Dmitri Sviridov

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint Genetic factors affecting HDL levels, structure, metabolism and function
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 18:157-63. 2007
  2. pmc HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux
    Huanhuan L Cui
    Baker Heart and Diabetes Institute, Melbourne, Vic, Australia
    J Lipid Res 53:696-708. 2012
  3. doi request reprint ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis
    Ying Fu
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Cell Metab 18:225-38. 2013
  4. pmc HIV infection and high density lipoprotein metabolism
    Honor Rose
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 199:79-86. 2008
  5. pmc Prion infection impairs cholesterol metabolism in neuronal cells
    Huanhuan L Cui
    From the Baker Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 289:789-802. 2014
  6. pmc Skeletal muscle insulin resistance associated with cholesterol-induced activation of macrophages is prevented by high density lipoprotein
    Andrew L Carey
    Metabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
    PLoS ONE 8:e56601. 2013
  7. doi request reprint Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages
    Yi Fu
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Arterioscler Thromb Vasc Biol 32:e117-25. 2012
  8. pmc Antiretroviral compounds and cholesterol efflux from macrophages
    Nigora Mukhamedova
    BakerIDI Heart and Diabetes Institute, Melbourne, Australia
    Atherosclerosis 206:439-43. 2009
  9. pmc The effect of HIV infection on atherosclerosis and lipoprotein metabolism: a one year prospective study
    Honor Rose
    Baker Heart and Diabetes Institute, Melbourne, Australia
    Atherosclerosis 229:206-11. 2013
  10. ncbi request reprint The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux
    Nigora Mukhamedova
    Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008 Australia
    Biochemistry 46:9388-98. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Genetic factors affecting HDL levels, structure, metabolism and function
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 18:157-63. 2007
    ..The present review focuses on various approaches to establish genetic determinants of the HDL concentration, structure and function...
  2. pmc HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux
    Huanhuan L Cui
    Baker Heart and Diabetes Institute, Melbourne, Vic, Australia
    J Lipid Res 53:696-708. 2012
    ..These findings demonstrate that Nef-dependent inhibition of ABCA1 is an essential component of the viral replication strategy and underscore the role of ABCA1 as an innate anti-HIV factor...
  3. doi request reprint ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis
    Ying Fu
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Cell Metab 18:225-38. 2013
    ..Thus, ABCA12 regulates the cellular cholesterol metabolism via an LXRβ-dependent posttranscriptional mechanism...
  4. pmc HIV infection and high density lipoprotein metabolism
    Honor Rose
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 199:79-86. 2008
    ..Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directing cholesterol to the apoB-containing lipoproteins and likely reducing the functionality of reverse cholesterol transport...
  5. pmc Prion infection impairs cholesterol metabolism in neuronal cells
    Huanhuan L Cui
    From the Baker Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 289:789-802. 2014
    ..These findings demonstrate a reciprocal connection between prion infection and cellular cholesterol metabolism, which plays an important role in the pathogenesis of prion infection in neuronal cells. ..
  6. pmc Skeletal muscle insulin resistance associated with cholesterol-induced activation of macrophages is prevented by high density lipoprotein
    Andrew L Carey
    Metabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
    PLoS ONE 8:e56601. 2013
    ..We hypothesized that HDL may also increase skeletal muscle insulin sensitivity via cholesterol removal and anti-inflammatory actions in macrophages associated with excess adiposity and ectopic lipid deposition...
  7. doi request reprint Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages
    Yi Fu
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Arterioscler Thromb Vasc Biol 32:e117-25. 2012
    ..The structure protein of caveolae, caveolin-1, is increased in primary monocytes after its adhesion to endothelium. We explore the hypothesis that caveolin-1 plays a role in monocyte differentiation to macrophages...
  8. pmc Antiretroviral compounds and cholesterol efflux from macrophages
    Nigora Mukhamedova
    BakerIDI Heart and Diabetes Institute, Melbourne, Australia
    Atherosclerosis 206:439-43. 2009
    ..The objective of this study was to assess the effect of various classes of anti-HIV drugs on cellular cholesterol efflux...
