Paul Nestel

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint Fish oil and cardiovascular disease: lipids and arterial function
    P J Nestel
    Cardiovascular Nutrition Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Am J Clin Nutr 71:228S-31S. 2000
  2. ncbi request reprint Nutritional aspects in the causation and management of the metabolic syndrome
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, Commercial Road, Prahan 3181, Melbourne, Victoria, Australia
    Endocrinol Metab Clin North Am 33:483-92, v. 2004
  3. ncbi request reprint Metabolic syndrome: the new cardiovascular target
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, PO Box 6492 St Kilda Rd Central, Melbourne 8008, Australia
    Curr Opin Lipidol 15:1-3. 2004
  4. ncbi request reprint Relation of diet to cardiovascular disease risk factors in subjects with cardiovascular disease in Australia and New Zealand: analysis of the Long-Term Intervention with Pravastatin in Ischaemic Disease trial
    Paul J Nestel
    Baker Heart Research Institute, Melbourne, Australia
    Am J Clin Nutr 81:1322-9. 2005
  5. ncbi request reprint Effects of long-term consumption and single meals of chickpeas on plasma glucose, insulin, and triacylglycerol concentrations
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Am J Clin Nutr 79:390-5. 2004
  6. ncbi request reprint Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine
    Paul J Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Atherosclerosis 171:83-6. 2003
  7. ncbi request reprint Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects
    P J Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Eur J Clin Nutr 59:1059-63. 2005
  8. ncbi request reprint Metabolic syndrome: recent prevalence in East and Southeast Asian populations
    Paul Nestel
    Baker Heart Research Institute, PO Box 6492, St Kilda Central, Melbourne, 8008, Australia
    Asia Pac J Clin Nutr 16:362-7. 2007
  9. ncbi request reprint Isoflavones: their effects on cardiovascular risk and functions
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Curr Opin Lipidol 14:3-8. 2003
  10. ncbi request reprint The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans
    Paul Nestel
    Laboratory of Cardiovascular Nutrition, Baker Medical Research Institute, Melbourne, Australia
    Am J Clin Nutr 76:326-30. 2002

Detail Information

Publications44

  1. ncbi request reprint Fish oil and cardiovascular disease: lipids and arterial function
    P J Nestel
    Cardiovascular Nutrition Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Am J Clin Nutr 71:228S-31S. 2000
    ..Future trials will be needed to determine minimum effective dosages of eicosapentaenoic and docosahexaenoic acids over lengthy periods and to show cardiovascular disease reduction through intervention...
  2. ncbi request reprint Nutritional aspects in the causation and management of the metabolic syndrome
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, Commercial Road, Prahan 3181, Melbourne, Victoria, Australia
    Endocrinol Metab Clin North Am 33:483-92, v. 2004
    ....
  3. ncbi request reprint Metabolic syndrome: the new cardiovascular target
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, PO Box 6492 St Kilda Rd Central, Melbourne 8008, Australia
    Curr Opin Lipidol 15:1-3. 2004
  4. ncbi request reprint Relation of diet to cardiovascular disease risk factors in subjects with cardiovascular disease in Australia and New Zealand: analysis of the Long-Term Intervention with Pravastatin in Ischaemic Disease trial
    Paul J Nestel
    Baker Heart Research Institute, Melbourne, Australia
    Am J Clin Nutr 81:1322-9. 2005
    ..Patients in Australia and New Zealand (n = 9014) who participated in a large secondary prevention trial had significantly different CHD mortality rates...
  5. ncbi request reprint Effects of long-term consumption and single meals of chickpeas on plasma glucose, insulin, and triacylglycerol concentrations
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Am J Clin Nutr 79:390-5. 2004
    ..Legumes are recommended for better glucose control in persons with diabetes. Whether subjects with normal insulin sensitivity would also benefit from legume consumption is not clear...
  6. ncbi request reprint Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine
    Paul J Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Atherosclerosis 171:83-6. 2003
    ..Adjustment for confounders (age, arterial pressure, BMI, LDL cholesterol) did not affect conclusions. Thus, arterial stiffness in the central elastic arterial system increased rapidly at high plasma homocysteine concentrations...
