D Sviridov

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint Efflux of cellular cholesterol and phospholipid to apolipoprotein A-I mutants
    D Sviridov
    Baker Medical Research Institute, Commercial Road, Prahran, Victoria 3181, Australia
    J Biol Chem 271:33277-83. 1996
  2. ncbi request reprint Low-density lipoprotein receptor and apolipoprotein A-I and B expression in human enterocytes
    Dmitri Sviridov
    Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Digestion 67:67-70. 2003
  3. ncbi request reprint Statins and metabolism of high density lipoprotein
    Dmitri Sviridov
    Baker Heart Research Institute, Commercial Rd, Central, Melbourne, Vic, 8008, Australia
    Cardiovasc Hematol Agents Med Chem 5:215-21. 2007
  4. ncbi request reprint Single session exercise stimulates formation of pre beta 1-HDL in leg muscle
    Dmitri Sviridov
    Wynn Domain, Baker Medical Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Lipid Res 44:522-6. 2003
  5. ncbi request reprint Delineation of the role of pre-beta 1-HDL in cholesterol efflux using isolated pre-beta 1-HDL
    Dmitri Sviridov
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 22:1482-8. 2002
  6. ncbi request reprint Antiatherogenic functionality of high density lipoprotein: how much versus how good
    Dmitri Sviridov
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Atheroscler Thromb 15:52-62. 2008
  7. ncbi request reprint Dynamics of reverse cholesterol transport: protection against atherosclerosis
    Dmitri Sviridov
    Baker Medical Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 161:245-54. 2002
  8. pmc Apolipoprotein A-I stimulates the transport of intracellular cholesterol to cell-surface cholesterol-rich domains (caveolae)
    D Sviridov
    Baker Medical Research Institute, P O Box 6492, Melbourne, VIC 8008, Australia
    Biochem J 358:79-86. 2001
  9. ncbi request reprint Identification of a sequence of apolipoprotein A-I associated with the activation of Lecithin:Cholesterol acyltransferase
    D Sviridov
    Baker Medical Research Institute, Melbourne 8008 and the Department of Biochemistry, University of Melbourne, Parkville 3052, Victoria, Australia
    J Biol Chem 275:19707-12. 2000
  10. ncbi request reprint Intracellular cholesterol trafficking
    D Sviridov
    Baker Medical Research Institute, Melbourne, Australia
    Histol Histopathol 14:305-19. 1999

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Efflux of cellular cholesterol and phospholipid to apolipoprotein A-I mutants
    D Sviridov
    Baker Medical Research Institute, Commercial Road, Prahran, Victoria 3181, Australia
    J Biol Chem 271:33277-83. 1996
    ..A second lipid-binding region is exposed when the carboxyl-terminal half of apoA-I is absent...
  2. ncbi request reprint Low-density lipoprotein receptor and apolipoprotein A-I and B expression in human enterocytes
    Dmitri Sviridov
    Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Digestion 67:67-70. 2003
    ..Immunoprecipitation of [(35)S]methionine pulse-labeled intracellular proteins from these cell types demonstrated that human enterocytes synthesize more apoA-I and apoB, while HepG2 cells synthesize a slightly higher amount of LDL-R...
  3. ncbi request reprint Statins and metabolism of high density lipoprotein
    Dmitri Sviridov
    Baker Heart Research Institute, Commercial Rd, Central, Melbourne, Vic, 8008, Australia
    Cardiovasc Hematol Agents Med Chem 5:215-21. 2007
    ..In this review we analyze what is currently known about effect of statins on HDL metabolism and on reverse cholesterol transport in particular...
  4. ncbi request reprint Single session exercise stimulates formation of pre beta 1-HDL in leg muscle
    Dmitri Sviridov
    Wynn Domain, Baker Medical Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Lipid Res 44:522-6. 2003
    ..In the combined population, formation of pre beta 1-HDL at rest was 9.9 +/- 5.2 mg/min and exercise enhanced pre beta 1-HDL formation 6.6-fold in both groups...
  5. ncbi request reprint Delineation of the role of pre-beta 1-HDL in cholesterol efflux using isolated pre-beta 1-HDL
    Dmitri Sviridov
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 22:1482-8. 2002
    ....
  6. ncbi request reprint Antiatherogenic functionality of high density lipoprotein: how much versus how good
    Dmitri Sviridov
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Atheroscler Thromb 15:52-62. 2008
    ..A single common denominator reflecting the multiple HDL functions is yet to be found and may not exist leaving direct measurements of each HDL function as the way to assess atheroprotective capacity of HDL...