  9. pmc The effect of HIV infection on atherosclerosis and lipoprotein metabolism: a one year prospective study
    Honor Rose
    Baker Heart and Diabetes Institute, Melbourne, Australia
    Atherosclerosis 229:206-11. 2013
    ..The effects of HIV infection and antiretroviral treatment on surrogate markers of atherosclerosis, and lipoprotein metabolism were evaluated in a 12 month prospective study...
  10. ncbi request reprint The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux
    Nigora Mukhamedova
    Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008 Australia
    Biochemistry 46:9388-98. 2007
    ..We conclude that a site on the first extracellular loop is required for cholesterol efflux, whereas a site on the fourth extracellular loop may be responsible for ABCA1 stability...
  11. doi request reprint High-density lipoprotein reduces the human monocyte inflammatory response
    Andrew J Murphy
    Laboratories of Vascular Pharmacology, Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 28:2071-7. 2008
    ..Whereas the anti-inflammatory effects of high-density lipoprotein (HDL) on endothelial cells are well described, such effects on monocytes are less studied...
  12. ncbi request reprint The effect of cholesteryl ester transfer protein overexpression and inhibition on reverse cholesterol transport
    Urbain Tchoua
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Cardiovasc Res 77:732-9. 2008
    ..Cholesteryl ester transfer protein (CETP) has a well-established role in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear...
  13. ncbi request reprint Elevated HDL cholesterol is functionally ineffective in cardiac transplant recipients: evidence for impaired reverse cholesterol transport
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Transplantation 81:361-6. 2006
    ..Cardiac transplant recipients frequently have high plasma HDL levels but it is unclear whether these promote a cardioprotective profile...
  14. pmc An apolipoprotein A-I mimetic peptide designed with a reductionist approach stimulates reverse cholesterol transport and reduces atherosclerosis in mice
    Michael Ditiatkovski
    Baker Heart and Diabetes Institute, Melbourne, Vic, Australia
    PLoS ONE 8:e68802. 2013
    ..Thus, ELK-2A2K2E peptide reduced atherosclerosis in Apoe(-/-) mice, however, the functional activity profile after chronic in vivo administration was different from that found in acute in vitro studies. ..
  15. doi request reprint Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion
    Andrew L Siebel
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circ Res 113:167-75. 2013
    ..High-density lipoprotein cholesterol elevation via cholesteryl ester transfer protein (CETP) inhibition represents a novel therapy for atherosclerosis, which also may have relevance for type 2 diabetes mellitus...
  16. doi request reprint Anti-inflammatory functions of apolipoprotein A-I and high-density lipoprotein are preserved in trimeric apolipoprotein A-I
    Andrew J Murphy
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Pharmacol Exp Ther 344:41-9. 2013
    ..Our data suggest that trimeric rHDL particles can be constructed without any loss of function, preserving the anti-inflammatory effects of HDL that are key to its in vivo actions...
  17. doi request reprint Mechanism of cholesterol efflux in humans after infusion of reconstituted high-density lipoprotein
    Anh Hoang
    Baker Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Eur Heart J 33:657-65. 2012
    ....
  18. doi request reprint Neutrophil activation is attenuated by high-density lipoprotein and apolipoprotein A-I in in vitro and in vivo models of inflammation
    Andrew J Murphy
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 31:1333-41. 2011
    ..High-density lipoproteins (HDL) are antiinflammatory particles, exerting beneficial cardiovascular influences. We determined whether HDL exerts antiinflammatory effects on neutrophils and explored the mechanisms by which these occur...
  19. doi request reprint High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circulation 119:2103-11. 2009
    ..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
  20. ncbi request reprint Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages
    Genevieve Escher
    Baker Heart Research Institute, Melbourne, Victoria, 8008, Australia
    J Lipid Res 46:356-65. 2005
    ..However, transfection with CYP27A1 led to a 2- to 4-fold increase of cholesterol efflux. We conclude that treatment with 5-azacytidine can be used for high-efficiency transient transfection of macrophages...