  7. ncbi request reprint Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects
    P J Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Eur J Clin Nutr 59:1059-63. 2005
    ..To determine whether dairy fat in cheese raises low-density lipoprotein (LDL) cholesterol as much as in butter, since epidemiology suggests a different impact on cardiovascular disease...
  8. ncbi request reprint Metabolic syndrome: recent prevalence in East and Southeast Asian populations
    Paul Nestel
    Baker Heart Research Institute, PO Box 6492, St Kilda Central, Melbourne, 8008, Australia
    Asia Pac J Clin Nutr 16:362-7. 2007
    ..The prevalence of the metabolic syndrome among a number of Asian populations as defined by several current criteria has been increasing rapidly and appears to resemble that among Western populations...
  9. ncbi request reprint Isoflavones: their effects on cardiovascular risk and functions
    Paul Nestel
    Baker Heart Research Institute Wynn Domain, Melbourne, Australia
    Curr Opin Lipidol 14:3-8. 2003
    ..Their similarity to steroidal oestrogens has stimulated research into potential cardiovascular benefits. The two major areas, those of lipid lowering and of improved vascular function, are reviewed...
  10. ncbi request reprint The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans
    Paul Nestel
    Laboratory of Cardiovascular Nutrition, Baker Medical Research Institute, Melbourne, Australia
    Am J Clin Nutr 76:326-30. 2002
    ..SAC, which reflects arterial elasticity, is emerging as a new cardiovascular risk factor and appears to predict future cardiovascular events...
  11. ncbi request reprint An isoflavone metabolite reduces arterial stiffness and blood pressure in overweight men and postmenopausal women
    Paul Nestel
    Baker Heart Research Institute Wynm Domain, Melbourne, Australia
    Atherosclerosis 192:184-9. 2007
    ..The effect of supplemental trans-tetrahydrodaidzein (THD) a metabolite of daidzein on pulse wave velocity (PWV), a measure of arterial stiffness was tested in overweight men and postmenopausal women...
  12. ncbi request reprint Relationship between arterial stiffness and glucose metabolism in women with metabolic syndrome
    Paul Nestel
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 33:883-6. 2006
    ..5. In conclusion, in post-menopausal women with metabolic syndrome, fasting plasma glucose and systolic blood pressure, and possibly HbA1c and the 2 h glucose post-glucose load, predicted increased arterial stiffness...
  13. ncbi request reprint Post-prandial remnant lipids impair arterial compliance
    P J Nestel
    Baker Medical Research Institute, Melbourne, Australia
    J Am Coll Cardiol 37:1929-35. 2001
    ..We sought to examine the effects of plasma lipids, especially in remnants after a fat meal, on systemic arterial compliance (SAC), a newly recognized cardiovascular risk factor...
  14. ncbi request reprint Effects of fish oils and fish on cardiovascular disease
    P Nestel
    Baker Medical Research Institute, PO Box 6492, St Kilda Road, Central Melbourne 8008, Australia
    Curr Atheroscler Rep 3:68-73. 2001
    ..Thus, the triad of evidence comprising epidemiology, biologic plausibility, and interventional success through a randomized, controlled trial has been established...
  15. ncbi request reprint The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice
    Paul Nestel
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 189:282-7. 2006
    ..In this study, the major naturally occurring CLA isomer (cis-9,trans-11) was tested in an atherosclerosis-prone mouse model...
  16. doi request reprint A novel antioxidant 3,7-dihydroxy-isoflav-3-ene (DHIF) inhibits neointimal hyperplasia after vessel injury attenuating reactive oxygen species and nuclear factor-kappaB signaling
    Peter Kanellakis
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Atherosclerosis 204:66-72. 2009
    ..DHIF's ability to attenuate NF-kappaB activation suggests that it may not only be useful in preventing restenosis but also in attenuating atherosclerosis...
  17. ncbi request reprint Elevated HDL cholesterol is functionally ineffective in cardiac transplant recipients: evidence for impaired reverse cholesterol transport
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Transplantation 81:361-6. 2006
    ..Cardiac transplant recipients frequently have high plasma HDL levels but it is unclear whether these promote a cardioprotective profile...
