Andrew J Sinclair

Summary

Affiliation: Deakin University
Country: Australia

Publications

  1. ncbi request reprint Omega 3 fatty acids and the brain: review of studies in depression
    Andrew J Sinclair
    School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Asia Pac J Clin Nutr 16:391-7. 2007
  2. ncbi request reprint Orally administered [¹⁴C]DPA and [¹⁴C]DHA are metabolised differently to [¹⁴C]EPA in rats
    Gunveen Kaur
    Metabolic Research Unit, Deakin University, Waurn Ponds, 3217 Victoria, Australia
    Br J Nutr 109:441-8. 2013
  3. doi request reprint A short-term n-3 DPA supplementation study in humans
    Eliza Miller
    School of Exercise and Nutrition Sciences, Deakin University, Burwood, Vic, 3126, Australia
    Eur J Nutr 52:895-904. 2013
  4. doi request reprint Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source
    Denovan P Begg
    School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia
    Hypertens Res 33:808-13. 2010
  5. doi request reprint Effects of zinc and DHA on the epigenetic regulation of human neuronal cells
    Nadia Sadli
    NeuroAllergy Research Laboratory NARL, School of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia
    Cell Physiol Biochem 29:87-98. 2012
  6. pmc Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation
    Ramez Alhazzaa
    School of Life and Environmental Sciences, Deakin University, Victoria, Australia
    PLoS ONE 8:e73719. 2013
  7. doi request reprint Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension
    Denovan P Begg
    School of Medicine, Deakin University, Geelong, Victoria, Australia
    Hypertens Res 35:381-7. 2012
  8. doi request reprint Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells
    Gunveen Kaur
    Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, 3217 Victoria, Australia
    Prostaglandins Leukot Essent Fatty Acids 85:155-61. 2011
  9. doi request reprint Docosapentaenoic acid (22:5n-3): a review of its biological effects
    Gunveen Kaur
    Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, 3217 Victoria, Australia
    Prog Lipid Res 50:28-34. 2011
  10. doi request reprint Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats
    Gunveen Kaur
    School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds 3217, Victoria, Australia
    Br J Nutr 103:32-7. 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Omega 3 fatty acids and the brain: review of studies in depression
    Andrew J Sinclair
    School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Asia Pac J Clin Nutr 16:391-7. 2007
    ..It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties...
  2. ncbi request reprint Orally administered [¹⁴C]DPA and [¹⁴C]DHA are metabolised differently to [¹⁴C]EPA in rats
    Gunveen Kaur
    Metabolic Research Unit, Deakin University, Waurn Ponds, 3217 Victoria, Australia
    Br J Nutr 109:441-8. 2013
    ..The higher incorporation of DHA and DPA into the heart and skeletal muscle, compared with EPA, suggests that these C22 n-3 PUFA might play an important role in these tissues...
  3. doi request reprint A short-term n-3 DPA supplementation study in humans
    Eliza Miller
    School of Exercise and Nutrition Sciences, Deakin University, Burwood, Vic, 3126, Australia
    Eur J Nutr 52:895-904. 2013
    ..The aim of this study was to investigate the uptake and incorporation of pure DPA and EPA into human plasma and RBC lipids...
  4. doi request reprint Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source
    Denovan P Begg
    School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia
    Hypertens Res 33:808-13. 2010
    ..The differences observed between DEF, SUF-F and SUF-C phenotypes indicate that body fat and leptin may be involved in omega-3 fatty acid deficiency hypertension...
  5. doi request reprint Effects of zinc and DHA on the epigenetic regulation of human neuronal cells
    Nadia Sadli
    NeuroAllergy Research Laboratory NARL, School of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia
    Cell Physiol Biochem 29:87-98. 2012
    ..Our novel findings show the opposing effects of zinc and DHA on the epigenetic regulation of human neuronal cells and highlight the potential benefit of dietary intake of DHA for management of neurodegenerative diseases...
  6. pmc Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation
    Ramez Alhazzaa
    School of Life and Environmental Sciences, Deakin University, Victoria, Australia
    PLoS ONE 8:e73719. 2013
    ..The FAMB proved to be a powerful and inexpensive method to generate a detailed description of the kinetics of n-3 LC-PUFA biosynthesis enzymes activities in vitro...
  7. doi request reprint Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension
    Denovan P Begg
    School of Medicine, Deakin University, Geelong, Victoria, Australia
    Hypertens Res 35:381-7. 2012
    ..The data may indicate that hypertension resulting from ω-3 DEF is mediated by the central adrenergic system...