  21. doi request reprint Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL--monocyte interactions
    Steffen U Eisenhardt
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    Atherosclerosis 224:384-93. 2012
    ..Our results elucidate the physiological relevance of the CRP-mmLDL interaction and furthermore confirm the importance of the previously described pCRP dissociation to mCRP as a localized inflammatory "activation" mechanism...
  22. doi request reprint Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo
    Nigora Mukhamedova
    BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Lipid Res 49:2312-22. 2008
    ..We conclude that pathways of cholesterol efflux using apoA-I as an acceptor make a predominant contribution to cholesterol export from macrophages in vivo...
  23. ncbi request reprint Antiatherogenic functionality of high density lipoprotein: how much versus how good
    Dmitri Sviridov
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Atheroscler Thromb 15:52-62. 2008
    ..A single common denominator reflecting the multiple HDL functions is yet to be found and may not exist leaving direct measurements of each HDL function as the way to assess atheroprotective capacity of HDL...
  24. ncbi request reprint Statins and metabolism of high density lipoprotein
    Dmitri Sviridov
    Baker Heart Research Institute, Commercial Rd, Central, Melbourne, Vic, 8008, Australia
    Cardiovasc Hematol Agents Med Chem 5:215-21. 2007
    ..In this review we analyze what is currently known about effect of statins on HDL metabolism and on reverse cholesterol transport in particular...
  25. ncbi request reprint ABCA1 expression in humans is associated with physical activity and alcohol consumption
    Anh Hoang
    Baker Heart Research Institute, Commercial Road, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 197:197-203. 2008
    ..In conclusion, ABCA1 expression in human leukocytes and muscle is associated with physical activity and alcohol consumption, respectively...
  26. doi request reprint Global functional knockdown of ATP binding cassette transporter A1 stimulates development of atherosclerosis in apoE K/O mice
    Nigora Mukhamedova
    Baker Heart and Diabetes Institute, Melbourne, Australia
    Biochem Biophys Res Commun 412:446-9. 2011
    ..We conclude that functional blocking of ABCA1-dependent cholesterol efflux stimulates development of atherosclerosis in apoE K/O mice independently from HDL-C levels...
  27. ncbi request reprint Indices of reverse cholesterol transport in subjects with metabolic syndrome after treatment with rosuvastatin
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 197:732-9. 2008
    ..The effects of the statin, rosuvastatin on indices of reverse cholesterol transport were studied in a randomized, placebo-controlled, cross-over trial in 25 overweight subjects with defined metabolic syndrome...
  28. doi request reprint Impact of freezing on high-density lipoprotein functionality
    J Rajinda Kekulawala
    Baker Heart Research Institute, Melbourne, VIC 8008, Australia
    Anal Biochem 379:213-5. 2008
    ..Freezing also resulted in approximately 10% loss of HDL in the samples. We conclude that freezing HDL in the presence of 10% sucrose preserves its structural and functional properties...
  29. ncbi request reprint Physical fitness and reverse cholesterol transport
    Beata Olchawa
    Baker Heart Research Institute, Wynn Domain, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 24:1087-91. 2004
    ..The most consistent effect of exercise on lipoprotein metabolism is an increase in high-density lipoprotein (HDL)...
  30. ncbi request reprint Delineation of the role of pre-beta 1-HDL in cholesterol efflux using isolated pre-beta 1-HDL
    Dmitri Sviridov
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 22:1482-8. 2002
    ....
  31. doi request reprint Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque
    James A Shaw
    Department of Cardiovascular Medicine, Alfred Hospital Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central 8008, Australia
    Circ Res 103:1084-91. 2008
    ..These changes may contribute to the cardioprotective effects of HDL...
  32. ncbi request reprint Dynamics of reverse cholesterol transport: protection against atherosclerosis
    Dmitri Sviridov
    Baker Medical Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 161:245-54. 2002
    ..The particular role of pre-beta(1)-HDL is reviewed drawing attention to the relationship between its concentration and the flux of cholesterol through the RCT system...
  33. ncbi request reprint Structure-function studies of apoA-I variants: site-directed mutagenesis and natural mutations
    Dmitri Sviridov
    Baker Medical Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    J Lipid Res 43:1283-92. 2002
    ....
