Research Topics
| Peter A DargavilleSummaryCountry: Australia Publications
| Collaborators
|
Detail Information
Publications
Blood aspiration syndrome as a cause of respiratory distress in the newborn infantEmma Gordon
Department of Neonatology and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia
J Pediatr 142:200-2. 2003..Blood aspiration syndrome is a distinct diagnostic entity that can result in significant respiratory distress in the neonate...
Fluid recovery during lung lavage in meconium aspiration syndromePeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, TAS, Australia Menzies Research Institute, Hobart, TAS, Australia Department of Neonatology, Royal Children s Hospital, Melbourne, Vic, Australia Murdoch Childrens Research Institute, Melbourne, Vic, Australia
Acta Paediatr 102:e90-3. 2013..CONCLUSION: Recovery of instilled lavage fluid is paramount in effective lung lavage in MAS and must be afforded priority in the lavage technique...- Minimally-invasive surfactant therapy in preterm infants on continuous positive airway pressurePeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital, Liverpool Street, Hobart TAS 7000, Australia
Arch Dis Child Fetal Neonatal Ed 98:F122-6. 2013..To evaluate the applicability and potential effectiveness of a technique of minimally-invasive surfactant therapy (MIST) in preterm infants on continuous positive airway pressure (CPAP)... - Lung protective ventilation in extremely preterm infantsPeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, Tasmania, Australia
J Paediatr Child Health 48:740-6. 2012..From a practical perspective, this means setting positive end-expiratory pressure at the lowest value that maintains oxygenation and restricting tidal volume using a volume-targeted mode of ventilation... - Innovation in surfactant therapy I: surfactant lavage and surfactant administration by fluid bolus using minimally invasive techniquesPeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital, University of Tasmania and Neonatal Respiratory Group, Menzies Research Institute Tasmania, Hobart, TAS, Australia
Neonatology 101:326-36. 2012..We are now commencing large-scale clinical trials of this method in preterm infants on CPAP... - Therapeutic lung lavage in meconium aspiration syndrome: a preliminary reportPeter A Dargaville
Department of Neonatology, Royal Children s Hospital, Melbourne, Victoria, Australia
J Paediatr Child Health 43:539-45. 2007..To explore the effects of a large volume lung lavage procedure in ventilated infants with meconium aspiration syndrome... - Comparison of four methods of lung volume recruitment during high frequency oscillatory ventilationAnastasia Pellicano
Department of Neonatology, Royal Children s Hospital, Melbourne, Australia
Intensive Care Med 35:1990-8. 2009..To compare four methods of volume recruitment upon initiation of high frequency oscillatory ventilation (HFOV)... - Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvrePeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Liverpool Street, Hobart, TAS, 7000, Australia
Intensive Care Med 36:1953-61. 2010..To determine whether, during mechanical ventilation, an optimal positive end-expiratory pressure (PEEP) can be identified by measurement of regional tidal volume and compliance [V (T(reg)), C (RS(reg))]... - Randomized controlled trial of lung lavage with dilute surfactant for meconium aspiration syndromePeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, Australia
J Pediatr 158:383-389.e2. 2011..To evaluate whether lung lavage with surfactant changes the duration of mechanical respiratory support or other outcomes in meconium aspiration syndrome (MAS)... - Preliminary evaluation of a new technique of minimally invasive surfactant therapyPeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, Australia
Arch Dis Child Fetal Neonatal Ed 96:F243-8. 2011.... - The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcomePeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital, Hobart, Australia
Pediatrics 117:1712-21. 2006..We sought to examine, in a large cohort of infants within a definable population of live births, the incidence, risk factors, treatments, complications, and outcomes of meconium aspiration syndrome (MAS)... - Surfactant therapy for meconium aspiration syndrome: current statusPeter A Dargaville
Department of Paediatrics, Royal Hobart Hospital, Hobart, Tasmania, Australia
Drugs 65:2569-91. 2005..Several randomised controlled trials of surfactant lavage in MAS are underway, and until the results are known, lavage must be considered an unproven and experimental therapy... - Refining the method of therapeutic lung lavage in meconium aspiration syndromePeter A Dargaville
Neonatal Research Group, Murdoch Children s Research Institute, University of Melbourne, Melbourne, Victoria, Australia