  7. ncbi request reprint Dynamics of reverse cholesterol transport: protection against atherosclerosis
    Dmitri Sviridov
    Baker Medical Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 161:245-54. 2002
    ..The particular role of pre-beta(1)-HDL is reviewed drawing attention to the relationship between its concentration and the flux of cholesterol through the RCT system...
  8. pmc Apolipoprotein A-I stimulates the transport of intracellular cholesterol to cell-surface cholesterol-rich domains (caveolae)
    D Sviridov
    Baker Medical Research Institute, P O Box 6492, Melbourne, VIC 8008, Australia
    Biochem J 358:79-86. 2001
    ..2-fold. We conclude that apoA-I induces the transport of intracellular cholesterol to cell-surface caveolae, possibly in part through the stimulation of caveolin expression...
  9. ncbi request reprint Identification of a sequence of apolipoprotein A-I associated with the activation of Lecithin:Cholesterol acyltransferase
    D Sviridov
    Baker Medical Research Institute, Melbourne 8008 and the Department of Biochemistry, University of Melbourne, Parkville 3052, Victoria, Australia
    J Biol Chem 275:19707-12. 2000
    ....
  10. ncbi request reprint Intracellular cholesterol trafficking
    D Sviridov
    Baker Medical Research Institute, Melbourne, Australia
    Histol Histopathol 14:305-19. 1999
    ..In this review we describe the intracellular machinery involved in the intracellular transfer of cholesterol and give an overview of both the general and specialized pathways of intracellular cholesterol trafficking known to date...
  11. ncbi request reprint Elevated HDL cholesterol is functionally ineffective in cardiac transplant recipients: evidence for impaired reverse cholesterol transport
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Transplantation 81:361-6. 2006
    ..Cardiac transplant recipients frequently have high plasma HDL levels but it is unclear whether these promote a cardioprotective profile...
  12. ncbi request reprint Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties
    A Hoang
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Diabetologia 50:1770-9. 2007
    ..However, the precise mechanisms remain to be established. In the present study, we examined whether AGE modification of apolipoprotein A-I (apoA-I) affects its functionality, thus altering its cardioprotective profile...
  13. doi request reprint Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo
    Nigora Mukhamedova
    BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Lipid Res 49:2312-22. 2008
    ..We conclude that pathways of cholesterol efflux using apoA-I as an acceptor make a predominant contribution to cholesterol export from macrophages in vivo...
  14. ncbi request reprint The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux
    Nigora Mukhamedova
    Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008 Australia
    Biochemistry 46:9388-98. 2007
    ..We conclude that a site on the first extracellular loop is required for cholesterol efflux, whereas a site on the fourth extracellular loop may be responsible for ABCA1 stability...
  15. pmc 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice
    Marcelo J A Amar
    Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pharmacol Exp Ther 334:634-41. 2010
    ..In summary, 5A promotes cholesterol efflux both in vitro and in vivo and reduces atherosclerosis in apoE-KO mice, indicating that it may be a useful alternative to apoA-I for HDL therapy...
  16. pmc HIV infection and high density lipoprotein metabolism
    Honor Rose
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 199:79-86. 2008
    ..Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directing cholesterol to the apoB-containing lipoproteins and likely reducing the functionality of reverse cholesterol transport...
  17. doi request reprint High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circulation 119:2103-11. 2009
    ..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
  18. doi request reprint Cholesterol efflux from macrophages is influenced differentially by plasmas from overweight insulin-sensitive and -resistant subjects
    P Nestel
    Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Int J Obes (Lond) 36:407-13. 2012
    ..We investigated whether cholesterol efflux from macrophages incubated with plasmas from overweight/obese subjects with metabolic syndrome was influenced by the presence of insulin resistance...
  19. ncbi request reprint Effectivity of expression of mature forms of mutant human apolipoprotein A-I
    D Sviridov
    Baker Medical Research Institute, Melbourne, Victoria, 8008, Australia
    Protein Expr Purif 17:231-8. 1999
    ..These results demonstrate that at least in the model of insect cells, the efficiency of apoA-I synthesis, processing, and secretion depends on apoA-I secondary structure and/or folding...
  20. ncbi request reprint Characterization of the maturation of human pro-apolipoprotein A-I in an in vitro model
    L E Pyle
    Baker Medical Research Institute, Melbourne, Victoria, 3008, Australia
    Biochemistry 40:3101-8. 2001
    ..Thus, residues within -2 to +4 are involved in forming the cleavage site for the maturation enzyme. The reaction of maturation is inhibited by metalloprotease inhibitors and is dependent upon calcium...
