The present data suggest that 22:5n-3 and 20:3n-6 may play a role in the structural function of the platelet membrane... - Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthoodAnura P Jayasooriya
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria 3052, Australia
Proc Natl Acad Sci U S A 102:7133-8. 2005..Conceivably, the influence of dietary omega-3 PUFA on brain zinc metabolism could explain the observation made in population studies that the consumption of fish is associated with a reduced risk of dementia and Alzheimer's disease... - Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expressionKlara Kitajka
Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, H 6701, Szeged, Hungary
Proc Natl Acad Sci U S A 101:10931-6. 2004.... - Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human healthEric N Ponnampalam
Department of Food Science, RMIT University, Melbourne, Victoria 3001, Australia
Asia Pac J Clin Nutr 15:21-9. 2006..Data from the present study show that grain feeding decreases functional lipid components (long chain n-3 FA and CLA) in Australian beef regardless of meat cuts, while increasing total trans 18:1 and saturated FA levels... - Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletionDuo Li
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China
Prostaglandins Leukot Essent Fatty Acids 74:391-9. 2006..The increased ALA and reduced DHA proportions in the animals re-fed ALA in later life are consistent with a dysfunction or down-regulation of the conversion of ALA to 18:4n-3 by the delta-6 desaturase... - Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivoKaren J Murphy
University of Adelaide, White Campus, PMB1, Glen Osmond, South Australia, Australia 5064
Asia Pac J Clin Nutr 15:418-24. 2006..Further studies are warranted including dose response trials and studies in populations with inflammatory conditions... - Facts on fatsElaine W T Chong
Centre for Eye Research Australia, The University of Melbourne, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 34:464-71. 2006..This review aims to give an overview of fatty acids, particularly the trans-unsaturated fatty acids, and the relevant food groups... - Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohortAllison M Hodge
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Nutr Metab Cardiovasc Dis 17:415-26. 2007.... - Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing aqueous outflowChristine T O Nguyen
Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
Invest Ophthalmol Vis Sci 48:756-62. 2007..To determine whether there is an association between dietary omega-3 (omega-3) fatty acid intake, age, and intraocular pressure (IOP) caused by altered aqueous outflow... - Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acidAllison M Hodge
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Am J Clin Nutr 86:189-97. 2007..Dietary fatty acids may be associated with diabetes but are difficult to measure accurately... - The role of omega-3 fatty acids in mood disordersLauren A Stahl
La Trobe University, School of Psychological Science, Bundoora, Vic, Australia
Curr Opin Investig Drugs 9:57-64. 2008.... - Retinal sensitivity loss in third-generation n-3 PUFA-deficient ratsHarrison S Weisinger
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
Lipids 37:759-65. 2002..However, the benefit for retinal function of adding preformed DHA to diets already replete in n-3 PUFA remains unclear...