  18. ncbi request reprint Indices of reverse cholesterol transport in subjects with metabolic syndrome after treatment with rosuvastatin
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Australia
    Atherosclerosis 197:732-9. 2008
    ..The effects of the statin, rosuvastatin on indices of reverse cholesterol transport were studied in a randomized, placebo-controlled, cross-over trial in 25 overweight subjects with defined metabolic syndrome...
  19. doi request reprint Mechanism of cholesterol efflux in humans after infusion of reconstituted high-density lipoprotein
    Anh Hoang
    Baker Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Eur Heart J 33:657-65. 2012
    ....
  20. ncbi request reprint Physical fitness and reverse cholesterol transport
    Beata Olchawa
    Baker Heart Research Institute, Wynn Domain, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 24:1087-91. 2004
    ..The most consistent effect of exercise on lipoprotein metabolism is an increase in high-density lipoprotein (HDL)...
  21. ncbi request reprint Statins and metabolism of high density lipoprotein
    Dmitri Sviridov
    Baker Heart Research Institute, Commercial Rd, Central, Melbourne, Vic, 8008, Australia
    Cardiovasc Hematol Agents Med Chem 5:215-21. 2007
    ..In this review we analyze what is currently known about effect of statins on HDL metabolism and on reverse cholesterol transport in particular...
  22. doi request reprint Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
    ..Glucose ingestion stimulates sympathetic nervous system (SNS) activity in lean subjects, whereas blunted responses have been reported in the obese...
  23. ncbi request reprint Antiatherogenic functionality of high density lipoprotein: how much versus how good
    Dmitri Sviridov
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Atheroscler Thromb 15:52-62. 2008
    ..A single common denominator reflecting the multiple HDL functions is yet to be found and may not exist leaving direct measurements of each HDL function as the way to assess atheroprotective capacity of HDL...
  24. ncbi request reprint Single session exercise stimulates formation of pre beta 1-HDL in leg muscle
    Dmitri Sviridov
    Wynn Domain, Baker Medical Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Lipid Res 44:522-6. 2003
    ..In the combined population, formation of pre beta 1-HDL at rest was 9.9 +/- 5.2 mg/min and exercise enhanced pre beta 1-HDL formation 6.6-fold in both groups...
  25. ncbi request reprint Dynamics of reverse cholesterol transport: protection against atherosclerosis
    Dmitri Sviridov
    Baker Medical Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 161:245-54. 2002
    ..The particular role of pre-beta(1)-HDL is reviewed drawing attention to the relationship between its concentration and the flux of cholesterol through the RCT system...
  26. pmc Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
    ..The purpose of this study was to examine the effects of weight loss on sympathetic nervous system responsiveness to glucose ingestion in obese subjects with metabolic syndrome, in whom such responses are reportedly blunted...
  27. ncbi request reprint Genetic factors affecting HDL levels, structure, metabolism and function
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 18:157-63. 2007
    ..The present review focuses on various approaches to establish genetic determinants of the HDL concentration, structure and function...
  28. ncbi request reprint Management of dyslipidaemia in patients with type 2 diabetes in Australian primary care
    Merlin C Thomas
    Baker Heart Research Institute, Melbourne, Vic
    Med J Aust 186:128-30. 2007
    ..To examine the frequency of dyslipidaemia and treatment with lipid-lowering drugs in patients with type 2 diabetes managed in Australian primary care...
  29. ncbi request reprint Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome
    Nora E Straznicky
    Cardiovascular Nutrition Laboratory, Wynn Domain, Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 90:5998-6005. 2005
    ....
  30. pmc Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
    ..This study was conducted to examine the effects of lifestyle interventions (weight loss alone or together with exercise) on SNS function...
  31. ncbi request reprint Absorption in humans of isoflavones from soy and red clover is similar
    Nobuyo Tsunoda
    Baker Medical Research Institute, Melbourne, Australia
    J Nutr 132:2199-201. 2002
    ..Although interindividual variability was high, there was less intraindividual variability; the amounts excreted when subjects consumed the two sources of isoflavone were correlated (r = 0.69; P = 0.007)...