  21. ncbi request reprint The anti inflammatory effects of high density lipoproteins
    A J Murphy
    Baker IDI Heart and Diabetes Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, 8008 VIC, Australia
    Curr Med Chem 16:667-75. 2009
    ....
  22. ncbi request reprint The effect of cholesteryl ester transfer protein overexpression and inhibition on reverse cholesterol transport
    Urbain Tchoua
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Cardiovasc Res 77:732-9. 2008
    ..Cholesteryl ester transfer protein (CETP) has a well-established role in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear...
  23. ncbi request reprint High-density lipoprotein reduces the human monocyte inflammatory response
    Andrew J Murphy
    Laboratories of Vascular Pharmacology, Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 28:2071-7. 2008
    ..Whereas the anti-inflammatory effects of high-density lipoprotein (HDL) on endothelial cells are well described, such effects on monocytes are less studied...
  24. pmc Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides
    Amar A Sethi
    Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1508, USA
    J Biol Chem 283:32273-82. 2008
    ..03)). In summary, we describe a novel bihelical peptide with asymmetry in the lipid affinity of its helices and properties similar to apoA-I in terms of specificity for cholesterol efflux by the ABCA1 transporter and low cytotoxicity...
  25. doi request reprint Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque
    James A Shaw
    Department of Cardiovascular Medicine, Alfred Hospital Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central 8008, Australia
    Circ Res 103:1084-91. 2008
    ..These changes may contribute to the cardioprotective effects of HDL...
  26. ncbi request reprint HIV infection and high-density lipoprotein: the effect of the disease vs the effect of treatment
    Honor Rose
    Baker Heart Research Institute, Melbourne 3004, Australia
    Metabolism 55:90-5. 2006
    ..These data suggest that hypoalphalipoproteinemia in patients with HIV is likely to be secondary to HIV infection itself...
  27. ncbi request reprint Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux
    Anna C Calkin
    Diabetes Complications Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Australia 8008
    Circulation 120:2095-104. 2009
    ..Reconstituted high-density lipoprotein (rHDL) has short-term beneficial effects on atherosclerotic plaques, but whether it can effectively reduce the reactivity of diabetic platelets is not known...
  28. ncbi request reprint Genetic factors affecting HDL levels, structure, metabolism and function
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 18:157-63. 2007
    ..The present review focuses on various approaches to establish genetic determinants of the HDL concentration, structure and function...
  29. pmc Structure/function relationships of apolipoprotein a-I mimetic peptides: implications for antiatherogenic activities of high-density lipoprotein
    Wilissa D'Souza
    Baker Heart and Diabetes Institute, PO Box 6492, St Kilda Rd, Melbourne 8008, Australia
    Circ Res 107:217-27. 2010
    ..Apolipoprotein (apoA)-I mimetic peptides are a promising type of anti-atherosclerosis therapy, but how the structural features of these peptides relate to the multiple antiatherogenic functions of HDL is poorly understood...
  30. ncbi request reprint Structure-function studies of apoA-I variants: site-directed mutagenesis and natural mutations
    Dmitri Sviridov
    Baker Medical Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    J Lipid Res 43:1283-92. 2002
    ....
  31. doi request reprint Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models
    H Low
    Baker Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Diabetologia 55:2513-21. 2012
    ..We investigated the contribution of AGEs to the impairment of reverse cholesterol transport (RCT) variables in diabetic individuals and in two animal models of diabetic obesity and of renal impairment...
  32. pmc Antiretroviral compounds and cholesterol efflux from macrophages
    Nigora Mukhamedova
    BakerIDI Heart and Diabetes Institute, Melbourne, Australia
    Atherosclerosis 206:439-43. 2009
    ..The objective of this study was to assess the effect of various classes of anti-HIV drugs on cellular cholesterol efflux...
  33. ncbi request reprint Physical fitness and reverse cholesterol transport
    Beata Olchawa
    Baker Heart Research Institute, Wynn Domain, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 24:1087-91. 2004
    ..The most consistent effect of exercise on lipoprotein metabolism is an increase in high-density lipoprotein (HDL)...
  34. ncbi request reprint Natural mutations of apolipoprotein A-I impairing activation of lecithin:cholesterol acyltransferase
    Anh Hoang
    Wynn Domain, Baker Medical Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne VIC 8008, Australia
    Biochim Biophys Acta 1631:72-6. 2003
    ....
