Duncan J Campbell

Summary

Country: Australia

Publications

  1. ncbi request reprint The renin-angiotensin and the kallikrein-kinin systems
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, VIC 3065, Australia
    Int J Biochem Cell Biol 35:784-91. 2003
  2. pmc Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Australia
    PLoS ONE 7:e49813. 2012
  3. doi request reprint Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart
    Duncan J Campbell
    St Vincent s Institute of Medical Research, University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 38:623-31. 2011
  4. pmc Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease
    Duncan J Campbell
    St Vincent s Institute of Medical Research, and Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    J Hypertens 28:1429-37. 2010
  5. doi request reprint Reduced microvascular density in non-ischemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Australia Department of Medicine, University of Melbourne, St Vincent s Health, Fitzroy, Australia Electronic address
    Int J Cardiol 167:1027-37. 2013
  6. pmc Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease
    Duncan J Campbell
    Department of Molecular Cardiology, St Vincent s Institute of Medical Research, Fitzroy, Australia
    Cardiovasc Diabetol 10:80. 2011
  7. doi request reprint Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver
    Duncan J Campbell
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hypertension 54:1248-53. 2009
  8. ncbi request reprint Angiotensin vaccination: what is the prospect of success?
    Duncan J Campbell
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Curr Hypertens Rep 11:63-8. 2009
  9. doi request reprint Differences in myocardial structure and coronary microvasculature between men and women with coronary artery disease
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Victoria 3065, Australia
    Hypertension 57:186-92. 2011
  10. doi request reprint The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME)
    Barry Dixon
    Department of Intensive Care, St Vincent s Institute of Medical Research, The Department of Medicine, University of Melbourne, Australia
    Transfusion 53:19-27. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The renin-angiotensin and the kallikrein-kinin systems
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, VIC 3065, Australia
    Int J Biochem Cell Biol 35:784-91. 2003
    ..Both angiotensin and kinin peptides are metabolised by many different peptidases that are important determinants of the activities of the RAS and KKS, and several of which participate in both systems...
  2. pmc Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Australia
    PLoS ONE 7:e49813. 2012
    ..Aging is associated with diastolic dysfunction and increased risk of heart failure, and we investigated the hypothesis that diastolic dysfunction of aging humans is associated with altered myocardial structure and plasma AGE levels...
  3. doi request reprint Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart
    Duncan J Campbell
    St Vincent s Institute of Medical Research, University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 38:623-31. 2011
    ..5. These data demonstrate that the aliskiren-induced increase in cardiac bradykinin levels is independent of renin inhibition and changes in bradykinin metabolism, but is associated with increased tissue kallikrein gene expression...
  4. pmc Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease
    Duncan J Campbell
    St Vincent s Institute of Medical Research, and Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    J Hypertens 28:1429-37. 2010
    ..The effect of increased dietary NaCl on the phenotype of prorenin transgenic rats has not been examined...
  5. doi request reprint Reduced microvascular density in non-ischemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Australia Department of Medicine, University of Melbourne, St Vincent s Health, Fitzroy, Australia Electronic address
    Int J Cardiol 167:1027-37. 2013
    ....
  6. pmc Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease
    Duncan J Campbell
    Department of Molecular Cardiology, St Vincent s Institute of Medical Research, Fitzroy, Australia
    Cardiovasc Diabetol 10:80. 2011
    ..We investigated whether type 2 diabetes and the metabolic syndrome are associated with altered myocardial structure, microvasculature, and expression of AGEs and receptor for AGEs (RAGE) in men with coronary artery disease...
  7. doi request reprint Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver
    Duncan J Campbell
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hypertension 54:1248-53. 2009
    ....
  8. ncbi request reprint Angiotensin vaccination: what is the prospect of success?
    Duncan J Campbell
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Curr Hypertens Rep 11:63-8. 2009
    ..A recent clinical study of angiotensin II vaccination provided some cause for optimism, but many hurdles remain before this strategy can compete with current oral medications for hypertension...
  9. doi request reprint Differences in myocardial structure and coronary microvasculature between men and women with coronary artery disease
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Victoria 3065, Australia
    Hypertension 57:186-92. 2011
    ..Additional studies of larger numbers of women with less extensive coronary artery disease are required to confirm these findings...
  10. doi request reprint The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME)
    Barry Dixon
    Department of Intensive Care, St Vincent s Institute of Medical Research, The Department of Medicine, University of Melbourne, Australia
    Transfusion 53:19-27. 2013