  34. ncbi request reprint Low-density lipoprotein receptor and apolipoprotein A-I and B expression in human enterocytes
    Dmitri Sviridov
    Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Digestion 67:67-70. 2003
    ..Immunoprecipitation of [(35)S]methionine pulse-labeled intracellular proteins from these cell types demonstrated that human enterocytes synthesize more apoA-I and apoB, while HepG2 cells synthesize a slightly higher amount of LDL-R...
  35. ncbi request reprint Expression of caveolin-1 enhances cholesterol efflux in hepatic cells
    Ying Fu
    Wynn Domain, Baker Heart Research Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 279:14140-6. 2004
    ..We conclude that overexpression of caveolin-1 in hepatic cells stimulates cholesterol efflux by enhancing transfer of cholesterol to cholesterol-rich domains in the plasma membrane...
  36. pmc A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis
    Ian Smyth
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    PLoS Genet 4:e1000192. 2008
    ..Furthermore, we identify Abca12 as a mediator of Abca1-regulated cellular cholesterol efflux, a finding that may have significant implications for other diseases of lipid metabolism and homeostasis, including atherosclerosis...
  37. ncbi request reprint HIV infection and high-density lipoprotein: the effect of the disease vs the effect of treatment
    Honor Rose
    Baker Heart Research Institute, Melbourne 3004, Australia
    Metabolism 55:90-5. 2006
    ..These data suggest that hypoalphalipoproteinemia in patients with HIV is likely to be secondary to HIV infection itself...
  38. ncbi request reprint Single session exercise stimulates formation of pre beta 1-HDL in leg muscle
    Dmitri Sviridov
    Wynn Domain, Baker Medical Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Lipid Res 44:522-6. 2003
    ..In the combined population, formation of pre beta 1-HDL at rest was 9.9 +/- 5.2 mg/min and exercise enhanced pre beta 1-HDL formation 6.6-fold in both groups...
  39. ncbi request reprint Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux
    Genevieve Escher
    Wynn Domain, Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 278:11015-9. 2003
    ..Expression of CYP27A1 in CHOP cells did not affect ABCA1 expression and abundance of ABCA1 protein. Thus, introduction of CYP27A1 into cells stimulates cholesterol efflux and therefore may increase protection against atherosclerosis...
  40. pmc Dose-dependent regulation of high-density lipoprotein metabolism with rosuvastatin in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia 6847, Australia
    J Clin Endocrinol Metab 93:430-7. 2008
    ..Rosuvastatin has been shown to increase HDL cholesterol concentration, but the mechanisms remain unclear...
  41. ncbi request reprint Human immunodeficiency virus infection and macrophage cholesterol metabolism
    Michael Bukrinsky
    Department of Microbiology, Immunology and Tropical Medicine, 2300 I St, N W, Ross Hall, Rm 234, Washington, DC 20037, USA
    J Leukoc Biol 80:1044-51. 2006
    ..Further elucidation of the mechanisms connecting viral infection and macrophage cholesterol metabolism may be fruitful for developing approaches to treatment of atherosclerosis and viral diseases...
  42. pmc Human immunodeficiency virus impairs reverse cholesterol transport from macrophages
    Zahedi Mujawar
    The George Washington University, Washington, District of Columbia, USA
    PLoS Biol 4:e365. 2006
    ....
  43. pmc HIV and cardiovascular disease: contribution of HIV-infected macrophages to development of atherosclerosis
    Michael Bukrinsky
    PLoS Med 4:e43. 2007
  44. ncbi request reprint Natural mutations of apolipoprotein A-I impairing activation of lecithin:cholesterol acyltransferase
    Anh Hoang
    Wynn Domain, Baker Medical Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne VIC 8008, Australia
    Biochim Biophys Acta 1631:72-6. 2003
    ....
  45. pmc Dose-dependent effect of rosuvastatin on VLDL-apolipoprotein C-III kinetics in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, Universityof Western Australia, Perth, Western Australia
    Diabetes Care 31:1656-61. 2008
    ..This study investigated the dose-dependent effect of rosuvastatin on VLDL apoC-III transport in men with the metabolic syndrome...