  35. pmc A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis
    Ian Smyth
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    PLoS Genet 4:e1000192. 2008
    ..Furthermore, we identify Abca12 as a mediator of Abca1-regulated cellular cholesterol efflux, a finding that may have significant implications for other diseases of lipid metabolism and homeostasis, including atherosclerosis...
  36. ncbi request reprint ABCA1 expression in humans is associated with physical activity and alcohol consumption
    Anh Hoang
    Baker Heart Research Institute, Commercial Road, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 197:197-203. 2008
    ..In conclusion, ABCA1 expression in human leukocytes and muscle is associated with physical activity and alcohol consumption, respectively...
  37. ncbi request reprint Expression of caveolin-1 enhances cholesterol efflux in hepatic cells
    Ying Fu
    Wynn Domain, Baker Heart Research Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 279:14140-6. 2004
    ..We conclude that overexpression of caveolin-1 in hepatic cells stimulates cholesterol efflux by enhancing transfer of cholesterol to cholesterol-rich domains in the plasma membrane...
  38. ncbi request reprint Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages
    Genevieve Escher
    Baker Heart Research Institute, Melbourne, Victoria, 8008, Australia
    J Lipid Res 46:356-65. 2005
    ..However, transfection with CYP27A1 led to a 2- to 4-fold increase of cholesterol efflux. We conclude that treatment with 5-azacytidine can be used for high-efficiency transient transfection of macrophages...
  39. ncbi request reprint Indices of reverse cholesterol transport in subjects with metabolic syndrome after treatment with rosuvastatin
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 197:732-9. 2008
    ..The effects of the statin, rosuvastatin on indices of reverse cholesterol transport were studied in a randomized, placebo-controlled, cross-over trial in 25 overweight subjects with defined metabolic syndrome...
  40. ncbi request reprint Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux
    Genevieve Escher
    Wynn Domain, Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 278:11015-9. 2003
    ..Expression of CYP27A1 in CHOP cells did not affect ABCA1 expression and abundance of ABCA1 protein. Thus, introduction of CYP27A1 into cells stimulates cholesterol efflux and therefore may increase protection against atherosclerosis...
  41. doi request reprint Impact of freezing on high-density lipoprotein functionality
    J Rajinda Kekulawala
    Baker Heart Research Institute, Melbourne, VIC 8008, Australia
    Anal Biochem 379:213-5. 2008
    ..Freezing also resulted in approximately 10% loss of HDL in the samples. We conclude that freezing HDL in the presence of 10% sucrose preserves its structural and functional properties...
  42. pmc HDL-replacement therapy: mechanism of action, types of agents and potential clinical indications
    Alan T Remaley
    National Institutes of Health, Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 21508, USA
    Expert Rev Cardiovasc Ther 6:1203-15. 2008
    ..Finally, HDL-replacement therapy will be put into perspective by summarizing the current gaps in our knowledge of HDL metabolism and identifying challenges for future research in this area...
  43. pmc HIV and cardiovascular disease: contribution of HIV-infected macrophages to development of atherosclerosis
    Michael Bukrinsky
    PLoS Med 4:e43. 2007
  44. pmc Human immunodeficiency virus impairs reverse cholesterol transport from macrophages
    Zahedi Mujawar
    The George Washington University, Washington, District of Columbia, USA
    PLoS Biol 4:e365. 2006
    ....
  45. pmc Dose-dependent regulation of high-density lipoprotein metabolism with rosuvastatin in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia 6847, Australia
    J Clin Endocrinol Metab 93:430-7. 2008
    ..Rosuvastatin has been shown to increase HDL cholesterol concentration, but the mechanisms remain unclear...
  46. ncbi request reprint Human immunodeficiency virus infection and macrophage cholesterol metabolism
    Michael Bukrinsky
    Department of Microbiology, Immunology and Tropical Medicine, 2300 I St, N W, Ross Hall, Rm 234, Washington, DC 20037, USA
    J Leukoc Biol 80:1044-51. 2006
    ..Further elucidation of the mechanisms connecting viral infection and macrophage cholesterol metabolism may be fruitful for developing approaches to treatment of atherosclerosis and viral diseases...
  47. pmc Dose-dependent effect of rosuvastatin on VLDL-apolipoprotein C-III kinetics in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, Universityof Western Australia, Perth, Western Australia
    Diabetes Care 31:1656-61. 2008
    ..This study investigated the dose-dependent effect of rosuvastatin on VLDL apoC-III transport in men with the metabolic syndrome...