    ..These studies did not, however, consider the possibility that bleeding may in itself be harmful, inasmuch as drains are inefficient at clearing blood from the chest and retained blood may compromise cardiac and lung function...
  11. doi request reprint Activity assays and immunoassays for plasma Renin and prorenin: information provided and precautions necessary for accurate measurement
    Duncan J Campbell
    Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Clin Chem 55:867-77. 2009
    ....
  12. doi request reprint Critical review of prorenin and (pro)renin receptor research
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hypertension 51:1259-64. 2008
  13. ncbi request reprint Vaccination against high blood pressure
    Duncan J Campbell
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Curr Pharm Des 18:1005-10. 2012
    ..Thus, the role of vaccination against renin angiotensin system components in hypertension management remains to be established...
  14. ncbi request reprint Interpretation of plasma renin concentration in patients receiving aliskiren therapy
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Hypertension 51:15-8. 2008
  15. pmc Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 36:547-53. 2009
    ..The data suggest that the vascular compartment is the main site of AngI and bradykinin-(1-9) formation and metabolism and that vascular ACE may limit AngI entry to the extravascular compartment of WT mice...
  16. pmc AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance
    Nicolas Dzamko
    Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 285:115-22. 2010
    ..We demonstrate that the loss of beta1 reduces food intake and protects against the deleterious effects of an obesity-inducing diet...
  17. ncbi request reprint Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide, C-reactive protein, and renin in subjects with cerebrovascular disease
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Circulation 112:110-6. 2005
    ..B-type natriuretic peptide (BNP), C-reactive protein (CRP), and renin are elevated in persons at risk for cardiovascular disease. However, data that directly compare these markers in the prediction of myocardial infarction (MI) are limited...
  18. ncbi request reprint Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    J Hypertens 22:1971-6. 2004
    ..To investigate the role of angiotensin-converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation...
  19. ncbi request reprint Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan Street, Parkville 3010, Victoria, Australia
    Mol Cell Endocrinol 194:201-9. 2002
    ..In conclusion, macrophages and epithelial cells are the source of active renin in the rat thymus. The thymic RAS may have actions systemically and may also influence local processes such as blood flow and cell growth...
  20. ncbi request reprint Myocardial uptake and biochemical and hemodynamic effects of ACE inhibitors in humans
    Christopher J Zeitz
    University of Adelaide, Department of Medicine, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Hypertension 41:482-7. 2003
    ..Under resting conditions, both drugs exerted small negative inotropic effects...
  21. ncbi request reprint Hypertension in the (mRen-2)27 rat is not explained by enhanced kinetics of transgenic Ren-2 renin
    Pei Rong
    Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
    Hypertension 42:523-7. 2003
    ..We conclude that hypertension in the Ren-2 rat is not related to renin kinetics. Other mechanisms are considered, with reference to human essential hypertension...
  22. ncbi request reprint Angiotensinogen and angiotensin-converting enzyme gene copy number and angiotensin and bradykinin peptide levels in mice
    Theodora Alexiou
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    J Hypertens 23:945-54. 2005
    ..To test the hypothesis that changes in gene expression that may accompany angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) gene polymorphism cause alteration in angiotensin and bradykinin peptide levels...
  23. ncbi request reprint Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 294:H659-67. 2008
    ....
  24. ncbi request reprint Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension
    Henry Krum
    National Health and Medical Research Council of Australia, Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, VIC 3004, Australia
    Am J Physiol Heart Circ Physiol 290:H1706-12. 2006
    ..We conclude that sympathetic nervous inhibition is not a major component of the blood pressure-lowering action of ARBs in essential hypertension...
  25. pmc Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung
    John A Polikandriotis
    Department of Medicine, Atlanta VA and Emory University Medical Center, Atlanta VAMC 151 P, 1670 Clairmont Rd, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 34:314-9. 2006
    ....
  26. ncbi request reprint L-NAME hypertension: trying to fit the pieces together
    Duncan J Campbell
    J Hypertens 24:33-6. 2006
  27. ncbi request reprint Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo
    Sebastien Fuchs
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Hypertension 51:267-74. 2008
    ..Although mice lacking C-domain activity have normal physiology under laboratory conditions, they respond less well to the stress of dehydration...
  28. ncbi request reprint Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency
    Fiona E Mackie
    Division of Nephrology, VA Palo Alto Health Care System and Stanford University, Palo Alto, California, USA
    Kidney Int 61:555-63. 2002
    ..This study examined whether these different means of blood pressure reduction have different effects on renal levels of angiotensin (Ang) and bradykinin peptides...