Megan Chircop

Summary

Country: Australia

Publications

  1. ncbi request reprint The actin-binding and bundling protein, EPLIN, is required for cytokinesis
    Megan Chircop
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Cell Cycle 8:757-64. 2009
  2. doi request reprint Calcineurin activity is required for the completion of cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Cell Mol Life Sci 67:3725-37. 2010
  3. doi request reprint Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Mol Cancer Ther 10:1553-62. 2011
  4. pmc Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Mol Cancer 12:4. 2013
  5. ncbi request reprint Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis
    Adam McCluskey
    Chemistry, Centre for Chemical Biology, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, 2308, Australia
    Traffic 14:1272-89. 2013
  6. pmc Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation
    Maggie P C Ma
    Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    PLoS ONE 8:e68387. 2013
  7. doi request reprint Clathrin-mediated endocytic proteins are involved in regulating mitotic progression and completion
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Traffic 13:1628-41. 2012
  8. doi request reprint Phosphorylation of dynamin II at serine-764 is associated with cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    Biochim Biophys Acta 1813:1689-99. 2011
  9. doi request reprint The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    Mol Cancer Ther 9:1995-2006. 2010
  10. pmc Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Mol Cancer 10:78. 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The actin-binding and bundling protein, EPLIN, is required for cytokinesis
    Megan Chircop
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Cell Cycle 8:757-64. 2009
    ..We suggest that EPLIN may function during cytokinesis to maintain local accumulation of key cytokinesis proteins at the furrow...
  2. doi request reprint Calcineurin activity is required for the completion of cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Cell Mol Life Sci 67:3725-37. 2010
    ..CaN activity and disassembly of the FMRs coincide with abscission. Thus, CaN activity at the midbody plays a key role in regulating the completion of cytokinesis in mammalian cells...
  3. doi request reprint Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Mol Cancer Ther 10:1553-62. 2011
    ..Thus, the dynoles are a second class of dynamin GTPase inhibitors, with dynole 34-2 as the lead compound, that are novel antimitotic compounds acting specifically at the abscission stage...
  4. pmc Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Mol Cancer 12:4. 2013
    ..Pitstop 2™ is the first small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis. We investigated its effects on a second function for clathrin in mitosis...
  5. ncbi request reprint Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis
    Adam McCluskey
    Chemistry, Centre for Chemical Biology, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, 2308, Australia
    Traffic 14:1272-89. 2013
    ..The data further suggest that the ring oligomerization state of dynamin is not required for clathrin-mediated endocytosis...
  6. pmc Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation
    Maggie P C Ma
    Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    PLoS ONE 8:e68387. 2013
    ..Therefore SNX9 and CHC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association. ..
  7. doi request reprint Clathrin-mediated endocytic proteins are involved in regulating mitotic progression and completion
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Traffic 13:1628-41. 2012
    ..Therefore, the role of endocytic proteins in mitosis is much broader than previously recognized...
  8. doi request reprint Phosphorylation of dynamin II at serine-764 is associated with cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    Biochim Biophys Acta 1813:1689-99. 2011
    ..Therefore, phosphorylation of dynamin II primarily occurs on a single site that regulates cytokinesis downstream of calcineurin, rather than regulating endocytosis or centrosome function...
  9. doi request reprint The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    Mol Cancer Ther 9:1995-2006. 2010
    ..Thus, MiTMABs have toxicity and antiproliferative properties that preferentially target cancer cells. This suggests that dynII may be a novel target for pharmacologic intervention for the treatment of cancer...
  10. pmc Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Mol Cancer 10:78. 2011
    ..The cellular response following cytokinesis failure and the mechanistic pathway involved is unknown...
  11. doi request reprint SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis
    Maggie P C Ma
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    J Cell Sci 125:4372-82. 2012
    ..We conclude that SNX9 subfamily members are required for mitosis through both endocytosis-dependent and -independent processes...
  12. doi request reprint Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors
    Andrew B McGeachie
    Cell Signalling Unit, Children s Medical Research Institute, The University of Sydney, Sydney, NSW 2145, Australia
    ACS Chem Biol 8:1507-18. 2013
    ..This dual mode of action provides an important new tool for molecular dissection of dynamin's role in endocytosis...
  13. pmc CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci
    Rose Boutros
    Princess Alexandra Hospital, The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia
    PLoS ONE 8:e67822. 2013
    ....