Mika Jormakka

Summary

Affiliation: Centenary Institute
Country: Australia

Publications

  1. ncbi request reprint Formate dehydrogenase--a versatile enzyme in changing environments
    Mika Jormakka
    Division of Biomedical Sciences Imperial College London, London SW7 2AZ, UK
    Curr Opin Struct Biol 13:418-23. 2003
  2. pmc The initiation of GTP hydrolysis by the G-domain of FeoB: insights from a transition-state complex structure
    Miriam Rose Ash
    School of Molecular Bioscience, University of Sydney, New South Wales, Australia
    PLoS ONE 6:e23355. 2011
  3. pmc Molecular mechanism of energy conservation in polysulfide respiration
    Mika Jormakka
    Department of Biophysics, University of New South Wales, Barker Street, Sydney, New South Wales 2052, Australia
    Nat Struct Mol Biol 15:730-7. 2008
  4. pmc Potassium-activated GTPase reaction in the G Protein-coupled ferrous iron transporter B
    Miriam Rose Ash
    Structural Biology Program, Centenary Institute, Sydney, New South Wales 2042, Australia
    J Biol Chem 285:14594-602. 2010
  5. pmc The structure of an N11A mutant of the G-protein domain of FeoB
    Miriam Rose Ash
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1511-5. 2011
  6. doi request reprint A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB
    Miriam Rose Ash
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Acta Crystallogr D Biol Crystallogr 67:973-80. 2011
  7. doi request reprint The cation-dependent G-proteins: in a class of their own
    Miriam Rose Ash
    School of Molecular Bioscience, The University of Sydney, Australia
    FEBS Lett 586:2218-24. 2012
  8. ncbi request reprint Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate
    Amy P Guilfoyle
    Structural Biology Program, Centenary Institute, Sydney, New South Wales, Australia Faculty of Medicine, Central Clinical School, University of Sydney, New South Wales, Australia
    FEBS J 281:2254-65. 2014
  9. pmc Structural basis of GDP release and gating in G protein coupled Fe2+ transport
    Amy Guilfoyle
    Centenary Institute, Sydney, New South Wales, Australia
    EMBO J 28:2677-85. 2009
  10. pmc Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer
    Chandrika N Deshpande
    Structural Biology Program, Centenary Institute, Sydney, NSW 2042, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:399-404. 2013

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Formate dehydrogenase--a versatile enzyme in changing environments
    Mika Jormakka
    Division of Biomedical Sciences Imperial College London, London SW7 2AZ, UK
    Curr Opin Struct Biol 13:418-23. 2003
    ..Together these have given detailed structural and mechanistic information about this family of enzymes...
  2. pmc The initiation of GTP hydrolysis by the G-domain of FeoB: insights from a transition-state complex structure
    Miriam Rose Ash
    School of Molecular Bioscience, University of Sydney, New South Wales, Australia
    PLoS ONE 6:e23355. 2011
    ..Together with the crystal structure, the findings suggest a new mechanism for hydrolysis initiation in small G-proteins, in which the attacking water molecule is aligned by contacts with the protein backbone only...
  3. pmc Molecular mechanism of energy conservation in polysulfide respiration
    Mika Jormakka
    Department of Biophysics, University of New South Wales, Barker Street, Sydney, New South Wales 2052, Australia
    Nat Struct Mol Biol 15:730-7. 2008
    ..thermophilus respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane via a previously unknown mechanism...
  4. pmc Potassium-activated GTPase reaction in the G Protein-coupled ferrous iron transporter B
    Miriam Rose Ash
    Structural Biology Program, Centenary Institute, Sydney, New South Wales 2042, Australia
    J Biol Chem 285:14594-602. 2010
    ..In addition, the accelerated hydrolysis rate opens up the possibility that FeoB might indeed function as an active transporter...
  5. pmc The structure of an N11A mutant of the G-protein domain of FeoB
    Miriam Rose Ash
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1511-5. 2011
    ..The structure demonstrates how the use of a derivatized nucleotide in cocrystallization experiments can facilitate the growth of diffraction-quality crystals...
  6. doi request reprint A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB
    Miriam Rose Ash
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Acta Crystallogr D Biol Crystallogr 67:973-80. 2011
    ..This provides the first evidence of nucleotide-dependent helical domain movement in NFeoB proteins, suggesting a mechanism by which the G-protein domain could structurally communicate with the membrane domain and mediate iron uptake...
  7. doi request reprint The cation-dependent G-proteins: in a class of their own
    Miriam Rose Ash
    School of Molecular Bioscience, The University of Sydney, Australia
    FEBS Lett 586:2218-24. 2012
    ..The results from this analysis effectively re-define the conditions under which many of these G-proteins should be studied in vitro...
  8. ncbi request reprint Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate
    Amy P Guilfoyle
    Structural Biology Program, Centenary Institute, Sydney, New South Wales, Australia Faculty of Medicine, Central Clinical School, University of Sydney, New South Wales, Australia
    FEBS J 281:2254-65. 2014
    ..We conclude that the identity of the residue at this position in the G5 loop plays a key role in the nucleotide release rate by allowing the correct positioning and hydrogen bonding of the nucleotide base...
  9. pmc Structural basis of GDP release and gating in G protein coupled Fe2+ transport
    Amy Guilfoyle
    Centenary Institute, Sydney, New South Wales, Australia
    EMBO J 28:2677-85. 2009
    ..From these results, structural parallels are drawn to eukaryotic G protein coupled membrane processes...
  10. pmc Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer
    Chandrika N Deshpande
    Structural Biology Program, Centenary Institute, Sydney, NSW 2042, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:399-404. 2013
    ..Unlike recent structures of NFeoB, the G. capsiferriformans NFeoB structure is highly unusual in that it does not contain a helical domain. The crystal structures of both apo and GDP-bound protein forms a domain-swapped dimer...
  11. ncbi request reprint Targeting glutamine transport to suppress melanoma cell growth
    Qian Wang
    Origins of Cancer Laboratory, Centenary Institute, Camperdown, NSW, Australia Gene and Stem Cell Therapy Program, Centenary Institute, Camperdown, NSW, Australia Sydney Medical School, University of Sydney, NSW, Australia
    Int J Cancer 135:1060-71. 2014
    ..Taken together, our study demonstrates that ASCT2-mediated glutamine transport is a potential therapeutic target for both BRAF(WT) and BRAF(V600E) melanoma. ..
  12. ncbi request reprint Molecular basis of proton motive force generation: structure of formate dehydrogenase-N
    Mika Jormakka
    Division of Biomedical Sciences, Imperial College, London SW7 2AZ, UK
    Science 295:1863-8. 2002
    ..This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes...
  13. ncbi request reprint Architecture of NarGH reveals a structural classification of Mo-bisMGD enzymes
    Mika Jormakka
    Division of Biomedical Sciences, Imperial College London, SW7 2AZ, UK
    Structure 12:95-104. 2004
    ..The Nar structure also demonstrates the first example of an Asp side chain acting as a Mo ligand providing a structural basis for the classification of Mo-bisMGD enzymes...