M Leigh Ackland

Summary

Affiliation: Deakin University
Country: Australia

Publications

  1. ncbi request reprint PMC42, a novel model for the differentiated human breast
    M L Ackland
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood Campus, Burwood, Victoria, 3125, Australia
    Exp Cell Res 263:14-22. 2001
  2. pmc Zinc deficiency and its inherited disorders -a review
    M Leigh Ackland
    Centre for Cellular and Molecular Biology, Deakin University, Burwood Campus, 221 Burwood Highway, 3125, Burwood, Victoria, Australia
    Genes Nutr 1:41-9. 2006
  3. ncbi request reprint Diesel exhaust particulate matter induces multinucleate cells and zinc transporter-dependent apoptosis in human airway cells
    Margaret Leigh Ackland
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia
    Immunol Cell Biol 85:617-22. 2007
  4. ncbi request reprint Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines
    Margaret Leigh Ackland
    Centre for Cellular and Molecular Biology, Deakin University, Burwood, Victoria
    In Vivo 19:69-76. 2005
  5. pmc Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors
    Stephanie C Lebret
    Deakin University, Burwood Highway, Burwood, Melbourne, 3125, Australia
    Breast Cancer Res 9:R19. 2007
  6. ncbi request reprint Myoepithelial molecular markers in human breast carcinoma PMC42-LA cells are induced by extracellular matrix and stromal cells
    Stephanie C Lebret
    Deakin University, Burwood, Melbourne 3125, Australia
    In Vitro Cell Dev Biol Anim 42:298-307. 2006
  7. ncbi request reprint Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk
    Agnes Michalczyk
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood Campus, 221 Burwood Highway, 3125, Burwood, Victoria, Australia
    Hum Genet 113:202-10. 2003
  8. doi request reprint The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport
    Cenk Suphioglu
    School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia
    FEBS Lett 584:612-8. 2010
  9. pmc Copper transport during lactation in transgenic mice expressing the human ATP7A protein
    Roxana M Llanos
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Hwy, Burwood, VIC 3125, Australia
    Biochem Biophys Res Commun 372:613-7. 2008
  10. doi request reprint Molecular and cellular characterisation of the zinc uptake (Znu) system of Nostoc punctiforme
    Lee Hudek
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Vic, Australia
    FEMS Microbiol Ecol 86:149-71. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint PMC42, a novel model for the differentiated human breast
    M L Ackland
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood Campus, Burwood, Victoria, 3125, Australia
    Exp Cell Res 263:14-22. 2001
    ..PMC42 is a novel model for investigations into the molecular mechanisms of carcinogenesis and differentiation in the human breast...
  2. pmc Zinc deficiency and its inherited disorders -a review
    M Leigh Ackland
    Centre for Cellular and Molecular Biology, Deakin University, Burwood Campus, 221 Burwood Highway, 3125, Burwood, Victoria, Australia
    Genes Nutr 1:41-9. 2006
    ....
  3. ncbi request reprint Diesel exhaust particulate matter induces multinucleate cells and zinc transporter-dependent apoptosis in human airway cells
    Margaret Leigh Ackland
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia
    Immunol Cell Biol 85:617-22. 2007
    ..As exposure to diesel exhaust particles is associated with asthma and apoptosis in airway cells, diesel exhaust particles may directly contribute to asthma by inducing epithelial cell death through apoptotic pathway...
  4. ncbi request reprint Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines
    Margaret Leigh Ackland
    Centre for Cellular and Molecular Biology, Deakin University, Burwood, Victoria
    In Vivo 19:69-76. 2005
    ....
  5. pmc Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors
    Stephanie C Lebret
    Deakin University, Burwood Highway, Burwood, Melbourne, 3125, Australia
    Breast Cancer Res 9:R19. 2007
    ..Breast carcinoma is accompanied by changes in the acellular and cellular components of the microenvironment, the latter typified by a switch from fibroblasts to myofibroblasts...
  6. ncbi request reprint Myoepithelial molecular markers in human breast carcinoma PMC42-LA cells are induced by extracellular matrix and stromal cells
    Stephanie C Lebret
    Deakin University, Burwood, Melbourne 3125, Australia
    In Vitro Cell Dev Biol Anim 42:298-307. 2006
    ..Our results demonstrate a key role for the breast microenvironment in the regulation of breast lineage development...
  7. ncbi request reprint Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk
    Agnes Michalczyk
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood Campus, 221 Burwood Highway, 3125, Burwood, Victoria, Australia
    Hum Genet 113:202-10. 2003
    ..This observation, combined with phenotypic differences between the "lethal milk" mouse and the human disorder, suggests that the "lethal milk" mouse is not the corresponding model for the human zinc deficiency condition...
  8. doi request reprint The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport
    Cenk Suphioglu
    School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia
    FEBS Lett 584:612-8. 2010
    ..We propose that the neuroprotective function of DHA is exerted through a reduction in cellular zinc levels that in turn inhibits apoptosis...
  9. pmc Copper transport during lactation in transgenic mice expressing the human ATP7A protein
    Roxana M Llanos
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Hwy, Burwood, VIC 3125, Australia
    Biochem Biophys Res Commun 372:613-7. 2008
    ..These data suggest that ATP7A plays a role in removing excess copper from the mammary epithelial cells rather than supplying copper to milk...
  10. doi request reprint Molecular and cellular characterisation of the zinc uptake (Znu) system of Nostoc punctiforme
    Lee Hudek
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Vic, Australia
    FEMS Microbiol Ecol 86:149-71. 2013