Neonatology 94:160-3. 2008..Therapeutic lung lavage is an emerging treatment for meconium aspiration syndrome (MAS), but the ideal fluid volume and lavage technique remain unclear... - Indicators of optimal lung volume during high-frequency oscillatory ventilation in infantsDavid G Tingay
Neonatal Research, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
Crit Care Med 41:237-44. 2013.... - The effect of suction method, catheter size, and suction pressure on lung volume changes during endotracheal suction in pigletsBeverley Copnell
Neonatal Research, Murdoch Childrens Research Institute, Melbourne, Victoria 3052, Australia
Pediatr Res 66:405-10. 2009..With commonly used suction pressures and catheter sizes, closed suction has no advantage in preventing loss of volume in this animal model... - The effects of closed endotracheal suction on ventilation during conventional and high-frequency oscillatory ventilationNicholas J Kiraly
Neonatal Research, Murdoch Childrens Research Institute, Parkville, Victoria, Australia
Pediatr Res 66:400-4. 2009..We conclude that airway pressures and VT are not maintained during closed endotracheal suction with either CMV or HFOV, and choice of equipment and settings will affect the degree of interruption to ventilation... - A comparison of the effectiveness of open and closed endotracheal suctionBeverley Copnell
Royal Children s Hospital, Department of Neonatology, Flemington Rd, VIC 3052, Parkville, Australia
Intensive Care Med 33:1655-62. 2007..To compare the effectiveness of open and closed endotracheal suction in recovering thin and thick secretions in normal and injured lungs during conventional and high frequency ventilation... - Therapeutic lung lavage in the piglet model of meconium aspiration syndromePeter A Dargaville
Department of Neonatology, Royal Children s Hospital, Flemington Road, Parkville, VIC 3052, Australia
Am J Respir Crit Care Med 168:456-63. 2003..Dilute surfactant lavage using two 15-ml/kg aliquots is an effective therapy in the piglet model of meconium aspiration, and should be evaluated in human infants with this condition... - Trends in use and outcome of newborn infants treated with high frequency ventilation in Australia and New Zealand, 1996-2003David G Tingay
Department of Neonatology, Royal Children s Hospital, Melbourne, Vic, Australia
J Paediatr Child Health 43:160-6. 2007..To examine the use of high frequency ventilation (HFV) to treat newborn infants in Australia and New Zealand and the associated complications and outcomes... - The deflation limb of the pressure-volume relationship in infants during high-frequency ventilationDavid G Tingay
Department of Neonatology, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
Am J Respir Crit Care Med 173:414-20. 2006..Currently, a lack of reliable methods for assessing lung volume limits clinicians' ability to achieve the optimum volume range... - Effects of tidal volume and positive end-expiratory pressure during resuscitation of very premature lambsMegan E Probyn
Department of Physiology, Monash University, Melbourne, VIC 3800, Australia
Acta Paediatr 94:1764-70. 2005..PEEP halved the oxygen requirement compared with no PEEP. Resuscitating premature babies with controlled tidal volumes and PEEP might improve their outcome... - Massive hepatic congenital haemangioma: clinical dilemmasAntonio G De Paoli
Department of Paediatrics, Royal Hobart Hospital, and University of Tasmania, Hobart, Tasmania, Australia
J Paediatr Child Health 43:312-4. 2007..This infant died after withdrawal of neonatal intensive care support, following massive intracerebral haemorrhage. There remains considerable uncertainty regarding the classification of, and therapy for, hepatic vascular anomalies... - Aspiration of bile as a cause of respiratory distress in the newborn infantVanessa Ellison
Department of Neonatology, Royal Children s Hospital, Melbourne, the Department of Newborn Care, Royal Hospital for Women, Sydney, Australia
J Pediatr 144:389-90. 2004..Bile aspiration syndrome should be considered whenever there is early-onset respiratory distress in a neonate with high intestinal obstruction... - Lung volume recruitment after surfactant administration modifies spatial distribution of ventilationInez Frerichs
Department of Anesthesiological Research, University of Gottingen, Germany
Am J Respir Crit Care Med 174:772-9. 2006..Although surfactant replacement therapy is an established treatment in infant respiratory distress syndrome, the optimum strategy for ventilatory management before, during, and after surfactant instillation remains to be elucidated... - Blood gases and pulmonary blood flow during resuscitation of very preterm lambs treated with antenatal betamethasone and/or Curosurf: effect of positive end-expiratory pressureKelly J Crossley
Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
Pediatr Res 62:37-42. 2007..These treatments do not alter the deleterious effects of high levels of PEEP on PBF...