Johnson Mak

Summary

Affiliation: Deakin University
Country: Australia

Publications

  1. pmc Visualising single molecules of HIV-1 and miRNA nucleic acids
    Kate L Jones
    Centre for Virology, Burnet Institute, Melbourne, Australia
    BMC Cell Biol 14:21. 2013
  2. pmc The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA
    Cameron P Keating
    Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Nucleic Acids Res 37:945-56. 2009
  3. pmc X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells
    Kate L Jones
    Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:18603-14. 2010
  4. pmc Primary T-lymphocytes rescue the replication of HIV-1 DIS RNA mutants in part by facilitating reverse transcription
    Kate L Jones
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Nucleic Acids Res 36:1578-88. 2008
  5. ncbi request reprint Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner
    Melissa K Hill
    Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Curr HIV Res 5:69-78. 2007
  6. pmc Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol
    Anna Figueiredo
    Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    PLoS Pathog 2:e119. 2006
  7. pmc HIV taken by STORM: super-resolution fluorescence microscopy of a viral infection
    Candida F Pereira
    Centre for Virology, Burnet Institute, Melbourne, Australia
    Virol J 9:84. 2012
  8. pmc Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer
    Johanna Wapling
    Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Road, GPO Box 2284, Melbourne, Victoria 3001, Australia
    J Virol 79:10247-57. 2005
  9. ncbi request reprint Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: underlying mechanisms and modulation by adjunctive cytokine therapy
    Katherine Kedzierska
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Punt and Commercials Rds, Prahran, Melbourne, VIC 3181, Australia
    J Clin Virol 26:247-63. 2003
  10. ncbi request reprint The packaging and maturation of the HIV-1 Pol proteins
    Melissa Hill
    Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Curr HIV Res 3:73-85. 2005

Collaborators

Detail Information

Publications18

  1. pmc Visualising single molecules of HIV-1 and miRNA nucleic acids
    Kate L Jones
    Centre for Virology, Burnet Institute, Melbourne, Australia
    BMC Cell Biol 14:21. 2013
    ..Here, we offer a generic and highly sensitive visualization approach (oligo fluorescent in situ hybridization, O-FISH) that can be used to detect such nucleic acids using a single-oligonucleotide probe of 19-26 nucleotides in length...
  2. pmc The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA
    Cameron P Keating
    Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Nucleic Acids Res 37:945-56. 2009
    ....
  3. pmc X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells
    Kate L Jones
    Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:18603-14. 2010
    ..These differences may result from activation of distinct signaling cascades and/or infection of divergent T-lymphocyte subpopulations...
  4. pmc Primary T-lymphocytes rescue the replication of HIV-1 DIS RNA mutants in part by facilitating reverse transcription
    Kate L Jones
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Nucleic Acids Res 36:1578-88. 2008
    ....
  5. ncbi request reprint Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner
    Melissa K Hill
    Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Curr HIV Res 5:69-78. 2007
    ..The p1 proline residues were found to be functionally distinct from P24, P25 and P30 in p6(Gag). This work affords novel insights into our understanding of the role of p1 in HIV-1 replication...
  6. pmc Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol
    Anna Figueiredo
    Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    PLoS Pathog 2:e119. 2006
    ..Furthermore, these drugs can serve as useful probes to further understand processes involved in HIV-1 particle assembly and maturation...
  7. pmc HIV taken by STORM: super-resolution fluorescence microscopy of a viral infection
    Candida F Pereira
    Centre for Virology, Burnet Institute, Melbourne, Australia
    Virol J 9:84. 2012
    ....
  8. pmc Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer
    Johanna Wapling
    Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Road, GPO Box 2284, Melbourne, Victoria 3001, Australia
    J Virol 79:10247-57. 2005
    ..The inhibition of RT activity is most likely due to a defect in RT maturation, suggesting that RT dimerization represents a valid drug target for chemotherapeutic intervention...
  9. ncbi request reprint Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: underlying mechanisms and modulation by adjunctive cytokine therapy
    Katherine Kedzierska
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Punt and Commercials Rds, Prahran, Melbourne, VIC 3181, Australia
    J Clin Virol 26:247-63. 2003
    ..In this review we present examples of clinical applications of GM-CSF and IFN-gamma therapy for the treatment of opportunistic infections in HIV-infected individuals receiving antiretroviral drugs...
  10. ncbi request reprint The packaging and maturation of the HIV-1 Pol proteins
    Melissa Hill
    Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Curr HIV Res 3:73-85. 2005
    ..Effective inhibitors of PR and RT are well established and we will discuss the next generation inhibitors of these enzymes as well recent investigations that have highlighted the potential of IN and RNase H as antiretroviral targets...
  11. doi request reprint Early events of HIV-1 infection: can signaling be the next therapeutic target?
    Kate L Jones
    Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia
    J Neuroimmune Pharmacol 6:269-83. 2011
    ..We argue that these pathways may represent novel targets for antiviral therapy...
  12. pmc RNA interference: more than a research tool in the vertebrates' adaptive immunity
    Johnson Mak
    Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Retrovirology 2:35. 2005
    ....
  13. pmc Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton
    Paul U Cameron
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Proc Natl Acad Sci U S A 107:16934-9. 2010
    ..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue...
  14. ncbi request reprint Lipid membrane; a novel target for viral and bacterial pathogens
    David J Hawkes
    Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Roads, Melbourne, 3004 Victoria, Australia
    Curr Drug Targets 7:1615-21. 2006
    ....
  15. pmc Labeling of multiple HIV-1 proteins with the biarsenical-tetracysteine system
    Candida F Pereira
    Centre for Virology, Burnet Institute, Melbourne, Victoria, Australia
    PLoS ONE 6:e17016. 2011
    ..This approach can be adapted to other viral systems for the visualization of the interplay between virus and host cell during infection...
  16. doi request reprint The origin of genetic diversity in HIV-1
    Redmond P Smyth
    Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia
    Virus Res 169:415-29. 2012
    ..Understanding the mechanistic origin of genetic diversity is essential to combating HIV...
  17. pmc Proline residues within spacer peptide p1 are important for human immunodeficiency virus type 1 infectivity, protein processing, and genomic RNA dimer stability
    Melissa K Hill
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Institute for Medical Research and Public Health, Monash University, Melbourne, Victoria, Australia
    J Virol 76:11245-53. 2002
    ..The unique ability of proline to confer conformational constraints on a peptide suggests that the correct folding of p1 may be important for viral function...
  18. pmc Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity
    Heidi E Drummer
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    PLoS Pathog 9:e1003218. 2013
    ..We propose that this represents a mechanism for functional adaptation of the gp120-gp41 association site to an evolving glycan shield in a setting of NAb selection...