Michelle L Baker
- Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoireMichelle L Baker
CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria, 3220, Australia
Immunogenetics 62:173-84. 2010....
- Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencingChristopher Cowled
CSIRO Australian Animal Health Laboratory, 5 Portarlington Rd, Geelong East, Victoria 3220, Australia
BMC Genomics 15:682. 2014..MicroRNAs are a major mechanism of post-transcriptional gene regulation, however very little is known about them in bats...
- Type III IFN receptor expression and functional characterisation in the pteropid bat, Pteropus alectoPeng Zhou
Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria, Australia
PLoS ONE 6:e25385. 2011..To our knowledge, this report represents the first description of an IFN receptor in any species of bat. The responsiveness of bat cells to IFN-λ support a role for the type III IFN system by epithelial and immune cells in bats...
- Antiviral immune responses of bats: a reviewM L Baker
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Vic, Australia
Zoonoses Public Health 60:104-16. 2013..These observations warrant further investigation to determine whether such differences are associated with the asymptomatic nature of viral infections in bats...
- The immune gene repertoire of an important viral reservoir, the Australian black flying foxAnthony T Papenfuss
The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia
BMC Genomics 13:261. 2012..In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity...
- Bat Mx1 and Oas1, but not Pkr are highly induced by bat interferon and viral infectionPeng Zhou
CSIRO Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
Dev Comp Immunol 40:240-7. 2013..Our results have important implications for the different roles of ISGs in bats and provide the first step in understanding the role of these molecules in the ability of bats to coexist with viruses...
- Interferon production and signaling pathways are antagonized during henipavirus infection of fruit bat cell linesElena R Virtue
Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Australia
PLoS ONE 6:e22488. 2011..This is the first report of henipavirus infection in bat cells specifically investigating aspects of the innate immune system...
- Type III IFNs in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunityPeng Zhou
Commonwealth Scientific and Industrial Research Organization Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
J Immunol 186:3138-47. 2011..These results may have important implications for the role of type III IFNs in the ability of bats to coexist with viruses...
- Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alectoVijaya Janardhana
CSIRO Livestock Industries, Australian Animal Health Laboratory, P O Bag 24, Geelong, VIC 3220, Australia
Dev Comp Immunol 36:610-8. 2012..alecto cells. These results provide the first evidence for an antiviral role for bat IFNγin vitro in addition to the application of important immunological reagents for further studies of bat antiviral immunity...
- Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alectoChristopher Cowled
CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Rd, East Geelong, Victoria 3220, Australia
Dev Comp Immunol 36:657-64. 2012..alecto. This study provides the foundation for further investigations into the interactions between bat RIG-I-like helicases and viruses to elucidate the mechanisms responsible for the asymptomatic nature of viral infections in bats...
- Studying immunity to zoonotic diseases in the natural host - keeping it realAndrew G D Bean
CSIRO Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
Nat Rev Immunol 13:851-61. 2013..Such studies will not only lead to a greater understanding of how these infections induce variable disease and immune responses in distinct species but also offer important insights into the evolution of mammalian immune systems. ..
- Purification and characterisation of immunoglobulins from the Australian black flying fox (Pteropus alecto) using anti-fab affinity chromatography reveals the low abundance of IgAJames W Wynne
Australian Animal Health Laboratory, CSIRO Animal, Food and Health Sciences, Geelong, Victoria, Australia
PLoS ONE 8:e52930. 2013..Knowledge and reagents developed within this study can be used in the future to examine class-specific antibody response within this important viral host...