Katharine N Bossart

Summary

Country: Australia

Publications

  1. pmc Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Virol J 2:57. 2005
  2. ncbi Functional studies of host-specific ephrin-B ligands as Henipavirus receptors
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Virology 372:357-71. 2008
  3. ncbi Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
    J Virol Methods 142:29-40. 2007
  4. ncbi Developments towards effective treatments for Nipah and Hendra virus infection
    Katharine N Bossart
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria 3220, Australia
    Expert Rev Anti Infect Ther 4:43-55. 2006
  5. pmc A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    PLoS Pathog 5:e1000642. 2009
  6. doi A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats
    Jennifer A McEachern
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    Vaccine 26:3842-52. 2008
  7. pmc Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus
    Michelle L Colgrave
    Queensland Bioscience Precinct, CSIRO Livestock Industries, St Lucia, QLD 4067, Australia
    Glycobiology 22:572-84. 2012
  8. doi Expression of novel genes encoded by the paramyxovirus J virus
    Philippa J M Jack
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24 Geelong, Victoria 3220, Australia
    J Gen Virol 89:1434-41. 2008
  9. doi Serotype-independent detection of foot-and-mouth disease virus
    Janine D Muller
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    J Virol Methods 151:146-53. 2008
  10. pmc Targeted strategies for henipavirus therapeutics
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Open Virol J 1:14-25. 2007

Collaborators

Detail Information

Publications19

  1. pmc Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Virol J 2:57. 2005
    ..Here, we have evaluated these peptides as well as the corresponding scrambled peptide controls in Nipah virus and Hendra virus-mediated membrane fusion and against infection by live virus in vitro...
  2. ncbi Functional studies of host-specific ephrin-B ligands as Henipavirus receptors
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Virology 372:357-71. 2008
    ....
  3. ncbi Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
    J Virol Methods 142:29-40. 2007
    ..Sera from henipavirus-seropositive animals differentially blocked ephrin-B2 binding, suggesting that detection and differentiation of HeV and NiV neutralizing antibodies can be done simultaneously in the absence of live virus...
  4. ncbi Developments towards effective treatments for Nipah and Hendra virus infection
    Katharine N Bossart
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria 3220, Australia
    Expert Rev Anti Infect Ther 4:43-55. 2006
    ....
  5. pmc A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    PLoS Pathog 5:e1000642. 2009
    ..This study is the first successful post-exposure passive antibody therapy for Nipah virus using a human monoclonal antibody...
  6. doi A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats
    Jennifer A McEachern
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    Vaccine 26:3842-52. 2008
    ..The ability to elicit protective systemic and mucosal immunity in this animal model provides significant progress towards the development of a human subunit vaccine against henipaviruses...
  7. pmc Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus
    Michelle L Colgrave
    Queensland Bioscience Precinct, CSIRO Livestock Industries, St Lucia, QLD 4067, Australia
    Glycobiology 22:572-84. 2012
    ..The structural features of G protein glycosylation were also determined by X-ray crystallography and interactions with the ephrin-B2 receptor are discussed...
  8. doi Expression of novel genes encoded by the paramyxovirus J virus
    Philippa J M Jack
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24 Geelong, Victoria 3220, Australia
    J Gen Virol 89:1434-41. 2008
    ..Preliminary studies indicate that the novel TM protein is a type II glycosylated integral membrane protein, orientated with its C terminus exposed at the cell surface...
  9. doi Serotype-independent detection of foot-and-mouth disease virus
    Janine D Muller
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    J Virol Methods 151:146-53. 2008
    ....
  10. pmc Targeted strategies for henipavirus therapeutics
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Open Virol J 1:14-25. 2007
    ..Assessments of protective host immunity and drug pharmacokinetics will be crucial to the further advancement of therapeutic compounds...
  11. pmc Residues in the stalk domain of the hendra virus g glycoprotein modulate conformational changes associated with receptor binding
    Kimberly A Bishop
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Virol 82:11398-409. 2008
    ..Together, these data suggest the stalk domain of G plays an important role in the conformational stability and receptor binding-triggered changes leading to productive fusion, such as the dissociation of G and F...
  12. doi Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody
    Zhongyu Zhu
    Protein Interactions Group, Center for Cancer Research Nanobiology Program, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    J Infect Dis 197:846-53. 2008
    ..These results suggest that m102.4 has potential as a therapeutic agent for the treatment of diseases caused by henipaviruses. It could be also used for prophylaxis and diagnosis, and as a research reagent...
  13. pmc Identification of Hendra virus G glycoprotein residues that are critical for receptor binding
    Kimberly A Bishop
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Virol 81:5893-901. 2007
    ....
  14. pmc Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine
    Bruce A Mungall
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Virol 80:12293-302. 2006
    ..These results indicate that the cat provides a consistent model for acute NiV infection and associated pathogenesis and an effective subunit vaccine strategy appears achievable...
  15. pmc Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies
    Zhongyu Zhu
    CCRNP, CCR, NCI Frederick, NIH, Frederick, MD 21702, USA
    J Virol 80:891-9. 2006
    ....
  16. pmc Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus
    Matthew I Bonaparte
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:10652-7. 2005
    ..Together, these data indicate that EFNB2 serves as a functional receptor for both HeV and NiV. The highly conserved nature of EFNB2 in humans and animals is consistent with the broad tropism exhibited by these emerging zoonotic viruses...
  17. pmc Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus
    Katharine N Bossart
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    J Virol 79:6690-702. 2005
    ..This HeV sG glycoprotein will be exceedingly useful for structural studies, receptor identification strategies, and vaccine development goals for these important emerging viral agents...
  18. pmc Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    J Virol 76:11186-98. 2002
    ..However, no heterotypic activity was observed with envelope glycoproteins of the morbilliviruses Measles virus and Canine distemper virus...
  19. ncbi Viral glycoprotein-mediated cell fusion assays using vaccinia virus vectors
    Katharine N Bossart
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA
    Methods Mol Biol 269:309-32. 2004
    ..This chapter will detail the methods of the vaccinia virus-based reporter-gene fusion assay and how it may be used to characterize the fusion mediated by the BSL-4-classified Hendra and Nipah viruses...