Mahindra T Makhija

Summary

Affiliation: Curtin University of Technology
Country: Australia

Publications

  1. ncbi request reprint De novo design and synthesis of HIV-1 integrase inhibitors
    Mahindra T Makhija
    Pharmaceutical Division, Department of Chemical Technology, University of Mumbai, Matunga, Mumbai 400019, India
    Bioorg Med Chem 12:2317-33. 2004
  2. ncbi request reprint 3D-QSAR and molecular modeling of HIV-1 integrase inhibitors
    Mahindra T Makhija
    Department of Chemical Technology, University of Mumbai, Matunga, India
    J Comput Aided Mol Des 16:181-200. 2002
  3. ncbi request reprint QSAR of HIV-1 integrase inhibitors by genetic function approximation method
    Mahindra T Makhija
    Pharmaceutical Division, Department of Chemical Technology, University of Mumbai, Mumbai 400 019, Matunga, India
    Bioorg Med Chem 10:1483-97. 2002
  4. ncbi request reprint Designing HIV integrase inhibitors--shooting the last arrow
    Mahindra T Makhija
    West Australian Biomedical Research Institute, School of Biomedical Sciences, Curtin University of Technology, Kent Street, Bentley, WA 6102, Australia
    Curr Med Chem 13:2429-41. 2006

Collaborators

Detail Information

Publications4

  1. ncbi request reprint De novo design and synthesis of HIV-1 integrase inhibitors
    Mahindra T Makhija
    Pharmaceutical Division, Department of Chemical Technology, University of Mumbai, Matunga, Mumbai 400019, India
    Bioorg Med Chem 12:2317-33. 2004
    ..Nonetheless, these compounds possess structural features not seen in known HIV-1 integrase inhibitors and thus can serve as excellent leads for further optimization of anti-HIV-1 integrase activity...
  2. ncbi request reprint 3D-QSAR and molecular modeling of HIV-1 integrase inhibitors
    Mahindra T Makhija
    Department of Chemical Technology, University of Mumbai, Matunga, India
    J Comput Aided Mol Des 16:181-200. 2002
    ..The binding site was formed by the amino acid residues 64-67, 116, 148, 151-152, 155-156, and 159. The comparison of coefficient contour maps with the steric and electrostatic properties of the receptor shows high level of compatibility...
  3. ncbi request reprint QSAR of HIV-1 integrase inhibitors by genetic function approximation method
    Mahindra T Makhija
    Pharmaceutical Division, Department of Chemical Technology, University of Mumbai, Mumbai 400 019, Matunga, India
    Bioorg Med Chem 10:1483-97. 2002
    ..Models generated for catechols show that electronic, shape related, and thermodynamic parameters are important whereas for noncatechols, spatial, structural, and thermodynamic properties play an important role for the activity...
  4. ncbi request reprint Designing HIV integrase inhibitors--shooting the last arrow
    Mahindra T Makhija
    West Australian Biomedical Research Institute, School of Biomedical Sciences, Curtin University of Technology, Kent Street, Bentley, WA 6102, Australia
    Curr Med Chem 13:2429-41. 2006
    ..This review details the existing knowledge of the biological functions of the HIV-1 integrase with the focus on its available inhibitors, their disadvantages, and the current trends in designing novel compounds as anti-integrase...