Research Topics
| B A KunzSummaryAffiliation: Deakin University Country: Australia Publications
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Detail Information
Publications
Inhibitors of thymine nucleotide biosynthesis: antimetabolites that provoke genetic change via primary non-DNA targetsB A Kunz
School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, Australia
Mutat Res 355:129-40. 1996..These agents induce genetic change not by attacking DNA, but by interfering with the control of DNA precursor metabolism. This review surveys the genetic effects attributable to selected representatives of this class of antimetabolites...
Components of nucleotide excision repair and DNA damage tolerance in Arabidopsis thalianaBernard A Kunz
School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, Australia
Environ Mol Mutagen 45:115-27. 2005....
DNA damage-induced mutation: tolerance via translesion synthesisB A Kunz
School of Biological and Chemical Sciences, Deakin University, Victoria 3217, Geelong, Australia
Mutat Res 451:169-85. 2000..In this article, we review and link the evidence for translesion synthesis in yeast, and the involvement of nonreplicative DNA polymerases, to recent findings in mammalian cells...
Differences in the mutational specificities of sunlight and UVB radiation suggest a role for transversion-inducing DNA damage in solar photocarcinogenesisB A Kunz
School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, Australia
Mutat Res 422:77-83. 1998..The relevance of these findings to skin cancer is discussed...
Defects in base excision repair combined with elevated intracellular dCTP levels dramatically reduce mutation induction in yeast by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidineB A Kunz
School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, Australia
Environ Mol Mutagen 32:173-8. 1998..In addition, the results point to a role for AP sites in the production of some EMS- and MNNG-induced G x C --> A x T transitions as well as other substitutions in the dcd1 strain...
DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiaeB A Kunz
School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, Australia
Genetics 148:1491-505. 1998..The implications of selected aspects of the data are considered with respect to the mechanisms of spontaneous mutagenesis...
Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2Heather J Anderson
School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3217, Australia
Plant J 55:895-908. 2008..These observations indicate that AtPoleta can catalyse TLS past UV-induced DNA damage, and links the biological activity of AtPoleta in UV-irradiated cells to PCNA2 and PCNA- and ubiquitin-binding motifs in AtPoleta...
Detection of Arabidopsis thaliana AtRAD1 cDNA variants and assessment of function by expression in a yeast rad1 mutantEdward J Vonarx
School of Biological and Chemical Sciences, Deakin University, Geelong, Vic. 3217, Australia
Gene 296:1-9. 2002..These results suggest that alternative splicing may modulate the levels of functional AtRad1 protein...
Arabidopsis homologue of human transcription factor IIH/nucleotide excision repair factor p44 can function in transcription and DNA repair and interacts with AtXPDEdward J Vonarx
School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3217, Australia
Plant J 46:512-21. 2006..Our results indicate that AtGTF2H2 can act in transcription and NER, and suggest that it participates in both processes in Arabidopsis as part of TFIIH...
UV-induced DNA damage promotes resistance to the biotrophic pathogen Hyaloperonospora parasitica in ArabidopsisBernard A Kunz
School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3217, Australia
Plant Physiol 148:1021-31. 2008..They also suggest UV treatment can circumvent the requirement for recognition of H. parasitica molecules by Arabidopsis proteins to activate an immune response...
Plant responses to UV radiation and links to pathogen resistanceBernard A Kunz
School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3217, Australia
Int Rev Cytol 255:1-40. 2006..Indeed, pathogen resistance can be enhanced by UV treatment, and recent experiments suggest DNA damage and its processing may have a role...
Age and exposure to arsenic alter base excision repair transcript levels in miceMegan J Osmond
School of Life and Environmental Sciences, Deakin University, Pigdons Road, Geelong, Victoria 3217, Australia
Mutagenesis 25:517-22. 2010..Reduction of BER transcript levels in 24-week-old mice exposed to As for 2 weeks suggests As may potentiate sensitivity to itself in older animals...