  8. doi request reprint Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells
    Gunveen Kaur
    Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, 3217 Victoria, Australia
    Prostaglandins Leukot Essent Fatty Acids 85:155-61. 2011
    ..The gene expression profiling of the lipogenic genes repeated at 8h confirmed that the inhibitory effect of DPA on mRNA expression levels of the lipogenic genes was most likely due to DPA itself and not due to its conversion into EPA...
  9. doi request reprint Docosapentaenoic acid (22:5n-3): a review of its biological effects
    Gunveen Kaur
    Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, 3217 Victoria, Australia
    Prog Lipid Res 50:28-34. 2011
    ..However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA...
  10. doi request reprint Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats
    Gunveen Kaur
    School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds 3217, Victoria, Australia
    Br J Nutr 103:32-7. 2010
    ..Future studies should examine the physiological effect of DPA in tissues such as liver and heart...
  11. doi request reprint Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids
    Giovanni M Turchini
    School of Life and Environmental Sciences, Deakin University, Warrnambool, Vic, Australia
    Crit Rev Food Sci Nutr 52:795-803. 2012
    ..Such information, when available, would then avoid misleading information and empower consumers to make a more informed choice in their food purchasing behavior...
  12. pmc Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes
    Elizabeth Manickam
    Molecular Nutrition Unit, School of Exercise and Nutrition Sciences, Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University, Melbourne, Victoria, Australia
    Lipids Health Dis 9:57. 2010
    ..Cells were supplemented with 100 microM FA during 7-day differentiation...
  13. pmc Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment
    James F Markworth
    School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 305:R1281-96. 2013
    ....
  14. doi request reprint Thirst deficits in aged rats are reversed by dietary omega-3 fatty acid supplementation
    Denovan P Begg
    School of Psychological Science, La Trobe University, Melbourne, Victoria, Australia
    Neurobiol Aging 33:2422-30. 2012
    ..Hypothalamic PGE(2) was negatively correlated with drinking induced by both dehydration and hypertonicity. The results indicate that PGE(2) may be the underlying mechanism of the reduced thirst observed in aging...
  15. doi request reprint Dietary protein level interacts with omega-3 polyunsaturated fatty acid deficiency to induce hypertension
    Denovan P Begg
    School of Medicine, Deakin University, Geelong, Australia
    Am J Hypertens 23:125-8. 2010
    ..We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in omega-3 fatty acids...
  16. ncbi request reprint The role of eicosanoids in the brain
    Daniella Tassoni
    Deakin University, School of Exercise and Nutrition Sciences, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Asia Pac J Clin Nutr 17:220-8. 2008
    ..In contrast, DHA-derived compounds can prevent neuroinflammation. Clearly, the eicosanoids are very important for the normal functioning of the brain, while the PUFA themselves are important in membrane structure and function...
  17. doi request reprint Comparison of the bioavailability of docosapentaenoic acid (DPA, 22:5n-3) and eicosapentaenoic acid (EPA, 20:5n-3) in the rat
    Samaneh Ghasemi Fard
    Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia
    Prostaglandins Leukot Essent Fatty Acids 90:23-6. 2014
    ..This study showed that DPA and EPA, both provided in free form, are metabolised differently, despite being chemically similar. ..
  18. doi request reprint Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells
    Cenk Suphioglu
    Faculty of Science and Technology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia
    Br J Nutr 103:344-51. 2010
    ..Such novel information provides possible clues to the molecular basis of neuroprotection by Zn and DHA that may contribute to the future treatment, prevention and management of neurodegenerative diseases such as Alzheimer's disease...
  19. ncbi request reprint Does perinatal omega-3 polyunsaturated fatty acid deficiency increase appetite signaling?
    Michael L Mathai
    Howard Florey Institute, University of Melbourne, 3010 Victoria, Australia
    Obes Res 12:1886-94. 2004
    ..To investigate the effect of maternal dietary omega-3 polyunsaturated fatty acid (PUFA) deficiency and repletion on food appetite signaling...
  20. ncbi request reprint The role of omega-3 fatty acids in mood disorders
    Lauren A Stahl
    La Trobe University, School of Psychological Science, Bundoora, Vic, Australia
    Curr Opin Investig Drugs 9:57-64. 2008
    ....
