Frank Arfuso


Affiliation: Curtin University of Technology
Country: Australia


  1. Girisa S, Shabnam B, Monisha J, Fan L, Halim C, Arfuso F, et al. Potential of Zerumbone as an Anti-Cancer Agent. Molecules. 2019;24: pubmed publisher
    ..The current review briefly summarizes the modes of action and therapeutic potential of zerumbone against various cancers. ..
  2. Merarchi M, Sethi G, Shanmugam M, Fan L, Arfuso F, Ahn K. Role of Natural Products in Modulating Histone Deacetylases in Cancer. Molecules. 2019;24: pubmed publisher
    ..This review will briefly emphasize the potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors. ..
  3. Raghunath A, Sundarraj K, Arfuso F, Sethi G, Perumal E. Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance. Cancers (Basel). 2018;10: pubmed publisher
    ..This review summarizes the role and mechanism(s) of action of Nrf2 dysregulation in HCC and therapeutic options that can be employed to modulate this transcription factor. ..
  4. Ko J, Arfuso F, Sethi G, Ahn K. Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy. Int J Mol Sci. 2018;19: pubmed publisher
    ..The present review focuses on the potential anti-neoplastic effects of bergamottin in different tumor models and briefly describes the molecular targets affected by this agent. ..
  5. Bhuvanalakshmi G, Gamit N, Patil M, Arfuso F, Sethi G, Dharmarajan A, et al. Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma. Cancers (Basel). 2018;11: pubmed publisher
    ..This study unveils a novel nuclear role for sFRP4 to promote apoptosis by a possible activation of DNA damage machinery in glioblastoma. ..
  6. Jung Y, Hwang S, Sethi G, Fan L, Arfuso F, Ahn K. Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol. Molecules. 2018;23: pubmed publisher
    ..Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies. ..
  7. Bordoloi D, Banik K, Shabnam B, Padmavathi G, Monisha J, Arfuso F, et al. TIPE Family of Proteins and Its Implications in Different Chronic Diseases. Int J Mol Sci. 2018;19: pubmed publisher
    ..This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases. ..
  8. Merarchi M, Sethi G, Fan L, Mishra S, Arfuso F, Ahn K. Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models. Molecules. 2018;23: pubmed publisher
    ..This mini-review briefly describes the potential effects of fangchinoline on important hallmarks of cancer and highlights the molecular targets modulated by this alkaloid in various tumor cell lines and preclinical models. ..
  9. Arora L, Kumar A, Arfuso F, Chng W, Sethi G. The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies. Cancers (Basel). 2018;10: pubmed publisher
    ..e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway. ..

More Information


  1. Sethi G, Shanmugam M, Warrier S, Merarchi M, Arfuso F, Kumar A, et al. Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review. Nutrients. 2018;10: pubmed publisher
  2. Monisha J, Roy N, Padmavathi G, Banik K, Bordoloi D, Khwairakpam A, et al. NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance. Cancers (Basel). 2018;10: pubmed publisher
    ..Thus, from our study, it is evident that downregulation of NGAL activates the mTOR pathway and helps in the progression of oral cancer. ..
  3. Puar Y, Shanmugam M, Fan L, Arfuso F, Sethi G, Tergaonkar V. Evidence for the Involvement of the Master Transcription Factor NF-?B in Cancer Initiation and Progression. Biomedicines. 2018;6: pubmed publisher
    ..This review briefly highlights the major mechanisms of NF-?B activation, the role of NF-?B in tumor promotion and suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-?B function. ..
  4. Ko J, Sethi G, Um J, Shanmugam M, Arfuso F, Kumar A, et al. The Role of Resveratrol in Cancer Therapy. Int J Mol Sci. 2017;18: pubmed publisher
    ..This is also accompanied by a comprehensive update of the various clinical trials that have demonstrated it to be a promising therapeutic and chemopreventive agent. ..
  5. Visweswaran M, Arfuso F, Dilley R, Newsholme P, Dharmarajan A. The inhibitory influence of adipose tissue-derived mesenchymal stem cell environment and Wnt antagonism on breast tumour cell lines. Int J Biochem Cell Biol. 2018;95:63-72 pubmed publisher