    ..The N. punctiforme zur was also able to complement the E. coli zur(-) mutant...
  11. doi request reprint Effects of zinc and DHA on the epigenetic regulation of human neuronal cells
    Nadia Sadli
    NeuroAllergy Research Laboratory NARL, School of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia
    Cell Physiol Biochem 29:87-98. 2012
    ..Our novel findings show the opposing effects of zinc and DHA on the epigenetic regulation of human neuronal cells and highlight the potential benefit of dietary intake of DHA for management of neurodegenerative diseases...
  12. pmc Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood
    Anura P Jayasooriya
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 102:7133-8. 2005
    ..Conceivably, the influence of dietary omega-3 PUFA on brain zinc metabolism could explain the observation made in population studies that the consumption of fish is associated with a reduced risk of dementia and Alzheimer's disease...
  13. pmc Bioinformatic and expression analyses of genes mediating zinc homeostasis in Nostoc punctiforme
    Lee Hudek
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia
    Appl Environ Microbiol 75:784-91. 2009
    ..These results demonstrate differential regulation of zinc transporters over time, indicating a role for them in zinc homeostasis in N. punctiforme...
  14. ncbi request reprint Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
    Honor Hugo
    Embryology Laboratory, Murdoch Children s Research Institute, The Royal Children s Hospital, Victoria, Australia
    J Cell Physiol 213:374-83. 2007
    ..Finally, perspectives from a clinical and translational viewpoint are discussed...
  15. pmc Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells
    Agnes A Michalczyk
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood Campus, Burwood, VIC 3125, Australia
    Biochem J 364:105-13. 2002
    ..We conclude that hZnT4 is constitutively expressed in the human breast and may be one of the several members of the ZnT family involved in the transport of zinc into milk...
  16. ncbi request reprint Physiological metal uptake by Nostoc punctiforme
    L Hudek
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 181 Burwood Hwy, Burwood, Vic, 3125, Australia
    Biometals 25:893-903. 2012
    ..5 μM Cd(2+), while 2 μM Co(2+) increased Zn(2+) uptake. This study demonstrates that N. punctiforme discriminates between different metals and favourably substitutes their uptake to avoid the toxic effects of particular metals...
  17. doi request reprint Copper levels in buccal cells of vineyard workers engaged in various activities
    Tim Thompson
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Ann Occup Hyg 56:305-14. 2012
    ..It would be determined if occupational exposure of vineyard workers to copper-based sprays was associated with raised body copper levels through analysis of saliva and buccal cells...
  18. doi request reprint Defining the E-cadherin repressor interactome in epithelial-mesenchymal transition: the PMC42 model as a case study
    Honor J Hugo
    VBCRC Invasion and Metastasis Unit, St Vincent s Institute of Medical Research, Melbourne, Vic, Australia
    Cells Tissues Organs 193:23-40. 2011
    ..Finally, we evaluated how these findings may influence approaches to current cancer treatment...
  19. ncbi request reprint Fresh and cultured buccal cells as a source of mRNA and protein for molecular analysis
    Agnes Michalczyk
    Deakin University, Melbourne, Vic, Australia
    Biotechniques 37:262-4, 266-9. 2004
    ..A population of the buccal cells can be maintained in culture for up to 2 weeks using keratinocyte-specific medium in combination with extracellular matrix...
  20. pmc Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells
    Belinda Hardman
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Melbourne Campus, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Biochem J 402:241-50. 2007
    ..These data show for the first time that MNK and WND are differentially regulated by the hormones insulin and oestrogen in human placental cells...
  21. ncbi request reprint Apoptosis may underlie the pathology of zinc-deficient skin
    Dallas Wilson
    Centre for Cellular and Molecular Biology, Deakin University, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:28-37. 2006
    ..This role is consistent with the previously unexplained diverse range of degenerative cellular changes seen at the ultrastructural level in zinc-deficient keratinocytes...
  22. pmc Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: emerging roles
    Sharon La Fontaine
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Int J Biochem Cell Biol 42:206-9. 2010
    ..This review summarizes the recent literature that is revealing the emerging roles of the Cu-ATPases in health and disease...
  23. ncbi request reprint Extracellular matrix induces formation of organoids and changes in cell surface morphology in cultured human breast carcinoma cells PMC42-LA
    M Leigh Ackland
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood Campus, Burwood, Victoria 3125, Australia
    In Vitro Cell Dev Biol Anim 39:428-33. 2003
    ..This is accompanied by organization of the extracellular matrix. PMC42-LA is a relevant model of the human breast for investigations into cell-cell and cell-matrix interactions...
  24. doi request reprint Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models
    David Freestone
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria 3121, Australia
    J Nutr Biochem 25:377-87. 2014
    ....
  25. ncbi request reprint Anthropometric and biochemical markers for nutritional risk among residents within an Australian residential care facility
    Jessica Grieger
    School of Exercise and Nutrition Sciences, Deakin University 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Asia Pac J Clin Nutr 16:178-86. 2007
    ..This indicates that the elderly in long term residential care facilities are at high risk for poor nutritional status, potentially increasing morbidity and mortality...