  21. ncbi request reprint Relationship between platelet phospholipid FA and mean platelet volume in healthy men
    Duo Li
    Department of Food Science, RMIT University, Melbourne 3001, Australia
    Lipids 37:901-6. 2002
    ..003) and 22:5n-3 (P = 0.001). The present data suggest that 22:5n-3 and 20:3n-6 may play a role in the structural function of the platelet membrane...
  22. ncbi request reprint Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans
    Yolande L Yep
    Department of Food Science, RMIT University, Melbourne, Victoria, Australia
    Asia Pac J Clin Nutr 11:285-91. 2002
    ..05) at the endpoint compared with the baseline. This study showed that a low dose of LC n-3 PUFA, consumed as MTO-enriched bread, was bioavailable, as measured by an increase in LC n-3 PUFA levels in the plasma of human subjects...
  23. ncbi request reprint Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids
    Barbara J Meyer
    Department of Biomedical Science and Smart Foods Centre, University of Wollongong, Wollongong NSW 2522, Australia
    Lipids 38:391-8. 2003
    ..2 g per day) and emphasize the need for strategies to increase the availability and consumption of n-3-containing foods...
  24. ncbi request reprint Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency
    James A Armitage
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, 3010 Victoria, Australia
    Lipids 38:459-64. 2003
    ..These findings indicate that inadequate levels of DHA in the perinatal period are associated with altered blood pressure control in later life. The way in which these long-term effects are produced remains to be elucidated...
  25. ncbi request reprint Immune function and adjustment style: do they predict survival in breast cancer?
    Richard H Osborne
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Australia
    Psychooncology 13:199-210. 2004
    ....
  26. pmc Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression
    Klara Kitajka
    Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, H 6701, Szeged, Hungary
    Proc Natl Acad Sci U S A 101:10931-6. 2004
    ....
  27. pmc Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood
    Anura P Jayasooriya
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 102:7133-8. 2005
    ..Conceivably, the influence of dietary omega-3 PUFA on brain zinc metabolism could explain the observation made in population studies that the consumption of fish is associated with a reduced risk of dementia and Alzheimer's disease...
  28. ncbi request reprint Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human health
    Eric N Ponnampalam
    Department of Food Science, RMIT University, Melbourne, Victoria 3001, Australia
    Asia Pac J Clin Nutr 15:21-9. 2006
    ..Data from the present study show that grain feeding decreases functional lipid components (long chain n-3 FA and CLA) in Australian beef regardless of meat cuts, while increasing total trans 18:1 and saturated FA levels...
  29. ncbi request reprint Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion
    Duo Li
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China
    Prostaglandins Leukot Essent Fatty Acids 74:391-9. 2006
    ..The increased ALA and reduced DHA proportions in the animals re-fed ALA in later life are consistent with a dysfunction or down-regulation of the conversion of ALA to 18:4n-3 by the delta-6 desaturase...
  30. ncbi request reprint Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo
    Karen J Murphy
    University of Adelaide, White Campus, PMB1, Glen Osmond, South Australia, Australia 5064
    Asia Pac J Clin Nutr 15:418-24. 2006
    ..Further studies are warranted including dose response trials and studies in populations with inflammatory conditions...
  31. ncbi request reprint Facts on fats
    Elaine W T Chong
    Centre for Eye Research Australia, The University of Melbourne, Melbourne, Victoria, Australia
    Clin Experiment Ophthalmol 34:464-71. 2006
    ..This review aims to give an overview of fatty acids, particularly the trans-unsaturated fatty acids, and the relevant food groups...
  32. ncbi request reprint Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort
    Allison M Hodge
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
    Nutr Metab Cardiovasc Dis 17:415-26. 2007
    ....
  33. ncbi request reprint Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing aqueous outflow
    Christine T O Nguyen
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
    Invest Ophthalmol Vis Sci 48:756-62. 2007
    ..To determine whether there is an association between dietary omega-3 (omega-3) fatty acid intake, age, and intraocular pressure (IOP) caused by altered aqueous outflow...
  34. ncbi request reprint Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid
    Allison M Hodge
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
    Am J Clin Nutr 86:189-97. 2007
    ..Dietary fatty acids may be associated with diabetes but are difficult to measure accurately...
  35. ncbi request reprint Retinal sensitivity loss in third-generation n-3 PUFA-deficient rats
    Harrison S Weisinger
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    Lipids 37:759-65. 2002
    ..However, the benefit for retinal function of adding preformed DHA to diets already replete in n-3 PUFA remains unclear...