  32. ncbi request reprint Angioplasty-induced superoxide anions and neointimal hyperplasia in the rabbit carotid artery: suppression by the isoflavone trans-tetrahydrodaidzein
    Peter Kanellakis
    Cell Biology Laboratory, Baker Heart Research Institute, AMREP, Alfred Hospital Campus, P O Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 176:63-72. 2004
    ..Strategies using such isoflavones may be useful for preventing restenosis after vascular manipulations in humans...
  33. ncbi request reprint Delineation of the role of pre-beta 1-HDL in cholesterol efflux using isolated pre-beta 1-HDL
    Dmitri Sviridov
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 22:1482-8. 2002
    ....
  34. ncbi request reprint The role of fats in the lifecycle stages. Adulthood--prevention: cardiovascular disease
    Paul J Nestel
    Cardiovascular Nutrition Laboratory, Baker Medical Research Institute, Prahran, VIC 3181, Australia
    Med J Aust 176:S118-9. 2002
    ....
  35. ncbi request reprint Management of dyslipidaemia - evidence and practical recommendations
    Paul J Nestel
    Cardiovascular Nutrition Laboratory, Baker Heart Research Institute, Melbourne, Victoria
    Aust Fam Physician 37:521-7. 2008
    ..Dyslipidaemia is a common condition managed in general practice...
  36. pmc Dose-dependent effect of rosuvastatin on VLDL-apolipoprotein C-III kinetics in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, Universityof Western Australia, Perth, Western Australia
    Diabetes Care 31:1656-61. 2008
    ..This study investigated the dose-dependent effect of rosuvastatin on VLDL apoC-III transport in men with the metabolic syndrome...
  37. ncbi request reprint Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women
    Helena J Teede
    Vascular Research Group, Department of Medicine, Monash University, Clayton, Australia
    Arterioscler Thromb Vasc Biol 23:1066-71. 2003
    ..This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin...
  38. doi request reprint The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study
    Malcolm J West
    University of Queensland, Brisbane, Australia
    Eur Heart J 29:923-31. 2008
    ....
  39. ncbi request reprint Dietary plant sterols supplementation does not alter lipoprotein kinetics in men with the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Perth, Western Australia 6847, Australia
    Asia Pac J Clin Nutr 16:624-31. 2007
    ..Future studies with larger sample size, stratification to low and high cholesterol absorbers and cholesterol balance studies are warranted...
  40. ncbi request reprint Dose-dependent effect of rosuvastatin on apolipoprotein B-100 kinetics in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia
    Atherosclerosis 197:139-46. 2008
    ..Higher dose rosuvastatin may also decrease LDL apoB production. The findings provide a dose-related mechanism for the benefits of rosuvastatin on cardiovascular disease in the metabolic syndrome...
  41. ncbi request reprint A 1,3-diacylglycerol-rich oil induces less atherosclerosis and lowers plasma cholesterol in diabetic apoE-deficient mice
    Akihiko Fujii
    Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 312 3497, Japan
    Atherosclerosis 193:55-61. 2007
    ....
  42. pmc Dose-dependent regulation of high-density lipoprotein metabolism with rosuvastatin in the metabolic syndrome
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia 6847, Australia
    J Clin Endocrinol Metab 93:430-7. 2008
    ..Rosuvastatin has been shown to increase HDL cholesterol concentration, but the mechanisms remain unclear...
  43. ncbi request reprint The isoflavone metabolite cis-tetrahydrodaidzein inhibits ERK-1 activation and proliferation in human vascular smooth muscle cells
    Shanhong Ling
    Hormones and the Vasculature Laboratory, Baker Medical Research Institute, Melbourne, Australia
    J Cardiovasc Pharmacol 43:622-8. 2004
    ..Thus, the isoflavone metabolite cis-THD inhibits PDGF-induced ERK-1 activation and cell proliferation in human VSMC, suggesting a potential beneficial effect in cardiovascular protection...
  44. ncbi request reprint White blood cell count predicts reduction in coronary heart disease mortality with pravastatin
    Ralph A H Stewart
    Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
    Circulation 111:1756-62. 2005
    ....